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Items: 1 to 50 of 66

1.

Regulatory T cells and their derived cytokine, interleukin-35, reduce pain in experimental autoimmune encephalomyelitis.

Duffy SS, Keating BA, Perera CJ, Lees JG, Tonkin RS, Makker PGS, Carrive P, Butovsky O, Moalem-Taylor G.

J Neurosci. 2019 Jan 16. pii: 1815-18. doi: 10.1523/JNEUROSCI.1815-18.2019. [Epub ahead of print]

PMID:
30651334
2.

Dorsal root ganglion explants derived from chemotherapy-treated mice have reduced neurite outgrowth in culture.

Livni L, Lees JG, Barkl-Luke ME, Goldstein D, Moalem-Taylor G.

Neurosci Lett. 2019 Feb 16;694:14-19. doi: 10.1016/j.neulet.2018.11.016. Epub 2018 Nov 13.

PMID:
30439399
3.

CATH: expanding the horizons of structure-based functional annotations for genome sequences.

Sillitoe I, Dawson N, Lewis TE, Das S, Lees JG, Ashford P, Tolulope A, Scholes HM, Senatorov I, Bujan A, Ceballos Rodriguez-Conde F, Dowling B, Thornton J, Orengo CA.

Nucleic Acids Res. 2019 Jan 8;47(D1):D280-D284. doi: 10.1093/nar/gky1097.

4.

Comprehensive analysis of long noncoding RNA expression in dorsal root ganglion reveals cell-type specificity and dysregulation after nerve injury.

Baskozos G, Dawes JM, Austin JS, Antunes-Martins A, McDermott L, Clark AJ, Trendafilova T, Lees JG, McMahon SB, Mogil JS, Orengo C, Bennett DL.

Pain. 2019 Feb;160(2):463-485. doi: 10.1097/j.pain.0000000000001416.

PMID:
30335683
5.

cath-resolve-hits: a new tool that resolves domain matches suspiciously quickly.

Lewis TE, Sillitoe I, Lees JG.

Bioinformatics. 2018 Oct 8. doi: 10.1093/bioinformatics/bty863. [Epub ahead of print]

PMID:
30295745
6.

Mitochondrial and glycolytic remodeling during nascent neural differentiation of human pluripotent stem cells.

Lees JG, Gardner DK, Harvey AJ.

Development. 2018 Oct 22;145(20). pii: dev168997. doi: 10.1242/dev.168997.

PMID:
30266828
7.

A unified model of the excitability of mouse sensory and motor axons.

Makker PGS, Matamala JM, Park SB, Lees JG, Kiernan MC, Burke D, Moalem-Taylor G, Howells J.

J Peripher Nerv Syst. 2018 Sep;23(3):159-173. doi: 10.1111/jns.12278. Epub 2018 Jul 15.

PMID:
29920851
8.

Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice.

Tonkin RS, Bowles C, Perera CJ, Keating BA, Makker PGS, Duffy SS, Lees JG, Tran C, Don AS, Fath T, Liu L, O'Carroll SJ, Nicholson LFB, Green CR, Gorrie C, Moalem-Taylor G.

Exp Neurol. 2018 Feb;300:1-12. doi: 10.1016/j.expneurol.2017.10.016. Epub 2017 Oct 18.

PMID:
29055716
9.

Analysis of temporal transcription expression profiles reveal links between protein function and developmental stages of Drosophila melanogaster.

Wan C, Lees JG, Minneci F, Orengo CA, Jones DT.

PLoS Comput Biol. 2017 Oct 18;13(10):e1005791. doi: 10.1371/journal.pcbi.1005791. eCollection 2017 Oct.

10.

Oxaliplatin induces muscle loss and muscle-specific molecular changes in Mice.

Feather CE, Lees JG, Makker PGS, Goldstein D, Kwok JB, Moalem-Taylor G, Polly P.

Muscle Nerve. 2018 Apr;57(4):650-658. doi: 10.1002/mus.25966. Epub 2017 Oct 6.

PMID:
28881481
11.

Managing Neuropathic Pain in Multiple Sclerosis: Pharmacological Interventions.

Duffy SS, Lees JG, Perera CJ, Moalem-Taylor G.

Med Chem. 2018 Feb 6;14(2):106-119. doi: 10.2174/1573406413666170906122508. Review.

PMID:
28875858
12.

Structural and Functional View of Polypharmacology.

Moya-García A, Adeyelu T, Kruger FA, Dawson NL, Lees JG, Overington JP, Orengo C, Ranea JAG.

Sci Rep. 2017 Aug 31;7(1):10102. doi: 10.1038/s41598-017-10012-x.

13.

Pluripotent Stem Cell Metabolism and Mitochondria: Beyond ATP.

Lees JG, Gardner DK, Harvey AJ.

Stem Cells Int. 2017;2017:2874283. doi: 10.1155/2017/2874283. Epub 2017 Jul 19. Review.

14.

Characterisation of Peptide5 systemic administration for treating traumatic spinal cord injured rats.

Mao Y, Nguyen T, Tonkin RS, Lees JG, Warren C, O'Carroll SJ, Nicholson LFB, Green CR, Moalem-Taylor G, Gorrie CA.

Exp Brain Res. 2017 Oct;235(10):3033-3048. doi: 10.1007/s00221-017-5023-3. Epub 2017 Jul 19.

PMID:
28725925
15.

CATH-Gene3D: Generation of the Resource and Its Use in Obtaining Structural and Functional Annotations for Protein Sequences.

Dawson NL, Sillitoe I, Lees JG, Lam SD, Orengo CA.

Methods Mol Biol. 2017;1558:79-110. doi: 10.1007/978-1-4939-6783-4_4.

PMID:
28150234
16.

Characterisation of Immune and Neuroinflammatory Changes Associated with Chemotherapy-Induced Peripheral Neuropathy.

Makker PG, Duffy SS, Lees JG, Perera CJ, Tonkin RS, Butovsky O, Park SB, Goldstein D, Moalem-Taylor G.

PLoS One. 2017 Jan 26;12(1):e0170814. doi: 10.1371/journal.pone.0170814. eCollection 2017.

17.

Immune-mediated processes implicated in chemotherapy-induced peripheral neuropathy.

Lees JG, Makker PG, Tonkin RS, Abdulla M, Park SB, Goldstein D, Moalem-Taylor G.

Eur J Cancer. 2017 Mar;73:22-29. doi: 10.1016/j.ejca.2016.12.006. Epub 2017 Jan 16. Review.

PMID:
28104535
18.

CATH: an expanded resource to predict protein function through structure and sequence.

Dawson NL, Lewis TE, Das S, Lees JG, Lee D, Ashford P, Orengo CA, Sillitoe I.

Nucleic Acids Res. 2017 Jan 4;45(D1):D289-D295. doi: 10.1093/nar/gkw1098. Epub 2016 Nov 28.

19.

Peripheral and Central Neuroinflammatory Changes and Pain Behaviors in an Animal Model of Multiple Sclerosis.

Duffy SS, Perera CJ, Makker PG, Lees JG, Carrive P, Moalem-Taylor G.

Front Immunol. 2016 Sep 22;7:369. eCollection 2016.

20.

An expanded evaluation of protein function prediction methods shows an improvement in accuracy.

Jiang Y, Oron TR, Clark WT, Bankapur AR, D'Andrea D, Lepore R, Funk CS, Kahanda I, Verspoor KM, Ben-Hur A, Koo da CE, Penfold-Brown D, Shasha D, Youngs N, Bonneau R, Lin A, Sahraeian SM, Martelli PL, Profiti G, Casadio R, Cao R, Zhong Z, Cheng J, Altenhoff A, Skunca N, Dessimoz C, Dogan T, Hakala K, Kaewphan S, Mehryary F, Salakoski T, Ginter F, Fang H, Smithers B, Oates M, Gough J, Törönen P, Koskinen P, Holm L, Chen CT, Hsu WL, Bryson K, Cozzetto D, Minneci F, Jones DT, Chapman S, Bkc D, Khan IK, Kihara D, Ofer D, Rappoport N, Stern A, Cibrian-Uhalte E, Denny P, Foulger RE, Hieta R, Legge D, Lovering RC, Magrane M, Melidoni AN, Mutowo-Meullenet P, Pichler K, Shypitsyna A, Li B, Zakeri P, ElShal S, Tranchevent LC, Das S, Dawson NL, Lee D, Lees JG, Sillitoe I, Bhat P, Nepusz T, Romero AE, Sasidharan R, Yang H, Paccanaro A, Gillis J, Sedeño-Cortés AE, Pavlidis P, Feng S, Cejuela JM, Goldberg T, Hamp T, Richter L, Salamov A, Gabaldon T, Marcet-Houben M, Supek F, Gong Q, Ning W, Zhou Y, Tian W, Falda M, Fontana P, Lavezzo E, Toppo S, Ferrari C, Giollo M, Piovesan D, Tosatto SC, Del Pozo A, Fernández JM, Maietta P, Valencia A, Tress ML, Benso A, Di Carlo S, Politano G, Savino A, Rehman HU, Re M, Mesiti M, Valentini G, Bargsten JW, van Dijk AD, Gemovic B, Glisic S, Perovic V, Veljkovic V, Veljkovic N, Almeida-E-Silva DC, Vencio RZ, Sharan M, Vogel J, Kansakar L, Zhang S, Vucetic S, Wang Z, Sternberg MJ, Wass MN, Huntley RP, Martin MJ, O'Donovan C, Robinson PN, Moreau Y, Tramontano A, Babbitt PC, Brenner SE, Linial M, Orengo CA, Rost B, Greene CS, Mooney SD, Friedberg I, Radivojac P.

Genome Biol. 2016 Sep 7;17(1):184. doi: 10.1186/s13059-016-1037-6.

21.

Functional classification of CATH superfamilies: a domain-based approach for protein function annotation.

Das S, Lee D, Sillitoe I, Dawson NL, Lees JG, Orengo CA.

Bioinformatics. 2016 Sep 15;32(18):2889. doi: 10.1093/bioinformatics/btw473. Epub 2016 Jul 31. No abstract available.

22.

Functional innovation from changes in protein domains and their combinations.

Lees JG, Dawson NL, Sillitoe I, Orengo CA.

Curr Opin Struct Biol. 2016 Jun;38:44-52. doi: 10.1016/j.sbi.2016.05.016. Epub 2016 Jun 13. Review.

PMID:
27309309
23.

The Pain in Neuropathy Study (PiNS): a cross-sectional observational study determining the somatosensory phenotype of painful and painless diabetic neuropathy.

Themistocleous AC, Ramirez JD, Shillo PR, Lees JG, Selvarajah D, Orengo C, Tesfaye S, Rice AS, Bennett DL.

Pain. 2016 May;157(5):1132-45. doi: 10.1097/j.pain.0000000000000491.

24.

Gene3D: expanding the utility of domain assignments.

Lam SD, Dawson NL, Das S, Sillitoe I, Ashford P, Lee D, Lehtinen S, Orengo CA, Lees JG.

Nucleic Acids Res. 2016 Jan 4;44(D1):D404-9. doi: 10.1093/nar/gkv1231. Epub 2015 Nov 17.

25.

Cytokines in Neuropathic Pain and Associated Depression.

Lees JG, Fivelman B, Duffy SS, Makker PG, Perera CJ, Moalem-Taylor G.

Mod Trends Pharmacopsychiatry. 2015;30:51-66. doi: 10.1159/000435932. Epub 2015 Sep 18. Review.

PMID:
26437375
26.

Effects of active immunisation with myelin basic protein and myelin-derived altered peptide ligand on pain hypersensitivity and neuroinflammation.

Perera CJ, Lees JG, Duffy SS, Makker PG, Fivelman B, Apostolopoulos V, Moalem-Taylor G.

J Neuroimmunol. 2015 Sep 15;286:59-70. doi: 10.1016/j.jneuroim.2015.07.004. Epub 2015 Jul 13.

PMID:
26298325
27.

Identifying and characterising key alternative splicing events in Drosophila development.

Lees JG, Ranea JA, Orengo CA.

BMC Genomics. 2015 Aug 16;16:608. doi: 10.1186/s12864-015-1674-2.

28.

Distinct profiles of human embryonic stem cell metabolism and mitochondria identified by oxygen.

Lees JG, Rathjen J, Sheedy JR, Gardner DK, Harvey AJ.

Reproduction. 2015 Oct;150(4):367-82. doi: 10.1530/REP-14-0633. Epub 2015 Jul 9.

PMID:
26159831
29.

Functional classification of CATH superfamilies: a domain-based approach for protein function annotation.

Das S, Lee D, Sillitoe I, Dawson NL, Lees JG, Orengo CA.

Bioinformatics. 2015 Nov 1;31(21):3460-7. doi: 10.1093/bioinformatics/btv398. Epub 2015 Jul 2. Erratum in: Bioinformatics. 2016 Sep 15;32(18):2889.

30.

CATH FunFHMMer web server: protein functional annotations using functional family assignments.

Das S, Sillitoe I, Lee D, Lees JG, Dawson NL, Ward J, Orengo CA.

Nucleic Acids Res. 2015 Jul 1;43(W1):W148-53. doi: 10.1093/nar/gkv488. Epub 2015 May 11.

31.

Active immunization with myelin-derived altered peptide ligand reduces mechanical pain hypersensitivity following peripheral nerve injury.

Perera CJ, Duffy SS, Lees JG, Kim CF, Cameron B, Apostolopoulos V, Moalem-Taylor G.

J Neuroinflammation. 2015 Feb 13;12:28. doi: 10.1186/s12974-015-0253-4.

32.

FUN-L: gene prioritization for RNAi screens.

Lees JG, Hériché JK, Morilla I, Fernández JM, Adler P, Krallinger M, Vilo J, Valencia A, Ellenberg J, Ranea JA, Orengo C.

Bioinformatics. 2015 Jun 15;31(12):2052-3. doi: 10.1093/bioinformatics/btv073. Epub 2015 Feb 8.

PMID:
25667547
33.

Role of dynamin in elongated cell migration in a 3D matrix.

Lees JG, Gorgani NN, Ammit AJ, McCluskey A, Robinson PJ, O'Neill GM.

Biochim Biophys Acta. 2015 Mar;1853(3):611-8. doi: 10.1016/j.bbamcr.2014.12.008. Epub 2014 Dec 10.

34.

Depletion of Foxp3+ regulatory T cells increases severity of mechanical allodynia and significantly alters systemic cytokine levels following peripheral nerve injury.

Lees JG, Duffy SS, Perera CJ, Moalem-Taylor G.

Cytokine. 2015 Feb;71(2):207-14. doi: 10.1016/j.cyto.2014.10.028. Epub 2014 Nov 20.

PMID:
25461400
35.

The contribution of immune and glial cell types in experimental autoimmune encephalomyelitis and multiple sclerosis.

Duffy SS, Lees JG, Moalem-Taylor G.

Mult Scler Int. 2014;2014:285245. doi: 10.1155/2014/285245. Epub 2014 Oct 12. Review.

36.

CATH: comprehensive structural and functional annotations for genome sequences.

Sillitoe I, Lewis TE, Cuff A, Das S, Ashford P, Dawson NL, Furnham N, Laskowski RA, Lee D, Lees JG, Lehtinen S, Studer RA, Thornton J, Orengo CA.

Nucleic Acids Res. 2015 Jan;43(Database issue):D376-81. doi: 10.1093/nar/gku947. Epub 2014 Oct 27.

37.

Integration of biological data by kernels on graph nodes allows prediction of new genes involved in mitotic chromosome condensation.

Hériché JK, Lees JG, Morilla I, Walter T, Petrova B, Roberti MJ, Hossain MJ, Adler P, Fernández JM, Krallinger M, Haering CH, Vilo J, Valencia A, Ranea JA, Orengo C, Ellenberg J.

Mol Biol Cell. 2014 Aug 15;25(16):2522-36. doi: 10.1091/mbc.E13-04-0221. Epub 2014 Jun 18.

38.

Scaffolds for islets and stem cells differentiated into insulin-secreting cells.

Tuch BE, Gao SY, Lees JG.

Front Biosci (Landmark Ed). 2014 Jan 1;19:126-38. Review.

PMID:
24389176
39.

Immunotherapy targeting cytokines in neuropathic pain.

Lees JG, Duffy SS, Moalem-Taylor G.

Front Pharmacol. 2013 Nov 22;4:142. doi: 10.3389/fphar.2013.00142. eCollection 2013. No abstract available.

40.

Gene3D: Multi-domain annotations for protein sequence and comparative genome analysis.

Lees JG, Lee D, Studer RA, Dawson NL, Sillitoe I, Das S, Yeats C, Dessailly BH, Rentzsch R, Orengo CA.

Nucleic Acids Res. 2014 Jan;42(Database issue):D240-5. doi: 10.1093/nar/gkt1205. Epub 2013 Nov 21.

41.

Tropomyosin regulates cell migration during skin wound healing.

Lees JG, Ching YW, Adams DH, Bach CT, Samuel MS, Kee AJ, Hardeman EC, Gunning P, Cowin AJ, O'Neill GM.

J Invest Dermatol. 2013 May;133(5):1330-9. doi: 10.1038/jid.2012.489. Epub 2013 Jan 10.

42.

New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures.

Sillitoe I, Cuff AL, Dessailly BH, Dawson NL, Furnham N, Lee D, Lees JG, Lewis TE, Studer RA, Rentzsch R, Yeats C, Thornton JM, Orengo CA.

Nucleic Acids Res. 2013 Jan;41(Database issue):D490-8. doi: 10.1093/nar/gks1211. Epub 2012 Nov 29.

43.

Systematic computational prediction of protein interaction networks.

Lees JG, Heriche JK, Morilla I, Ranea JA, Orengo CA.

Phys Biol. 2011 Jun;8(3):035008. doi: 10.1088/1478-3975/8/3/035008. Epub 2011 May 13.

PMID:
21572181
44.

Interior decoration: tropomyosin in actin dynamics and cell migration.

Lees JG, Bach CT, O'Neill GM.

Cell Adh Migr. 2011 Mar-Apr;5(2):181-6. Epub 2011 Mar 1. Review.

45.

The actin-associating protein Tm5NM1 blocks mesenchymal motility without transition to amoeboid motility.

Lees JG, Bach CT, Bradbury P, Paul A, Gunning PW, O'Neill GM.

Oncogene. 2011 Mar 10;30(10):1241-51. doi: 10.1038/onc.2010.516. Epub 2010 Nov 15.

PMID:
21076470
46.

Transient protein-protein interactions: structural, functional, and network properties.

Perkins JR, Diboun I, Dessailly BH, Lees JG, Orengo C.

Structure. 2010 Oct 13;18(10):1233-43. doi: 10.1016/j.str.2010.08.007. Review.

47.

Finding the "dark matter" in human and yeast protein network prediction and modelling.

Ranea JA, Morilla I, Lees JG, Reid AJ, Yeats C, Clegg AB, Sanchez-Jimenez F, Orengo C.

PLoS Comput Biol. 2010 Sep 23;6(9). pii: e1000945. doi: 10.1371/journal.pcbi.1000945.

48.

Assessment of protein domain fusions in human protein interaction networks prediction: application to the human kinetochore model.

Morilla I, Lees JG, Reid AJ, Orengo C, Ranea JA.

N Biotechnol. 2010 Dec 31;27(6):755-65. doi: 10.1016/j.nbt.2010.09.005. Epub 2010 Sep 17.

PMID:
20851221
49.

Derivation of a new human embryonic stem cell line, Endeavour-2, and its characterization.

Sidhu KS, Ryan JP, Lees JG, Tuch BE.

In Vitro Cell Dev Biol Anim. 2010 Apr;46(3-4):269-75. doi: 10.1007/s11626-010-9280-8. Epub 2010 Feb 23.

PMID:
20178001
50.

Definitive endoderm derived from human embryonic stem cells highly express the integrin receptors alphaV and beta5.

Wong JC, Gao SY, Lees JG, Best MB, Wang R, Tuch BE.

Cell Adh Migr. 2010 Jan-Mar;4(1):39-45. Epub 2010 Jan 13.

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