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Items: 1 to 50 of 76

1.

Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethality.

Saha A, Taylor PA, Lees CJ, Panoskaltsis-Mortari A, Osborn MJ, Feser CJ, Thangavelu G, Melchinger W, Refaeli Y, Hill GR, Munn DH, Murphy WJ, Serody JS, Maillard I, Kreymborg K, van den Brink M, Dong C, Huang S, Zang X, Allison JP, Zeiser R, Blazar BR.

JCI Insight. 2019 Oct 3;4(19). pii: 127716. doi: 10.1172/jci.insight.127716.

2.

Revertant mosaic fibroblasts in recessive dystrophic epidermolysis bullosa.

Twaroski K, Eide C, Riddle MJ, Xia L, Lees CJ, Chen W, Mathews W, Keene DR, McGrath JA, Tolar J.

Br J Dermatol. 2019 Mar 29. doi: 10.1111/bjd.17943. [Epub ahead of print]

PMID:
30924923
3.

CRISPR/Cas9-Based Cellular Engineering for Targeted Gene Overexpression.

Osborn MJ, Lees CJ, McElroy AN, Merkel SC, Eide CR, Mathews W, Feser CJ, Tschann M, McElmury RT, Webber BR, Kim CJ, Blazar BR, Tolar J.

Int J Mol Sci. 2018 Mar 22;19(4). pii: E946. doi: 10.3390/ijms19040946.

4.

Rapid generation of Col7a1-/- mouse model of recessive dystrophic epidermolysis bullosa and partial rescue via immunosuppressive dermal mesenchymal stem cells.

Webber BR, O'Connor KT, McElmurry RT, Durgin EN, Eide CR, Lees CJ, Riddle MJ, Mathews WE, Frank NY, Kluth MA, Ganss C, Moriarity BS, Frank MH, Osborn MJ, Tolar J.

Lab Invest. 2017 Oct;97(10):1218-1224. doi: 10.1038/labinvest.2017.85. Epub 2017 Sep 11.

6.

MUC1 immunotherapy against a metastatic mammary adenocarcinoma model: Importance of IFN-gamma.

Lees CJ, Smorodinsky N, Horn G, Wreschner DH, McKenzie IF, Pietersz G, Stojanovska L, Apostolopoulos V.

Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2016;37(1):15-25. doi: 10.1515/prilozi-2016-0001.

PMID:
27442413
7.

Late Effects of Total-Body Gamma Irradiation on Cardiac Structure and Function in Male Rhesus Macaques.

DeBo RJ, Lees CJ, Dugan GO, Caudell DL, Michalson KT, Hanbury DB, Kavanagh K, Cline JM, Register TC.

Radiat Res. 2016 Jul;186(1):55-64. doi: 10.1667/RR14357.1. Epub 2016 Jun 22.

8.

Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques.

Dewi FN, Wood CE, Willson CJ, Register TC, Lees CJ, Howard TD, Huang Z, Murphy SK, Tooze JA, Chou JW, Miller LD, Cline JM.

Cancer Prev Res (Phila). 2016 May;9(5):385-95. doi: 10.1158/1940-6207.CAPR-15-0165. Epub 2016 Mar 22.

9.

Behavioral response inhibition and maturation of goal representation in prefrontal cortex after puberty.

Zhou X, Zhu D, King SG, Lees CJ, Bennett AJ, Salinas E, Stanford TR, Constantinidis C.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3353-8. doi: 10.1073/pnas.1518147113. Epub 2016 Mar 7.

10.

CRISPR/Cas9-based genetic correction for recessive dystrophic epidermolysis bullosa.

Webber BR, Osborn MJ, McElroy AN, Twaroski K, Lonetree CL, DeFeo AP, Xia L, Eide C, Lees CJ, McElmurry RT, Riddle MJ, Kim CJ, Patel DD, Blazar BR, Tolar J.

NPJ Regen Med. 2016;1. pii: 16014. doi: 10.1038/npjregenmed.2016.14. Epub 2016 Dec 8.

11.

The Evolving Mcart Multimodal Imaging Core: Establishing a Protocol for Computed Tomography and Echocardiography in the Rhesus Macaque to Perform Longitudinal Analysis of Radiation-Induced Organ Injury.

de Faria EB, Barrow KR, Ruehle BT, Parker JT, Swartz E, Taylor-Howell C, Kieta KM, Lees CJ, Sleeper MM, Dobbin T, Baron AD, Mohindra P, MacVittie TJ.

Health Phys. 2015 Nov;109(5):479-92. doi: 10.1097/HP.0000000000000344.

12.

Age-dependent changes in prefrontal intrinsic connectivity.

Zhou X, Zhu D, Katsuki F, Qi XL, Lees CJ, Bennett AJ, Salinas E, Stanford TR, Constantinidis C.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3853-8. doi: 10.1073/pnas.1316594111. Epub 2014 Feb 24.

13.

Patient-specific naturally gene-reverted induced pluripotent stem cells in recessive dystrophic epidermolysis bullosa.

Tolar J, McGrath JA, Xia L, Riddle MJ, Lees CJ, Eide C, Keene DR, Liu L, Osborn MJ, Lund TC, Blazar BR, Wagner JE.

J Invest Dermatol. 2014 May;134(5):1246-1254. doi: 10.1038/jid.2013.523. Epub 2013 Dec 6.

14.

Working memory performance and neural activity in prefrontal cortex of peripubertal monkeys.

Zhou X, Zhu D, Qi XL, Lees CJ, Bennett AJ, Salinas E, Stanford TR, Constantinidis C.

J Neurophysiol. 2013 Dec;110(11):2648-60. doi: 10.1152/jn.00370.2013. Epub 2013 Sep 18.

15.

Dietary soy effects on mammary gland development during the pubertal transition in nonhuman primates.

Dewi FN, Wood CE, Lees CJ, Willson CJ, Register TC, Tooze JA, Franke AA, Cline JM.

Cancer Prev Res (Phila). 2013 Aug;6(8):832-42. doi: 10.1158/1940-6207.CAPR-13-0128. Epub 2013 Jun 14.

16.

Keratinocytes from induced pluripotent stem cells in junctional epidermolysis bullosa.

Tolar J, Xia L, Lees CJ, Riddle M, McElroy A, Keene DR, Lund TC, Osborn MJ, Marinkovich MP, Blazar BR, Wagner JE.

J Invest Dermatol. 2013 Feb;133(2):562-5. doi: 10.1038/jid.2012.278. Epub 2012 Aug 30. No abstract available.

17.

Suppression of Tak1 promotes prostate tumorigenesis.

Wu M, Shi L, Cimic A, Romero L, Sui G, Lees CJ, Cline JM, Seals DF, Sirintrapun JS, McCoy TP, Liu W, Kim JW, Hawkins GA, Peehl DM, Xu J, Cramer SD.

Cancer Res. 2012 Jun 1;72(11):2833-43. doi: 10.1158/0008-5472.CAN-11-2724. Epub 2012 Mar 30.

18.

Life stage differences in mammary gland gene expression profile in non-human primates.

Stute P, Sielker S, Wood CE, Register TC, Lees CJ, Dewi FN, Williams JK, Wagner JD, Stefenelli U, Cline JM.

Breast Cancer Res Treat. 2012 Jun;133(2):617-34. doi: 10.1007/s10549-011-1811-9. Epub 2011 Oct 25.

19.

Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides.

Rayner KJ, Esau CC, Hussain FN, McDaniel AL, Marshall SM, van Gils JM, Ray TD, Sheedy FJ, Goedeke L, Liu X, Khatsenko OG, Kaimal V, Lees CJ, Fernandez-Hernando C, Fisher EA, Temel RE, Moore KJ.

Nature. 2011 Oct 19;478(7369):404-7. doi: 10.1038/nature10486.

20.

Induced pluripotent stem cells from individuals with recessive dystrophic epidermolysis bullosa.

Tolar J, Xia L, Riddle MJ, Lees CJ, Eide CR, McElmurry RT, Titeux M, Osborn MJ, Lund TC, Hovnanian A, Wagner JE, Blazar BR.

J Invest Dermatol. 2011 Apr;131(4):848-56. doi: 10.1038/jid.2010.346. Epub 2010 Dec 2.

21.

Minicircle DNA-based gene therapy coupled with immune modulation permits long-term expression of α-L-iduronidase in mice with mucopolysaccharidosis type I.

Osborn MJ, McElmurry RT, Lees CJ, DeFeo AP, Chen ZY, Kay MA, Naldini L, Freeman G, Tolar J, Blazar BR.

Mol Ther. 2011 Mar;19(3):450-60. doi: 10.1038/mt.2010.249. Epub 2010 Nov 16.

22.

Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome).

Tolar J, Park IH, Xia L, Lees CJ, Peacock B, Webber B, McElmurry RT, Eide CR, Orchard PJ, Kyba M, Osborn MJ, Lund TC, Wagner JE, Daley GQ, Blazar BR.

Blood. 2011 Jan 20;117(3):839-47. doi: 10.1182/blood-2010-05-287607. Epub 2010 Oct 29.

23.

Impairment of ovarian function and associated health-related abnormalities are attributable to low social status in premenopausal monkeys and not mitigated by a high-isoflavone soy diet.

Kaplan JR, Chen H, Appt SE, Lees CJ, Franke AA, Berga SL, Wilson ME, Manuck SB, Clarkson TB.

Hum Reprod. 2010 Dec;25(12):3083-94. doi: 10.1093/humrep/deq288. Epub 2010 Oct 17.

24.

Effects of soy vs. casein protein on body weight and glycemic control in female monkeys and their offspring.

Wagner JD, Jorgensen MJ, Cline JM, Lees CJ, Franke AA, Zhang L, Ayers MR, Schultz C, Kaplan JR.

Am J Primatol. 2009 Sep;71(9):802-11. doi: 10.1002/ajp.20716.

PMID:
19484707
25.

Mammary gland and endometrial effects of testosterone in combination with oral estradiol and progesterone.

Wood CE, Lees CJ, Cline JM.

Menopause. 2009 May-Jun;16(3):466-76. doi: 10.1097/gme.0b013e318191747a.

26.

Flagellin-F1-V fusion protein is an effective plague vaccine in mice and two species of nonhuman primates.

Mizel SB, Graff AH, Sriranganathan N, Ervin S, Lees CJ, Lively MO, Hantgan RR, Thomas MJ, Wood J, Bell B.

Clin Vaccine Immunol. 2009 Jan;16(1):21-8. doi: 10.1128/CVI.00333-08. Epub 2008 Nov 5.

27.

Age-related neuroanatomical differences from the juvenile period to adulthood in mother-reared macaques (Macaca radiata).

Pierre PJ, Hopkins WD, Taglialatela JP, Lees CJ, Bennett AJ.

Brain Res. 2008 Aug 21;1226:56-60. doi: 10.1016/j.brainres.2008.06.001. Epub 2008 Jun 9.

PMID:
18619575
28.

TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection.

Taylor PA, Ehrhardt MJ, Lees CJ, Panoskaltsis-Mortari A, Krieg AM, Sharpe AH, Murphy WJ, Serody JS, Hemmi H, Akira S, Levy RB, Blazar BR.

Blood. 2008 Oct 15;112(8):3508-16. doi: 10.1182/blood-2007-09-113670. Epub 2008 Jul 9.

29.

Effects of lasofoxifene on the uterus, vagina, and breast in ovariectomized cynomolgus monkeys (Macaca fascicularis).

Cline JM, Botts S, Lees CJ, Brommage R.

Am J Obstet Gynecol. 2008 Aug;199(2):158.e1-8. doi: 10.1016/j.ajog.2008.02.020. Epub 2008 May 23.

PMID:
18501325
30.

Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies.

Huang X, Guo H, Kang J, Choi S, Zhou TC, Tammana S, Lees CJ, Li ZZ, Milone M, Levine BL, Tolar J, June CH, Scott McIvor R, Wagner JE, Blazar BR, Zhou X.

Mol Ther. 2008 Mar;16(3):580-9. doi: 10.1038/sj.mt.6300404. Epub 2008 Jan 29.

31.

Characterization of adult prostatic progenitor/stem cells exhibiting self-renewal and multilineage differentiation.

Barclay WW, Axanova LS, Chen W, Romero L, Maund SL, Soker S, Lees CJ, Cramer SD.

Stem Cells. 2008 Mar;26(3):600-10. Epub 2007 Nov 29.

32.

Hormone therapy effects on social behavior and activity levels of surgically postmenopausal cynomolgus monkeys.

Shively CA, Wood CE, Register TC, Willard SL, Lees CJ, Chen H, Sitruk-Ware RL, Tsong YY, Cline JM.

Psychoneuroendocrinology. 2007 Sep-Nov;32(8-10):981-90. Epub 2007 Sep 4.

PMID:
17768011
33.

Bone mass and soy isoflavones in socially housed, premenopausal macaques.

Lees CJ, Kaplan JR, Chen H, Jerome CP, Register TC, Franke AA.

Am J Clin Nutr. 2007 Jul;86(1):245-50.

PMID:
17616787
34.

Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD).

Taylor PA, Ehrhardt MJ, Lees CJ, Tolar J, Weigel BJ, Panoskaltsis-Mortari A, Serody JS, Brinkmann V, Blazar BR.

Blood. 2007 Nov 1;110(9):3480-8. Epub 2007 Jul 2.

35.
36.

Effects of estradiol with oral or intravaginal progesterone on risk markers for breast cancer in a postmenopausal monkey model.

Wood CE, Sitruk-Ware RL, Tsong YY, Register TC, Lees CJ, Cline JM.

Menopause. 2007 Jul-Aug;14(4):639-47.

PMID:
17224855
37.

Effects of estradiol with micronized progesterone or medroxyprogesterone acetate on risk markers for breast cancer in postmenopausal monkeys.

Wood CE, Register TC, Lees CJ, Chen H, Kimrey S, Cline JM.

Breast Cancer Res Treat. 2007 Jan;101(2):125-34.

PMID:
16841178
38.

Effects of high-dose soy isoflavones and equol on reproductive tissues in female cynomolgus monkeys.

Wood CE, Appt SE, Clarkson TB, Franke AA, Lees CJ, Doerge DR, Cline JM.

Biol Reprod. 2006 Sep;75(3):477-86. Epub 2006 May 24.

PMID:
16723506
39.

Low dose estrogens inhibit coronary artery atherosclerosis in postmenopausal monkeys.

Appt SE, Clarkson TB, Lees CJ, Anthony MS.

Maturitas. 2006 Sep 20;55(2):187-94. Epub 2006 Mar 29.

PMID:
16574351
40.

Flagellin is an effective adjuvant for immunization against lethal respiratory challenge with Yersinia pestis.

Honko AN, Sriranganathan N, Lees CJ, Mizel SB.

Infect Immun. 2006 Feb;74(2):1113-20.

41.

Effects of tibolone on bone quality in ovariectomized monkeys.

Lees CJ, Ederveen AG, Spanjers CP, Clarkson TB.

Menopause. 2005 Sep-Oct;12(5):613-8. Epub 2005 Sep 1.

PMID:
16145316
42.

Multisystem evaluations of the long-term effects of tibolone on postmenopausal monkeys.

Clarkson TB, Anthony MS, Cline JM, Lees CJ, Ederveen AG.

Maturitas. 2004 Aug 30;48 Suppl 1:S24-9.

PMID:
15337245
43.

B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via T-T interactions [corrections].

Taylor PA, Lees CJ, Fournier S, Allison JP, Sharpe AH, Blazar BR.

J Immunol. 2004 Jan 1;172(1):34-9. Erratum in: J Immunol. 2004 Apr 15;172(8):following 5127.

44.
45.

Combined effects of calcineurin inhibitors or sirolimus with anti-CD40L mAb on alloengraftment under nonmyeloablative conditions.

Taylor PA, Lees CJ, Wilson JM, Ehrhardt MJ, Campbell MT, Noelle RJ, Blazar BR.

Blood. 2002 Nov 1;100(9):3400-7.

PMID:
12384443
46.

Effects of raloxifene on bone density, biomarkers, and histomorphometric and biomechanical measures in ovariectomized cynomolgus monkeys.

Lees CJ, Register TC, Turner CH, Wang T, Stancill M, Jerome CP.

Menopause. 2002 Sep-Oct;9(5):320-8.

PMID:
12218720
47.
49.

Levormeloxifene prevents increased bone turnover and vertebral bone loss following ovariectomy in cynomolgus monkeys.

Hotchkiss CE, Stavisky R, Nowak J, Brommage R, Lees CJ, Kaplan J.

Bone. 2001 Jul;29(1):7-15.

PMID:
11472885
50.

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