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Items: 34

1.

The Pore-Lipid Interface: Role of Amino-Acid Determinants of Lipophilic Access by Ivabradine to the hERG1 Pore Domain.

Perissinotti L, Guo J, Kudaibergenova M, Lees-Miller J, Ol'khovich M, Sharapova A, Perlovich GL, Muruve DA, Gerull B, Noskov SY, Duff HJ.

Mol Pharmacol. 2019 Aug;96(2):259-271. doi: 10.1124/mol.118.115642. Epub 2019 Jun 10.

PMID:
31182542
2.

Role of the pH in state-dependent blockade of hERG currents.

Wang Y, Guo J, Perissinotti LL, Lees-Miller J, Teng G, Durdagi S, Duff HJ, Noskov SY.

Sci Rep. 2016 Oct 12;6:32536. doi: 10.1038/srep32536.

3.

In response to Melgari et al. "hERG potassium channel inhibition by ivabradine requires channel gating".

Lees-Miller JP, Guo J, Wang Y, Perissinotti LL, Noskov SY, Duff HJ.

J Mol Cell Cardiol. 2015 Oct;87:192-3. doi: 10.1016/j.yjmcc.2015.08.003. Epub 2015 Aug 20. No abstract available.

PMID:
26299838
4.

Ivabradine prolongs phase 3 of cardiac repolarization and blocks the hERG1 (KCNH2) current over a concentration-range overlapping with that required to block HCN4.

Lees-Miller JP, Guo J, Wang Y, Perissinotti LL, Noskov SY, Duff HJ.

J Mol Cell Cardiol. 2015 Aug;85:71-8. doi: 10.1016/j.yjmcc.2015.05.009. Epub 2015 May 16.

PMID:
25986146
5.

NS1643 interacts around L529 of hERG to alter voltage sensor movement on the path to activation.

Guo J, Cheng YM, Lees-Miller JP, Perissinotti LL, Claydon TW, Hull CM, Thouta S, Roach DE, Durdagi S, Noskov SY, Duff HJ.

Biophys J. 2015 Mar 24;108(6):1400-1413. doi: 10.1016/j.bpj.2014.12.055.

6.

Role of mutation and pharmacologic block of human KCNH2 in vasculogenesis and fetal mortality: partial rescue by transforming growth factor-β.

Teng G, Zhao X, Lees-Miller JP, Belke D, Shi C, Chen Y, O'Brien ER, Fedak PW, Bracey N, Cross JC, Duff HJ.

Circ Arrhythm Electrophysiol. 2015 Apr;8(2):420-8. doi: 10.1161/CIRCEP.114.001837. Epub 2015 Feb 3.

PMID:
25648353
7.

The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin-1β.

Bracey NA, Beck PL, Muruve DA, Hirota SA, Guo J, Jabagi H, Wright JR Jr, Macdonald JA, Lees-Miller JP, Roach D, Semeniuk LM, Duff HJ.

Exp Physiol. 2013 Feb;98(2):462-72. doi: 10.1113/expphysiol.2012.068338. Epub 2012 Jul 30.

8.

Structure-guided topographic mapping and mutagenesis to elucidate binding sites for the human ether-a-go-go-related gene 1 potassium channel (KCNH2) activator NS1643.

Durdagi S, Guo J, Lees-Miller JP, Noskov SY, Duff HJ.

J Pharmacol Exp Ther. 2012 Aug;342(2):441-52. doi: 10.1124/jpet.111.189159. Epub 2012 May 9.

PMID:
22573844
9.

Structural refinement of the hERG1 pore and voltage-sensing domains with ROSETTA-membrane and molecular dynamics simulations.

Subbotina J, Yarov-Yarovoy V, Lees-Miller J, Durdagi S, Guo J, Duff HJ, Noskov SY.

Proteins. 2010 Nov 1;78(14):2922-34. doi: 10.1002/prot.22815.

10.

Insights into the molecular mechanism of hERG1 channel activation and blockade by drugs.

Durdagi S, Subbotina J, Lees-Miller J, Guo J, Duff HJ, Noskov SY.

Curr Med Chem. 2010;17(30):3514-32. Review.

PMID:
20738248
11.

Interactions of H562 in the S5 helix with T618 and S621 in the pore helix are important determinants of hERG1 potassium channel structure and function.

Lees-Miller JP, Subbotina JO, Guo J, Yarov-Yarovoy V, Noskov SY, Duff HJ.

Biophys J. 2009 May 6;96(9):3600-10. doi: 10.1016/j.bpj.2009.01.028.

12.

Homozygous missense N629D hERG (KCNH2) potassium channel mutation causes developmental defects in the right ventricle and its outflow tract and embryonic lethality.

Teng GQ, Zhao X, Lees-Miller JP, Quinn FR, Li P, Rancourt DE, London B, Cross JC, Duff HJ.

Circ Res. 2008 Dec 5;103(12):1483-91. doi: 10.1161/CIRCRESAHA.108.177055. Epub 2008 Oct 23.

13.

iNOS in cardiac myocytes plays a critical role in death in a murine model of hypertrophy induced by calcineurin.

Somers JR, Beck PL, Lees-Miller JP, Roach D, Li Y, Guo J, Loken S, Zhan S, Semeniuk L, Duff HJ.

Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H1122-H1131. doi: 10.1152/ajpheart.00386.2008. Epub 2008 Jul 11.

14.

Decrease in density of INa is in the common final pathway to heart block in murine hearts overexpressing calcineurin.

Guo J, Zhan S, Somers J, Westenbroek RE, Catterall WA, Roach DE, Sheldon RS, Lees-Miller JP, Li P, Shimoni Y, Duff HJ.

Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H2669-79. Epub 2006 Jun 2.

15.
16.

Prolonged repolarization and triggered activity induced by adenoviral expression of HERG N629D in cardiomyocytes derived from stem cells.

Teng G, Zhao X, Cross JC, Li P, Lees-Miller JP, Guo J, Dyck JR, Duff HJ.

Cardiovasc Res. 2004 Feb 1;61(2):268-77.

PMID:
14736543
17.
18.

Selective knockout of mouse ERG1 B potassium channel eliminates I(Kr) in adult ventricular myocytes and elicits episodes of abrupt sinus bradycardia.

Lees-Miller JP, Guo J, Somers JR, Roach DE, Sheldon RS, Rancourt DE, Duff HJ.

Mol Cell Biol. 2003 Mar;23(6):1856-62.

19.

Overexpression of calcineurin in mouse causes sudden cardiac death associated with decreased density of K+ channels.

Dong D, Duan Y, Guo J, Roach DE, Swirp SL, Wang L, Lees-Miller JP, Sheldon RS, Molkentin JD, Duff HJ.

Cardiovasc Res. 2003 Feb;57(2):320-32.

PMID:
12566105
20.

Novel gain-of-function mechanism in K(+) channel-related long-QT syndrome: altered gating and selectivity in the HERG1 N629D mutant.

Lees-Miller JP, Duan Y, Teng GQ, Thorstad K, Duff HJ.

Circ Res. 2000 Mar 17;86(5):507-13.

PMID:
10720411
21.

Molecular determinant of high-affinity dofetilide binding to HERG1 expressed in Xenopus oocytes: involvement of S6 sites.

Lees-Miller JP, Duan Y, Teng GQ, Duff HJ.

Mol Pharmacol. 2000 Feb;57(2):367-74.

PMID:
10648647
22.

Electrophysiological characterization of an alternatively processed ERG K+ channel in mouse and human hearts.

Lees-Miller JP, Kondo C, Wang L, Duff HJ.

Circ Res. 1997 Nov;81(5):719-26.

PMID:
9351446
23.

[3H]dofetilide binding to cardiac myocytes: modulation by extracellular potassium.

Duff HJ, Feng ZP, Fiset C, Wang L, Lees-Miller J, Sheldon RS.

J Mol Cell Cardiol. 1997 Jan;29(1):183-91.

PMID:
9040033
24.

Brain-specific tropomyosins TMBr-1 and TMBr-3 have distinct patterns of expression during development and in adult brain.

Stamm S, Casper D, Lees-Miller JP, Helfman DM.

Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):9857-61.

25.
26.
27.

The molecular basis for tropomyosin isoform diversity.

Lees-Miller JP, Helfman DM.

Bioessays. 1991 Sep;13(9):429-37. Review.

PMID:
1796905
28.

Four fibroblast tropomyosin isoforms are expressed from the rat alpha-tropomyosin gene via alternative RNA splicing and the use of two promoters.

Goodwin LO, Lees-Miller JP, Leonard MA, Cheley SB, Helfman DM.

J Biol Chem. 1991 May 5;266(13):8408-15.

29.

Structure and complete nucleotide sequence of the gene encoding rat fibroblast tropomyosin 4.

Lees-Miller JP, Yan A, Helfman DM.

J Mol Biol. 1990 Jun 5;213(3):399-405.

PMID:
2112608
31.
32.

Amino acid sequence of chicken gizzard smooth muscle SM22 alpha.

Pearlstone JR, Weber M, Lees-Miller JP, Carpenter MR, Smillie LB.

J Biol Chem. 1987 May 5;262(13):5985-91.

33.

Isolation and characterization of an abundant and novel 22-kDa protein (SM22) from chicken gizzard smooth muscle.

Lees-Miller JP, Heeley DH, Smillie LB, Kay CM.

J Biol Chem. 1987 Mar 5;262(7):2988-93.

34.

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