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Canine NAPEPLD-associated models of human myelin disorders.

Minor KM, Letko A, Becker D, Drögemüller M, Mandigers PJJ, Bellekom SR, Leegwater PAJ, Stassen QEM, Putschbach K, Fischer A, Flegel T, Matiasek K, Ekenstedt KJ, Furrow E, Patterson EE, Platt SR, Kelly PA, Cassidy JP, Shelton GD, Lucot K, Bannasch DL, Martineau H, Muir CF, Priestnall SL, Henke D, Oevermann A, Jagannathan V, Mickelson JR, Drögemüller C.

Sci Rep. 2018 Apr 11;8(1):5818. doi: 10.1038/s41598-018-23938-7.


Paroxysmal Dyskinesia in Border Terriers: Clinical, Epidemiological, and Genetic Investigations.

Stassen QEM, Koskinen LLE, van Steenbeek FG, Seppälä EH, Jokinen TS, Prins PGM, Bok HGJ, Zandvliet MMJM, Vos-Loohuis M, Leegwater PAJ, Lohi H.

J Vet Intern Med. 2017 Jul;31(4):1123-1131. doi: 10.1111/jvim.14731.


Current insights into the molecular genetic basis of dwarfism in livestock.

Boegheim IJM, Leegwater PAJ, van Lith HA, Back W.

Vet J. 2017 Jun;224:64-75. doi: 10.1016/j.tvjl.2017.05.014. Epub 2017 Jun 2. Review.


A novel VWF variant associated with type 2 von Willebrand disease in German Wirehaired Pointers and German Shorthaired Pointers.

Vos-Loohuis M, van Oost BA, Dangel C, Langbein-Detsch I, Leegwater PA.

Anim Genet. 2017 Aug;48(4):493-496. doi: 10.1111/age.12544. Epub 2017 Feb 3.


In vitro and in vivo effects of kisspeptin antagonists p234, p271, p354, and p356 on GPR54 activation.

Albers-Wolthers CHJ, de Gier J, Walen M, van Kooten PJS, Lambalk CB, Leegwater PAJ, Roelen BAJ, Schaefers-Okkens AC, Rutten VPMG, Millar RPM, Kooistra HS.

PLoS One. 2017 Jun 26;12(6):e0179156. doi: 10.1371/journal.pone.0179156. eCollection 2017.


Disease burden in four populations of dog and cat breeds compared to mixed-breed dogs and European shorthair cats.

Keijser SFA, Meijndert LE, Fieten H, Carrière BJ, van Steenbeek FG, Leegwater PAJ, Rothuizen J, Nielen M.

Prev Vet Med. 2017 May 1;140:38-44. doi: 10.1016/j.prevetmed.2017.02.016. Epub 2017 Mar 2.


Population genetic analysis and genome-wide association study of patellar luxation in a Thai population of Pomeranian dogs.

Wangdee C, Leegwater PA, Heuven HC, van Steenbeek FG, Techakumphu M, Hazewinkel HA.

Res Vet Sci. 2017 Apr;111:9-13. doi: 10.1016/j.rvsc.2016.11.006. Epub 2016 Nov 11.


FEELnc: a tool for long non-coding RNA annotation and its application to the dog transcriptome.

Wucher V, Legeai F, Hédan B, Rizk G, Lagoutte L, Leeb T, Jagannathan V, Cadieu E, David A, Lohi H, Cirera S, Fredholm M, Botherel N, Leegwater PAJ, Le Béguec C, Fieten H, Johnson J, Alföldi J, André C, Lindblad-Toh K, Hitte C, Derrien T.

Nucleic Acids Res. 2017 May 5;45(8):e57. doi: 10.1093/nar/gkw1306.


Dwarfism with joint laxity in Friesian horses is associated with a splice site mutation in B4GALT7.

Leegwater PA, Vos-Loohuis M, Ducro BJ, Boegheim IJ, van Steenbeek FG, Nijman IJ, Monroe GR, Bastiaansen JW, Dibbits BW, van de Goor LH, Hellinga I, Back W, Schurink A.

BMC Genomics. 2016 Oct 28;17(1):839.


The canine era: the rise of a biomedical model.

van Steenbeek FG, Hytönen MK, Leegwater PA, Lohi H.

Anim Genet. 2016 Oct;47(5):519-27. doi: 10.1111/age.12460. Epub 2016 Jun 21. Review.


Epidemiology, presentation and population genetics of patent ductus arteriosus (PDA) in the Dutch Stabyhoun dog.

den Toom ML, Meiling AE, Thomas RE, Leegwater PA, Heuven HC.

BMC Vet Res. 2016 Jun 13;12(1):105. doi: 10.1186/s12917-016-0720-x.


The effects of kisspeptin agonist canine KP-10 and kisspeptin antagonist p271 on plasma LH concentrations during different stages of the estrous cycle and anestrus in the bitch.

Albers-Wolthers CH, de Gier J, Rutten VP, van Kooten PJ, Leegwater PA, Schaefers-Okkens AC, Kooistra HS.

Theriogenology. 2016 Jul 15;86(2):589-95. doi: 10.1016/j.theriogenology.2016.02.009. Epub 2016 Feb 23.


Canine Models for Copper Homeostasis Disorders.

Wu X, Leegwater PA, Fieten H.

Int J Mol Sci. 2016 Feb 4;17(2):196. doi: 10.3390/ijms17020196. Review.


The Menkes and Wilson disease genes counteract in copper toxicosis in Labrador retrievers: a new canine model for copper-metabolism disorders.

Fieten H, Gill Y, Martin AJ, Concilli M, Dirksen K, van Steenbeek FG, Spee B, van den Ingh TS, Martens EC, Festa P, Chesi G, van de Sluis B, Houwen RH, Watson AL, Aulchenko YS, Hodgkinson VL, Zhu S, Petris MJ, Polishchuk RS, Leegwater PA, Rothuizen J.

Dis Model Mech. 2016 Jan;9(1):25-38. doi: 10.1242/dmm.020263.


Central Hypothyroidism in Miniature Schnauzers.

Voorbij AM, Leegwater PA, Buijtels JJ, Daminet S, Kooistra HS.

J Vet Intern Med. 2016 Jan-Feb;30(1):85-91. doi: 10.1111/jvim.13818. Epub 2015 Dec 23.


Reference genes for reverse transcription quantitative PCR in canine brain tissue.

Stassen QE, Riemers FM, Reijmerink H, Leegwater PA, Penning LC.

BMC Res Notes. 2015 Dec 9;8:761. doi: 10.1186/s13104-015-1628-4.


A nonsense mutation in B3GALNT2 is concordant with hydrocephalus in Friesian horses.

Ducro BJ, Schurink A, Bastiaansen JW, Boegheim IJ, van Steenbeek FG, Vos-Loohuis M, Nijman IJ, Monroe GR, Hellinga I, Dibbits BW, Back W, Leegwater PA.

BMC Genomics. 2015 Oct 9;16:761. doi: 10.1186/s12864-015-1936-z.


COLQ variant associated with Devon Rex and Sphynx feline hereditary myopathy.

Gandolfi B, Grahn RA, Creighton EK, Williams DC, Dickinson PJ, Sturges BK, Guo LT, Shelton GD, Leegwater PA, Longeri M, Malik R, Lyons LA.

Anim Genet. 2015 Dec;46(6):711-5. doi: 10.1111/age.12350. Epub 2015 Sep 16.


Dietary management of labrador retrievers with subclinical hepatic copper accumulation.

Fieten H, Biourge VC, Watson AL, Leegwater PA, van den Ingh TS, Rothuizen J.

J Vet Intern Med. 2015 May-Jun;29(3):822-7. doi: 10.1111/jvim.12574. Epub 2015 Mar 16.


Pituitary dwarfism in Saarloos and Czechoslovakian wolfdogs is associated with a mutation in LHX3.

Voorbij AM, Leegwater PA, Kooistra HS.

J Vet Intern Med. 2014 Nov-Dec;28(6):1770-4. doi: 10.1111/jvim.12448. Epub 2014 Oct 1.


Prevalence and genetics of patellar luxation in Kooiker dogs.

Wangdee C, Leegwater PA, Heuven HC, van Steenbeek FG, Meutstege FJ, Meij BP, Hazewinkel HA.

Vet J. 2014 Sep;201(3):333-7. doi: 10.1016/j.tvjl.2014.05.036. Epub 2014 May 28.


Identification of a novel kisspeptin with high gonadotrophin stimulatory activity in the dog.

Albers-Wolthers KH, de Gier J, Kooistra HS, Rutten VP, van Kooten PJ, de Graaf JJ, Leegwater PA, Millar RP, Schaefers-Okkens AC.

Neuroendocrinology. 2014;99(3-4):178-89. doi: 10.1159/000364877. Epub 2014 Jun 5.


Genome-wide survey indicates involvement of loci on canine chromosomes 7 and 31 in patellar luxation in Flat-Coated Retrievers.

Lavrijsen IC, Leegwater PA, Wangdee C, van Steenbeek FG, Schwencke M, Breur GJ, Meutstege FJ, Nijman IJ, Cuppen E, Heuven HC, Hazewinkel HA.

BMC Genet. 2014 May 28;15:64. doi: 10.1186/1471-2156-15-64.


New canine models of copper toxicosis: diagnosis, treatment, and genetics.

Fieten H, Penning LC, Leegwater PA, Rothuizen J.

Ann N Y Acad Sci. 2014 May;1314:42-8. doi: 10.1111/nyas.12442. Epub 2014 Apr 23.


Prevalence and co-occurrence of hip dysplasia and elbow dysplasia in Dutch pure-bred dogs.

Lavrijsen IC, Heuven HC, Meij BP, Theyse LF, Nap RC, Leegwater PA, Hazewinkel HA.

Prev Vet Med. 2014 May 1;114(2):114-22. doi: 10.1016/j.prevetmed.2014.02.001. Epub 2014 Feb 13.


Genome wide analysis indicates genes for basement membrane and cartilage matrix proteins as candidates for hip dysplasia in Labrador Retrievers.

Lavrijsen IC, Leegwater PA, Martin AJ, Harris SJ, Tryfonidou MA, Heuven HC, Hazewinkel HA.

PLoS One. 2014 Jan 30;9(1):e87735. doi: 10.1371/journal.pone.0087735. eCollection 2014.


Nutritional management of inherited copper-associated hepatitis in the Labrador retriever.

Fieten H, Biourge VC, Watson AL, Leegwater PA, van den Ingh TS, Rothuizen J.

Vet J. 2014 Mar;199(3):429-33. doi: 10.1016/j.tvjl.2013.12.017. Epub 2013 Dec 22.


Phenotypic and genetic trends of patellar luxation in Dutch Flat-Coated Retrievers.

Lavrijsen IC, Heuven HC, Breur GJ, Leegwater PA, Meutstege FJ, Hazewinkel HA.

Anim Genet. 2013 Dec;44(6):736-41. doi: 10.1111/age.12077. Epub 2013 Aug 23.


Urinary excretion of copper, zinc and iron with and without D-penicillamine administration in relation to hepatic copper concentration in dogs.

Fieten H, Hugen S, van den Ingh TS, Hendriks WH, Vernooij JC, Bode P, Watson AL, Leegwater PA, Rothuizen J.

Vet J. 2013 Aug;197(2):468-73. doi: 10.1016/j.tvjl.2013.03.003. Epub 2013 Apr 9.


Altered subcellular localization of heat shock protein 90 is associated with impaired expression of the aryl hydrocarbon receptor pathway in dogs.

van Steenbeek FG, Spee B, Penning LC, Kummeling A, van Gils IH, Grinwis GC, Van Leenen D, Holstege FC, Vos-Loohuis M, Rothuizen J, Leegwater PA.

PLoS One. 2013;8(3):e57973. doi: 10.1371/journal.pone.0057973. Epub 2013 Mar 5.


Aberrant gene expression in dogs with portosystemic shunts.

van Steenbeek FG, Van den Bossche L, Grinwis GC, Kummeling A, van Gils IH, Koerkamp MJ, van Leenen D, Holstege FC, Penning LC, Rothuizen J, Leegwater PA, Spee B.

PLoS One. 2013;8(2):e57662. doi: 10.1371/journal.pone.0057662. Epub 2013 Feb 25. Erratum in: PLoS One. 2013;8(10). doi:10.1371/annotation/5cccaae3-f06c-413f-857e-46546e87fce1.


D-penicillamine treatment of copper-associated hepatitis in Labrador retrievers.

Fieten H, Dirksen K, van den Ingh TS, Winter EA, Watson AL, Leegwater PA, Rothuizen J.

Vet J. 2013 Jun;196(3):522-7. doi: 10.1016/j.tvjl.2012.12.013. Epub 2013 Jan 31.


Association of dietary copper and zinc levels with hepatic copper and zinc concentration in Labrador Retrievers.

Fieten H, Hooijer-Nouwens BD, Biourge VC, Leegwater PA, Watson AL, van den Ingh TS, Rothuizen J.

J Vet Intern Med. 2012 Nov-Dec;26(6):1274-80. doi: 10.1111/j.1939-1676.2012.01001.x. Epub 2012 Sep 24.


Tandem repeats modify the structure of the canine CD1D gene.

Looringh van Beeck FA, Leegwater PA, Herrmann T, Broere F, Rutten VP, Willemse T, Van Rhijn I.

Anim Genet. 2013 Jun;44(3):352-5. doi: 10.1111/age.12002. Epub 2012 Sep 19.


Incidence and genetic aspects of patellar luxation in Pomeranian dogs in Thailand.

Soontornvipart K, Wangdee C, Kalpravidh M, Brahmasa A, Sarikaputi M, Temwichitr J, Lavrijsen IC, Theyse LF, Leegwater PA, Hazewinkel HA.

Vet J. 2013 Apr;196(1):122-5. doi: 10.1016/j.tvjl.2012.07.027. Epub 2012 Aug 28.


Distribution of extrahepatic congenital portosystemic shunt morphology in predisposed dog breeds.

Van den Bossche L, van Steenbeek FG, Favier RP, Kummeling A, Leegwater PA, Rothuizen J.

BMC Vet Res. 2012 Jul 11;8:112. doi: 10.1186/1746-6148-8-112.


Rethinking dog domestication by integrating genetics, archeology, and biogeography.

Larson G, Karlsson EK, Perri A, Webster MT, Ho SY, Peters J, Stahl PW, Piper PJ, Lingaas F, Fredholm M, Comstock KE, Modiano JF, Schelling C, Agoulnik AI, Leegwater PA, Dobney K, Vigne JD, Vilà C, Andersson L, Lindblad-Toh K.

Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8878-83. doi: 10.1073/pnas.1203005109. Epub 2012 May 21.


Phenotypic and genetic evaluation of elbow dysplasia in Dutch Labrador Retrievers, Golden Retrievers, and Bernese Mountain dogs.

Lavrijsen IC, Heuven HC, Voorhout G, Meij BP, Theyse LF, Leegwater PA, Hazewinkel HA.

Vet J. 2012 Aug;193(2):486-92. doi: 10.1016/j.tvjl.2012.01.001. Epub 2012 Feb 14.


Canine models of copper toxicosis for understanding mammalian copper metabolism.

Fieten H, Leegwater PA, Watson AL, Rothuizen J.

Mamm Genome. 2012 Feb;23(1-2):62-75. doi: 10.1007/s00335-011-9378-7. Epub 2011 Dec 7. Review.


A contracted DNA repeat in LHX3 intron 5 is associated with aberrant splicing and pituitary dwarfism in German shepherd dogs.

Voorbij AM, van Steenbeek FG, Vos-Loohuis M, Martens EE, Hanson-Nilsson JM, van Oost BA, Kooistra HS, Leegwater PA.

PLoS One. 2011;6(11):e27940. doi: 10.1371/journal.pone.0027940. Epub 2011 Nov 23.


Inherited liver shunts in dogs elucidate pathways regulating embryonic development and clinical disorders of the portal vein.

van Steenbeek FG, van den Bossche L, Leegwater PA, Rothuizen J.

Mamm Genome. 2012 Feb;23(1-2):76-84. doi: 10.1007/s00335-011-9364-0. Epub 2011 Nov 4. Review.


Severe combined immunodeficiency in Frisian Water Dogs caused by a RAG1 mutation.

Verfuurden B, Wempe F, Reinink P, van Kooten PJ, Martens E, Gerritsen R, Vos JH, Rutten VP, Leegwater PA.

Genes Immun. 2011 Jun;12(4):310-3. doi: 10.1038/gene.2011.6. Epub 2011 Feb 3.


[Hypopituitarism associated dwarfism in German Shepherds, saarloos wolf dogs and Czechoslovakian wolf dogs. Access to genetic testing].

Voorbij AM, Leegwater PA, Kooistra HS.

Tijdschr Diergeneeskd. 2010 Dec 15;135(24):950-4. Dutch. No abstract available.


Evaluation of radiographic and genetic aspects of hereditary subluxation of the radial head in Bouviers des Flandres.

Temwichitr J, Leegwater PA, Auriemma E, Van't Veld EM, Zijlstra C, Voorhout G, Hazewinkel HA.

Am J Vet Res. 2010 Aug;71(8):884-90. doi: 10.2460/ajvr.71.8.884.


Analysis of variation in the melanocortin-4 receptor gene (mc4r) in Golden Retriever dogs.

van den Berg L, van den Berg SM, Martens EE, Hazewinkel HA, Dijkshoorn NA, Delemarre-van de Waal HA, Heutink P, Leegwater PA, Heuven HC.

Anim Genet. 2010 Oct;41(5):557. doi: 10.1111/j.1365-2052.2010.02049.x. No abstract available.


Evaluation of candidate genes as a cause of chondrodysplasia in Labrador retrievers.

Smit JJ, Temwitchitr J, Brocks BA, Nikkels PG, Hazewinkel HA, Leegwater PA.

Vet J. 2011 Feb;187(2):269-71. doi: 10.1016/j.tvjl.2009.11.009. Epub 2009 Dec 16.


Fragmented coronoid process in the dog: a heritable disease.

Temwichitr J, Leegwater PA, Hazewinkel HA.

Vet J. 2010 Aug;185(2):123-9. doi: 10.1016/j.tvjl.2009.06.022. Epub 2009 Jul 28.


Evidence of inheritance of intrahepatic portosystemic shunts in Irish Wolfhounds.

van Steenbeek FG, Leegwater PA, van Sluijs FJ, Heuven HC, Rothuizen J.

J Vet Intern Med. 2009 Jul-Aug;23(4):950-2. doi: 10.1111/j.1939-1676.2009.0319.x. Epub 2009 May 30.


Heritabilities of copper-accumulating traits in Labrador retrievers.

Hoffmann G, Heuven HC, Leegwater PA, Jones PG, van den Ingh TS, Bode P, Rothuizen J.

Anim Genet. 2008 Aug;39(4):454. No abstract available.


Evaluation of the serotonergic genes htr1A, htr1B, htr2A, and slc6A4 in aggressive behavior of golden retriever dogs.

van den Berg L, Vos-Loohuis M, Schilder MB, van Oost BA, Hazewinkel HA, Wade CM, Karlsson EK, Lindblad-Toh K, Liinamo AE, Leegwater PA.

Behav Genet. 2008 Jan;38(1):55-66. Epub 2007 Dec 7.

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