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Items: 1 to 50 of 117

1.

RhierBAPS: An R implementation of the population clustering algorithm hierBAPS.

Tonkin-Hill G, Lees JA, Bentley SD, Frost SDW, Corander J.

Wellcome Open Res. 2018 Jul 30;3:93. doi: 10.12688/wellcomeopenres.14694.1. eCollection 2018.

2.

VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites.

Kumar N, Leonzino M, Hancock-Cerutti W, Horenkamp FA, Li P, Lees JA, Wheeler H, Reinisch KM, De Camilli P.

J Cell Biol. 2018 Oct 1;217(10):3625-3639. doi: 10.1083/jcb.201807019. Epub 2018 Aug 9.

PMID:
30093493
3.

The Rb tumor suppressor regulates epithelial cell migration and polarity.

Parisi T, Balsamo M, Gertler F, Lees JA.

Mol Carcinog. 2018 Nov;57(11):1640-1650. doi: 10.1002/mc.22886. Epub 2018 Aug 26.

PMID:
30084175
4.

SuperDCA for genome-wide epistasis analysis.

Puranen S, Pesonen M, Pensar J, Xu YY, Lees JA, Bentley SD, Croucher NJ, Corander J.

Microb Genom. 2018 May 29. doi: 10.1099/mgen.0.000184. [Epub ahead of print]

5.

Evaluation of phylogenetic reconstruction methods using bacterial whole genomes: a simulation based study.

Lees JA, Kendall M, Parkhill J, Colijn C, Bentley SD, Harris SR.

Wellcome Open Res. 2018 Mar 23;3:33. doi: 10.12688/wellcomeopenres.14265.2. eCollection 2018.

6.

Uveal melanoma driver mutations in GNAQ/11 yield numerous changes in melanocyte biology.

Perez DE, Henle AM, Amsterdam A, Hagen HR, Lees JA.

Pigment Cell Melanoma Res. 2018 Mar 23. doi: 10.1111/pcmr.12700. [Epub ahead of print]

PMID:
29570931
7.

Architecture of the human PI4KIIIα lipid kinase complex.

Lees JA, Zhang Y, Oh MS, Schauder CM, Yu X, Baskin JM, Dobbs K, Notarangelo LD, De Camilli P, Walz T, Reinisch KM.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):13720-13725. doi: 10.1073/pnas.1718471115. Epub 2017 Dec 11.

8.

EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling.

Guen VJ, Chavarria TE, Kröger C, Ye X, Weinberg RA, Lees JA.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):E10532-E10539. doi: 10.1073/pnas.1711534114. Epub 2017 Nov 20.

9.

A homozygous deleterious CDK10 mutation in a patient with agenesis of corpus callosum, retinopathy, and deafness.

Guen VJ, Edvardson S, Fraenkel ND, Fattal-Valevski A, Jalas C, Anteby I, Shaag A, Dor T, Gillis D, Kerem E, Lees JA, Colas P, Elpeleg O.

Am J Med Genet A. 2018 Jan;176(1):92-98. doi: 10.1002/ajmg.a.38506. Epub 2017 Nov 12.

PMID:
29130579
10.

Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma.

Braun CJ, Stanciu M, Boutz PL, Patterson JC, Calligaris D, Higuchi F, Neupane R, Fenoglio S, Cahill DP, Wakimoto H, Agar NYR, Yaffe MB, Sharp PA, Hemann MT, Lees JA.

Cancer Cell. 2017 Oct 9;32(4):411-426.e11. doi: 10.1016/j.ccell.2017.08.018. Epub 2017 Sep 28.

11.

Stronger together.

Lees JA, Tonkin-Hill G, Bentley SD.

Nat Rev Microbiol. 2017 Sep;15(9):516. doi: 10.1038/nrmicro.2017.95. Epub 2017 Aug 7. No abstract available.

PMID:
28781366
12.

Genome-wide identification of lineage and locus specific variation associated with pneumococcal carriage duration.

Lees JA, Croucher NJ, Goldblatt D, Nosten F, Parkhill J, Turner C, Turner P, Bentley SD.

Elife. 2017 Jul 25;6. pii: e26255. doi: 10.7554/eLife.26255.

13.

Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis.

Mori M, Hazan R, Danielian PS, Mahoney JE, Li H, Lu J, Miller ES, Zhu X, Lees JA, Cardoso WV.

Nat Commun. 2017 Jul 4;8:15857. doi: 10.1038/ncomms15857.

14.

Large scale genomic analysis shows no evidence for pathogen adaptation between the blood and cerebrospinal fluid niches during bacterial meningitis.

Lees JA, Kremer PH, Manso AS, Croucher NJ, Ferwerda B, Serón MV, Oggioni MR, Parkhill J, Brouwer MC, van der Ende A, van de Beek D, Bentley SD.

Microb Genom. 2017 Jan 31;3(1):e000103. doi: 10.1099/mgen.0.000103. eCollection 2017 Jan.

15.

Within-Host Sampling of a Natural Population Shows Signs of Selection on Pde1 during Bacterial Meningitis.

Lees JA, Brouwer M, van der Ende A, Parkhill J, van de Beek D, Bentley SD.

Infect Immun. 2017 Feb 23;85(3). pii: e01061-16. doi: 10.1128/IAI.01061-16. Print 2017 Mar. No abstract available.

16.

Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion.

Lees JA, Messa M, Sun EW, Wheeler H, Torta F, Wenk MR, De Camilli P, Reinisch KM.

Science. 2017 Feb 17;355(6326). pii: eaah6171. doi: 10.1126/science.aah6171.

17.

The awakening of the CDK10/Cyclin M protein kinase.

Guen VJ, Gamble C, Lees JA, Colas P.

Oncotarget. 2017 Jul 25;8(30):50174-50186. doi: 10.18632/oncotarget.15024. Review.

18.

Benzalkonium tolerance genes and outcome in Listeria monocytogenes meningitis.

Kremer PH, Lees JA, Koopmans MM, Ferwerda B, Arends AW, Feller MM, Schipper K, Valls Seron M, van der Ende A, Brouwer MC, van de Beek D, Bentley SD.

Clin Microbiol Infect. 2017 Apr;23(4):265.e1-265.e7. doi: 10.1016/j.cmi.2016.12.008. Epub 2016 Dec 18.

19.

Adults with suspected central nervous system infection: A prospective study of diagnostic accuracy.

Khatib U, van de Beek D, Lees JA, Brouwer MC.

J Infect. 2017 Jan;74(1):1-9. doi: 10.1016/j.jinf.2016.09.007. Epub 2016 Oct 13.

PMID:
27746160
20.

Sequence element enrichment analysis to determine the genetic basis of bacterial phenotypes.

Lees JA, Vehkala M, Välimäki N, Harris SR, Chewapreecha C, Croucher NJ, Marttinen P, Davies MR, Steer AC, Tong SY, Honkela A, Parkhill J, Bentley SD, Corander J.

Nat Commun. 2016 Sep 16;7:12797. doi: 10.1038/ncomms12797.

21.

Bacterial GWAS: not just gilding the lily.

Lees JA, Bentley SD.

Nat Rev Microbiol. 2016 Jul;14(7):406. doi: 10.1038/nrmicro.2016.82. Epub 2016 May 31. No abstract available.

PMID:
27241043
22.

STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis.

Guen VJ, Gamble C, Perez DE, Bourassa S, Zappel H, Gärtner J, Lees JA, Colas P.

Cell Cycle. 2016;15(5):678-88. doi: 10.1080/15384101.2016.1147632.

23.

E2f4 and E2f5 are essential for the development of the male reproductive system.

Danielian PS, Hess RA, Lees JA.

Cell Cycle. 2016;15(2):250-60. doi: 10.1080/15384101.2015.1121350.

24.

BMI1 induces an invasive signature in melanoma that promotes metastasis and chemoresistance.

Ferretti R, Bhutkar A, McNamara MC, Lees JA.

Genes Dev. 2016 Jan 1;30(1):18-33. doi: 10.1101/gad.267757.115. Epub 2015 Dec 17.

25.

Using genomics to combat infectious diseases on a global scale.

Cain AK, Lees JA.

Genome Biol. 2015 Nov 19;16:250. doi: 10.1186/s13059-015-0822-y.

26.

Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation.

Nicolay BN, Danielian PS, Kottakis F, Lapek JD Jr, Sanidas I, Miles WO, Dehnad M, Tschöp K, Gierut JJ, Manning AL, Morris R, Haigis K, Bardeesy N, Lees JA, Haas W, Dyson NJ.

Genes Dev. 2015 Sep 1;29(17):1875-89. doi: 10.1101/gad.264127.115. Epub 2015 Aug 27.

27.

Variations in dysfunction of sister chromatid cohesion in esco2 mutant zebrafish reflect the phenotypic diversity of Roberts syndrome.

Percival SM, Thomas HR, Amsterdam A, Carroll AJ, Lees JA, Yost HJ, Parant JM.

Dis Model Mech. 2015 Aug 1;8(8):941-55. doi: 10.1242/dmm.019059. Epub 2015 Jun 4.

28.

Minor Changes in Expression of the Mismatch Repair Protein MSH2 Exert a Major Impact on Glioblastoma Response to Temozolomide.

McFaline-Figueroa JL, Braun CJ, Stanciu M, Nagel ZD, Mazzucato P, Sangaraju D, Cerniauskas E, Barford K, Vargas A, Chen Y, Tretyakova N, Lees JA, Hemann MT, White FM, Samson LD.

Cancer Res. 2015 Aug 1;75(15):3127-38. doi: 10.1158/0008-5472.CAN-14-3616. Epub 2015 May 29.

29.

Inactivation of the retinoblastoma gene yields a mouse model of malignant colorectal cancer.

Parisi T, Bronson RT, Lees JA.

Oncogene. 2015 Nov 26;34(48):5890-9. doi: 10.1038/onc.2015.30. Epub 2015 Mar 9.

30.

Evidence for global cooling in the Late Cretaceous.

Linnert C, Robinson SA, Lees JA, Bown PR, Pérez-Rodríguez I, Petrizzo MR, Falzoni F, Littler K, Arz JA, Russell EE.

Nat Commun. 2014 Jun 17;5:4194. doi: 10.1038/ncomms5194.

31.

Comparative oncogenomic analysis of copy number alterations in human and zebrafish tumors enables cancer driver discovery.

Zhang G, Hoersch S, Amsterdam A, Whittaker CA, Beert E, Catchen JM, Farrington S, Postlethwait JH, Legius E, Hopkins N, Lees JA.

PLoS Genet. 2013 Aug;9(8):e1003734. doi: 10.1371/journal.pgen.1003734. Epub 2013 Aug 29.

32.

Bmi1 is required for tumorigenesis in a mouse model of intestinal cancer.

Maynard MA, Ferretti R, Hilgendorf KI, Perret C, Whyte P, Lees JA.

Oncogene. 2014 Jul 10;33(28):3742-7. doi: 10.1038/onc.2013.333. Epub 2013 Aug 19.

33.

The retinoblastoma protein induces apoptosis directly at the mitochondria.

Hilgendorf KI, Leshchiner ES, Nedelcu S, Maynard MA, Calo E, Ianari A, Walensky LD, Lees JA.

Genes Dev. 2013 May 1;27(9):1003-15. doi: 10.1101/gad.211326.112. Epub 2013 Apr 25.

34.

Loss of pRB and p107 disrupts cartilage development and promotes enchondroma formation.

Landman AS, Danielian PS, Lees JA.

Oncogene. 2013 Oct;32(40):4798-805. doi: 10.1038/onc.2012.496. Epub 2012 Nov 12.

35.

Proliferation and tumorigenesis of a murine sarcoma cell line in the absence of DICER1.

Ravi A, Gurtan AM, Kumar MS, Bhutkar A, Chin C, Lu V, Lees JA, Jacks T, Sharp PA.

Cancer Cell. 2012 Jun 12;21(6):848-55. doi: 10.1016/j.ccr.2012.04.037.

36.

Molecular organization of the COG vesicle tethering complex.

Lees JA, Yip CK, Walz T, Hughson FM.

Nat Struct Mol Biol. 2010 Nov;17(11):1292-7. doi: 10.1038/nsmb.1917. Epub 2010 Oct 24.

37.

Highly aneuploid zebrafish malignant peripheral nerve sheath tumors have genetic alterations similar to human cancers.

Zhang G, Hoersch S, Amsterdam A, Whittaker CA, Lees JA, Hopkins N.

Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16940-5. doi: 10.1073/pnas.1011548107. Epub 2010 Sep 13.

38.

Rb regulates fate choice and lineage commitment in vivo.

Calo E, Quintero-Estades JA, Danielian PS, Nedelcu S, Berman SD, Lees JA.

Nature. 2010 Aug 26;466(7310):1110-4. doi: 10.1038/nature09264. Epub 2010 Aug 4.

39.

Disruption of calvarial ossification in E2f4 mutant embryos correlates with increased proliferation and progenitor cell populations.

Miller ES, Berman SD, Yuan TL, Lees JA.

Cell Cycle. 2010 Jul 1;9(13):2620-8. doi: 10.4161/cc.9.13.12108.

40.

A vertebrate gene, ticrr, is an essential checkpoint and replication regulator.

Sansam CL, Cruz NM, Danielian PS, Amsterdam A, Lau ML, Hopkins N, Lees JA.

Genes Dev. 2010 Jan 15;24(2):183-94. doi: 10.1101/gad.1860310.

41.

pRB and E2F4 play distinct cell-intrinsic roles in fetal erythropoiesis.

Zhang J, Lee EY, Liu Y, Berman SD, Lodish HF, Lees JA.

Cell Cycle. 2010 Jan 15;9(2):371-6. Epub 2010 Jan 29.

42.

Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects.

Berman SD, West JC, Danielian PS, Caron AM, Stone JR, Lees JA.

Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14932-6. doi: 10.1073/pnas.0902408106. Epub 2009 Aug 19.

43.

Zebrafish Hagoromo mutants up-regulate fgf8 postembryonically and develop neuroblastoma.

Amsterdam A, Lai K, Komisarczuk AZ, Becker TS, Bronson RT, Hopkins N, Lees JA.

Mol Cancer Res. 2009 Jun;7(6):841-50. doi: 10.1158/1541-7786.MCR-08-0555. Epub 2009 Jun 16.

44.

E2F4 cooperates with pRB in the development of extra-embryonic tissues.

Lee EY, Yuan TL, Danielian PS, West JC, Lees JA.

Dev Biol. 2009 Aug 1;332(1):104-15. doi: 10.1016/j.ydbio.2009.05.541. Epub 2009 May 9.

45.

Proapoptotic function of the retinoblastoma tumor suppressor protein.

Ianari A, Natale T, Calo E, Ferretti E, Alesse E, Screpanti I, Haigis K, Gulino A, Lees JA.

Cancer Cell. 2009 Mar 3;15(3):184-94. doi: 10.1016/j.ccr.2009.01.026.

46.

Many ribosomal protein mutations are associated with growth impairment and tumor predisposition in zebrafish.

Lai K, Amsterdam A, Farrington S, Bronson RT, Hopkins N, Lees JA.

Dev Dyn. 2009 Jan;238(1):76-85. doi: 10.1002/dvdy.21815.

47.

E2F3 plays an essential role in cardiac development and function.

King JC, Moskowitz IP, Burgon PG, Ahmad F, Stone JR, Seidman JG, Lees JA.

Cell Cycle. 2008 Dec;7(23):3775-80. Epub 2008 Dec 22.

48.
49.

The retinoblastoma protein tumor suppressor is important for appropriate osteoblast differentiation and bone development.

Berman SD, Yuan TL, Miller ES, Lee EY, Caron A, Lees JA.

Mol Cancer Res. 2008 Sep;6(9):1440-51. doi: 10.1158/1541-7786.MCR-08-0176.

50.

Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage.

Berman SD, Calo E, Landman AS, Danielian PS, Miller ES, West JC, Fonhoue BD, Caron A, Bronson R, Bouxsein ML, Mukherjee S, Lees JA.

Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11851-6. doi: 10.1073/pnas.0805462105. Epub 2008 Aug 12.

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