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Items: 1 to 50 of 217

1.

A novel pharmacological strategy by PTEN inhibition for improving metabolic resuscitation and survival after mouse cardiac arrest.

Li J, Wang H, Zhong Q, Zhu X, Chen SJ, Qian Y, Costakis J, Bunney G, Beiser DG, Leff AR, Lewandowski ED, ÓDonnell JM, Vanden Hoek TL.

Am J Physiol Heart Circ Physiol. 2015 Jun 1;308(11):H1414-22. doi: 10.1152/ajpheart.00748.2014. Epub 2015 Mar 20.

2.

TAT-protein blockade during ischemia/reperfusion reveals critical role for p85 PI3K-PTEN interaction in cardiomyocyte injury.

Zhu X, Shao ZH, Li C, Li J, Zhong Q, Learoyd J, Meliton A, Meliton L, Leff AR, Vanden Hoek TL.

PLoS One. 2014 Apr 21;9(4):e95622. doi: 10.1371/journal.pone.0095622. eCollection 2014.

3.

Mechanical induction of group V phospholipase A(2) causes lung inflammation and acute lung injury.

Meliton AY, Muñoz NM, Meliton LN, Birukova AA, Leff AR, Birukov KG.

Am J Physiol Lung Cell Mol Physiol. 2013 May 15;304(10):L689-700. doi: 10.1152/ajplung.00047.2013. Epub 2013 Mar 22.

4.

Group V phospholipase A(2) increases pulmonary endothelial permeability through direct hydrolysis of the cell membrane.

Muñoz NM, Desai A, Meliton LN, Meliton AY, Zhou T, Leff AR, Dudek SM.

Pulm Circ. 2012 Apr-Jun;2(2):182-92. doi: 10.4103/2045-8932.97604.

5.

Inhibition of Pyk2 blocks lung inflammation and injury in a mouse model of acute lung injury.

Duan Y, Learoyd J, Meliton AY, Leff AR, Zhu X.

Respir Res. 2012 Jan 18;13:4. doi: 10.1186/1465-9921-13-4.

6.

Therapeutic hypothermia cardioprotection in murine hemorrhagic shock/resuscitation differentially affects p38α/p38γ, Akt, and HspB1.

Li J, Beiser DG, Wang H, Das A, Berdyshev E, Li J, Leff AR, Stern SA, Vanden Hoek TL.

J Trauma. 2011 Nov;71(5):1262-70. doi: 10.1097/TA.0b013e31821280c5.

PMID:
22071928
7.

The "other" airway.

Leff AR.

Proc Am Thorac Soc. 2011 Mar;8(1):29. No abstract available.

PMID:
21364217
8.

Hematopoietic Pyk2 regulates migration of differentiated HL-60 cells.

Wang L, Learoyd J, Duan Y, Leff AR, Zhu X.

J Inflamm (Lond). 2010 May 27;7:26. doi: 10.1186/1476-9255-7-26.

9.

Group V phospholipase A2 mediates barrier disruption of human pulmonary endothelial cells caused by LPS in vitro.

Dudek SM, Muñoz NM, Desai A, Osan CM, Meliton AY, Leff AR.

Am J Respir Cell Mol Biol. 2011 Mar;44(3):361-8. doi: 10.1165/rcmb.2009-0446OC. Epub 2010 May 6.

10.

Cytosolic group IVa phospholipase A2 mediates IL-8/CXCL8-induced transmigration of human polymorphonuclear leukocytes in vitro.

Meliton AY, Muñoz NM, Meliton LN, Binder DC, Osan CM, Zhu X, Dudek SM, Leff AR.

J Inflamm (Lond). 2010 Mar 18;7:14. doi: 10.1186/1476-9255-7-14.

11.

Impact factor and its role in academic promotion.

Brusasco V, Dinh-Xuan AT, Leff AR, Adler KB, Glenny RW, Dempsey JA, Levy ML, Panettieri R, Reddel HK, Singh D, Virchow JC.

Eur Respir J. 2009 Dec;34(6):1499-500. doi: 10.1183/09031936.00094109. No abstract available.

12.

Leukotriene D4 activates {beta}2-integrin adhesion in human polymorphonuclear leukocytes.

Meliton AY, Muñoz NM, Osan CM, Meliton LN, Leff AR.

Eur Respir J. 2010 Feb;35(2):402-9. doi: 10.1183/09031936.00009309. Epub 2009 Aug 13.

13.

Impact factor and its role in academic promotion.

Leff AR.

Proc Am Thorac Soc. 2009 Aug 1;6(4):337. doi: 10.1513/pats.200906-038ED. No abstract available.

PMID:
19675343
14.

Inhibition of Pyk2 blocks airway inflammation and hyperresponsiveness in a mouse model of asthma.

Duan Y, Learoyd J, Meliton AY, Clay BS, Leff AR, Zhu X.

Am J Respir Cell Mol Biol. 2010 Apr;42(4):491-7. doi: 10.1165/rcmb.2008-0469OC. Epub 2009 Jun 11.

15.

Secretory group V phospholipase A2 regulates acute lung injury and neutrophilic inflammation caused by LPS in mice.

Muñoz NM, Meliton AY, Meliton LN, Dudek SM, Leff AR.

Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L879-87. doi: 10.1152/ajplung.90580.2008. Epub 2009 Mar 13.

16.

The ATS journals' policy on image manipulation.

Abraham E, Adler KB, Shapiro SD, Leff AR.

Proc Am Thorac Soc. 2008 Dec 15;5(9):869. doi: 10.1513/pats.200809-106ED. No abstract available.

PMID:
19056709
17.

Foreword: "The Big Three".

Rennard SI, Higenbottam T, Leff AR.

Proc Am Thorac Soc. 2008 Dec 1;5(8):795. doi: 10.1513/pats.200807-061TH. No abstract available.

PMID:
19017731
18.

The ATS Journals' policy on image manipulation.

Abraham E, Adler KB, Shapiro SD, Leff AR.

Am J Respir Cell Mol Biol. 2008 Nov;39(5):499. doi: 10.1165/rcmb.2008-0010ED. No abstract available.

PMID:
18927351
19.

Proline-rich tyrosine kinase 2 regulates spreading and migration of eosinophils after beta2-integrin adhesion.

Zhu X, Boetticher E, Wang L, Duan Y, Learoyd J, Leff AR.

Am J Respir Cell Mol Biol. 2008 Sep;39(3):263-9. doi: 10.1165/rcmb.2008-0047OC. Epub 2008 Mar 26.

20.

Future treatment to lessen exacerbations of chronic obstructive pulmonary disease.

Leff AR, Muñoz NM.

Proc Am Thorac Soc. 2007 Dec;4(8):659-66. Review. Erratum in: Proc Am Thorac Soc. 2008 Feb 15;5(2):283-4.

PMID:
18073398
21.
22.

Blockade of avidity and focal clustering of beta 2-integrin by cysteinyl leukotriene antagonism attenuates eosinophil adhesion.

Meliton AY, Munoz NM, Leff AR.

J Allergy Clin Immunol. 2007 Dec;120(6):1316-23. Epub 2007 Sep 29.

PMID:
17904626
23.

Deletion of secretory group V phospholipase A2 attenuates cell migration and airway hyperresponsiveness in immunosensitized mice.

Muñoz NM, Meliton AY, Arm JP, Bonventre JV, Cho W, Leff AR.

J Immunol. 2007 Oct 1;179(7):4800-7.

25.

Racemic = R enantiomer: a dual citation.

Leff AR.

Am J Respir Crit Care Med. 2007 Mar 15;175(6):628; author reply 628-9. No abstract available.

PMID:
17341650
26.

Lysophosphatidic acid induces interleukin-13 (IL-13) receptor alpha2 expression and inhibits IL-13 signaling in primary human bronchial epithelial cells.

Zhao Y, He D, Zhao J, Wang L, Leff AR, Spannhake EW, Georas S, Natarajan V.

J Biol Chem. 2007 Apr 6;282(14):10172-9. Epub 2007 Feb 6.

27.

Regulation of eosinophil adhesion by lysophosphatidylcholine via a non-store-operated Ca2+ channel.

Zhu X, Learoyd J, Butt S, Zhu L, Usatyuk PV, Natarajan V, Munoz NM, Leff AR.

Am J Respir Cell Mol Biol. 2007 May;36(5):585-93. Epub 2007 Jan 11.

28.

Phosphodiesterase 4 inhibition of beta2-integrin adhesion caused by leukotriene B4 and TNF-alpha in human neutrophils.

Meliton AY, Muñoz NM, Lambertino A, Boetticher E, Learoyd J, Zhu X, Leff AR.

Eur Respir J. 2006 Nov;28(5):920-8. Epub 2006 Jun 28.

29.

Transcellular secretion of group V phospholipase A2 from epithelium induces beta 2-integrin-mediated adhesion and synthesis of leukotriene C4 in eosinophils.

Muñoz NM, Meliton AY, Lambertino A, Boetticher E, Learoyd J, Sultan F, Zhu X, Cho W, Leff AR.

J Immunol. 2006 Jul 1;177(1):574-82.

30.

The unintended consequences of noble intentions to inform.

Leff AR, Shapiro SD, Abraham E.

Proc Am Thorac Soc. 2005;2(1):2-3. No abstract available.

PMID:
16113461
31.

The NIH Public Access Policy and ATS journals.

Abraham E, Shapiro SD, Leff AR.

Proc Am Thorac Soc. 2005;2(1):1-2. No abstract available.

PMID:
16113460
32.

Regulation of interleukin-5-induced beta2-integrin adhesion of human eosinophils by phosphoinositide 3-kinase.

Sano M, Leff AR, Myou S, Boetticher E, Meliton AY, Learoyd J, Lambertino AT, Munoz NM, Zhu X.

Am J Respir Cell Mol Biol. 2005 Jul;33(1):65-70. Epub 2005 Mar 31.

33.

The NIH Public Access Policy and ATS journals.

Abraham E, Shapiro SD, Leff AR.

Am J Respir Crit Care Med. 2005 Apr 1;171(7):671-2. No abstract available.

PMID:
15790862
34.

Glucocorticoid-induced surface expression of annexin 1 blocks beta2-integrin adhesion of human eosinophils to intercellular adhesion molecule 1 surrogate protein.

Liu J, Zhu X, Myo S, Lambertino AT, Xu C, Boetticher E, Muñoz NM, Sano M, Cordoba M, Learoyd J, Meliton A, Johnson M, Leff AR.

J Allergy Clin Immunol. 2005 Mar;115(3):493-500.

PMID:
15753895
35.

Radiofrequency ablation of airway smooth muscle for sustained treatment of asthma: preliminary investigations.

Cox PG, Miller J, Mitzner W, Leff AR.

Eur Respir J. 2004 Oct;24(4):659-63. Review.

36.

Reduction in airway hyperresponsiveness to methacholine by the application of RF energy in dogs.

Danek CJ, Lombard CM, Dungworth DL, Cox PG, Miller JD, Biggs MJ, Keast TM, Loomas BE, Wizeman WJ, Hogg JC, Leff AR.

J Appl Physiol (1985). 2004 Nov;97(5):1946-53. Epub 2004 Jul 16.

37.

Beta2-integrin adhesion caused by eotaxin but not IL-5 is blocked by PDE-4 inhibition and beta2-adrenoceptor activation in human eosinophils.

Liu J, Muñoz NM, Meliton AY, Zhu X, Lambertino AT, Xu C, Myo S, Myou S, Boetticher E, Johnson M, Leff AR.

Pulm Pharmacol Ther. 2004;17(2):73-9.

PMID:
15123228
38.

Additive blockade of beta 2-integrin adhesion of eosinophils by salmeterol and fluticasone propionate.

Myo S, Zhu X, Myou S, Meliton AY, Liu J, Boetticher E, Lambertino AT, Xu C, Muñoz NM, Leff AR.

Eur Respir J. 2004 Apr;23(4):511-7.

39.

Blockade of inflammation and airway hyperresponsiveness in immune-sensitized mice by dominant-negative phosphoinositide 3-kinase-TAT.

Myou S, Leff AR, Myo S, Boetticher E, Tong J, Meliton AY, Liu J, Munoz NM, Zhu X.

J Exp Med. 2003 Nov 17;198(10):1573-82.

40.

Activation of group IV cytosolic phospholipase A2 in human eosinophils by phosphoinositide 3-kinase through a mitogen-activated protein kinase-independent pathway.

Myou S, Leff AR, Myo S, Boetticher E, Meliton AY, Lambertino AT, Liu J, Xu C, Munoz NM, Zhu X.

J Immunol. 2003 Oct 15;171(8):4399-405.

41.

Blockade of airway inflammation and hyperresponsiveness by HIV-TAT-dominant negative Ras.

Myou S, Zhu X, Myo S, Boetticher E, Meliton AY, Liu J, Munoz NM, Leff AR.

J Immunol. 2003 Oct 15;171(8):4379-84.

42.

Structural determinants of blockade of eosinophil activation, adhesion and secretion by synthetic analogs of phomactin.

Zhu X, Lambertino AT, Houghton TJ, McGilvra JD, Xu C, Rawal VH, Leff AR.

Life Sci. 2003 Oct 24;73(23):3005-16.

PMID:
14519449
43.

Blockade of LTC4 synthesis caused by additive inhibition of gIV-PLA2 phosphorylation: Effect of salmeterol and PDE4 inhibition in human eosinophils.

Meliton AY, Muñoz NM, Liu J, Lambertino AT, Boetticher E, Myo S, Myou S, Zhu X, Johnson M, Leff AR.

J Allergy Clin Immunol. 2003 Aug;112(2):404-10.

PMID:
12897749
44.

Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human eosinophils.

Muñoz NM, Kim YJ, Meliton AY, Kim KP, Han SK, Boetticher E, O'Leary E, Myou S, Zhu X, Bonventre JV, Leff AR, Cho W.

J Biol Chem. 2003 Oct 3;278(40):38813-20. Epub 2003 Jun 9.

45.

Churg-Strauss syndrome.

Noth I, Strek ME, Leff AR.

Lancet. 2003 Feb 15;361(9357):587-94. Review.

PMID:
12598156
46.

IL-5-induced integrin adhesion of human eosinophils caused by ERK1/2-mediated activation of cPLA2.

Zhu X, Jacobs B, Boetticher E, Myou S, Meliton A, Sano H, Lambertino AT, Muñoz NM, Leff AR.

J Leukoc Biol. 2002 Nov;72(5):1046-53.

PMID:
12429728
47.

Regulation of adhesion of AML14.3D10 cells by surface clustering of beta2-integrin caused by ERK-independent activation of cPLA2.

Myou S, Zhu X, Boetticher E, Qin Y, Myo S, Meliton A, Lambertino A, Munoz NM, Hamann KJ, Leff AR.

Immunology. 2002 Sep;107(1):77-85.

48.
49.

Group V phospholipase A2 induces leukotriene biosynthesis in human neutrophils through the activation of group IVA phospholipase A2.

Kim YJ, Kim KP, Han SK, Munoz NM, Zhu X, Sano H, Leff AR, Cho W.

J Biol Chem. 2002 Sep 27;277(39):36479-88. Epub 2002 Jul 17.

50.

Studying human airway pharmacology in microsections: application of videomicrometry.

Schmidt DT, Dent G, Rühlmann E, Muñoz NM, Leff AR, Rabe KF.

Eur Respir J. 2002 Jun;19(6):991-6.

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