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Items: 1 to 50 of 233

1.

Cardiometabolic Heart Failure and HFpEF: Still Chasing Unicorns.

Sharp TE 3rd, Lefer DJ, Houser SR.

JACC Basic Transl Sci. 2019 Jun 24;4(3):422-424. doi: 10.1016/j.jacbts.2019.05.003. eCollection 2019 Jun. No abstract available.

2.

Renal Denervation Update From the International Sympathetic Nervous System Summit: JACC State-of-the-Art Review.

Kiuchi MG, Esler MD, Fink GD, Osborn JW, Banek CT, Böhm M, Denton KM, DiBona GF, Everett TH 4th, Grassi G, Katholi RE, Knuepfer MM, Kopp UC, Lefer DJ, Lohmeier TE, May CN, Mahfoud F, Paton JFR, Schmieder RE, Pellegrino PR, Sharabi Y, Schlaich MP.

J Am Coll Cardiol. 2019 Jun 18;73(23):3006-3017. doi: 10.1016/j.jacc.2019.04.015. Review.

PMID:
31196459
3.

Hydrogen Sulfide Ameliorates Homocysteine-Induced Cardiac Remodeling and Dysfunction.

Kar S, Shahshahan HR, Kambis TN, Yadav SK, Li Z, Lefer DJ, Mishra PK.

Front Physiol. 2019 May 24;10:598. doi: 10.3389/fphys.2019.00598. eCollection 2019.

4.

Update on Gaseous Signaling Molecules Nitric Oxide and Hydrogen Sulfide: Strategies to Capture their Functional Activity for Human Therapeutics.

Bryan NS, Lefer DJ.

Mol Pharmacol. 2019 Jul;96(1):109-114. doi: 10.1124/mol.118.113910. Epub 2019 May 6. Erratum in: Mol Pharmacol. 2019 Aug;96(2):127.

PMID:
31061006
5.

Effects of a novel hydrogen sulfide prodrug in a porcine model of acute limb ischemia.

Rushing AM, Donnarumma E, Polhemus DJ, Au KR, Victoria SE, Schumacher JD, Li Z, Jenkins JS, Lefer DJ, Goodchild TT.

J Vasc Surg. 2019 Jun;69(6):1924-1935. doi: 10.1016/j.jvs.2018.08.172. Epub 2019 Feb 15.

PMID:
30777693
6.

Repeated cell transplantation and adjunct renal denervation in ischemic heart failure: exploring modalities for improving cell therapy efficacy.

Polhemus DJ, Trivedi RK, Sharp TE, Li Z, Goodchild TT, Scarborough A, de Couto G, Marbán E, Lefer DJ.

Basic Res Cardiol. 2019 Jan 17;114(2):9. doi: 10.1007/s00395-019-0718-1.

PMID:
30656501
7.

Hydrogen Sulfide Attenuates Renin Angiotensin and Aldosterone Pathological Signaling to Preserve Kidney Function and Improve Exercise Tolerance in Heart Failure.

Li Z, Organ CL, Kang J, Polhemus DJ, Trivedi RK, Sharp TE 3rd, Jenkins JS, Tao YX, Xian M, Lefer DJ.

JACC Basic Transl Sci. 2018 Dec 31;3(6):796-809. doi: 10.1016/j.jacbts.2018.08.011. eCollection 2018 Dec. Erratum in: JACC Basic Transl Sci. 2019 Feb 25;4(1):134.

8.

Renal Denervation Prevents Heart Failure Progression Via Inhibition of the Renin-Angiotensin System.

Sharp TE 3rd, Polhemus DJ, Li Z, Spaletra P, Jenkins JS, Reilly JP, White CJ, Kapusta DR, Lefer DJ, Goodchild TT.

J Am Coll Cardiol. 2018 Nov 27;72(21):2609-2621. doi: 10.1016/j.jacc.2018.08.2186.

PMID:
30466519
9.

Angiotensin Receptor-Neprilysin Inhibitors Emerge as Potential Treatment for Acute Myocardial Infarction.

Lefer DJ, Sharp TE 3rd.

J Am Coll Cardiol. 2018 Nov 6;72(19):2357-2359. doi: 10.1016/j.jacc.2018.08.2170. No abstract available.

PMID:
30384892
10.

Evolution of Hydrogen Sulfide Therapeutics to Treat Cardiovascular Disease.

Li Z, Polhemus DJ, Lefer DJ.

Circ Res. 2018 Aug 17;123(5):590-600. doi: 10.1161/CIRCRESAHA.118.311134.

PMID:
30355137
11.

A novel fibroblast activation inhibitor attenuates left ventricular remodeling and preserves cardiac function in heart failure.

Bradley JM, Spaletra P, Li Z, Sharp TE 3rd, Goodchild TT, Corral LG, Fung L, Chan KWH, Sullivan RW, Swindlehurst CA, Lefer DJ.

Am J Physiol Heart Circ Physiol. 2018 Sep 1;315(3):H563-H570. doi: 10.1152/ajpheart.00603.2017. Epub 2018 Jun 27.

PMID:
29949382
12.

Combined Angiotensin Receptor-Neprilysin Inhibitors Improve Cardiac and Vascular Function Via Increased NO Bioavailability in Heart Failure.

Trivedi RK, Polhemus DJ, Li Z, Yoo D, Koiwaya H, Scarborough A, Goodchild TT, Lefer DJ.

J Am Heart Assoc. 2018 Mar 3;7(5). pii: e008268. doi: 10.1161/JAHA.117.008268.

13.

Hydrogen sulfide regulates cardiac mitochondrial biogenesis via the activation of AMPK.

Shimizu Y, Polavarapu R, Eskla KL, Nicholson CK, Koczor CA, Wang R, Lewis W, Shiva S, Lefer DJ, Calvert JW.

J Mol Cell Cardiol. 2018 Mar;116:29-40. doi: 10.1016/j.yjmcc.2018.01.011. Epub 2018 Feb 3.

14.

Guidelines for experimental models of myocardial ischemia and infarction.

Lindsey ML, Bolli R, Canty JM Jr, Du XJ, Frangogiannis NG, Frantz S, Gourdie RG, Holmes JW, Jones SP, Kloner RA, Lefer DJ, Liao R, Murphy E, Ping P, Przyklenk K, Recchia FA, Schwartz Longacre L, Ripplinger CM, Van Eyk JE, Heusch G.

Am J Physiol Heart Circ Physiol. 2018 Apr 1;314(4):H812-H838. doi: 10.1152/ajpheart.00335.2017. Epub 2018 Jan 12.

15.

A novel mtDNA repair fusion protein attenuates maladaptive remodeling and preserves cardiac function in heart failure.

Bradley JM, Li Z, Organ CL, Polhemus DJ, Otsuka H, Islam KN, Bhushan S, Gorodnya OM, Ruchko MV, Gillespie MN, Wilson GL, Lefer DJ.

Am J Physiol Heart Circ Physiol. 2018 Feb 1;314(2):H311-H321. doi: 10.1152/ajpheart.00515.2017. Epub 2017 Nov 3.

16.

Renal Sympathetic Denervation Protects the Failing Heart Via Inhibition of Neprilysin Activity in the Kidney.

Polhemus DJ, Trivedi RK, Gao J, Li Z, Scarborough AL, Goodchild TT, Varner KJ, Xia H, Smart FW, Kapusta DR, Lefer DJ.

J Am Coll Cardiol. 2017 Oct 24;70(17):2139-2153. doi: 10.1016/j.jacc.2017.08.056.

17.

An Esterase-Sensitive Prodrug Approach for Controllable Delivery of Persulfide Species.

Zheng Y, Yu B, Li Z, Yuan Z, Organ CL, Trivedi RK, Wang S, Lefer DJ, Wang B.

Angew Chem Int Ed Engl. 2017 Sep 18;56(39):11749-11753. doi: 10.1002/anie.201704117. Epub 2017 Aug 16.

PMID:
28700817
18.

Is Cardioprotection Dead?

Lefer DJ, Marbán E.

Circulation. 2017 Jul 4;136(1):98-109. doi: 10.1161/CIRCULATIONAHA.116.027039. Review.

19.

Protective Actions of H2S in Acute Myocardial Infarction and Heart Failure.

Donnarumma E, Trivedi RK, Lefer DJ.

Compr Physiol. 2017 Mar 16;7(2):583-602. doi: 10.1002/cphy.c160023. Review.

PMID:
28333381
20.

Slow generation of hydrogen sulfide from sulfane sulfurs and NADH models.

Peng B, Liu C, Li Z, Day JJ, Lu Y, Lefer DJ, Xian M.

Bioorg Med Chem Lett. 2017 Feb 1;27(3):542-545. doi: 10.1016/j.bmcl.2016.12.023. Epub 2016 Dec 9.

21.

An endovascular model of ischemic myopathy from peripheral arterial disease.

Long CA, Timmins LH, Koutakis P, Goodchild TT, Lefer DJ, Pipinos II, Casale GP, Brewster LP.

J Vasc Surg. 2017 Sep;66(3):891-901. doi: 10.1016/j.jvs.2016.07.127. Epub 2016 Sep 29.

22.

Nitrite Therapy Ameliorates Myocardial Dysfunction via H2S and Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2)-Dependent Signaling in Chronic Heart Failure.

Donnarumma E, Bhushan S, Bradley JM, Otsuka H, Donnelly EL, Lefer DJ, Islam KN.

J Am Heart Assoc. 2016 Jul 29;5(8). pii: e003551. doi: 10.1161/JAHA.116.003551.

23.

Dietary Nitrate and the Epidemiology of Cardiovascular Disease: Report From a National Heart, Lung, and Blood Institute Workshop.

Ahluwalia A, Gladwin M, Coleman GD, Hord N, Howard G, Kim-Shapiro DB, Lajous M, Larsen FJ, Lefer DJ, McClure LA, Nolan BT, Pluta R, Schechter A, Wang CY, Ward MH, Harman JL.

J Am Heart Assoc. 2016 Jul 6;5(7). pii: e003402. doi: 10.1161/JAHA.116.003402. No abstract available.

24.

Zofenopril Protects Against Myocardial Ischemia-Reperfusion Injury by Increasing Nitric Oxide and Hydrogen Sulfide Bioavailability.

Donnarumma E, Ali MJ, Rushing AM, Scarborough AL, Bradley JM, Organ CL, Islam KN, Polhemus DJ, Evangelista S, Cirino G, Jenkins JS, Patel RA, Lefer DJ, Goodchild TT.

J Am Heart Assoc. 2016 Jul 5;5(7). pii: e003531. doi: 10.1161/JAHA.116.003531.

25.

Radiofrequency Renal Denervation Protects the Ischemic Heart via Inhibition of GRK2 and Increased Nitric Oxide Signaling.

Polhemus DJ, Gao J, Scarborough AL, Trivedi R, McDonough KH, Goodchild TT, Smart F, Kapusta DR, Lefer DJ.

Circ Res. 2016 Jul 22;119(3):470-80. doi: 10.1161/CIRCRESAHA.115.308278. Epub 2016 Jun 13.

26.

IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction.

Tejada T, Tan L, Torres RA, Calvert JW, Lambert JP, Zaidi M, Husain M, Berce MD, Naib H, Pejler G, Abrink M, Graham RM, Lefer DJ, Naqvi N, Husain A.

Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):6949-54. doi: 10.1073/pnas.1603127113. Epub 2016 Jun 6.

27.

pH-Controlled Hydrogen Sulfide Release for Myocardial Ischemia-Reperfusion Injury.

Kang J, Li Z, Organ CL, Park CM, Yang CT, Pacheco A, Wang D, Lefer DJ, Xian M.

J Am Chem Soc. 2016 May 25;138(20):6336-9. doi: 10.1021/jacs.6b01373. Epub 2016 May 17.

PMID:
27172143
28.

Vasomotor Function Comparative Assessment at 1 and 2 Years Following Implantation of the Absorb Everolimus-Eluting Bioresorbable Vascular Scaffold and the Xience V Everolimus-Eluting Metallic Stent in Porcine Coronary Arteries: Insights From In Vivo Angiography, Ex Vivo Assessment, and Gene Analysis at the Stented/Scaffolded Segments and the Proximal and Distal Edges.

Gogas BD, Benham JJ, Hsu S, Sheehy A, Lefer DJ, Goodchild TT, Polhemus DJ, Bouchi YH, Hung OY, Yoo SY, Joshi U, Giddens DP, Veneziani A, Quyyumi A, Rapoza R, King SB 3rd, Samady H.

JACC Cardiovasc Interv. 2016 Apr 11;9(7):728-41. doi: 10.1016/j.jcin.2015.12.018.

29.

Garlic-Derived Organic Polysulfides and Myocardial Protection.

Bradley JM, Organ CL, Lefer DJ.

J Nutr. 2016 Feb;146(2):403S-409S. doi: 10.3945/jn.114.208066. Epub 2016 Jan 13. Review.

30.

Nebivolol Acts as a S-Nitrosoglutathione Reductase Inhibitor: A New Mechanism of Action.

Jiang H, Polhemus DJ, Islam KN, Torregrossa AC, Li Z, Potts A, Lefer DJ, Bryan NS.

J Cardiovasc Pharmacol Ther. 2016 Sep;21(5):478-85. doi: 10.1177/1074248415626300. Epub 2016 Jan 8.

PMID:
26746429
31.

Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure.

Organ CL, Otsuka H, Bhushan S, Wang Z, Bradley J, Trivedi R, Polhemus DJ, Tang WH, Wu Y, Hazen SL, Lefer DJ.

Circ Heart Fail. 2016 Jan;9(1):e002314. doi: 10.1161/CIRCHEARTFAILURE.115.002314. Epub 2015 Dec 23.

32.

Design, Synthesis, and Cardioprotective Effects of N-Mercapto-Based Hydrogen Sulfide Donors.

Zhao Y, Yang C, Organ C, Li Z, Bhushan S, Otsuka H, Pacheco A, Kang J, Aguilar HC, Lefer DJ, Xian M.

J Med Chem. 2015 Sep 24;58(18):7501-11. doi: 10.1021/acs.jmedchem.5b01033. Epub 2015 Sep 4.

33.

Nitric Oxide Contributes to Vasomotor Tone in Hypertensive African Americans Treated With Nebivolol and Metoprolol.

Neuman RB, Hayek SS, Poole JC, Rahman A, Menon V, Kavtaradze N, Polhemus D, Veledar E, Lefer DJ, Quyyumi AA.

J Clin Hypertens (Greenwich). 2016 Mar;18(3):223-31. doi: 10.1111/jch.12649. Epub 2015 Aug 19.

34.

CD163 interacts with TWEAK to regulate tissue regeneration after ischaemic injury.

Akahori H, Karmali V, Polavarapu R, Lyle AN, Weiss D, Shin E, Husain A, Naqvi N, Van Dam R, Habib A, Choi CU, King AL, Pachura K, Taylor WR, Lefer DJ, Finn AV.

Nat Commun. 2015 Aug 5;6:7792. doi: 10.1038/ncomms8792.

35.

Inhibition of the Prostaglandin Transporter PGT Lowers Blood Pressure in Hypertensive Rats and Mice.

Chi Y, Jasmin JF, Seki Y, Lisanti MP, Charron MJ, Lefer DJ, Schuster VL.

PLoS One. 2015 Jun 29;10(6):e0131735. doi: 10.1371/journal.pone.0131735. eCollection 2015.

36.

Hydrogen Sulfide Levels and Nuclear Factor-Erythroid 2-Related Factor 2 (NRF2) Activity Are Attenuated in the Setting of Critical Limb Ischemia (CLI).

Islam KN, Polhemus DJ, Donnarumma E, Brewster LP, Lefer DJ.

J Am Heart Assoc. 2015 May 14;4(5). pii: e001986. doi: 10.1161/JAHA.115.001986.

37.

Sustained release nitrite therapy results in myocardial protection in a porcine model of metabolic syndrome with peripheral vascular disease.

Bradley JM, Islam KN, Polhemus DJ, Donnarumma E, Brewster LP, Tao YX, Goodchild TT, Lefer DJ.

Am J Physiol Heart Circ Physiol. 2015 Jul 15;309(2):H305-17. doi: 10.1152/ajpheart.00163.2015. Epub 2015 May 8.

38.

Therapeutic potential of sustained-release sodium nitrite for critical limb ischemia in the setting of metabolic syndrome.

Polhemus DJ, Bradley JM, Islam KN, Brewster LP, Calvert JW, Tao YX, Chang CC, Pipinos II, Goodchild TT, Lefer DJ.

Am J Physiol Heart Circ Physiol. 2015 Jul 1;309(1):H82-92. doi: 10.1152/ajpheart.00115.2015. Epub 2015 Apr 24.

39.

The NHLBI-sponsored Consortium for preclinicAl assESsment of cARdioprotective therapies (CAESAR): a new paradigm for rigorous, accurate, and reproducible evaluation of putative infarct-sparing interventions in mice, rabbits, and pigs.

Jones SP, Tang XL, Guo Y, Steenbergen C, Lefer DJ, Kukreja RC, Kong M, Li Q, Bhushan S, Zhu X, Du J, Nong Y, Stowers HL, Kondo K, Hunt GN, Goodchild TT, Orr A, Chang CC, Ockaili R, Salloum FN, Bolli R.

Circ Res. 2015 Feb 13;116(4):572-86. doi: 10.1161/CIRCRESAHA.116.305462. Epub 2014 Dec 11.

40.

Effects of storage-aged red blood cell transfusions on endothelial function in hospitalized patients.

Neuman R, Hayek S, Rahman A, Poole JC, Menon V, Sher S, Newman JL, Karatela S, Polhemus D, Lefer DJ, De Staercke C, Hooper C, Quyyumi AA, Roback JD.

Transfusion. 2015 Apr;55(4):782-90. doi: 10.1111/trf.12919. Epub 2014 Nov 13.

41.

The cardioprotective actions of hydrogen sulfide in acute myocardial infarction and heart failure.

Polhemus DJ, Calvert JW, Butler J, Lefer DJ.

Scientifica (Cairo). 2014;2014:768607. doi: 10.1155/2014/768607. Epub 2014 Jun 22. Review.

42.

A proliferative burst during preadolescence establishes the final cardiomyocyte number.

Naqvi N, Li M, Calvert JW, Tejada T, Lambert JP, Wu J, Kesteven SH, Holman SR, Matsuda T, Lovelock JD, Howard WW, Iismaa SE, Chan AY, Crawford BH, Wagner MB, Martin DI, Lefer DJ, Graham RM, Husain A.

Cell. 2014 May 8;157(4):795-807. doi: 10.1016/j.cell.2014.03.035.

43.

Nitrite therapy improves left ventricular function during heart failure via restoration of nitric oxide-mediated cytoprotective signaling.

Bhushan S, Kondo K, Polhemus DJ, Otsuka H, Nicholson CK, Tao YX, Huang H, Georgiopoulou VV, Murohara T, Calvert JW, Butler J, Lefer DJ.

Circ Res. 2014 Apr 11;114(8):1281-91. doi: 10.1161/CIRCRESAHA.114.301475. Epub 2014 Mar 5.

44.

Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease.

Polhemus DJ, Lefer DJ.

Circ Res. 2014 Feb 14;114(4):730-7. doi: 10.1161/CIRCRESAHA.114.300505. Review.

45.

Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent.

King AL, Polhemus DJ, Bhushan S, Otsuka H, Kondo K, Nicholson CK, Bradley JM, Islam KN, Calvert JW, Tao YX, Dugas TR, Kelley EE, Elrod JW, Huang PL, Wang R, Lefer DJ.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3182-7. doi: 10.1073/pnas.1321871111. Epub 2014 Feb 10.

46.

Convergence of G protein-coupled receptor and S-nitrosylation signaling determines the outcome to cardiac ischemic injury.

Huang ZM, Gao E, Fonseca FV, Hayashi H, Shang X, Hoffman NE, Chuprun JK, Tian X, Tilley DG, Madesh M, Lefer DJ, Stamler JS, Koch WJ.

Sci Signal. 2013 Oct 29;6(299):ra95. doi: 10.1126/scisignal.2004225.

47.

Chronic exercise downregulates myocardial myoglobin and attenuates nitrite reductase capacity during ischemia-reperfusion.

Nicholson CK, Lambert JP, Chow CW, Lefer DJ, Calvert JW.

J Mol Cell Cardiol. 2013 Nov;64:1-10. doi: 10.1016/j.yjmcc.2013.08.002. Epub 2013 Aug 17.

48.

Role of β-adrenergic receptors and nitric oxide signaling in exercise-mediated cardioprotection.

Calvert JW, Lefer DJ.

Physiology (Bethesda). 2013 Jul;28(4):216-24. doi: 10.1152/physiol.00011.2013. Review.

49.

Hydrogen sulfide attenuates cardiac dysfunction after heart failure via induction of angiogenesis.

Polhemus D, Kondo K, Bhushan S, Bir SC, Kevil CG, Murohara T, Lefer DJ, Calvert JW.

Circ Heart Fail. 2013 Sep 1;6(5):1077-86. doi: 10.1161/CIRCHEARTFAILURE.113.000299. Epub 2013 Jun 28.

50.

Controllable hydrogen sulfide donors and their activity against myocardial ischemia-reperfusion injury.

Zhao Y, Bhushan S, Yang C, Otsuka H, Stein JD, Pacheco A, Peng B, Devarie-Baez NO, Aguilar HC, Lefer DJ, Xian M.

ACS Chem Biol. 2013;8(6):1283-90. doi: 10.1021/cb400090d. Epub 2013 Apr 16.

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