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Items: 1 to 50 of 131

1.

Immune exclusion by naturally-acquired secretory IgA to the pneumococcal pilus-1.

Binsker U, Lees JA, Hammond AJ, Weiser JN.

J Clin Invest. 2019 Nov 5. pii: 132005. doi: 10.1172/JCI132005. [Epub ahead of print]

2.

Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance.

Dalin S, Sullivan MR, Lau AN, Grauman-Boss B, Mueller HS, Kreidl E, Fenoglio S, Luengo A, Lees JA, Vander Heiden MG, Lauffenburger DA, Hemann MT.

Cancer Res. 2019 Sep 4. pii: canres.0960.2019. doi: 10.1158/0008-5472.CAN-19-0960. [Epub ahead of print]

PMID:
31484670
3.

Genome-wide epistasis and co-selection study using mutual information.

Pensar J, Puranen S, Arnold B, MacAlasdair N, Kuronen J, Tonkin-Hill G, Pesonen M, Xu Y, Sipola A, Sánchez-Busó L, Lees JA, Chewapreecha C, Bentley SD, Harris SR, Parkhill J, Croucher NJ, Corander J.

Nucleic Acids Res. 2019 Oct 10;47(18):e112. doi: 10.1093/nar/gkz656.

4.

Author Correction: Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics.

Davies MR, McIntyre L, Mutreja A, Lacey JA, Lees JA, Towers RJ, Duchêne S, Smeesters PR, Frost HR, Price DJ, Holden MTG, David S, Giffard PM, Worthing KA, Seale AC, Berkley JA, Harris SR, Rivera-Hernandez T, Berking O, Cork AJ, Torres RSLA, Lithgow T, Strugnell RA, Bergmann R, Nitsche-Schmitz P, Chhatwal GS, Bentley SD, Fraser JD, Moreland NJ, Carapetis JR, Steer AC, Parkhill J, Saul A, Williamson DA, Currie BJ, Tong SYC, Dougan G, Walker MJ.

Nat Genet. 2019 Aug;51(8):1295. doi: 10.1038/s41588-019-0482-z.

PMID:
31324894
5.

Pneumococcal lineages associated with serotype replacement and antibiotic resistance in childhood invasive pneumococcal disease in the post-PCV13 era: an international whole-genome sequencing study.

Lo SW, Gladstone RA, van Tonder AJ, Lees JA, du Plessis M, Benisty R, Givon-Lavi N, Hawkins PA, Cornick JE, Kwambana-Adams B, Law PY, Ho PL, Antonio M, Everett DB, Dagan R, von Gottberg A, Klugman KP, McGee L, Breiman RF, Bentley SD; Global Pneumococcal Sequencing Consortium.

Lancet Infect Dis. 2019 Jul;19(7):759-769. doi: 10.1016/S1473-3099(19)30297-X. Epub 2019 Jun 10.

6.

Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics.

Davies MR, McIntyre L, Mutreja A, Lacey JA, Lees JA, Towers RJ, Duchêne S, Smeesters PR, Frost HR, Price DJ, Holden MTG, David S, Giffard PM, Worthing KA, Seale AC, Berkley JA, Harris SR, Rivera-Hernandez T, Berking O, Cork AJ, Torres RSLA, Lithgow T, Strugnell RA, Bergmann R, Nitsche-Schmitz P, Chhatwal GS, Bentley SD, Fraser JD, Moreland NJ, Carapetis JR, Steer AC, Parkhill J, Saul A, Williamson DA, Currie BJ, Tong SYC, Dougan G, Walker MJ.

Nat Genet. 2019 Jun;51(6):1035-1043. doi: 10.1038/s41588-019-0417-8. Epub 2019 May 27. Erratum in: Nat Genet. 2019 Jul 19;:.

PMID:
31133745
7.

Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis.

Lees JA, Ferwerda B, Kremer PHC, Wheeler NE, Serón MV, Croucher NJ, Gladstone RA, Bootsma HJ, Rots NY, Wijmega-Monsuur AJ, Sanders EAM, Trzciński K, Wyllie AL, Zwinderman AH, van den Berg LH, van Rheenen W, Veldink JH, Harboe ZB, Lundbo LF, de Groot LCPGM, van Schoor NM, van der Velde N, Ängquist LH, Sørensen TIA, Nohr EA, Mentzer AJ, Mills TC, Knight JC, du Plessis M, Nzenze S, Weiser JN, Parkhill J, Madhi S, Benfield T, von Gottberg A, van der Ende A, Brouwer MC, Barrett JC, Bentley SD, van de Beek D.

Nat Commun. 2019 May 15;10(1):2176. doi: 10.1038/s41467-019-09976-3.

8.

Fast hierarchical Bayesian analysis of population structure.

Tonkin-Hill G, Lees JA, Bentley SD, Frost SDW, Corander J.

Nucleic Acids Res. 2019 Jun 20;47(11):5539-5549. doi: 10.1093/nar/gkz361.

9.

International genomic definition of pneumococcal lineages, to contextualise disease, antibiotic resistance and vaccine impact.

Gladstone RA, Lo SW, Lees JA, Croucher NJ, van Tonder AJ, Corander J, Page AJ, Marttinen P, Bentley LJ, Ochoa TJ, Ho PL, du Plessis M, Cornick JE, Kwambana-Adams B, Benisty R, Nzenze SA, Madhi SA, Hawkins PA, Everett DB, Antonio M, Dagan R, Klugman KP, von Gottberg A, McGee L, Breiman RF, Bentley SD; Global Pneumococcal Sequencing Consortium.

EBioMedicine. 2019 May;43:338-346. doi: 10.1016/j.ebiom.2019.04.021. Epub 2019 Apr 16.

10.

ATG2 transports lipids to promote autophagosome biogenesis.

Valverde DP, Yu S, Boggavarapu V, Kumar N, Lees JA, Walz T, Reinisch KM, Melia TJ.

J Cell Biol. 2019 Jun 3;218(6):1787-1798. doi: 10.1083/jcb.201811139. Epub 2019 Apr 5.

PMID:
30952800
11.

Fast and flexible bacterial genomic epidemiology with PopPUNK.

Lees JA, Harris SR, Tonkin-Hill G, Gladstone RA, Lo SW, Weiser JN, Corander J, Bentley SD, Croucher NJ.

Genome Res. 2019 Feb;29(2):304-316. doi: 10.1101/gr.241455.118. Epub 2019 Jan 24.

12.

Pneumococcal quorum sensing drives an asymmetric owner-intruder competitive strategy during carriage via the competence regulon.

Shen P, Lees JA, Bee GCW, Brown SP, Weiser JN.

Nat Microbiol. 2019 Jan;4(1):198-208. doi: 10.1038/s41564-018-0314-4. Epub 2018 Dec 10.

13.

pyseer: a comprehensive tool for microbial pangenome-wide association studies.

Lees JA, Galardini M, Bentley SD, Weiser JN, Corander J.

Bioinformatics. 2018 Dec 15;34(24):4310-4312. doi: 10.1093/bioinformatics/bty539.

14.

Author Correction: Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis.

Mori M, Hazan R, Danielian PS, Mahoney JE, Li H, Lu J, Miller ES, Zhu X, Lees JA, Cardoso WV.

Nat Commun. 2018 Nov 19;9:16157. doi: 10.1038/ncomms16157.

15.

RhierBAPS: An R implementation of the population clustering algorithm hierBAPS.

Tonkin-Hill G, Lees JA, Bentley SD, Frost SDW, Corander J.

Wellcome Open Res. 2018 Jul 30;3:93. doi: 10.12688/wellcomeopenres.14694.1. eCollection 2018.

16.

VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites.

Kumar N, Leonzino M, Hancock-Cerutti W, Horenkamp FA, Li P, Lees JA, Wheeler H, Reinisch KM, De Camilli P.

J Cell Biol. 2018 Oct 1;217(10):3625-3639. doi: 10.1083/jcb.201807019. Epub 2018 Aug 9.

17.

The Rb tumor suppressor regulates epithelial cell migration and polarity.

Parisi T, Balsamo M, Gertler F, Lees JA.

Mol Carcinog. 2018 Nov;57(11):1640-1650. doi: 10.1002/mc.22886. Epub 2018 Aug 26.

18.

SuperDCA for genome-wide epistasis analysis.

Puranen S, Pesonen M, Pensar J, Xu YY, Lees JA, Bentley SD, Croucher NJ, Corander J.

Microb Genom. 2018 Jun;4(6). doi: 10.1099/mgen.0.000184. Epub 2018 May 29.

19.

Evaluation of phylogenetic reconstruction methods using bacterial whole genomes: a simulation based study.

Lees JA, Kendall M, Parkhill J, Colijn C, Bentley SD, Harris SR.

Wellcome Open Res. 2018 Mar 23;3:33. doi: 10.12688/wellcomeopenres.14265.2. eCollection 2018.

20.

Uveal melanoma driver mutations in GNAQ/11 yield numerous changes in melanocyte biology.

Perez DE, Henle AM, Amsterdam A, Hagen HR, Lees JA.

Pigment Cell Melanoma Res. 2018 Sep;31(5):604-613. doi: 10.1111/pcmr.12700. Epub 2018 Apr 6.

21.

Architecture of the human PI4KIIIα lipid kinase complex.

Lees JA, Zhang Y, Oh MS, Schauder CM, Yu X, Baskin JM, Dobbs K, Notarangelo LD, De Camilli P, Walz T, Reinisch KM.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):13720-13725. doi: 10.1073/pnas.1718471115. Epub 2017 Dec 11.

22.

EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling.

Guen VJ, Chavarria TE, Kröger C, Ye X, Weinberg RA, Lees JA.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):E10532-E10539. doi: 10.1073/pnas.1711534114. Epub 2017 Nov 20.

23.

A homozygous deleterious CDK10 mutation in a patient with agenesis of corpus callosum, retinopathy, and deafness.

Guen VJ, Edvardson S, Fraenkel ND, Fattal-Valevski A, Jalas C, Anteby I, Shaag A, Dor T, Gillis D, Kerem E, Lees JA, Colas P, Elpeleg O.

Am J Med Genet A. 2018 Jan;176(1):92-98. doi: 10.1002/ajmg.a.38506. Epub 2017 Nov 12.

24.

Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma.

Braun CJ, Stanciu M, Boutz PL, Patterson JC, Calligaris D, Higuchi F, Neupane R, Fenoglio S, Cahill DP, Wakimoto H, Agar NYR, Yaffe MB, Sharp PA, Hemann MT, Lees JA.

Cancer Cell. 2017 Oct 9;32(4):411-426.e11. doi: 10.1016/j.ccell.2017.08.018. Epub 2017 Sep 28.

25.

Stronger together.

Lees JA, Tonkin-Hill G, Bentley SD.

Nat Rev Microbiol. 2017 Sep;15(9):516. doi: 10.1038/nrmicro.2017.95. Epub 2017 Aug 7. No abstract available.

PMID:
28781366
26.

Genome-wide identification of lineage and locus specific variation associated with pneumococcal carriage duration.

Lees JA, Croucher NJ, Goldblatt D, Nosten F, Parkhill J, Turner C, Turner P, Bentley SD.

Elife. 2017 Jul 25;6. pii: e26255. doi: 10.7554/eLife.26255.

27.

Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis.

Mori M, Hazan R, Danielian PS, Mahoney JE, Li H, Lu J, Miller ES, Zhu X, Lees JA, Cardoso WV.

Nat Commun. 2017 Jul 4;8:15857. doi: 10.1038/ncomms15857. Erratum in: Nat Commun. 2018 Nov 19;9:16157.

28.

Large scale genomic analysis shows no evidence for pathogen adaptation between the blood and cerebrospinal fluid niches during bacterial meningitis.

Lees JA, Kremer PHC, Manso AS, Croucher NJ, Ferwerda B, Serón MV, Oggioni MR, Parkhill J, Brouwer MC, van der Ende A, van de Beek D, Bentley SD.

Microb Genom. 2017 Jan 31;3(1):e000103. doi: 10.1099/mgen.0.000103. eCollection 2017 Jan.

29.

Within-Host Sampling of a Natural Population Shows Signs of Selection on Pde1 during Bacterial Meningitis.

Lees JA, Brouwer M, van der Ende A, Parkhill J, van de Beek D, Bentley SD.

Infect Immun. 2017 Feb 23;85(3). pii: e01061-16. doi: 10.1128/IAI.01061-16. Print 2017 Mar. No abstract available.

30.

Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion.

Lees JA, Messa M, Sun EW, Wheeler H, Torta F, Wenk MR, De Camilli P, Reinisch KM.

Science. 2017 Feb 17;355(6326). pii: eaah6171. doi: 10.1126/science.aah6171.

31.

The awakening of the CDK10/Cyclin M protein kinase.

Guen VJ, Gamble C, Lees JA, Colas P.

Oncotarget. 2017 Jul 25;8(30):50174-50186. doi: 10.18632/oncotarget.15024. Review.

32.

Benzalkonium tolerance genes and outcome in Listeria monocytogenes meningitis.

Kremer PH, Lees JA, Koopmans MM, Ferwerda B, Arends AW, Feller MM, Schipper K, Valls Seron M, van der Ende A, Brouwer MC, van de Beek D, Bentley SD.

Clin Microbiol Infect. 2017 Apr;23(4):265.e1-265.e7. doi: 10.1016/j.cmi.2016.12.008. Epub 2016 Dec 18.

33.

Adults with suspected central nervous system infection: A prospective study of diagnostic accuracy.

Khatib U, van de Beek D, Lees JA, Brouwer MC.

J Infect. 2017 Jan;74(1):1-9. doi: 10.1016/j.jinf.2016.09.007. Epub 2016 Oct 13.

PMID:
27746160
34.

Sequence element enrichment analysis to determine the genetic basis of bacterial phenotypes.

Lees JA, Vehkala M, Välimäki N, Harris SR, Chewapreecha C, Croucher NJ, Marttinen P, Davies MR, Steer AC, Tong SY, Honkela A, Parkhill J, Bentley SD, Corander J.

Nat Commun. 2016 Sep 16;7:12797. doi: 10.1038/ncomms12797.

35.

Bacterial GWAS: not just gilding the lily.

Lees JA, Bentley SD.

Nat Rev Microbiol. 2016 Jul;14(7):406. doi: 10.1038/nrmicro.2016.82. Epub 2016 May 31. No abstract available.

PMID:
27241043
36.

STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis.

Guen VJ, Gamble C, Perez DE, Bourassa S, Zappel H, Gärtner J, Lees JA, Colas P.

Cell Cycle. 2016;15(5):678-88. doi: 10.1080/15384101.2016.1147632.

37.

E2f4 and E2f5 are essential for the development of the male reproductive system.

Danielian PS, Hess RA, Lees JA.

Cell Cycle. 2016;15(2):250-60. doi: 10.1080/15384101.2015.1121350.

38.

BMI1 induces an invasive signature in melanoma that promotes metastasis and chemoresistance.

Ferretti R, Bhutkar A, McNamara MC, Lees JA.

Genes Dev. 2016 Jan 1;30(1):18-33. doi: 10.1101/gad.267757.115. Epub 2015 Dec 17.

39.

Using genomics to combat infectious diseases on a global scale.

Cain AK, Lees JA.

Genome Biol. 2015 Nov 19;16:250. doi: 10.1186/s13059-015-0822-y.

40.

Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation.

Nicolay BN, Danielian PS, Kottakis F, Lapek JD Jr, Sanidas I, Miles WO, Dehnad M, Tschöp K, Gierut JJ, Manning AL, Morris R, Haigis K, Bardeesy N, Lees JA, Haas W, Dyson NJ.

Genes Dev. 2015 Sep 1;29(17):1875-89. doi: 10.1101/gad.264127.115. Epub 2015 Aug 27.

41.

Variations in dysfunction of sister chromatid cohesion in esco2 mutant zebrafish reflect the phenotypic diversity of Roberts syndrome.

Percival SM, Thomas HR, Amsterdam A, Carroll AJ, Lees JA, Yost HJ, Parant JM.

Dis Model Mech. 2015 Aug 1;8(8):941-55. doi: 10.1242/dmm.019059. Epub 2015 Jun 4.

42.

Minor Changes in Expression of the Mismatch Repair Protein MSH2 Exert a Major Impact on Glioblastoma Response to Temozolomide.

McFaline-Figueroa JL, Braun CJ, Stanciu M, Nagel ZD, Mazzucato P, Sangaraju D, Cerniauskas E, Barford K, Vargas A, Chen Y, Tretyakova N, Lees JA, Hemann MT, White FM, Samson LD.

Cancer Res. 2015 Aug 1;75(15):3127-38. doi: 10.1158/0008-5472.CAN-14-3616. Epub 2015 May 29.

43.

Inactivation of the retinoblastoma gene yields a mouse model of malignant colorectal cancer.

Parisi T, Bronson RT, Lees JA.

Oncogene. 2015 Nov 26;34(48):5890-9. doi: 10.1038/onc.2015.30. Epub 2015 Mar 9.

44.

Evidence for global cooling in the Late Cretaceous.

Linnert C, Robinson SA, Lees JA, Bown PR, Pérez-Rodríguez I, Petrizzo MR, Falzoni F, Littler K, Arz JA, Russell EE.

Nat Commun. 2014 Jun 17;5:4194. doi: 10.1038/ncomms5194.

45.

Comparative oncogenomic analysis of copy number alterations in human and zebrafish tumors enables cancer driver discovery.

Zhang G, Hoersch S, Amsterdam A, Whittaker CA, Beert E, Catchen JM, Farrington S, Postlethwait JH, Legius E, Hopkins N, Lees JA.

PLoS Genet. 2013 Aug;9(8):e1003734. doi: 10.1371/journal.pgen.1003734. Epub 2013 Aug 29.

46.

Bmi1 is required for tumorigenesis in a mouse model of intestinal cancer.

Maynard MA, Ferretti R, Hilgendorf KI, Perret C, Whyte P, Lees JA.

Oncogene. 2014 Jul 10;33(28):3742-7. doi: 10.1038/onc.2013.333. Epub 2013 Aug 19.

47.

The retinoblastoma protein induces apoptosis directly at the mitochondria.

Hilgendorf KI, Leshchiner ES, Nedelcu S, Maynard MA, Calo E, Ianari A, Walensky LD, Lees JA.

Genes Dev. 2013 May 1;27(9):1003-15. doi: 10.1101/gad.211326.112. Epub 2013 Apr 25.

48.

Loss of pRB and p107 disrupts cartilage development and promotes enchondroma formation.

Landman AS, Danielian PS, Lees JA.

Oncogene. 2013 Oct;32(40):4798-805. doi: 10.1038/onc.2012.496. Epub 2012 Nov 12.

49.

Proliferation and tumorigenesis of a murine sarcoma cell line in the absence of DICER1.

Ravi A, Gurtan AM, Kumar MS, Bhutkar A, Chin C, Lu V, Lees JA, Jacks T, Sharp PA.

Cancer Cell. 2012 Jun 12;21(6):848-55. doi: 10.1016/j.ccr.2012.04.037.

50.

Molecular organization of the COG vesicle tethering complex.

Lees JA, Yip CK, Walz T, Hughson FM.

Nat Struct Mol Biol. 2010 Nov;17(11):1292-7. doi: 10.1038/nsmb.1917. Epub 2010 Oct 24.

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