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Items: 1 to 50 of 140

1.

Dendritic cell line AP284 supports Th17 amplification.

de Oliveira PG, Gomes CM, Ávila LR, Ribeiro-Dias F, Leenen PJM, de Oliveira MAP.

Cell Immunol. 2019 Mar;337:54-61. doi: 10.1016/j.cellimm.2019.02.003. Epub 2019 Feb 10.

PMID:
30773217
2.

Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging?

van Beek AA, Van den Bossche J, Mastroberardino PG, de Winther MPJ, Leenen PJM.

Trends Immunol. 2019 Feb;40(2):113-127. doi: 10.1016/j.it.2018.12.007. Epub 2019 Jan 6. Review.

PMID:
30626541
3.

Comparative proteomic analysis of cat eye syndrome critical region protein 1- function in tumor-associated macrophages and immune response regulation of glial tumors.

Zhu C, Mustafa DAM, Krebber MM, Chrifi I, Leenen PJM, Duncker DJ, Dekker L, Luider TM, Kros JM, Cheng C.

Oncotarget. 2018 Sep 11;9(71):33500-33514. doi: 10.18632/oncotarget.26063. eCollection 2018 Sep 11.

4.

Three-dimensional tubule formation assay as therapeutic screening model for ocular microvascular disorders.

Shariatzadeh M, Brandt MM, Cheng C, Ten Berge JC, Rothova A, Leenen PJM, Dik WA.

Eye (Lond). 2018 Aug;32(8):1380-1386. doi: 10.1038/s41433-018-0089-0. Epub 2018 May 10.

5.

The interplay between critical transcription factors and microRNAs in the control of normal and malignant myelopoiesis.

Stavast CJ, Leenen PJM, Erkeland SJ.

Cancer Lett. 2018 Jul 28;427:28-37. doi: 10.1016/j.canlet.2018.04.010. Epub 2018 Apr 16. Review.

6.

Regulation of Intracellular Triiodothyronine Is Essential for Optimal Macrophage Function.

van der Spek AH, Surovtseva OV, Jim KK, van Oudenaren A, Brouwer MC, Vandenbroucke-Grauls CMJE, Leenen PJM, van de Beek D, Hernandez A, Fliers E, Boelen A.

Endocrinology. 2018 May 1;159(5):2241-2252. doi: 10.1210/en.2018-00053.

7.

Pharmacodynamic Monitoring of Tacrolimus-Based Immunosuppression in CD14+ Monocytes After Kidney Transplantation.

Kannegieter NM, Hesselink DA, Dieterich M, de Graav GN, Kraaijeveld R, Rowshani AT, Leenen PJM, Baan CC.

Ther Drug Monit. 2017 Oct;39(5):463-471. doi: 10.1097/FTD.0000000000000426.

PMID:
28640063
8.

Unacylated ghrelin modulates circulating angiogenic cell number in insulin-resistant states.

Özcan B, Leenen PJM, Delhanty PJD, Baldéon-Rojas LY, Neggers SJ, van der Lely AJ.

Diabetol Metab Syndr. 2017 May 31;9:43. doi: 10.1186/s13098-017-0239-8. eCollection 2017.

9.

CECR1-mediated cross talk between macrophages and vascular mural cells promotes neovascularization in malignant glioma.

Zhu C, Chrifi I, Mustafa D, van der Weiden M, Leenen PJM, Duncker DJ, Kros JM, Cheng C.

Oncogene. 2017 Sep 21;36(38):5356-5368. doi: 10.1038/onc.2017.145. Epub 2017 May 22.

10.

Activation of CECR1 in M2-like TAMs promotes paracrine stimulation-mediated glial tumor progression.

Zhu C, Mustafa D, Zheng PP, van der Weiden M, Sacchetti A, Brandt M, Chrifi I, Tempel D, Leenen PJM, Duncker DJ, Cheng C, Kros JM.

Neuro Oncol. 2017 May 1;19(5):648-659. doi: 10.1093/neuonc/now251.

11.

Interactions between Type 1 Interferons and the Th17 Response in Tuberculosis: Lessons Learned from Autoimmune Diseases.

Mourik BC, Lubberts E, de Steenwinkel JEM, Ottenhoff THM, Leenen PJM.

Front Immunol. 2017 Apr 5;8:294. doi: 10.3389/fimmu.2017.00294. eCollection 2017. Review.

12.

CD16+ Monocytes and Skewed Macrophage Polarization toward M2 Type Hallmark Heart Transplant Acute Cellular Rejection.

van den Bosch TP, Caliskan K, Kraaij MD, Constantinescu AA, Manintveld OC, Leenen PJ, von der Thüsen JH, Clahsen-van Groningen MC, Baan CC, Rowshani AT.

Front Immunol. 2017 Mar 24;8:346. doi: 10.3389/fimmu.2017.00346. eCollection 2017.

13.

The Effect of Tacrolimus and Mycophenolic Acid on CD14+ Monocyte Activation and Function.

Kannegieter NM, Hesselink DA, Dieterich M, Kraaijeveld R, Rowshani AT, Leenen PJ, Baan CC.

PLoS One. 2017 Jan 25;12(1):e0170806. doi: 10.1371/journal.pone.0170806. eCollection 2017.

14.

Supplementation with Lactobacillus plantarum WCFS1 Prevents Decline of Mucus Barrier in Colon of Accelerated Aging Ercc1-/Δ7 Mice.

van Beek AA, Sovran B, Hugenholtz F, Meijer B, Hoogerland JA, Mihailova V, van der Ploeg C, Belzer C, Boekschoten MV, Hoeijmakers JH, Vermeij WP, de Vos P, Wells JM, Leenen PJ, Nicoletti C, Hendriks RW, Savelkoul HF.

Front Immunol. 2016 Oct 7;7:408. eCollection 2016.

15.

Immunotherapy Added to Antibiotic Treatment Reduces Relapse of Disease in a Mouse Model of Tuberculosis.

Mourik BC, Leenen PJ, de Knegt GJ, Huizinga R, van der Eerden BC, Wang J, Krois CR, Napoli JL, Bakker-Woudenberg IA, de Steenwinkel JE.

Am J Respir Cell Mol Biol. 2017 Feb;56(2):233-241. doi: 10.1165/rcmb.2016-0185OC.

PMID:
27654457
16.

The Immune Pathogenesis of Type 1 Diabetes: Not Only Thinking Outside the Cell but Also Outside the Islet and Out of the Box.

Drexhage HA, Dik WA, Leenen PJ, Versnel MA.

Diabetes. 2016 Aug;65(8):2130-3. doi: 10.2337/dbi16-0030. No abstract available.

17.

Frontline Science: Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1-/Δ7 mice.

van Beek AA, Hugenholtz F, Meijer B, Sovran B, Perdijk O, Vermeij WP, Brandt RM, Barnhoorn S, Hoeijmakers JH, de Vos P, Leenen PJ, Hendriks RW, Savelkoul HF.

J Leukoc Biol. 2017 Apr;101(4):811-821. doi: 10.1189/jlb.1HI0216-062RR. Epub 2016 Jul 14.

18.

Langerhans cell histiocytosis is a neoplasm and consequently its recurrence is a relapse: In memory of Bob Arceci.

Egeler RM, Katewa S, Leenen PJ, Beverley P, Collin M, Ginhoux F, Arceci RJ, Rollins BJ; Steering Committee of the Nikolas Symposium.

Pediatr Blood Cancer. 2016 Oct;63(10):1704-12. doi: 10.1002/pbc.26104. Epub 2016 Jun 17. Review.

PMID:
27314817
19.

Lifelong challenge of calcium homeostasis in male mice lacking TRPV5 leads to changes in bone and calcium metabolism.

van der Eerden BC, Koek WN, Roschger P, Zillikens MC, Waarsing JH, van der Kemp A, Schreuders-Koedam M, Fratzl-Zelman N, Leenen PJ, Hoenderop JG, Klaushofer K, Bindels RJ, van Leeuwen JP.

Oncotarget. 2016 May 3;7(18):24928-41. doi: 10.18632/oncotarget.8779.

20.

IL-1β differently stimulates proliferation and multinucleation of distinct mouse bone marrow osteoclast precursor subsets.

Cao Y, Jansen ID, Sprangers S, Stap J, Leenen PJ, Everts V, de Vries TJ.

J Leukoc Biol. 2016 Sep;100(3):513-23. doi: 10.1189/jlb.1A1215-543R. Epub 2016 Mar 8.

PMID:
26957213
21.

Study on inflammation-related genes and microRNAs, with special emphasis on the vascular repair factor HGF and miR-574-3p, in monocytes and serum of patients with T2D.

Baldeón Rojas L, Weigelt K, de Wit H, Ozcan B, van Oudenaren A, Sempértegui F, Sijbrands E, Grosse L, van Zonneveld AJ, Drexhage HA, Leenen PJ.

Diabetol Metab Syndr. 2016 Jan 15;8:6. doi: 10.1186/s13098-015-0113-5. eCollection 2016.

22.

Interaction of mouse splenocytes and macrophages with bacterial strains in vitro: the effect of age in the immune response.

Van Beek AA, Hoogerland JA, Belzer C, De Vos P, De Vos WM, Savelkoul HF, Leenen PJ.

Benef Microbes. 2016;7(2):275-87. doi: 10.3920/BM2015.0094. Epub 2015 Dec 21.

PMID:
26689225
23.

Type 2 Diabetes Monocyte MicroRNA and mRNA Expression: Dyslipidemia Associates with Increased Differentiation-Related Genes but Not Inflammatory Activation.

Baldeón R L, Weigelt K, de Wit H, Ozcan B, van Oudenaren A, Sempértegui F, Sijbrands E, Grosse L, van Zonneveld AJ, Drexhage HA, Leenen PJ.

PLoS One. 2015 Jun 17;10(6):e0129421. doi: 10.1371/journal.pone.0129421. eCollection 2015.

24.

Decreased serum level of miR-146a as sign of chronic inflammation in type 2 diabetic patients.

Baldeón R L, Weigelt K, de Wit H, Ozcan B, van Oudenaren A, Sempértegui F, Sijbrands E, Grosse L, Freire W, Drexhage HA, Leenen PJ.

PLoS One. 2014 Dec 12;9(12):e115209. doi: 10.1371/journal.pone.0115209. eCollection 2014.

25.

Immune suppression via glucocorticoid-stimulated monocytes: a novel mechanism to cope with inflammation.

Varga G, Ehrchen J, Brockhausen A, Weinhage T, Nippe N, Belz M, Tsianakas A, Ross M, Bettenworth D, Spieker T, Wolf M, Lippe R, Tenbrock K, Leenen PJ, Roth J, Sunderkötter C.

J Immunol. 2014 Aug 1;193(3):1090-9. doi: 10.4049/jimmunol.1300891. Epub 2014 Jul 2.

26.

M-CSF priming of osteoclast precursors can cause osteoclastogenesis-insensitivity, which can be prevented and overcome on bone.

De Vries TJ, Schoenmaker T, Aerts D, Grevers LC, Souza PP, Nazmi K, van de Wiel M, Ylstra B, Lent PL, Leenen PJ, Everts V.

J Cell Physiol. 2015 Jan;230(1):210-25. doi: 10.1002/jcp.24702.

PMID:
24962140
27.

Human monocytes produce interferon-gamma upon stimulation with LPS.

Kraaij MD, Vereyken EJ, Leenen PJ, van den Bosch TP, Rezaee F, Betjes MG, Baan CC, Rowshani AT.

Cytokine. 2014 May;67(1):7-12. doi: 10.1016/j.cyto.2014.02.001. Epub 2014 Feb 26.

PMID:
24680476
28.

MicroRNA-Mediated Down-Regulation of M-CSF Receptor Contributes to Maturation of Mouse Monocyte-Derived Dendritic Cells.

Riepsaame J, van Oudenaren A, den Broeder BJ, van Ijcken WF, Pothof J, Leenen PJ.

Front Immunol. 2013 Oct 30;4:353. doi: 10.3389/fimmu.2013.00353. eCollection 2013.

29.

Arginase activity is associated with fibrosis in experimental infection with Taenia crassiceps, but does not play a major role in resistance to infection.

Moura VB, Silva MM, Batista LF, Gomes CM, Leenen PJ, Lino RS Jr, Oliveira MA.

Exp Parasitol. 2013 Nov;135(3):599-605. doi: 10.1016/j.exppara.2013.09.014. Epub 2013 Sep 30.

PMID:
24090570
30.

A shift towards pro-inflammatory CD16+ monocyte subsets with preserved cytokine production potential after kidney transplantation.

Vereyken EJ, Kraaij MD, Baan CC, Rezaee F, Weimar W, Wood KJ, Leenen PJ, Rowshani AT.

PLoS One. 2013 Jul 29;8(7):e70152. doi: 10.1371/journal.pone.0070152. Print 2013.

31.

The kinetics of plasmacytoid dendritic cell accumulation in the pancreas of the NOD mouse during the early phases of insulitis.

Welzen-Coppens JM, van Helden-Meeuwsen CG, Leenen PJ, Drexhage HA, Versnel MA.

PLoS One. 2013;8(1):e55071. doi: 10.1371/journal.pone.0055071. Epub 2013 Jan 25.

32.

Des-acyl ghrelin analogs prevent high-fat-diet-induced dysregulation of glucose homeostasis.

Delhanty PJ, Huisman M, Baldeon-Rojas LY, van den Berge I, Grefhorst A, Abribat T, Leenen PJ, Themmen AP, van der Lely AJ.

FASEB J. 2013 Apr;27(4):1690-700. doi: 10.1096/fj.12-221143. Epub 2013 Jan 8.

PMID:
23299855
33.

Relapse of tuberculosis versus primary tuberculosis; course, pathogenesis and therapy in mice.

de Steenwinkel JE, de Knegt GJ, ten Kate MT, Verbrugh HA, Hernandez-Pando R, Leenen PJ, Bakker-Woudenberg IA.

Tuberculosis (Edinb). 2013 Mar;93(2):213-21. doi: 10.1016/j.tube.2012.11.006. Epub 2012 Dec 23.

PMID:
23266260
34.

Reduced numbers of dendritic cells with a tolerogenic phenotype in the prediabetic pancreas of NOD mice.

Welzen-Coppens JM, van Helden-Meeuwsen CG, Leenen PJ, Drexhage HA, Versnel MA.

J Leukoc Biol. 2012 Dec;92(6):1207-13. doi: 10.1189/jlb.0312168. Epub 2012 Sep 25.

PMID:
23012431
35.

Kupffer cells express a unique combination of phenotypic and functional characteristics compared with splenic and peritoneal macrophages.

Movita D, Kreefft K, Biesta P, van Oudenaren A, Leenen PJ, Janssen HL, Boonstra A.

J Leukoc Biol. 2012 Oct;92(4):723-33. doi: 10.1189/jlb.1111566. Epub 2012 Jun 8.

PMID:
22685319
36.

Atherosclerotic Plaque Stability Is Affected by the Chemokine CXCL10 in Both Mice and Humans.

Segers D, Lipton JA, Leenen PJ, Cheng C, Tempel D, Pasterkamp G, Moll FL, de Crom R, Krams R.

Int J Inflam. 2011;2011:936109. doi: 10.4061/2011/936109. Epub 2011 Nov 13.

37.

Myeloid IκBα deficiency promotes atherogenesis by enhancing leukocyte recruitment to the plaques.

Goossens P, Vergouwe MN, Gijbels MJ, Curfs DM, van Woezik JH, Hoeksema MA, Xanthoulea S, Leenen PJ, Rupec RA, Hofker MH, de Winther MP.

PLoS One. 2011;6(7):e22327. doi: 10.1371/journal.pone.0022327. Epub 2011 Jul 21.

38.

Intravenously delivered glucocorticoid liposomes inhibit osteoclast activity and bone erosion in murine antigen-induced arthritis.

Hofkens W, Grevers LC, Walgreen B, de Vries TJ, Leenen PJ, Everts V, Storm G, van den Berg WB, van Lent PL.

J Control Release. 2011 Jun 30;152(3):363-9. doi: 10.1016/j.jconrel.2011.03.001. Epub 2011 Mar 17.

PMID:
21396411
39.

S100A8 enhances osteoclastic bone resorption in vitro through activation of Toll-like receptor 4: implications for bone destruction in murine antigen-induced arthritis.

Grevers LC, de Vries TJ, Vogl T, Abdollahi-Roodsaz S, Sloetjes AW, Leenen PJ, Roth J, Everts V, van den Berg WB, van Lent PL.

Arthritis Rheum. 2011 May;63(5):1365-75. doi: 10.1002/art.30290.

40.

Severe Listeria monocytogenes infection induces development of monocytes with distinct phenotypic and functional features.

Drevets DA, Schawang JE, Mandava VK, Dillon MJ, Leenen PJ.

J Immunol. 2010 Aug 15;185(4):2432-41. doi: 10.4049/jimmunol.1000486. Epub 2010 Jul 14.

41.

Nomenclature of monocytes and dendritic cells in blood.

Ziegler-Heitbrock L, Ancuta P, Crowe S, Dalod M, Grau V, Hart DN, Leenen PJ, Liu YJ, MacPherson G, Randolph GJ, Scherberich J, Schmitz J, Shortman K, Sozzani S, Strobl H, Zembala M, Austyn JM, Lutz MB.

Blood. 2010 Oct 21;116(16):e74-80. doi: 10.1182/blood-2010-02-258558. Epub 2010 Jul 13.

PMID:
20628149
42.

IFN-gamma triggers CCR2-independent monocyte entry into the brain during systemic infection by virulent Listeria monocytogenes.

Drevets DA, Dillon MJ, Schawang JE, Stoner JA, Leenen PJ.

Brain Behav Immun. 2010 Aug;24(6):919-29. doi: 10.1016/j.bbi.2010.02.011. Epub 2010 Mar 6.

PMID:
20211719
43.

Langerhans cell histiocytosis: fascinating dynamics of the dendritic cell-macrophage lineage.

Egeler RM, van Halteren AG, Hogendoorn PC, Laman JD, Leenen PJ.

Immunol Rev. 2010 Mar;234(1):213-32. doi: 10.1111/j.0105-2896.2009.00883.x. Review.

PMID:
20193021
44.

Synthetic human chorionic gonadotropin-related oligopeptides impair early innate immune responses to Listeria monocytogenes in Mice.

van der Zee M, Dik WA, Kap YS, Dillon MJ, Benner R, Leenen PJ, Khan NA, Drevets DA.

J Infect Dis. 2010 Apr 1;201(7):1072-80. doi: 10.1086/651134.

PMID:
20170375
45.

Heterogeneity in a mouse model of histiocytosis: transformation of Langerin+ dendritic cells, macrophages, and precursors.

Leenen PJ, Bechan GI, Melis M, den Broeder BJ, Löhler J, Egeler RM.

J Leukoc Biol. 2010 May;87(5):949-58. doi: 10.1189/jlb.0609432. Epub 2010 Feb 9.

PMID:
20145199
46.

Gr-1 antibody induces STAT signaling, macrophage marker expression and abrogation of myeloid-derived suppressor cell activity in BM cells.

Ribechini E, Leenen PJ, Lutz MB.

Eur J Immunol. 2009 Dec;39(12):3538-51. doi: 10.1002/eji.200939530.

47.

Plasmacytoid dendritic cells in autoimmune diabetes - potential tools for immunotherapy.

Nikolic T, Welzen-Coppens JM, Leenen PJ, Drexhage HA, Versnel MA.

Immunobiology. 2009;214(9-10):791-9. doi: 10.1016/j.imbio.2009.06.002. Epub 2009 Jul 22. Review.

PMID:
19628297
48.

Keratinocyte growth factor improves allogeneic bone marrow engraftment through a CD4+Foxp3+ regulatory T cell-dependent mechanism.

Bruinsma M, van Soest PL, Leenen PJ, Löwenberg B, Cornelissen JJ, Braakman E.

J Immunol. 2009 Jun 15;182(12):7364-9. doi: 10.4049/jimmunol.0803253.

49.

Chorionic gonadotropin alleviates thioglycollate-induced peritonitis by affecting macrophage function.

Wan H, Coppens JM, van Helden-Meeuwsen CG, Leenen PJ, van Rooijen N, Khan NA, Kiekens RC, Benner R, Versnel MA.

J Leukoc Biol. 2009 Aug;86(2):361-70. doi: 10.1189/jlb.0208126. Epub 2009 May 4.

PMID:
19414540
50.

Myeloid blasts are the mouse bone marrow cells prone to differentiate into osteoclasts.

de Vries TJ, Schoenmaker T, Hooibrink B, Leenen PJ, Everts V.

J Leukoc Biol. 2009 Jun;85(6):919-27. doi: 10.1189/jlb.0708402.

PMID:
19304896

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