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Items: 1 to 50 of 296

1.

Toward a harmonized approach to animal welfare law in Canada - A comment.

Lees W.

Can Vet J. 2018 May;59(5):459. No abstract available.

2.

Increased epitope complexity correlated with antibody affinity maturation and a novel binding mode revealed by structures of rabbit antibodies against the third variable loop (V3) of HIV-1 gp120.

Pan R, Qin Y, Banasik M, Lees W, Shepherd AJ, Cho MW, Kong XP.

J Virol. 2018 Jan 17. pii: JVI.01894-17. doi: 10.1128/JVI.01894-17. [Epub ahead of print]

3.

Investigating Substitutions in Antibody-Antigen Complexes Using Molecular Dynamics: A Case Study with Broad-spectrum, Influenza A Antibodies.

Lees WD, Stejskal L, Moss DS, Shepherd AJ.

Front Immunol. 2017 Feb 15;8:143. doi: 10.3389/fimmu.2017.00143. eCollection 2017.

4.

Evaluation of a novel multi-immunogen vaccine strategy for targeting 4E10/10E8 neutralizing epitopes on HIV-1 gp41 membrane proximal external region.

Banerjee S, Shi H, Banasik M, Moon H, Lees W, Qin Y, Harley A, Shepherd A, Cho MW.

Virology. 2017 May;505:113-126. doi: 10.1016/j.virol.2017.02.015. Epub 2017 Feb 23.

5.

Studying Antibody Repertoires with Next-Generation Sequencing.

Lees WD, Shepherd AJ.

Methods Mol Biol. 2017;1526:257-270.

PMID:
27896747
6.

The ultrafast reactions in the photochromic cycle of water-soluble fulgimide photoswitches.

Slavov C, Boumrifak C, Hammer CA, Trojanowski P, Chen X, Lees WJ, Wachtveitl J, Braun M.

Phys Chem Chem Phys. 2016 Apr 21;18(15):10289-96. doi: 10.1039/c5cp06866e. Epub 2016 Mar 29.

PMID:
27020260
7.

Utilities for High-Throughput Analysis of B-Cell Clonal Lineages.

Lees WD, Shepherd AJ.

J Immunol Res. 2015;2015:323506. doi: 10.1155/2015/323506. Epub 2015 Oct 7.

8.

N-linked glycans on influenza A H3N2 hemagglutinin constrain binding of host antibodies, but shielding is limited.

Pentiah K, Lees WD, Moss DS, Shepherd AJ.

Glycobiology. 2015 Jan;25(1):124-32. doi: 10.1093/glycob/cwu097. Epub 2014 Sep 16.

PMID:
25227423
9.

Selenium as an electron acceptor during the catalytic mechanism of thioredoxin reductase.

Lothrop AP, Snider GW, Ruggles EL, Patel AS, Lees WJ, Hondal RJ.

Biochemistry. 2014 Feb 4;53(4):654-63. doi: 10.1021/bi400658g. Epub 2014 Jan 23.

10.

Evolution in the influenza A H3 stalk - a challenge for broad-spectrum vaccines?

Lees WD, Moss DS, Shepherd AJ.

J Gen Virol. 2014 Feb;95(Pt 2):317-24. doi: 10.1099/vir.0.059410-0. Epub 2013 Nov 1.

PMID:
24187015
11.
12.

Survival after radiofrequency ablation in 122 patients with inoperable colorectal lung metastases.

Gillams A, Khan Z, Osborn P, Lees W.

Cardiovasc Intervent Radiol. 2013 Jun;36(3):724-30. doi: 10.1007/s00270-012-0500-3. Epub 2012 Oct 17.

PMID:
23070108
13.

Going non-native to improve oxidative protein folding.

Lees WJ.

Chembiochem. 2012 Aug 13;13(12):1725-7. doi: 10.1002/cbic.201200288. Epub 2012 Jul 4. No abstract available.

PMID:
22764127
14.

Oxidative folding of lysozyme with aromatic dithiols, and aliphatic and aromatic monothiols.

Patel AS, Lees WJ.

Bioorg Med Chem. 2012 Jan 15;20(2):1020-8. doi: 10.1016/j.bmc.2011.11.049. Epub 2011 Dec 1.

PMID:
22197395
15.

The age of the 20 meter Solo River terrace, Java, Indonesia and the survival of Homo erectus in Asia.

Indriati E, Swisher CC 3rd, Lepre C, Quinn RL, Suriyanto RA, Hascaryo AT, Grün R, Feibel CS, Pobiner BL, Aubert M, Lees W, Antón SC.

PLoS One. 2011;6(6):e21562. doi: 10.1371/journal.pone.0021562. Epub 2011 Jun 29.

16.

Analysis of antigenically important residues in human influenza A virus in terms of B-cell epitopes.

Lees WD, Moss DS, Shepherd AJ.

J Virol. 2011 Sep;85(17):8548-55. doi: 10.1128/JVI.00579-11. Epub 2011 Jun 15.

17.

Photochromic properties of a water-soluble methyl carboxylic acid indolylfulgimide.

Chen X, Islamova NI, Robles RV, Lees WJ.

Photochem Photobiol Sci. 2011 Jun;10(6):1023-9. doi: 10.1039/c1pp05016h. Epub 2011 Mar 7.

18.

Increasing the efficiency of the ring-opening reaction of photochromic indolylfulgides by optical pre-excitation.

Brust T, Draxler S, Eicher J, Lees WJ, Rück-Braun K, Zinth W, Braun M.

Chem Phys Lett. 2010 Apr 9;489(4-6):175-180.

19.

Stability and reaction dynamics of trifluorinated indolylfulgides.

Brust T, Draxler S, Popp A, Chen X, Lees WJ, Zinth W, Braun M.

Chem Phys Lett. 2009 Aug 6;477(4-6):298-303.

20.

A computational analysis of the antigenic properties of haemagglutinin in influenza A H3N2.

Lees WD, Moss DS, Shepherd AJ.

Bioinformatics. 2010 Jun 1;26(11):1403-8. doi: 10.1093/bioinformatics/btq160. Epub 2010 Apr 13.

21.

Thermal Stability and Photochromic Properties of a Fluorinated Indolylfulgimide in a Protic and Aprotic Solvent.

Islamova NI, Chen X, Digirolamo JA, Silva Y, Lees WJ.

J Photochem Photobiol A Chem. 2008 Sep;199(1):85-91.

22.

Synthesis and optical properties of aqueous soluble indolylfulgimides.

Chen X, Islamova NI, Garcia SP, DiGirolamo JA, Lees WJ.

J Org Chem. 2009 Sep 4;74(17):6777-83. doi: 10.1021/jo900909d.

23.

Ring-opening reaction of a trifluorinated indolylfulgide: mode-specific photochemistry after pre-excitation.

Draxler S, Brust T, Malkmus S, DiGirolamo JA, Lees WJ, Zinth W, Braun M.

Phys Chem Chem Phys. 2009 Jul 7;11(25):5019-27. doi: 10.1039/b819585d. Epub 2009 Apr 2.

24.

Comparison of the oxidative folding of lysozyme at a high protein concentration using aromatic thiols versus glutathione.

Madar DJ, Patel AS, Lees WJ.

J Biotechnol. 2009 Jul 15;142(3-4):214-9. doi: 10.1016/j.jbiotec.2009.05.003. Epub 2009 May 27.

PMID:
19477205
25.

Wavelength and solvent independent photochemistry: the electrocyclic ring-closure of indolylfulgides.

Cordes T, Herzog TT, Malkmus S, Draxler S, Brust T, Digirolamo JA, Lees WJ, Braun M.

Photochem Photobiol Sci. 2009 Apr;8(4):528-34. doi: 10.1039/b817627b. Epub 2009 Feb 11.

26.

Five-year survival in 309 patients with colorectal liver metastases treated with radiofrequency ablation.

Gillams AR, Lees WR.

Eur Radiol. 2009 May;19(5):1206-13. doi: 10.1007/s00330-008-1258-5. Epub 2009 Jan 10.

PMID:
19137310
27.

Early indicators of treatment success after percutaneous radiofrequency of pulmonary tumors.

Anderson EM, Lees WR, Gillams AR.

Cardiovasc Intervent Radiol. 2009 May;32(3):478-83. doi: 10.1007/s00270-008-9482-6. Epub 2009 Jan 6.

PMID:
19127381
28.

Accelerated and efficient photochemistry from higher excited electronic states in fulgide molecules.

Cordes T, Malkmus S, DiGirolamo JA, Lees WJ, Nenov A, de Vivie-Riedle R, Braun M, Zinth W.

J Phys Chem A. 2008 Dec 25;112(51):13364-71. doi: 10.1021/jp807097w.

PMID:
19049317
29.

Small-molecule catalysts of oxidative protein folding.

Lees WJ.

Curr Opin Chem Biol. 2008 Dec;12(6):740-5. doi: 10.1016/j.cbpa.2008.08.032. Epub 2008 Sep 25. Review.

PMID:
18824127
30.

Five-year survival following radiofrequency ablation of small, solitary, hepatic colorectal metastases.

Gillams AR, Lees WR.

J Vasc Interv Radiol. 2008 May;19(5):712-7. doi: 10.1016/j.jvir.2008.01.016. Epub 2008 Mar 17.

PMID:
18440460
31.

Feasibility of dynamic 3-D color Doppler ultrasound for imaging penile vascular change in renal transplant patients with erectile dysfunction responding to sildenafil.

Chatterjee R, Deng J, Pellerin D, Todd-Pokropek A, Neild GH, Lees WR, Rodeck CH.

Ultrasound Med Biol. 2008 Jun;34(6):885-91. doi: 10.1016/j.ultrasmedbio.2007.11.013. Epub 2008 Mar 4.

PMID:
18295391
32.
33.

Rate enhancement of the oxidative folding of lysozyme by the use of aromatic thiol containing redox buffers.

Gurbhele-Tupkar MC, Perez LR, Silva Y, Lees WJ.

Bioorg Med Chem. 2008 Mar 1;16(5):2579-90. Epub 2007 Nov 22.

PMID:
18065232
34.

Radiofrequency ablation of lung metastases: factors influencing success.

Gillams AR, Lees WR.

Eur Radiol. 2008 Apr;18(4):672-7. Epub 2007 Nov 16.

PMID:
18008074
35.

Autoimmune pancreatitis: clinical and radiological features and objective response to steroid therapy in a UK series.

Church NI, Pereira SP, Deheragoda MG, Sandanayake N, Amin Z, Lees WR, Gillams A, Rodriguez-Justo M, Novelli M, Seward EW, Hatfield AR, Webster GJ.

Am J Gastroenterol. 2007 Nov;102(11):2417-25. Epub 2007 Sep 25.

PMID:
17894845
36.

Correlation of MRCP quantification (MRCPQ) with conventional non-invasive pancreatic exocrine function tests.

Gillams A, Pereira S, Webster G, Lees W.

Abdom Imaging. 2008 Jul-Aug;33(4):469-73.

PMID:
17653788
37.

Quantitative secretin MRCP (MRCPQ): results in 215 patients with known or suspected pancreatic pathology.

Gillams AR, Lees WR.

Eur Radiol. 2007 Nov;17(11):2984-90. Epub 2007 Jul 10.

PMID:
17619882
38.

Analysis of the factors associated with radiofrequency ablation-induced pneumothorax.

Gillams AR, Lees WR.

Clin Radiol. 2007 Jul;62(7):639-44. Epub 2007 May 11.

PMID:
17556032
39.

Endovascular management of major arterial hemorrhage as a complication of inflammatory pancreatic disease.

Hyare H, Desigan S, Brookes JA, Guiney MJ, Lees WR.

J Vasc Interv Radiol. 2007 May;18(5):591-6.

PMID:
17494839
40.

Origines de la surveillance infranationale au Canada.

Inch C, Lees W.

Can Vet J. 1999 Jan;40(1):58-64. No abstract available.

41.

Radiofrequency ablation (RFA) as a cytoreductive strategy for hepatic metastasis from breast cancer.

Lawes D, Chopada A, Gillams A, Lees W, Taylor I.

Ann R Coll Surg Engl. 2006 Nov;88(7):639-42.

42.

Diagnosing pancreatic cancer: the role of percutaneous biopsy and CT.

Amin Z, Theis B, Russell RC, House C, Novelli M, Lees WR.

Clin Radiol. 2006 Dec;61(12):996-1002.

PMID:
17097419
43.

ortho- and meta-substituted aromatic thiols are efficient redox buffers that increase the folding rate of a disulfide-containing protein.

Gough JD, Barrett EJ, Silva Y, Lees WJ.

J Biotechnol. 2006 Aug 20;125(1):39-47. Epub 2006 Apr 17.

PMID:
16616966
44.

Multi-section CT angiography compared with digital subtraction angiography in diagnosing major arterial hemorrhage in inflammatory pancreatic disease.

Hyare H, Desigan S, Nicholl H, Guiney MJ, Brookes JA, Lees WR.

Eur J Radiol. 2006 Aug;59(2):295-300. Epub 2006 Mar 20.

PMID:
16542810
45.

Defective acute inflammation in Crohn's disease: a clinical investigation.

Marks DJ, Harbord MW, MacAllister R, Rahman FZ, Young J, Al-Lazikani B, Lees W, Novelli M, Bloom S, Segal AW.

Lancet. 2006 Feb 25;367(9511):668-78. Erratum in: Lancet. 2007 Jul 28;370(9584):318.

PMID:
16503465
46.

Diagnosis of duct disruption and assessment of pancreatic leak with dynamic secretin-stimulated MR cholangiopancreatography.

Gillams AR, Kurzawinski T, Lees WR.

AJR Am J Roentgenol. 2006 Feb;186(2):499-506.

PMID:
16423959
47.

Photodynamic therapy using meso tetra hydroxy phenyl chlorin (mTHPC) in early prostate cancer.

Moore CM, Nathan TR, Lees WR, Mosse CA, Freeman A, Emberton M, Bown SG.

Lasers Surg Med. 2006 Jun;38(5):356-63.

PMID:
16392142
48.

Real-time three-dimensional ultrasound visualization of erection and artificial coitus.

Deng J, Hall-Craggs MA, Pellerin D, Linney AD, Lees WR, Rodeck CH, Todd-Pokropek A.

Int J Androl. 2006 Apr;29(2):374-9. Epub 2005 Dec 22.

PMID:
16390496
49.

Has veterinary medicine lost its voice?

Lees W.

Can Vet J. 2005 Jul;46(7):649-54. No abstract available.

50.

CT mapping of the distribution of saline during radiofrequency ablation with perfusion electrodes.

Gillams AR, Lees WR.

Cardiovasc Intervent Radiol. 2005 Jul-Aug;28(4):476-80.

PMID:
16001137

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