Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 82


Determination of Site-Specific Phosphorylation Ratios in Proteins with Targeted Mass Spectrometry.

Dekker LJM, Zeneyedpour L, Snoeijers S, Joore J, Leenstra S, Luider TM.

J Proteome Res. 2018 Apr 6;17(4):1654-1663. doi: 10.1021/acs.jproteome.7b00911. Epub 2018 Mar 9.


Volumetric changes and clinical outcome for petroclival meningiomas after primary treatment with Gamma Knife radiosurgery.

Sadik ZHA, Lie ST, Leenstra S, Hanssens PEJ.

J Neurosurg. 2018 Jan 26:1-7. doi: 10.3171/2017.7.JNS17380. [Epub ahead of print]


Retreatment of vestibular schwannoma with Gamma Knife radiosurgery: clinical outcome, tumor control, and review of literature.

Fu VX, Verheul JB, Beute GN, Leenstra S, Kunst HPM, Mulder JJS, Hanssens PEJ.

J Neurosurg. 2018 Jul;129(1):137-145. doi: 10.3171/2017.3.JNS162033. Epub 2017 Oct 6.


Ultrasound Aided Vertebral Level Localization for Lumbar Surgery.

Baka N, Leenstra S, van Walsum T.

IEEE Trans Med Imaging. 2017 Oct;36(10):2138-2147. doi: 10.1109/TMI.2017.2738612. Epub 2017 Aug 10.


Random Forest-Based Bone Segmentation in Ultrasound.

Baka N, Leenstra S, van Walsum T.

Ultrasound Med Biol. 2017 Oct;43(10):2426-2437. doi: 10.1016/j.ultrasmedbio.2017.04.022. Epub 2017 Jul 21.


The Sequence of Delta24-RGD and TMZ Administration in Malignant Glioma Affects the Role of CD8+T Cell Anti-tumor Activity.

Kleijn A, van den Bossche W, Haefner ES, Belcaid Z, Burghoorn-Maas C, Kloezeman JJ, Pas SD, Leenstra S, Debets R, de Vrij J, Dirven CMF, Lamfers MLM.

Mol Ther Oncolytics. 2017 Mar 1;5:11-19. doi: 10.1016/j.omto.2017.02.002. eCollection 2017 Jun 16.


Does early resection of presumed low-grade glioma improve survival? A clinical perspective.

Wijnenga MMJ, Mattni T, French PJ, Rutten GJ, Leenstra S, Kloet F, Taphoorn MJB, van den Bent MJ, Dirven CMF, van Veelen ML, Vincent AJPE.

J Neurooncol. 2017 May;133(1):137-146. doi: 10.1007/s11060-017-2418-8. Epub 2017 Apr 11.


Treatment of Nonfunctional Pituitary Adenoma Postoperative Remnants: Adjuvant or Delayed Gamma Knife Radiosurgery?

Sadik ZHA, Voormolen EHJ, Depauw PRAM, Burhani B, Nieuwlaat WA, Verheul J, Leenstra S, Fleischeuer R, Hanssens PEJ.

World Neurosurg. 2017 Apr;100:361-368. doi: 10.1016/j.wneu.2017.01.028. Epub 2017 Jan 18.


TP53 mutated glioblastoma stem-like cell cultures are sensitive to dual mTORC1/2 inhibition while resistance in TP53 wild type cultures can be overcome by combined inhibition of mTORC1/2 and Bcl-2.

Venkatesan S, Hoogstraat M, Caljouw E, Pierson T, Spoor JK, Zeneyedpour L, Dubbink HJ, Dekker LJ, van der Kaaij M, Kloezeman J, Berghauser Pont LM, Besselink NJ, Luider TM, Joore J, Martens JW, Lamfers ML, Sleijfer S, Leenstra S.

Oncotarget. 2016 Sep 6;7(36):58435-58444. doi: 10.18632/oncotarget.11205.


Malignant Glioma In Vitro Models: On the Utilization of Stem-like Cells.

Balvers RK, Dirven CM, Leenstra S, Lamfers ML.

Curr Cancer Drug Targets. 2017;17(3):255-266. doi: 10.2174/1568009616666160813191809. Review.


A Systematic Comparison Identifies an ATP-Based Viability Assay as Most Suitable Read-Out for Drug Screening in Glioma Stem-Like Cells.

Kleijn A, Kloezeman JJ, Balvers RK, van der Kaaij M, Dirven CM, Leenstra S, Lamfers ML.

Stem Cells Int. 2016;2016:5623235. doi: 10.1155/2016/5623235. Epub 2016 May 5.


Genetic biomarkers of drug response for small-molecule therapeutics targeting the RTK/Ras/PI3K, p53 or Rb pathway in glioblastoma.

Venkatesan S, Lamfers ML, Dirven CM, Leenstra S.

CNS Oncol. 2016;5(2):77-90. doi: 10.2217/cns-2015-0005. Epub 2016 Mar 17. Review. Erratum in: CNS Oncol. 2016 Jul;5(3):188.


Gamma Knife radiosurgery for vestibular schwannomas: evaluation of tumor control and its predictors in a large patient cohort in The Netherlands.

Klijn S, Verheul JB, Beute GN, Leenstra S, Mulder JJ, Kunst HP, Hanssens PE.

J Neurosurg. 2016 Jun;124(6):1619-26. doi: 10.3171/2015.4.JNS142415. Epub 2015 Oct 2.


In vitro screening of clinical drugs identifies sensitizers of oncolytic viral therapy in glioblastoma stem-like cells.

Berghauser Pont LM, Balvers RK, Kloezeman JJ, Nowicki MO, van den Bossche W, Kremer A, Wakimoto H, van den Hoogen BG, Leenstra S, Dirven CM, Chiocca EA, Lawler SE, Lamfers ML.

Gene Ther. 2015 Dec;22(12):947-59. doi: 10.1038/gt.2015.72. Epub 2015 Jul 21.


The HDAC Inhibitors Scriptaid and LBH589 Combined with the Oncolytic Virus Delta24-RGD Exert Enhanced Anti-Tumor Efficacy in Patient-Derived Glioblastoma Cells.

Berghauser Pont LM, Kleijn A, Kloezeman JJ, van den Bossche W, Kaufmann JK, de Vrij J, Leenstra S, Dirven CM, Lamfers ML.

PLoS One. 2015 May 18;10(5):e0127058. doi: 10.1371/journal.pone.0127058. eCollection 2015.


The therapeutic efficacy of the oncolytic virus Delta24-RGD in a murine glioma model depends primarily on antitumor immunity.

Kleijn A, Kloezeman J, Treffers-Westerlaken E, Fulci G, Leenstra S, Dirven C, Debets R, Lamfers M.

Oncoimmunology. 2014 Dec 13;3(9):e955697. eCollection 2014 Oct.


ABT-888 enhances cytotoxic effects of temozolomide independent of MGMT status in serum free cultured glioma cells.

Balvers RK, Lamfers ML, Kloezeman JJ, Kleijn A, Berghauser Pont LM, Dirven CM, Leenstra S.

J Transl Med. 2015 Feb 26;13:74. doi: 10.1186/s12967-015-0427-y.


The Bcl-2 inhibitor Obatoclax overcomes resistance to histone deacetylase inhibitors SAHA and LBH589 as radiosensitizers in patient-derived glioblastoma stem-like cells.

Berghauser Pont LM, Spoor JK, Venkatesan S, Swagemakers S, Kloezeman JJ, Dirven CM, van der Spek PJ, Lamfers ML, Leenstra S.

Genes Cancer. 2014 Nov;5(11-12):445-59.


DNA damage response and anti-apoptotic proteins predict radiosensitization efficacy of HDAC inhibitors SAHA and LBH589 in patient-derived glioblastoma cells.

Pont LM, Naipal K, Kloezeman JJ, Venkatesan S, van den Bent M, van Gent DC, Dirven CM, Kanaar R, Lamfers ML, Leenstra S.

Cancer Lett. 2015 Jan 28;356(2 Pt B):525-35. doi: 10.1016/j.canlet.2014.09.049. Epub 2014 Oct 8.


Mutational profiling of kinases in glioblastoma.

Bleeker FE, Lamba S, Zanon C, Molenaar RJ, Hulsebos TJ, Troost D, van Tilborg AA, Vandertop WP, Leenstra S, van Noorden CJ, Bardelli A.

BMC Cancer. 2014 Sep 26;14:718. doi: 10.1186/1471-2407-14-718.


Locally-delivered T-cell-derived cellular vehicles efficiently track and deliver adenovirus delta24-RGD to infiltrating glioma.

Balvers RK, Belcaid Z, van den Hengel SK, Kloezeman J, de Vrij J, Wakimoto H, Hoeben RC, Debets R, Leenstra S, Dirven C, Lamfers ML.

Viruses. 2014 Aug 12;6(8):3080-96. doi: 10.3390/v6083080.


The in vivo therapeutic efficacy of the oncolytic adenovirus Delta24-RGD is mediated by tumor-specific immunity.

Kleijn A, Kloezeman J, Treffers-Westerlaken E, Fulci G, Leenstra S, Dirven C, Debets R, Lamfers M.

PLoS One. 2014 May 27;9(5):e97495. doi: 10.1371/journal.pone.0097495. eCollection 2014.


The combination of IDH1 mutations and MGMT methylation status predicts survival in glioblastoma better than either IDH1 or MGMT alone.

Molenaar RJ, Verbaan D, Lamba S, Zanon C, Jeuken JW, Boots-Sprenger SH, Wesseling P, Hulsebos TJ, Troost D, van Tilborg AA, Leenstra S, Vandertop WP, Bardelli A, van Noorden CJ, Bleeker FE.

Neuro Oncol. 2014 Sep;16(9):1263-73. doi: 10.1093/neuonc/nou005. Epub 2014 Feb 6.


Serum-free culture success of glial tumors is related to specific molecular profiles and expression of extracellular matrix-associated gene modules.

Balvers RK, Kleijn A, Kloezeman JJ, French PJ, Kremer A, van den Bent MJ, Dirven CM, Leenstra S, Lamfers ML.

Neuro Oncol. 2013 Dec;15(12):1684-95. doi: 10.1093/neuonc/not116. Epub 2013 Sep 17.


Quantification of nanosized extracellular membrane vesicles with scanning ion occlusion sensing.

de Vrij J, Maas SL, van Nispen M, Sena-Esteves M, Limpens RW, Koster AJ, Leenstra S, Lamfers ML, Broekman ML.

Nanomedicine (Lond). 2013 Sep;8(9):1443-58. doi: 10.2217/nnm.12.173. Epub 2013 Feb 5.


Recent advances in the molecular understanding of glioblastoma.

Bleeker FE, Molenaar RJ, Leenstra S.

J Neurooncol. 2012 May;108(1):11-27. doi: 10.1007/s11060-011-0793-0. Epub 2012 Jan 20. Review.


IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo.

Bralten LB, Kloosterhof NK, Balvers R, Sacchetti A, Lapre L, Lamfers M, Leenstra S, de Jonge H, Kros JM, Jansen EE, Struys EA, Jakobs C, Salomons GS, Diks SH, Peppelenbosch M, Kremer A, Hoogenraad CC, Smitt PA, French PJ.

Ann Neurol. 2011 Mar;69(3):455-63. doi: 10.1002/ana.22390.


Long-term impact of cognitive deficits and epilepsy on quality of life in patients with low-grade meningiomas.

Waagemans ML, van Nieuwenhuizen D, Dijkstra M, Wumkes M, Dirven CM, Leenstra S, Reijneveld JC, Klein M, Stalpers LJ.

Neurosurgery. 2011 Jul;69(1):72-8; discussion 78-9. doi: 10.1227/NEU.0b013e318212badb.


Gamma Knife surgery for trigeminal neuralgia: a review of 450 consecutive cases.

Verheul JB, Hanssens PE, Lie ST, Leenstra S, Piersma H, Beute GN.

J Neurosurg. 2010 Dec;113 Suppl:160-7.


Absence of the MGMT protein as well as methylation of the MGMT promoter predict the sensitivity for temozolomide.

van Nifterik KA, van den Berg J, van der Meide WF, Ameziane N, Wedekind LE, Steenbergen RD, Leenstra S, Lafleur MV, Slotman BJ, Stalpers LJ, Sminia P.

Br J Cancer. 2010 Jun 29;103(1):29-35. doi: 10.1038/sj.bjc.6605712. Epub 2010 Jun 1.


Absence of AKT1 mutations in glioblastoma.

Bleeker FE, Lamba S, Zanon C, van Tilborg AA, Leenstra S, Troost D, Hulsebos T, Vandertop WP, Bardelli A.

PLoS One. 2009 May 20;4(5):e5638. doi: 10.1371/journal.pone.0005638.


Organotypic glioma spheroids for screening of experimental therapies: how many spheroids and sections are required?

De Witt Hamer PC, Leenstra S, Van Noorden CJ, Zwinderman AH.

Cytometry A. 2009 Jun;75(6):528-34. doi: 10.1002/cyto.a.20716.


IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors.

Bleeker FE, Lamba S, Leenstra S, Troost D, Hulsebos T, Vandertop WP, Frattini M, Molinari F, Knowles M, Cerrato A, Rodolfo M, Scarpa A, Felicioni L, Buttitta F, Malatesta S, Marchetti A, Bardelli A.

Hum Mutat. 2009 Jan;30(1):7-11. doi: 10.1002/humu.20937.


Mutational profiling of cancer candidate genes in glioblastoma, melanoma and pancreatic carcinoma reveals a snapshot of their genomic landscapes.

Bleeker FE, Lamba S, Rodolfo M, Scarpa A, Leenstra S, Vandertop WP, Bardelli A.

Hum Mutat. 2009 Feb;30(2):E451-9. doi: 10.1002/humu.20927.


Late neurocognitive sequelae in patients with WHO grade I meningioma.

Dijkstra M, van Nieuwenhuizen D, Stalpers LJ, Wumkes M, Waagemans M, Vandertop WP, Heimans JJ, Leenstra S, Dirven CM, Reijneveld JC, Klein M.

J Neurol Neurosurg Psychiatry. 2009 Aug;80(8):910-5. doi: 10.1136/jnnp.2007.138925. Epub 2008 Jul 24.


AKT1(E17K) in human solid tumours.

Bleeker FE, Felicioni L, Buttitta F, Lamba S, Cardone L, Rodolfo M, Scarpa A, Leenstra S, Frattini M, Barbareschi M, Grammastro MD, Sciarrotta MG, Zanon C, Marchetti A, Bardelli A.

Oncogene. 2008 Sep 18;27(42):5648-50. doi: 10.1038/onc.2008.170. Epub 2008 May 26.


Differential radiosensitizing potential of temozolomide in MGMT promoter methylated glioblastoma multiforme cell lines.

van Nifterik KA, van den Berg J, Stalpers LJ, Lafleur MV, Leenstra S, Slotman BJ, Hulsebos TJ, Sminia P.

Int J Radiat Oncol Biol Phys. 2007 Nov 15;69(4):1246-53.


The genomic profile of human malignant glioma is altered early in primary cell culture and preserved in spheroids.

De Witt Hamer PC, Van Tilborg AA, Eijk PP, Sminia P, Troost D, Van Noorden CJ, Ylstra B, Leenstra S.

Oncogene. 2008 Mar 27;27(14):2091-6. Epub 2007 Oct 15.


Novel somatic and germline mutations in cancer candidate genes in glioblastoma, melanoma, and pancreatic carcinoma.

Balakrishnan A, Bleeker FE, Lamba S, Rodolfo M, Daniotti M, Scarpa A, van Tilborg AA, Leenstra S, Zanon C, Bardelli A.

Cancer Res. 2007 Apr 15;67(8):3545-50.


Differential effect of surgery and radiotherapy on neurocognitive functioning and health-related quality of life in WHO grade I meningioma patients.

van Nieuwenhuizen D, Klein M, Stalpers LJ, Leenstra S, Heimans JJ, Reijneveld JC.

J Neurooncol. 2007 Sep;84(3):271-8. Epub 2007 Apr 13.


Genetic profiling of a distant second glioblastoma multiforme after radiotherapy: Recurrence or second primary tumor?

van Nifterik KA, Elkhuizen PH, van Andel RJ, Stalpers LJ, Leenstra S, Lafleur MV, Vandertop WP, Slotman BJ, Hulsebos TJ, Sminia P.

J Neurosurg. 2006 Nov;105(5):739-44.


Effects of irradiation and cisplatin on human glioma spheroids: inhibition of cell proliferation and cell migration.

Fehlauer F, Muench M, Rades D, Stalpers LJ, Leenstra S, van der Valk P, Slotman B, Smid EJ, Sminia P.

J Cancer Res Clin Oncol. 2005 Nov;131(11):723-32. Epub 2005 Nov 1.


Localization of breast cancer resistance protein (BCRP) in microvessel endothelium of human control and epileptic brain.

Aronica E, Gorter JA, Redeker S, van Vliet EA, Ramkema M, Scheffer GL, Scheper RJ, van der Valk P, Leenstra S, Baayen JC, Spliet WG, Troost D.

Epilepsia. 2005 Jun;46(6):849-57.


Distribution, characterization and clinical significance of microglia in glioneuronal tumours from patients with chronic intractable epilepsy.

Aronica E, Gorter JA, Redeker S, Ramkema M, Spliet WG, van Rijen PC, Leenstra S, Troost D.

Neuropathol Appl Neurobiol. 2005 Jun;31(3):280-91.


Scrotal pain as the presenting symptom of lumbar disc herniation: a report of 2 cases.

Wouda EJ, Leenstra S, Vanneste JA.

Spine (Phila Pa 1976). 2005 Jan 15;30(2):E47-9.


Quantification of viability in organotypic multicellular spheroids of human malignant glioma using lactate dehydrogenase activity: a rapid and reliable automated assay.

De Witt Hamer PC, Jonker A, Leenstra S, Ruijter JM, Van Noorden CJ.

J Histochem Cytochem. 2005 Jan;53(1):23-34.


Expression and cellular distribution of high- and low-affinity neurotrophin receptors in malformations of cortical development.

Aronica E, Ozbas-Ger├žeker F, Redeker S, Ramkema M, Spliet WG, van Rijen PC, Leenstra S, Gorter JA, Troost D.

Acta Neuropathol. 2004 Nov;108(5):422-34. Epub 2004 Sep 15.


Functional magnetic resonance imaging for neurosurgical planning in neurooncology.

Vlieger EJ, Majoie CB, Leenstra S, Den Heeten GJ.

Eur Radiol. 2004 Jul;14(7):1143-53. Epub 2004 May 18. Review.


Molecular-genetic characterisation of gliomas that recur as same grade or higher grade tumours.

Hulsebos TJ, Troost D, Leenstra S.

J Neurol Neurosurg Psychiatry. 2004 May;75(5):723-6.

Supplemental Content

Loading ...
Support Center