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Items: 1 to 50 of 118

1.

Breast Cancer Brain Metastasis Response to Radiation After Microbubble Oxygen Delivery in a Murine Model.

Delaney LJ, Ciraku L, Oeffinger BE, Wessner CE, Liu JB, Li J, Nam K, Forsberg F, Leeper DB, O'Kane P, Wheatley MA, Reginato MJ, Eisenbrey JR.

J Ultrasound Med. 2019 May 23. doi: 10.1002/jum.15031. [Epub ahead of print]

PMID:
31124171
2.

Effect of Differences in Metabolic Activity of Melanoma Models on Response to Lonidamine plus Doxorubicin.

Nath K, Roman J, Nelson DS, Guo L, Lee SC, Orlovskiy S, Muriuki K, Heitjan DF, Pickup S, Leeper DB, Blair IA, Putt ME, Glickson JD.

Sci Rep. 2018 Oct 2;8(1):14654. doi: 10.1038/s41598-018-33019-4.

3.

Sensitization of Hypoxic Tumors to Radiation Therapy Using Ultrasound-Sensitive Oxygen Microbubbles.

Eisenbrey JR, Shraim R, Liu JB, Li J, Stanczak M, Oeffinger B, Leeper DB, Keith SW, Jablonowski LJ, Forsberg F, O'Kane P, Wheatley MA.

Int J Radiat Oncol Biol Phys. 2018 May 1;101(1):88-96. doi: 10.1016/j.ijrobp.2018.01.042. Epub 2018 Jan 31.

4.

Localized microbubble cavitation-based antivascular therapy for improving HCC treatment response to radiotherapy.

Daecher A, Stanczak M, Liu JB, Zhang J, Du S, Forsberg F, Leeper DB, Eisenbrey JR.

Cancer Lett. 2017 Dec 28;411:100-105. doi: 10.1016/j.canlet.2017.09.037. Epub 2017 Sep 29.

5.

Effect of Lonidamine on Systemic Therapy of DB-1 Human Melanoma Xenografts with Temozolomide.

Nath K, Nelson DS, Roman J, Putt ME, Lee SC, Leeper DB, Glickson JD.

Anticancer Res. 2017 Jul;37(7):3413-3421.

PMID:
28668829
6.

Mechanism of antineoplastic activity of lonidamine.

Nath K, Guo L, Nancolas B, Nelson DS, Shestov AA, Lee SC, Roman J, Zhou R, Leeper DB, Halestrap AP, Blair IA, Glickson JD.

Biochim Biophys Acta. 2016 Dec;1866(2):151-162. doi: 10.1016/j.bbcan.2016.08.001. Epub 2016 Aug 4. Review.

7.

Stereotactic Body Radiation Therapy Delivery in a Genetically Engineered Mouse Model of Lung Cancer.

Du S, Lockamy V, Zhou L, Xue C, LeBlanc J, Glenn S, Shukla G, Yu Y, Dicker AP, Leeper DB, Lu Y, Lu B.

Int J Radiat Oncol Biol Phys. 2016 Nov 1;96(3):529-37. doi: 10.1016/j.ijrobp.2016.07.008. Epub 2016 Jul 21.

8.

(13)C MRS and LC-MS Flux Analysis of Tumor Intermediary Metabolism.

Shestov AA, Lee SC, Nath K, Guo L, Nelson DS, Roman JC, Leeper DB, Wasik MA, Blair IA, Glickson JD.

Front Oncol. 2016 Jun 15;6:135. doi: 10.3389/fonc.2016.00135. eCollection 2016.

9.

Comparison of the Lonidamine Potentiated Effect of Nitrogen Mustard Alkylating Agents on the Systemic Treatment of DB-1 Human Melanoma Xenografts in Mice.

Nath K, Nelson DS, Putt ME, Leeper DB, Garman B, Nathanson KL, Glickson JD.

PLoS One. 2016 Jun 10;11(6):e0157125. doi: 10.1371/journal.pone.0157125. eCollection 2016.

10.

The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters.

Nancolas B, Guo L, Zhou R, Nath K, Nelson DS, Leeper DB, Blair IA, Glickson JD, Halestrap AP.

Biochem J. 2016 Apr 1;473(7):929-36. doi: 10.1042/BJ20151120. Epub 2016 Feb 1.

11.

Bonded Cumomer Analysis of Human Melanoma Metabolism Monitored by 13C NMR Spectroscopy of Perfused Tumor Cells.

Shestov AA, Mancuso A, Lee SC, Guo L, Nelson DS, Roman JC, Henry PG, Leeper DB, Blair IA, Glickson JD.

J Biol Chem. 2016 Mar 4;291(10):5157-71. doi: 10.1074/jbc.M115.701862. Epub 2015 Dec 24.

12.

Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine.

Guo L, Shestov AA, Worth AJ, Nath K, Nelson DS, Leeper DB, Glickson JD, Blair IA.

J Biol Chem. 2016 Jan 1;291(1):42-57. doi: 10.1074/jbc.M115.697516. Epub 2015 Oct 31.

13.

Effects of hyperglycemia on lonidamine-induced acidification and de-energization of human melanoma xenografts and sensitization to melphalan.

Nath K, Nelson DS, Heitjan DF, Zhou R, Leeper DB, Glickson JD.

NMR Biomed. 2015 Mar;28(3):395-403. doi: 10.1002/nbm.3260.

14.

Lonidamine induces intracellular tumor acidification and ATP depletion in breast, prostate and ovarian cancer xenografts and potentiates response to doxorubicin.

Nath K, Nelson DS, Heitjan DF, Leeper DB, Zhou R, Glickson JD.

NMR Biomed. 2015 Mar;28(3):281-90. doi: 10.1002/nbm.3240. Epub 2014 Dec 12.

15.

Thermal sensitisation by lonidamine of human melanoma cells grown at low extracellular pH.

Coss RA, Storck CW, Wells TC, Kulp KA, Wahl M, Leeper DB.

Int J Hyperthermia. 2014 Feb;30(1):75-8. doi: 10.3109/02656736.2013.858832. Epub 2013 Dec 3.

PMID:
24295212
16.

Metabolic network analysis of DB1 melanoma cells: how much energy is derived from aerobic glycolysis?

Shestov AA, Mancuso A, Leeper DB, Glickson JD.

Adv Exp Med Biol. 2013;765:265-271. doi: 10.1007/978-1-4614-4989-8_37.

PMID:
22879043
17.

(31) P and (1) H MRS of DB-1 melanoma xenografts: lonidamine selectively decreases tumor intracellular pH and energy status and sensitizes tumors to melphalan.

Nath K, Nelson DS, Ho AM, Lee SC, Darpolor MM, Pickup S, Zhou R, Heitjan DF, Leeper DB, Glickson JD.

NMR Biomed. 2013 Jan;26(1):98-105. doi: 10.1002/nbm.2824. Epub 2012 Jun 29.

18.

Control of Glycolytic Flux by AMP-Activated Protein Kinase in Tumor Cells Adapted to Low pH.

Mendoza EE, Pocceschi MG, Kong X, Leeper DB, Caro J, Limesand KH, Burd R.

Transl Oncol. 2012 Jun;5(3):208-16. Epub 2012 Jun 1.

19.

³¹P-MRS studies of melanoma xenografts with different metastatic potential.

Li LZ, Zhou R, Leeper DB, Glickson JD.

Adv Exp Med Biol. 2011;701:69-73. doi: 10.1007/978-1-4419-7756-4_10.

20.

Kadota Fund International Forum 2004. Application of thermal stress for the improvement of health, 15-18 June 2004, Awaji Yumebutai International Conference Center, Awaji Island, Hyogo, Japan. Final report.

Sugahara T, van der Zee J, Kampinga HH, Vujaskovic Z, Kondo M, Ohnishi T, Li G, Park HJ, Leeper DB, Ostapenko V, Repasky EA, Watanabe M, Song CW.

Int J Hyperthermia. 2008 Mar;24(2):123-40. doi: 10.1080/02656730701883675. No abstract available.

21.

Hsp27 anti-sense oligonucleotides sensitize the microtubular cytoskeleton of Chinese hamster ovary cells grown at low pH to 42 degrees C-induced reorganization.

Hargis MT, Storck CW, Wickstrom E, Yakubov LA, Leeper DB, Coss RA.

Int J Hyperthermia. 2004 Aug;20(5):491-502. Erratum in: Int J Hyperthermia. 2005 Feb;21(1):89.

PMID:
15277022
22.

Feasibility of lung cancer hyperthermia using breathable perfluorochemical (PFC) liquids. Part II: Ultrasound hyperthermia.

Sekins KM, Leeper DB, Hoffman JK, Keilman GW, Ziskin MC, Wolfson MR, Shaffer TH.

Int J Hyperthermia. 2004 May;20(3):278-99.

PMID:
15204526
23.

Feasibility of lung cancer hyperthermia using breathable perfluorochemical (PFC) liquids. Part I: Convective hyperthermia.

Sekins KM, Leeper DB, Hoffman JK, Wolfson MR, Shaffer TH.

Int J Hyperthermia. 2004 May;20(3):252-77.

PMID:
15204525
24.

Metaiodobenzylguanidine and hyperglycemia augment tumor response to isolated limb perfusion in a rodent model of human melanoma.

Canter RJ, Zhou R, Kesmodel SB, Zhang Y, Heitjan DF, Glickson JD, Leeper DB, Fraker DL.

Ann Surg Oncol. 2004 Mar;11(3):265-73.

PMID:
14993021
25.

Acute extracellular acidification reduces intracellular pH, 42 degrees C-induction of heat shock proteins and clonal survival of human melanoma cells grown at pH 6.7.

Coss RA, Storck CW, Wachsberger PR, Reilly J, Leeper DB, Berd D, Wahl ML.

Int J Hyperthermia. 2004 Feb;20(1):93-106.

PMID:
14612316
26.

Effect of mild hyperglycemia +/- meta-iodo-benzylguanidine on the radiation response of R3230 Ac tumors.

Lee I, Glickson JD, Dewhirst MW, Leeper DB, Burd R, Poptani H, Nadal L, McKenna WG, Biaglow JE.

Adv Exp Med Biol. 2003;530:177-86.

PMID:
14562715
27.

Quercetin sensitizes cells in a tumour-like low pH environment to hyperthermia.

Wachsberger PR, Burd R, Bhala A, Bobyock SB, Wahl ML, Owen CS, Rifat SB, Leeper DB.

Int J Hyperthermia. 2003 Sep-Oct;19(5):507-19.

PMID:
12944166
28.

Tumor oxygenation and acidification are increased in melanoma xenografts after exposure to hyperglycemia and meta-iodo-benzylguanidine.

Burd R, Lavorgna SN, Daskalakis C, Wachsberger PR, Wahl ML, Biaglow JE, Stevens CW, Leeper DB.

Radiat Res. 2003 Mar;159(3):328-35.

PMID:
12600235
29.

Regulation of intracellular pH in human melanoma: potential therapeutic implications.

Wahl ML, Owen JA, Burd R, Herlands RA, Nogami SS, Rodeck U, Berd D, Leeper DB, Owen CS.

Mol Cancer Ther. 2002 Jun;1(8):617-28.

30.

Acute extracellular acidification increases nuclear associated protein levels in human melanoma cells during 42 degrees C hyperthermia and enhances cell killing.

Han JS, Storck CW, Wachsberger PR, Leeper DB, Berd D, Wahl ML, Coss RA.

Int J Hyperthermia. 2002 Sep-Oct;18(5):404-15.

PMID:
12227927
31.

Non-invasive magnetic resonance thermometry using thulium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (TmDOTA(-)).

Hekmatyar SK, Poptani H, Babsky A, Leeper DB, Bansal N.

Int J Hyperthermia. 2002 May-Jun;18(3):165-79.

PMID:
12028635
32.

Betulinic acid sensitization of low pH adapted human melanoma cells to hyperthermia.

Wachsberger PR, Burd R, Wahl ML, Leeper DB.

Int J Hyperthermia. 2002 Mar-Apr;18(2):153-64.

PMID:
11911485
33.

Effects of hyperthermia on p53 protein expression and activity.

Guan J, Stavridi E, Leeper DB, Iliakis G.

J Cell Physiol. 2002 Mar;190(3):365-74.

PMID:
11857452
34.

Variability in glucose transporter-1 levels and hexokinase activity in human melanoma.

Wachsberger PR, Gressen EL, Bhala A, Bobyock SB, Storck C, Coss RA, Berd D, Leeper DB.

Melanoma Res. 2002 Feb;12(1):35-43.

PMID:
11828256
35.

Absence of Crabtree effect in human melanoma cells adapted to growth at low pH: reversal by respiratory inhibitors.

Burd R, Wachsberger PR, Biaglow JE, Wahl ML, Lee I, Leeper DB.

Cancer Res. 2001 Jul 15;61(14):5630-5.

36.

Enhancement of hyperglycemia-induced acidification of human melanoma xenografts with inhibitors of respiration and ion transport.

Zhou R, Bansal N, Leeper DB, Pickup S, Glickson JD.

Acad Radiol. 2001 Jul;8(7):571-82.

PMID:
11450957
38.
39.

Intracellular pH regulation in a nonmalignant and a derived malignant human breast cell line.

Wahl ML, Pooler PM, Briand P, Leeper DB, Owen CS.

J Cell Physiol. 2000 Jun;183(3):373-80.

PMID:
10797312
40.

The response of human tumour blood flow to a fractionated course of thermoradiotherapy.

Waterman FM, Komarnicky L, Leeper DB.

Int J Hyperthermia. 1998 Sep-Oct;14(5):421-34.

PMID:
9789767
41.
42.

Temporal association between alterations in proton extrusion and low pH adaptation.

Owen CS, Wahl ML, Pooler PM, Coss RA, Leeper DB.

Int J Hyperthermia. 1998 Mar-Apr;14(2):227-32.

PMID:
9589327
43.

Altered proton extrusion in cells adapted to growth at low extracellular pH.

Owen CS, Pooler PM, Wahl ML, Coss RA, Leeper DB.

J Cell Physiol. 1997 Dec;173(3):397-405.

PMID:
9369953
44.

Effects of 42 degrees C hyperthermia on intracellular pH in ovarian carcinoma cells during acute or chronic exposure to low extracellular pH.

Wahl ML, Bobyock SB, Leeper DB, Owen CS.

Int J Radiat Oncol Biol Phys. 1997 Aug 1;39(1):205-12.

PMID:
9300756
45.

Bicarbonate-dependent proton extrusion in Chinese hamster ovary (CHO) cells adapted to growth at pH 6.7.

Coss RA, Messinger JA, Wahl ML, Wachsberger PR, Leeper DB, Owen CS.

Int J Hyperthermia. 1997 May-Jun;13(3):325-36.

PMID:
9222815
46.

Mammalian cells adapted to growth at pH 6.7 have elevated HSP27 levels and are resistant to cisplatin.

Wachsberger PR, Landry J, Storck C, Davis K, O'Hara MD, Owen CS, Leeper DB, Coss RA.

Int J Hyperthermia. 1997 May-Jun;13(3):251-5; discussion 257-9.

PMID:
9222809
47.

Thermotolerance and intracellular pH in two Chinese hamster cell lines adapted to growth at low pH.

Wahl ML, Coss RA, Bobyock SB, Leeper DB, Owen CS.

J Cell Physiol. 1996 Feb;166(2):438-45.

PMID:
8592004
48.
49.

The development and magnitude of thermotolerance during chronic hyperthermia in murine granulocyte-macrophage progenitors: II.

Xiong QB, O'Hara MD, Pollard MD, Leeper DB.

Int J Hyperthermia. 1996 Jan-Feb;12(1):77-86.

PMID:
8676010
50.

Accurate whole-spectrum measurements of intracellular pH and [Na(+)].

Owen CS, Wahl ML, Leeper DB, Perry HD, Bobyock SB, Russell M, Woodward W.

J Fluoresc. 1995 Dec;5(4):329-35. doi: 10.1007/BF01152559.

PMID:
24226909

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