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Novel educational and goal-setting tool to improve knowledge of chronic kidney disease among liver transplant recipients: A pilot study.

Leek RB, Park JM, Koerschner C, Mawby J, Sonnenday CJ, Wright Nunes JA, Sharma P.

PLoS One. 2019 Jul 25;14(7):e0219856. doi: 10.1371/journal.pone.0219856. eCollection 2019.


Impact of direct-acting antivirals for hepatitis C virus therapy on tacrolimus dosing in liver transplant recipients.

Bixby AL, Fitzgerald L, Leek R, Mellinger J, Sharma P, Tischer S.

Transpl Infect Dis. 2019 Jun;21(3):e13078. doi: 10.1111/tid.13078. Epub 2019 Apr 1.


Role of Delta-like 4 in Jagged1-induced tumour angiogenesis and tumour growth.

Oon CE, Bridges E, Sheldon H, Sainson RCA, Jubb A, Turley H, Leek R, Buffa F, Harris AL, Li JL.

Oncotarget. 2017 Jun 20;8(25):40115-40131. doi: 10.18632/oncotarget.16969.


Association between hypoxic volume and underlying hypoxia-induced gene expression in oropharyngeal squamous cell carcinoma.

Suh YE, Lawler K, Henley-Smith R, Pike L, Leek R, Barrington S, Odell EW, Ng T, Pezzella F, Guerrero-Urbano T, Tavassoli M.

Br J Cancer. 2017 Apr 11;116(8):1057-1064. doi: 10.1038/bjc.2017.66. Epub 2017 Mar 21.


Scedosporiosis in a Combined Kidney and Liver Transplant Recipient: A Case Report of Possible Transmission from a Near-Drowning Donor.

Leek R, Aldag E, Nadeem I, Gunabushanam V, Sahajpal A, Kramer DJ, Walsh TJ.

Case Rep Transplant. 2016;2016:1879529. doi: 10.1155/2016/1879529. Epub 2016 Dec 13.


DiPALS: Diaphragm Pacing in patients with Amyotrophic Lateral Sclerosis - a randomised controlled trial.

McDermott CJ, Bradburn MJ, Maguire C, Cooper CL, Baird WO, Baxter SK, Cohen J, Cantrill H, Dixon S, Ackroyd R, Baudouin S, Bentley A, Berrisford R, Bianchi S, Bourke SC, Darlison R, Ealing J, Elliott M, Fitzgerald P, Galloway S, Hamdalla H, Hanemann CO, Hughes P, Imam I, Karat D, Leek R, Maynard N, Orrell RW, Sarela A, Stradling J, Talbot K, Taylor L, Turner M, Simonds AK, Williams T, Wedzicha W, Young C, Shaw PJ.

Health Technol Assess. 2016 Jun;20(45):1-186. doi: 10.3310/hta20450.


Methods: Using Three-Dimensional Culture (Spheroids) as an In Vitro Model of Tumour Hypoxia.

Leek R, Grimes DR, Harris AL, McIntyre A.

Adv Exp Med Biol. 2016;899:167-96. doi: 10.1007/978-3-319-26666-4_10. Review.


Why some tumours trigger neovascularisation and others don't: the story thus far.

Adighibe O, Leek RD, Fernandez-Mercado M, Hu J, Snell C, Gatter KC, Harris AL, Pezzella F.

Chin J Cancer. 2016 Feb 12;35:18. doi: 10.1186/s40880-016-0082-6.


Paracrine effect of GTP cyclohydrolase and angiopoietin-1 interaction in stromal fibroblasts on tumor Tie2 activation and breast cancer growth.

Chen L, Zeng X, Kleibeuker E, Buffa F, Barberis A, Leek RD, Roxanis I, Zhang W, Worth A, Beech JS, Harris AL, Cai S.

Oncotarget. 2016 Feb 23;7(8):9353-67. doi: 10.18632/oncotarget.6981.


A Phase I First-in-Human Study of Enoticumab (REGN421), a Fully Human Delta-like Ligand 4 (Dll4) Monoclonal Antibody in Patients with Advanced Solid Tumors.

Chiorean EG, LoRusso P, Strother RM, Diamond JR, Younger A, Messersmith WA, Adriaens L, Liu L, Kao RJ, DiCioccio AT, Kostic A, Leek R, Harris A, Jimeno A.

Clin Cancer Res. 2015 Jun 15;21(12):2695-703. doi: 10.1158/1078-0432.CCR-14-2797. Epub 2015 Feb 27.


Blood vessel invasion and other variables as predictors of long-term survival in Japanese and British patients with primary invasive breast cancer.

Kato T, Pezzella F, Steers G, Campo L, Leek RD, Turley H, Kameoka S, Nishikawa T, Harris AL, Gatter KC, Fox S.

Int J Clin Exp Pathol. 2014 Oct 15;7(11):7967-78. eCollection 2014.


JMY protein, a regulator of P53 and cytoplasmic actin filaments, is expressed in normal and neoplastic tissues.

Adighibe O, Turley H, Leek R, Harris A, Coutts AS, La Thangue N, Gatter K, Pezzella F.

Virchows Arch. 2014 Dec;465(6):715-22. doi: 10.1007/s00428-014-1660-0. Epub 2014 Oct 4.


ADAM10 mediates trastuzumab resistance and is correlated with survival in HER2 positive breast cancer.

Feldinger K, Generali D, Kramer-Marek G, Gijsen M, Ng TB, Wong JH, Strina C, Cappelletti M, Andreis D, Li JL, Bridges E, Turley H, Leek R, Roxanis I, Capala J, Murphy G, Harris AL, Kong A.

Oncotarget. 2014 Aug 30;5(16):6633-46.


Role of carbohydrate response element-binding protein (ChREBP) in generating an aerobic metabolic phenotype and in breast cancer progression.

Airley RE, McHugh P, Evans AR, Harris B, Winchester L, Buffa FM, Al-Tameemi W, Leek R, Harris AL.

Br J Cancer. 2014 Feb 4;110(3):715-23. doi: 10.1038/bjc.2013.765. Epub 2013 Dec 24.


The G-protein-coupled receptor CLR is upregulated in an autocrine loop with adrenomedullin in clear cell renal cell carcinoma and associated with poor prognosis.

Nikitenko LL, Leek R, Henderson S, Pillay N, Turley H, Generali D, Gunningham S, Morrin HR, Pellagatti A, Rees MC, Harris AL, Fox SB.

Clin Cancer Res. 2013 Oct 15;19(20):5740-8. doi: 10.1158/1078-0432.CCR-13-1712. Epub 2013 Aug 22.


Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts.

Kumar K, Wigfield S, Gee HE, Devlin CM, Singleton D, Li JL, Buffa F, Huffman M, Sinn AL, Silver J, Turley H, Leek R, Harris AL, Ivan M.

J Mol Med (Berl). 2013 Jun;91(6):749-58. doi: 10.1007/s00109-013-0996-2. Epub 2013 Jan 30.


Surface modification of the TiO2 nanoparticle surface enables fluorescence monitoring of aggregation and enhanced photoreactivity.

Kamps K, Leek R, Luebke L, Price R, Nelson M, Simonet S, Eggert DJ, Ateşin TA, Brown EM.

Integr Biol (Camb). 2013 Jan;5(1):133-43. doi: 10.1039/c2ib20166f.


CD31 angiogenesis and combined expression of HIF-1α and HIF-2α are prognostic in primary clear-cell renal cell carcinoma (CC-RCC), but HIFα transcriptional products are not: implications for antiangiogenic trials and HIFα biomarker studies in primary CC-RCC.

Biswas S, Charlesworth PJ, Turner GD, Leek R, Thamboo PT, Campo L, Turley H, Dildey P, Protheroe A, Cranston D, Gatter KC, Pezzella F, Harris AL.

Carcinogenesis. 2012 Sep;33(9):1717-25. doi: 10.1093/carcin/bgs222. Epub 2012 Jul 9.


Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy.

McIntyre A, Patiar S, Wigfield S, Li JL, Ledaki I, Turley H, Leek R, Snell C, Gatter K, Sly WS, Vaughan-Jones RD, Swietach P, Harris AL.

Clin Cancer Res. 2012 Jun 1;18(11):3100-11. doi: 10.1158/1078-0432.CCR-11-1877. Epub 2012 Apr 12.


Dye surface coating enables visible light activation of TiO2 nanoparticles leading to degradation of neighboring biological structures.

Blatnik J, Luebke L, Simonet S, Nelson M, Price R, Leek R, Zeng L, Wu A, Brown E.

Microsc Microanal. 2012 Feb;18(1):134-42. doi: 10.1017/S1431927611012414. Epub 2012 Jan 4.


DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo.

Li JL, Sainson RC, Oon CE, Turley H, Leek R, Sheldon H, Bridges E, Shi W, Snell C, Bowden ET, Wu H, Chowdhury PS, Russell AJ, Montgomery CP, Poulsom R, Harris AL.

Cancer Res. 2011 Sep 15;71(18):6073-83. doi: 10.1158/0008-5472.CAN-11-1704. Epub 2011 Jul 29.


The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosis.

Gee HE, Buffa FM, Camps C, Ramachandran A, Leek R, Taylor M, Patil M, Sheldon H, Betts G, Homer J, West C, Ragoussis J, Harris AL.

Br J Cancer. 2011 Mar 29;104(7):1168-77. doi: 10.1038/sj.bjc.6606076. Epub 2011 Mar 15.


Roles of tetrahydrobiopterin in promoting tumor angiogenesis.

Chen L, Zeng X, Wang J, Briggs SS, O'Neill E, Li J, Leek R, Kerr DJ, Harris AL, Cai S.

Am J Pathol. 2010 Nov;177(5):2671-80. doi: 10.2353/ajpath.2010.100025. Epub 2010 Sep 16.


The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth.

Yang J, Jubb AM, Pike L, Buffa FM, Turley H, Baban D, Leek R, Gatter KC, Ragoussis J, Harris AL.

Cancer Res. 2010 Aug 15;70(16):6456-66. doi: 10.1158/0008-5472.CAN-10-0413. Epub 2010 Aug 3.


Effects of HIF-1alpha and HIF2alpha on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts.

Biswas S, Troy H, Leek R, Chung YL, Li JL, Raval RR, Turley H, Gatter K, Pezzella F, Griffiths JR, Stubbs M, Harris AL.

J Oncol. 2010;2010:757908. doi: 10.1155/2010/757908. Epub 2010 Jun 27.


New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes.

Sheldon H, Heikamp E, Turley H, Dragovic R, Thomas P, Oon CE, Leek R, Edelmann M, Kessler B, Sainson RC, Sargent I, Li JL, Harris AL.

Blood. 2010 Sep 30;116(13):2385-94. doi: 10.1182/blood-2009-08-239228. Epub 2010 Jun 17.


Expression of vascular notch ligand delta-like 4 and inflammatory markers in breast cancer.

Jubb AM, Soilleux EJ, Turley H, Steers G, Parker A, Low I, Blades J, Li JL, Allen P, Leek R, Noguera-Troise I, Gatter KC, Thurston G, Harris AL.

Am J Pathol. 2010 Apr;176(4):2019-28. doi: 10.2353/ajpath.2010.090908. Epub 2010 Feb 18.


Automated uro-oncology data collection: the Cancer Research Uro-Oncology Database.

Charlesworth PJ, Kilbey N, Taylor M, Leek R, Cranston D, Turner G, Crew J, Harris A, Protheroe A.

BJU Int. 2010 Jun;105(12):1663-6. doi: 10.1111/j.1464-410X.2009.09058.x. Epub 2009 Nov 20.


Lactate dehydrogenase 5 expression in squamous cell head and neck cancer relates to prognosis following radical or postoperative radiotherapy.

Koukourakis MI, Giatromanolaki A, Winter S, Leek R, Sivridis E, Harris AL.

Oncology. 2009;77(5):285-92. doi: 10.1159/000259260. Epub 2009 Nov 16.


Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer.

Jubb AM, Turley H, Moeller HC, Steers G, Han C, Li JL, Leek R, Tan EY, Singh B, Mortensen NJ, Noguera-Troise I, Pezzella F, Gatter KC, Thurston G, Fox SB, Harris AL.

Br J Cancer. 2009 Nov 17;101(10):1749-57. doi: 10.1038/sj.bjc.6605368. Epub 2009 Oct 20.


Zinc presence in invasive ductal carcinoma of the breast and its correlation with oestrogen receptor status.

Farquharson MJ, Al-Ebraheem A, Geraki K, Leek R, Jubb A, Harris AL.

Phys Med Biol. 2009 Jul 7;54(13):4213-23. doi: 10.1088/0031-9155/54/13/016. Epub 2009 Jun 12.


The distribution of trace elements Ca, Fe, Cu and Zn and the determination of copper oxidation state in breast tumour tissue using muSRXRF and muXANES.

Farquharson MJ, Al-Ebraheem A, Falkenberg G, Leek R, Harris AL, Bradley DA.

Phys Med Biol. 2008 Jun 7;53(11):3023-37. doi: 10.1088/0031-9155/53/11/018. Epub 2008 May 19.


Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo.

Li JL, Sainson RC, Shi W, Leek R, Harrington LS, Preusser M, Biswas S, Turley H, Heikamp E, Hainfellner JA, Harris AL.

Cancer Res. 2007 Dec 1;67(23):11244-53.


Expression of the forkhead transcription factor FOXP1 is associated with that of estrogen receptor-beta in primary invasive breast carcinomas.

Bates GJ, Fox SB, Han C, Launchbury R, Leek RD, Harris AL, Banham AH.

Breast Cancer Res Treat. 2008 Oct;111(3):453-9. Epub 2007 Nov 17.


Prognostic significance of microvessel density and other variables in Japanese and British patients with primary invasive breast cancer.

Kato T, Steers G, Campo L, Roberts H, Leek RD, Turley H, Kimura T, Kameoka S, Nishikawa T, Kobayashi M, Harris AL, Gatter KC, Pezzella F.

Br J Cancer. 2007 Nov 5;97(9):1277-86. Epub 2007 Oct 9.


EGFR mutations in exons 18-21 in sporadic breast cancer.

Generali D, Leek R, Fox SB, Moore JW, Taylor C, Chambers P, Harris AL.

Ann Oncol. 2007 Jan;18(1):203-5. No abstract available.


Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse.

Bates GJ, Fox SB, Han C, Leek RD, Garcia JF, Harris AL, Banham AH.

J Clin Oncol. 2006 Dec 1;24(34):5373-80.


The localisation and micro-mapping of copper and other trace elements in breast tumours using a synchrotron micro-XRF system.

Farquharson MJ, Geraki K, Falkenberg G, Leek R, Harris A.

Appl Radiat Isot. 2007 Feb;65(2):183-8. Epub 2006 Oct 18.


Expression of terminally glycosylated calcitonin receptor-like receptor in uterine leiomyoma: endothelial phenotype and association with microvascular density.

Nikitenko LL, Cross T, Campo L, Turley H, Leek R, Manek S, Bicknell R, Rees MC.

Clin Cancer Res. 2006 Oct 1;12(19):5648-58.


The relation between hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression with anemia and outcome in surgically treated head and neck cancer.

Winter SC, Shah KA, Han C, Campo L, Turley H, Leek R, Corbridge RJ, Cox GJ, Harris AL.

Cancer. 2006 Aug 15;107(4):757-66.


Prognostic value of an activation state marker for epidermal growth factor receptor in tissue microarrays of head and neck cancer.

Kong A, Leboucher P, Leek R, Calleja V, Winter S, Harris A, Parker PJ, Larijani B.

Cancer Res. 2006 Mar 1;66(5):2834-43.


Isolation of DNA from tumor samples.

Robertson N, Leek R.

Methods Mol Med. 2006;120:61-3.


Isolation of RNA from tumor samples: single-step guanidinium acid-phenol method.

Robertson N, Leek R.

Methods Mol Med. 2006;120:55-9.


Frozen biopsy collection and storage: frozen biopsy samples.

Leek R.

Methods Mol Med. 2006;120:25-8.


Relation of erythropoietin and erythropoietin receptor expression to hypoxia and anemia in head and neck squamous cell carcinoma.

Winter SC, Shah KA, Campo L, Turley H, Leek R, Corbridge RJ, Cox GJ, Harris AL.

Clin Cancer Res. 2005 Nov 1;11(21):7614-20.


A quantitative analysis of lymphatic vessels in human breast cancer, based on LYVE-1 immunoreactivity.

Kato T, Prevo R, Steers G, Roberts H, Leek RD, Kimura T, Kameoka S, Nishikawa T, Kobayashi M, Jackson DG, Harris AL, Gatter KC, Pezzella F.

Br J Cancer. 2005 Nov 14;93(10):1168-74.


Bone morphogenetic protein 2 (BMP-2) and induction of tumor angiogenesis.

Raida M, Clement JH, Leek RD, Ameri K, Bicknell R, Niederwieser D, Harris AL.

J Cancer Res Clin Oncol. 2005 Nov;131(11):741-50. Epub 2005 Nov 1.


Expression of hypoxia-inducible factors is correlated with the presence of a fibrotic focus and angiogenesis in pancreatic ductal adenocarcinomas.

Couvelard A, O'Toole D, Leek R, Turley H, Sauvanet A, Degott C, Ruszniewski P, Belghiti J, Harris AL, Gatter K, Pezzella F.

Histopathology. 2005 Jun;46(6):668-76.


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