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Items: 1 to 50 of 152

1.

SSEThread: Integrative threading of the DNA-PKcs sequence based on data from chemical cross-linking and hydrogen deuterium exchange.

Saltzberg DJ, Hepburn M, Pilla KB, Schriemer DC, Lees-Miller SP, Blundell TL, Sali A.

Prog Biophys Mol Biol. 2019 Sep 27. pii: S0079-6107(19)30035-5. doi: 10.1016/j.pbiomolbio.2019.09.003. [Epub ahead of print]

PMID:
31570166
2.

Combined poly-ADP ribose polymerase and ataxia-telangiectasia mutated/Rad3-related inhibition targets ataxia-telangiectasia mutated-deficient lung cancer cells.

Jette NR, Radhamani S, Arthur G, Ye R, Goutam S, Bolyos A, Petersen LF, Bose P, Bebb DG, Lees-Miller SP.

Br J Cancer. 2019 Oct;121(7):600-610. doi: 10.1038/s41416-019-0565-8. Epub 2019 Sep 4.

PMID:
31481733
3.

Flexible Tethering of ASPP Proteins Facilitates PP-1c Catalysis.

Zhou Y, Millott R, Kim HJ, Peng S, Edwards RA, Skene-Arnold T, Hammel M, Lees-Miller SP, Tainer JA, Holmes CFB, Glover JNM.

Structure. 2019 Oct 1;27(10):1485-1496.e4. doi: 10.1016/j.str.2019.07.012. Epub 2019 Aug 8.

PMID:
31402222
4.

Nej1 Interacts with Mre11 to Regulate Tethering and Dna2 Binding at DNA Double-Strand Breaks.

Mojumdar A, Sorenson K, Hohl M, Toulouze M, Lees-Miller SP, Dubrana K, Petrini JHJ, Cobb JA.

Cell Rep. 2019 Aug 6;28(6):1564-1573.e3. doi: 10.1016/j.celrep.2019.07.018.

5.

Dissection of DNA double-strand-break repair using novel single-molecule forceps.

Wang JL, Duboc C, Wu Q, Ochi T, Liang S, Tsutakawa SE, Lees-Miller SP, Nadal M, Tainer JA, Blundell TL, Strick TR.

Nat Struct Mol Biol. 2018 Jun;25(6):482-487. doi: 10.1038/s41594-018-0065-1. Epub 2018 May 21.

6.

Anemia, leukocytosis and thrombocytosis as prognostic factors in patients with cervical cancer treated with radical chemoradiotherapy: A retrospective cohort study.

Koulis TA, Kornaga EN, Banerjee R, Phan T, Ghatage P, Magliocco AM, Lees-Miller SP, Doll CM.

Clin Transl Radiat Oncol. 2017 Jun 12;4:51-56. doi: 10.1016/j.ctro.2017.05.001. eCollection 2017 Jun.

7.

The non-homologous end-joining factor Nej1 inhibits resection mediated by Dna2-Sgs1 nuclease-helicase at DNA double strand breaks.

Sorenson KS, Mahaney BL, Lees-Miller SP, Cobb JA.

J Biol Chem. 2017 Sep 1;292(35):14576-14586. doi: 10.1074/jbc.M117.796011. Epub 2017 Jul 5.

8.

What Combined Measurements From Structures and Imaging Tell Us About DNA Damage Responses.

Brosey CA, Ahmed Z, Lees-Miller SP, Tainer JA.

Methods Enzymol. 2017;592:417-455. doi: 10.1016/bs.mie.2017.04.005. Epub 2017 May 29. Review.

9.

DNA requirements for interaction of the C-terminal region of Ku80 with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).

Radhakrishnan SK, Lees-Miller SP.

DNA Repair (Amst). 2017 Sep;57:17-28. doi: 10.1016/j.dnarep.2017.06.001. Epub 2017 Jun 9.

10.

Structural and functional characterization of the PNKP-XRCC4-LigIV DNA repair complex.

Aceytuno RD, Piett CG, Havali-Shahriari Z, Edwards RA, Rey M, Ye R, Javed F, Fang S, Mani R, Weinfeld M, Hammel M, Tainer JA, Schriemer DC, Lees-Miller SP, Glover JNM.

Nucleic Acids Res. 2017 Jun 2;45(10):6238-6251. doi: 10.1093/nar/gkx275.

11.

Loss of tumour-specific ATM protein expression is an independent prognostic factor in early resected NSCLC.

Petersen LF, Klimowicz AC, Otsuka S, Elegbede AA, Petrillo SK, Williamson T, Williamson CT, Konno M, Lees-Miller SP, Hao D, Morris D, Magliocco AM, Bebb DG.

Oncotarget. 2017 Jun 13;8(24):38326-38336. doi: 10.18632/oncotarget.16215.

12.

Recruitment of PP1 to the centrosomal scaffold protein CEP192.

Nasa I, Trinkle-Mulcahy L, Douglas P, Chaudhuri S, Lees-Miller SP, Lee KS, Moorhead GB.

Biochem Biophys Res Commun. 2017 Mar 18;484(4):864-870. doi: 10.1016/j.bbrc.2017.02.004. Epub 2017 Feb 8.

PMID:
28188792
13.

ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Olaparib.

Wang C, Jette N, Moussienko D, Bebb DG, Lees-Miller SP.

Transl Oncol. 2017 Apr;10(2):190-196. doi: 10.1016/j.tranon.2017.01.007. Epub 2017 Feb 6.

14.

Nanospray HX-MS configuration for structural interrogation of large protein systems.

Sheff JG, Hepburn M, Yu Y, Lees-Miller SP, Schriemer DC.

Analyst. 2017 Mar 13;142(6):904-910. doi: 10.1039/c6an02707e.

PMID:
28154854
15.

Expression of DNA damage response proteins in cervical cancer patients treated with radical chemoradiotherapy.

Ho CK, Kornaga EN, Klimowicz AC, Enwere EK, Dean M, Bebb GD, Phan T, Ghatage P, Magliocco AM, Lees-Miller SP, Doll CM.

Gynecol Oncol. 2017 Apr;145(1):176-184. doi: 10.1016/j.ygyno.2016.12.025. Epub 2017 Jan 26.

PMID:
28131528
16.

Significance of Co-expression of Epidermal Growth Factor Receptor and Ki67 on Clinical Outcome in Patients With Anal Cancer Treated With Chemoradiotherapy: An Analysis of NRG Oncology RTOG 9811.

Doll CM, Moughan J, Klimowicz A, Ho CK, Kornaga EN, Lees-Miller SP, Ajani JA, Crane CH, Kachnic LA, Okawara GS, Berk LB, Roof KS, Becker MJ, Grisell DL, Ellis RJ, Sperduto PW, Marsa GW, Guha C, Magliocco AM.

Int J Radiat Oncol Biol Phys. 2017 Mar 1;97(3):554-562. doi: 10.1016/j.ijrobp.2016.11.021. Epub 2016 Nov 23.

17.

Expression of PD-L1 and presence of CD8-positive T cells in pre-treatment specimens of locally advanced cervical cancer.

Enwere EK, Kornaga EN, Dean M, Koulis TA, Phan T, Kalantarian M, Köbel M, Ghatage P, Magliocco AM, Lees-Miller SP, Doll CM.

Mod Pathol. 2017 Apr;30(4):577-586. doi: 10.1038/modpathol.2016.221. Epub 2017 Jan 6.

18.

An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex.

Hammel M, Yu Y, Radhakrishnan SK, Chokshi C, Tsai MS, Matsumoto Y, Kuzdovich M, Remesh SG, Fang S, Tomkinson AE, Lees-Miller SP, Tainer JA.

J Biol Chem. 2016 Dec 30;291(53):26987-27006. doi: 10.1074/jbc.M116.751867. Epub 2016 Nov 14.

19.

Low Ki67/high ATM protein expression in malignant tumors predicts favorable prognosis in a retrospective study of early stage hormone receptor positive breast cancer.

Feng X, Li H, Kornaga EN, Dean M, Lees-Miller SP, Riabowol K, Magliocco AM, Morris D, Watson PH, Enwere EK, Bebb G, Paterson A.

Oncotarget. 2016 Dec 27;7(52):85798-85812. doi: 10.18632/oncotarget.12622.

20.

Phosphatidyl inositol-3 kinase (PIK3CA) E545K mutation confers cisplatin resistance and a migratory phenotype in cervical cancer cells.

Arjumand W, Merry CD, Wang C, Saba E, McIntyre JB, Fang S, Kornaga E, Ghatage P, Doll CM, Lees-Miller SP.

Oncotarget. 2016 Dec 13;7(50):82424-82439. doi: 10.18632/oncotarget.10955.

21.

Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions.

Hegde ML, Dutta A, Yang C, Mantha AK, Hegde PM, Pandey A, Sengupta S, Yu Y, Calsou P, Chen D, Lees-Miller SP, Mitra S.

Oncotarget. 2016 Aug 23;7(34):54430-54444. doi: 10.18632/oncotarget.9914.

22.

Noncoding RNA joins Ku and DNA-PKcs for DNA-break resistance in breast cancer.

Lees-Miller SP, Beattie TL, Tainer JA.

Nat Struct Mol Biol. 2016 Jun 7;23(6):509-10. doi: 10.1038/nsmb.3240. No abstract available.

23.

Fumarate in DNA repair.

Lees-Miller SP.

Nat Cell Biol. 2015 Sep;17(9):1096-7. doi: 10.1038/ncb3232.

PMID:
26316455
24.

Phosphorylation of SAF-A/hnRNP-U Serine 59 by Polo-Like Kinase 1 Is Required for Mitosis.

Douglas P, Ye R, Morrice N, Britton S, Trinkle-Mulcahy L, Lees-Miller SP.

Mol Cell Biol. 2015 Aug;35(15):2699-713. doi: 10.1128/MCB.01312-14. Epub 2015 May 18.

25.

Role of the yeast DNA repair protein Nej1 in end processing during the repair of DNA double strand breaks by non-homologous end joining.

Yang H, Matsumoto Y, Trujillo KM, Lees-Miller SP, Osley MA, Tomkinson AE.

DNA Repair (Amst). 2015 Jul;31:1-10. doi: 10.1016/j.dnarep.2015.04.003. Epub 2015 Apr 21.

26.

Low ATM protein expression in malignant tumor as well as cancer-associated stroma are independent prognostic factors in a retrospective study of early-stage hormone-negative breast cancer.

Feng X, Li H, Dean M, Wilson HE, Kornaga E, Enwere EK, Tang P, Paterson A, Lees-Miller SP, Magliocco AM, Bebb G.

Breast Cancer Res. 2015 May 3;17:65. doi: 10.1186/s13058-015-0575-2.

27.

The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis.

Jette N, Lees-Miller SP.

Prog Biophys Mol Biol. 2015 Mar;117(2-3):194-205. doi: 10.1016/j.pbiomolbio.2014.12.003. Epub 2014 Dec 27. Review.

28.

DNA double strand break repair in mitosis is suppressed by phosphorylation of XRCC4.

Lees-Miller SP.

PLoS Genet. 2014 Aug 28;10(8):e1004598. doi: 10.1371/journal.pgen.1004598. eCollection 2014 Aug. No abstract available.

29.

Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis.

Douglas P, Ye R, Trinkle-Mulcahy L, Neal JA, De Wever V, Morrice NA, Meek K, Lees-Miller SP.

Biosci Rep. 2014 Jun 25;34(3). pii: e00113. doi: 10.1042/BSR20140051.

30.

Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines.

Kubota E, Williamson CT, Ye R, Elegbede A, Peterson L, Lees-Miller SP, Bebb DG.

Cell Cycle. 2014;13(13):2129-37. doi: 10.4161/cc.29212. Epub 2014 May 19.

31.

Unraveling the complexities of DNA-dependent protein kinase autophosphorylation.

Neal JA, Sugiman-Marangos S, VanderVere-Carozza P, Wagner M, Turchi J, Lees-Miller SP, Junop MS, Meek K.

Mol Cell Biol. 2014 Jun;34(12):2162-75. doi: 10.1128/MCB.01554-13. Epub 2014 Mar 31.

32.

Structural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time.

Williams GJ, Hammel M, Radhakrishnan SK, Ramsden D, Lees-Miller SP, Tainer JA.

DNA Repair (Amst). 2014 May;17:110-20. doi: 10.1016/j.dnarep.2014.02.009. Epub 2014 Mar 20. Review.

33.

Non-homologous end joining: emerging themes and unanswered questions.

Radhakrishnan SK, Jette N, Lees-Miller SP.

DNA Repair (Amst). 2014 May;17:2-8. doi: 10.1016/j.dnarep.2014.01.009. Epub 2014 Feb 26. Review.

34.

The C-terminus of Nej1 is critical for nuclear localization and non-homologous end-joining.

Mahaney BL, Lees-Miller SP, Cobb JA.

DNA Repair (Amst). 2014 Feb;14:9-16. doi: 10.1016/j.dnarep.2013.12.002. Epub 2013 Dec 24.

35.

Telomerase contributes to fludarabine resistance in primary human leukemic lymphocytes.

Shawi M, Chu TW, Martinez-Marignac V, Yu Y, Gryaznov SM, Johnston JB, Lees-Miller SP, Assouline SE, Autexier C, Aloyz R.

PLoS One. 2013 Jul 29;8(7):e70428. doi: 10.1371/journal.pone.0070428. Print 2013.

36.

XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair.

Mahaney BL, Hammel M, Meek K, Tainer JA, Lees-Miller SP.

Biochem Cell Biol. 2013 Feb;91(1):31-41. doi: 10.1139/bcb-2012-0058. Epub 2013 Feb 5. Review.

37.

Detection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joining.

Wang C, Lees-Miller SP.

Int J Radiat Oncol Biol Phys. 2013 Jul 1;86(3):440-9. doi: 10.1016/j.ijrobp.2013.01.011. Epub 2013 Feb 20. Review.

38.

PIK3CA mutational status and overall survival in patients with cervical cancer treated with radical chemoradiotherapy.

McIntyre JB, Wu JS, Craighead PS, Phan T, Köbel M, Lees-Miller SP, Ghatage P, Magliocco AM, Doll CM.

Gynecol Oncol. 2013 Mar;128(3):409-14. doi: 10.1016/j.ygyno.2012.12.019. Epub 2012 Dec 22.

PMID:
23266353
39.

Nepenthesin from monkey cups for hydrogen/deuterium exchange mass spectrometry.

Rey M, Yang M, Burns KM, Yu Y, Lees-Miller SP, Schriemer DC.

Mol Cell Proteomics. 2013 Feb;12(2):464-72. doi: 10.1074/mcp.M112.025221. Epub 2012 Nov 29.

40.

Predicting PARP inhibitor sensitivity and resistance.

Bebb DG, Lees-Miller SP.

Cell Cycle. 2012 Nov 15;11(22):4110. doi: 10.4161/cc.22604. Epub 2012 Oct 25. No abstract available.

41.

Targeting protein for xenopus kinesin-like protein 2 (TPX2) regulates γ-histone 2AX (γ-H2AX) levels upon ionizing radiation.

Neumayer G, Helfricht A, Shim SY, Le HT, Lundin C, Belzil C, Chansard M, Yu Y, Lees-Miller SP, Gruss OJ, van Attikum H, Helleday T, Nguyen MD.

J Biol Chem. 2012 Dec 7;287(50):42206-22. doi: 10.1074/jbc.M112.385674. Epub 2012 Oct 8.

42.

The significance of tumoral ERCC1 status in patients with locally advanced cervical cancer treated with chemoradiation therapy: a multicenter clinicopathologic analysis.

Doll CM, Aquino-Parsons C, Pintilie M, Klimowicz AC, Petrillo SK, Milosevic M, Craighead PS, Clarke B, Lees-Miller SP, Fyles AW, Magliocco AM.

Int J Radiat Oncol Biol Phys. 2013 Mar 1;85(3):721-7. doi: 10.1016/j.ijrobp.2012.06.021. Epub 2012 Jul 24.

PMID:
22836058
43.

Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53.

Williamson CT, Kubota E, Hamill JD, Klimowicz A, Ye R, Muzik H, Dean M, Tu L, Gilley D, Magliocco AM, McKay BC, Bebb DG, Lees-Miller SP.

EMBO Mol Med. 2012 Jun;4(6):515-27. doi: 10.1002/emmm.201200229. Epub 2012 Mar 13.

44.

XRCC4's interaction with XLF is required for coding (but not signal) end joining.

Roy S, Andres SN, Vergnes A, Neal JA, Xu Y, Yu Y, Lees-Miller SP, Junop M, Modesti M, Meek K.

Nucleic Acids Res. 2012 Feb;40(4):1684-94. doi: 10.1093/nar/gkr1315. Epub 2012 Jan 6.

45.

N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku.

Meek K, Lees-Miller SP, Modesti M.

Nucleic Acids Res. 2012 Apr;40(7):2964-73. doi: 10.1093/nar/gkr1211. Epub 2011 Dec 13.

46.

Comparing ERCC1 protein expression, mRNA levels, and genotype in squamous cell carcinomas of the head and neck treated with concurrent chemoradiation stratified by HPV status.

Hao D, Lau HY, Eliasziw M, Box A, Diaz R, Klimowicz AC, Shin B, Lees-Miller SP, Magliocco AM.

Head Neck. 2012 Jun;34(6):785-91. doi: 10.1002/hed.21817. Epub 2011 Aug 24.

PMID:
22127805
47.

Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage.

Zolner AE, Abdou I, Ye R, Mani RS, Fanta M, Yu Y, Douglas P, Tahbaz N, Fang S, Dobbs T, Wang C, Morrice N, Hendzel MJ, Weinfeld M, Lees-Miller SP.

Nucleic Acids Res. 2011 Nov;39(21):9224-37. doi: 10.1093/nar/gkr647. Epub 2011 Aug 8.

48.

XRCC4 protein interactions with XRCC4-like factor (XLF) create an extended grooved scaffold for DNA ligation and double strand break repair.

Hammel M, Rey M, Yu Y, Mani RS, Classen S, Liu M, Pique ME, Fang S, Mahaney BL, Weinfeld M, Schriemer DC, Lees-Miller SP, Tainer JA.

J Biol Chem. 2011 Sep 16;286(37):32638-50. doi: 10.1074/jbc.M111.272641. Epub 2011 Jul 20.

49.

Inhibition of homologous recombination by DNA-dependent protein kinase requires kinase activity, is titratable, and is modulated by autophosphorylation.

Neal JA, Dang V, Douglas P, Wold MS, Lees-Miller SP, Meek K.

Mol Cell Biol. 2011 Apr;31(8):1719-33. doi: 10.1128/MCB.01298-10. Epub 2011 Feb 7.

50.

Estrogen receptor α-mediated transcription induces cell cycle-dependent DNA double-strand breaks.

Williamson LM, Lees-Miller SP.

Carcinogenesis. 2011 Mar;32(3):279-85. doi: 10.1093/carcin/bgq255. Epub 2010 Nov 26.

PMID:
21112959

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