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Items: 24

1.

Tumor Angiogenesis Is Differentially Regulated by Phosphorylation of Endothelial Cell Focal Adhesion Kinase Tyrosines-397 and -861.

Pedrosa AR, Bodrug N, Gomez-Escudero J, Carter EP, Reynolds LE, Georgiou PN, Fernandez I, Lees DM, Kostourou V, Alexopoulou AN, Batista S, Tavora B, Serrels B, Parsons M, Iskratsch T, Hodivala-Dilke KM.

Cancer Res. 2019 Sep 1;79(17):4371-4386. doi: 10.1158/0008-5472.CAN-18-3934. Epub 2019 Jun 12.

PMID:
31189647
2.

Focal Adhesion Kinase (FAK) tyrosine 397E mutation restores the vascular leakage defect in endothelium-specific FAK-kinase dead mice.

Alexopoulou AN, Lees DM, Bodrug N, Lechertier T, Fernandez I, D'Amico G, Dukinfield M, Batista S, Tavora B, Serrels B, Hodivala-Dilke K.

J Pathol. 2017 Jul;242(3):358-370. doi: 10.1002/path.4911. Epub 2017 Jun 1.

3.

Haematopoietic focal adhesion kinase deficiency alters haematopoietic homeostasis to drive tumour metastasis.

Batista S, Maniati E, Reynolds LE, Tavora B, Lees DM, Fernandez I, Elia G, Casanovas O, Lo Celso C, Hagemann T, Hodivala-Dilke K.

Nat Commun. 2014 Oct 1;5:5054. doi: 10.1038/ncomms6054.

PMID:
25270220
4.

Generation of point-mutant FAK knockin mice.

Tavora B, Batista S, Alexopoulou AN, Kostourou V, Fernandez I, Robinson SD, Lees DM, Serrels B, Hodivala-Dilke K.

Genesis. 2014 Nov;52(11):907-15. doi: 10.1002/dvg.22823. Epub 2014 Sep 30.

PMID:
25242698
5.

Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy.

Tavora B, Reynolds LE, Batista S, Demircioglu F, Fernandez I, Lechertier T, Lees DM, Wong PP, Alexopoulou A, Elia G, Clear A, Ledoux A, Hunter J, Perkins N, Gribben JG, Hodivala-Dilke KM.

Nature. 2014 Oct 2;514(7520):112-6. doi: 10.1038/nature13541. Epub 2014 Jul 27.

6.

FAK-heterozygous mice display enhanced tumour angiogenesis.

Kostourou V, Lechertier T, Reynolds LE, Lees DM, Baker M, Jones DT, Tavora B, Ramjaun AR, Birdsey GM, Robinson SD, Parsons M, Randi AM, Hart IR, Hodivala-Dilke K.

Nat Commun. 2013;4:2020. doi: 10.1038/ncomms3020.

7.

Stromal Claudin14-heterozygosity, but not deletion, increases tumour blood leakage without affecting tumour growth.

Baker M, Reynolds LE, Robinson SD, Lees DM, Parsons M, Elia G, Hodivala-Dilke K.

PLoS One. 2013 May 13;8(5):e62516. doi: 10.1371/journal.pone.0062516. Print 2013.

8.

Virtual forensic anthropology: Novel applications of anthropometry and technology in a child death case.

Davy-Jow SL, Lees DM, Russell S.

Forensic Sci Int. 2013 Jan 10;224(1-3):e7-10. doi: 10.1016/j.forsciint.2012.11.002. Epub 2012 Nov 29.

PMID:
23201465
9.

Regulation of vascular endothelial function by procyanidin-rich foods and beverages.

Caton PW, Pothecary MR, Lees DM, Khan NQ, Wood EG, Shoji T, Kanda T, Rull G, Corder R.

J Agric Food Chem. 2010 Apr 14;58(7):4008-13. doi: 10.1021/jf9031876.

PMID:
20108902
10.

Memorial: Emmanuelle Caron 1967-2009.

Lees DM, Hall A.

J Leukoc Biol. 2009 Oct;86(4):749-750. doi: 10.1189/jlb.0709509. No abstract available.

PMID:
29360245
11.

Existence of multiple isoforms of HS1-associated protein X-1 in murine and human tissues.

Lees DM, Hart IR, Marshall JF.

J Mol Biol. 2008 Jun 13;379(4):645-55. doi: 10.1016/j.jmb.2008.04.020. Epub 2008 Apr 12.

PMID:
18472110
12.

A simple, robust and versatile method to characterise intracellular parasitism.

Escaron CJ, Lees DM, Tewari R, Smith DF, Caron E.

Mol Biochem Parasitol. 2007 May;153(1):72-6. Epub 2007 Jan 17. No abstract available.

PMID:
17303261
13.

Homocysteine-induced endothelin-1 release is dependent on hyperglycaemia and reactive oxygen species production in bovine aortic endothelial cells.

Sethi AS, Lees DM, Douthwaite JA, Dawnay AB, Corder R.

J Vasc Res. 2006;43(2):175-83. Epub 2006 Jan 12.

PMID:
16410680
14.

The differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation.

Inglis JJ, Nissim A, Lees DM, Hunt SP, Chernajovsky Y, Kidd BL.

Arthritis Res Ther. 2005;7(4):R807-16. Epub 2005 Apr 12.

15.

Factor VIIa stimulates endothelin-1 synthesis in TNF-primed endothelial cells by activation of protease-activated receptor 2.

Sethi AS, Lees DM, Douthwaite JA, Corder R.

Clin Sci (Lond). 2005 Mar;108(3):255-63.

PMID:
15548135
16.

The procyanidin-induced pseudo laminar shear stress response: a new concept for the reversal of endothelial dysfunction.

Corder R, Warburton RC, Khan NQ, Brown RE, Wood EG, Lees DM.

Clin Sci (Lond). 2004 Nov;107(5):513-7.

PMID:
15324299
17.

A role for increased mRNA stability in the induction of endothelin-1 synthesis by lipopolysaccharide.

Douthwaite JA, Lees DM, Corder R.

Biochem Pharmacol. 2003 Aug 15;66(4):589-94.

PMID:
12906923
18.

Comparison of red wine extract and polyphenol constituents on endothelin-1 synthesis by cultured endothelial cells.

Khan NQ, Lees DM, Douthwaite JA, Carrier MJ, Corder R.

Clin Sci (Lond). 2002 Aug;103 Suppl 48:72S-75S.

PMID:
12193058
19.

Quantitative measurement of mRNA levels by RT-PCR. Studies of ECE-1 isoforms.

Lees DM, Khan NQ, Barker S, Corder R.

Methods Mol Biol. 2002;206:125-45. No abstract available.

PMID:
12152224
21.

Endothelin-1 synthesis reduced by red wine.

Corder R, Douthwaite JA, Lees DM, Khan NQ, Viseu Dos Santos AC, Wood EG, Carrier MJ.

Nature. 2001 Dec 20-27;414(6866):863-4.

PMID:
11780050
22.

Relationship between soluble intracellular endothelin-converting enzyme and endothelin-1 synthesis: effect of inhibitors of the secretory pathway.

Corder R, Khan NQ, Harrison VJ, Wood EG, Lees DM, Barker S.

J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S19-21.

PMID:
11078324
23.
24.

The p55 tumor necrosis factor receptor (CD120a) induces endothelin-1 synthesis in endothelial and epithelial cells.

Lees DM, Pallikaros Z, Corder R.

Eur J Pharmacol. 2000 Feb 25;390(1-2):89-94.

PMID:
10708710

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