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Alternative Splicing of the SLCO1B1 Gene: An Exploratory Analysis of Isoform Diversity in Pediatric Liver.

van Groen BD, Bi C, Gaedigk R, Staggs VS, Tibboel D, de Wildt SN, Leeder JS.

Clin Transl Sci. 2020 Jan 9. doi: 10.1111/cts.12733. [Epub ahead of print]


Normalized testosterone glucuronide (TG/AG) as a potential urinary biomarker for highly variable UGT2B17 in children 7 to 18 years.

Zhang H, Basit A, Wolford C, Chen KF, Gaedigk A, Lin YS, Leeder JS, Prasad B.

Clin Pharmacol Ther. 2020 Jan 3. doi: 10.1002/cpt.1764. [Epub ahead of print]


A Call for Clear and Consistent Communications Regarding the Role of Pharmacogenetics in Antidepressant Pharmacotherapy.

Hicks JK, Bishop JR, Gammal RS, Sangkuhl K, Bousman CA, Leeder JS, Llerena A, Mueller DJ, Ramsey LB, Scott SA, Skaar TC, Caudle KE, Klein TE, Gaedigk A.

Clin Pharmacol Ther. 2020 Jan;107(1):50-52. doi: 10.1002/cpt.1661. Epub 2019 Oct 30. No abstract available.


The effect of race and supplementation on maternal and umbilical cord plasma folates.

Maulik D, van Haandel L, Allsworth J, Chaisanguanthum KS, Yeast JD, Leeder JS.

J Matern Fetal Neonatal Med. 2019 Oct 21:1-9. doi: 10.1080/14767058.2019.1677597. [Epub ahead of print]


Examining the role of precision medicine with oral baclofen in pediatric patients with cerebral palsy.

McLaughlin MJ, Abdel-Rahman S, Leeder JS.

Curr Phys Med Rehabil Rep. 2019 Mar;7(1):40-45. Epub 2019 Jan 23.


Who Believes They Are "Just Average": Informing the Treatment of Individual Patients Using Population Data.

Leeder JS.

Clin Pharmacol Ther. 2019 Nov;106(5):939-941. doi: 10.1002/cpt.1612. Epub 2019 Sep 11. No abstract available.


A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents.

Ogungbenro K, Wagner JB, Abdel-Rahman S, Leeder JS, Galetin A.

Eur J Clin Pharmacol. 2019 Sep;75(9):1227-1235. doi: 10.1007/s00228-019-02697-y. Epub 2019 Jun 6.


Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism.

Ladumor MK, Bhatt DK, Gaedigk A, Sharma S, Thakur A, Pearce RE, Leeder JS, Bolger MB, Singh S, Prasad B.

Drug Metab Dispos. 2019 Aug;47(8):818-831. doi: 10.1124/dmd.119.086462. Epub 2019 May 17.


Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy.

Brown JT, Bishop JR, Sangkuhl K, Nurmi EL, Mueller DJ, Dinh JC, Gaedigk A, Klein TE, Caudle KE, McCracken JT, de Leon J, Leeder JS.

Clin Pharmacol Ther. 2019 Jul;106(1):94-102. doi: 10.1002/cpt.1409. Epub 2019 Apr 13. Review.


Evaluating metronidazole as a novel, safe CYP2A6 phenotyping probe in healthy adults.

Stancil SL, Pearce RE, Tyndale RF, Kearns GL, Vyhlidal CA, Leeder JS, Abdel-Rahman S.

Br J Clin Pharmacol. 2019 May;85(5):960-969. doi: 10.1111/bcp.13884. Epub 2019 Mar 12.


Impact of Genetic Variation on Pravastatin Systemic Exposure in Pediatric Hypercholesterolemia.

Wagner JB, Abdel-Rahman S, Gaedigk R, Gaedigk A, Raghuveer G, Staggs VS, Kauffman R, Van Haandel L, Leeder JS.

Clin Pharmacol Ther. 2019 Jun;105(6):1501-1512. doi: 10.1002/cpt.1330. Epub 2019 Feb 25.


Considerations for Implementing Precision Therapeutics for Children.

McLaughlin MJ, Wagner J, Shahknovich V, Carleton B, Leeder JS.

Clin Transl Sci. 2019 Mar;12(2):140-150. doi: 10.1111/cts.12607. Epub 2019 Jan 25. Erratum in: Clin Transl Sci. 2019 Sep;12(5):556.


Pharmacogenomics and implementation of precision therapeutics in the neonatal ICU: a new frontier?

Lewis T, Leeder JS.

Pharmacogenomics. 2018 Nov;19(16):1231-1233. doi: 10.2217/pgs-2018-0132. Epub 2018 Oct 18. No abstract available.


Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity.

Shakhnovich V, Abdel-Rahman S, Friesen CA, Weigel J, Pearce RE, Gaedigk A, Leeder JS, Kearns GL.

Pediatr Obes. 2019 Jan;14(1). doi: 10.1111/ijpo.12459. Epub 2018 Sep 26.


Proteomics of human liver membrane transporters: a focus on fetuses and newborn infants.

van Groen BD, van de Steeg E, Mooij MG, van Lipzig MMH, de Koning BAE, Verdijk RM, Wortelboer HM, Gaedigk R, Bi C, Leeder JS, van Schaik RHN, van Rosmalen J, Tibboel D, Vaes WH, de Wildt SN.

Eur J Pharm Sci. 2018 Nov 1;124:217-227. doi: 10.1016/j.ejps.2018.08.042. Epub 2018 Aug 30.


Intensive and prolonged urine collection in preterm infants reveals three distinct indomethacin metabolic patterns: potential implications for drug dosing.

Lewis T, Van Haandel L, Scott A, Leeder JS.

Pediatr Res. 2018 Sep;84(3):325-327. doi: 10.1038/s41390-018-0051-7. Epub 2018 Jul 2. No abstract available.


Age- and Genotype-Dependent Variability in the Protein Abundance and Activity of Six Major Uridine Diphosphate-Glucuronosyltransferases in Human Liver.

Bhatt DK, Mehrotra A, Gaedigk A, Chapa R, Basit A, Zhang H, Choudhari P, Boberg M, Pearce RE, Gaedigk R, Broeckel U, Leeder JS, Prasad B.

Clin Pharmacol Ther. 2019 Jan;105(1):131-141. doi: 10.1002/cpt.1109. Epub 2018 Jul 12. Erratum in: Clin Pharmacol Ther. 2019 Oct;106(4):891.


Novel Protective Role of Nicotinamide Phosphoribosyltransferase in Acetaminophen-Induced Acute Liver Injury in Mice.

Zhang LQ, Nsumu M, Huang P, Heruth DP, Riordan SM, Shortt K, Zhang N, Grigoryev DN, Li DY, Friesen CA, Van Haandel L, Leeder JS, Olson J, Ye SQ.

Am J Pathol. 2018 Jul;188(7):1640-1652. doi: 10.1016/j.ajpath.2018.04.004. Epub 2018 Apr 22.


Ten Years' Experience with the CYP2D6 Activity Score: A Perspective on Future Investigations to Improve Clinical Predictions for Precision Therapeutics.

Gaedigk A, Dinh JC, Jeong H, Prasad B, Leeder JS.

J Pers Med. 2018 Apr 17;8(2). pii: E15. doi: 10.3390/jpm8020015. Review.


Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.

Bhatt DK, Basit A, Zhang H, Gaedigk A, Lee SB, Claw KG, Mehrotra A, Chaudhry AS, Pearce RE, Gaedigk R, Broeckel U, Thornton TA, Nickerson DA, Schuetz EG, Amory JK, Leeder JS, Prasad B.

Drug Metab Dispos. 2018 Jun;46(6):888-896. doi: 10.1124/dmd.118.080952. Epub 2018 Mar 30.


PharmGKB summary: clobazam pathway, pharmacokinetics.

Huddart R, Leeder JS, Altman RB, Klein TE.

Pharmacogenet Genomics. 2018 Apr;28(4):110-115. doi: 10.1097/FPC.0000000000000327. No abstract available.


Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics.

Wagner JB, Abdel-Rahman S, Van Haandel L, Gaedigk A, Gaedigk R, Raghuveer G, Kauffman R, Leeder JS.

J Clin Pharmacol. 2018 Jun;58(6):823-833. doi: 10.1002/jcph.1080. Epub 2018 Feb 22.


Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects.

Volpi S, Bult CJ, Chisholm RL, Deverka PA, Ginsburg GS, Jacob HJ, Kasapi M, McLeod HL, Roden DM, Williams MS, Green ED, Rodriguez LL, Aronson S, Cavallari LH, Denny JC, Dressler LG, Johnson JA, Klein TE, Leeder JS, Piquette-Miller M, Perera M, Rasmussen-Torvik LJ, Rehm HL, Ritchie MD, Skaar TC, Wagle N, Weinshilboum R, Weitzel KW, Wildin R, Wilson J, Manolio TA, Relling MV.

Clin Pharmacol Ther. 2018 May;103(5):778-786. doi: 10.1002/cpt.1048. Epub 2018 Mar 30. Review.


The NSIGHT1-randomized controlled trial: rapid whole-genome sequencing for accelerated etiologic diagnosis in critically ill infants.

Petrikin JE, Cakici JA, Clark MM, Willig LK, Sweeney NM, Farrow EG, Saunders CJ, Thiffault I, Miller NA, Zellmer L, Herd SM, Holmes AM, Batalov S, Veeraraghavan N, Smith LD, Dimmock DP, Leeder JS, Kingsmore SF.

NPJ Genom Med. 2018 Feb 9;3:6. doi: 10.1038/s41525-018-0045-8. eCollection 2018.


Nicotinamide Phosphoribosyltransferase Deficiency Potentiates the Antiproliferative Activity of Methotrexate through Enhanced Depletion of Intracellular ATP.

Singh RK, van Haandel L, Heruth DP, Ye SQ, Leeder JS, Becker ML, Funk RS.

J Pharmacol Exp Ther. 2018 Apr;365(1):96-106. doi: 10.1124/jpet.117.246199. Epub 2018 Feb 2.


Ontogeny-related pharmacogene changes in the pediatric liver transcriptome.

Meier R, Bi C, Gaedigk R, Heruth DP, Ye SQ, Leeder JS, Fridley BL.

Pharmacogenet Genomics. 2018 Mar;28(3):86-94. doi: 10.1097/FPC.0000000000000326.


Response to 'Aprepitant and fosaprepitant decrease the effectiveness of hormonal contraceptives'.

Patel P, Leeder JS, Piquette-Miller M, Dupuis LL.

Br J Clin Pharmacol. 2018 Mar;84(3):604. doi: 10.1111/bcp.13487. Epub 2018 Jan 6. No abstract available.


Erratum: Constellation: a tool for rapid, automated phenotype assignment of a highly polymorphic pharmacogene, CYP2D6, from whole-genome sequences.

Twist GP, Gaedigk A, Miller NA, Farrow EG, Willig LK, Dinwiddie DL, Petrikin JE, Soden SE, Herd S, Gibson M, Cakici JA, Riffel AK, Leeder JS, Dinakarpandian D, Kingsmore SF.

NPJ Genom Med. 2017 Jan 11;2:16039. doi: 10.1038/npjgenmed.2016.39. eCollection 2017.


Cost and Potential Avoidability of Antibiotic-Associated Adverse Drug Reactions in Children.

Beck JN, Suppes SL, Smith CR, Lee BR, Leeder JS, VanDoren M, Newland JG, Goldman JL.

J Pediatric Infect Dis Soc. 2019 Mar 28;8(1):66-68. doi: 10.1093/jpids/pix096.


The Pharmacogene Variation (PharmVar) Consortium: Incorporation of the Human Cytochrome P450 (CYP) Allele Nomenclature Database.

Gaedigk A, Ingelman-Sundberg M, Miller NA, Leeder JS, Whirl-Carrillo M, Klein TE; PharmVar Steering Committee.

Clin Pharmacol Ther. 2018 Mar;103(3):399-401. doi: 10.1002/cpt.910. Epub 2017 Nov 14.


Research Directions in Genetic Predispositions to Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis.

Manolio TA, Hutter CM, Avigan M, Cibotti R, Davis RL, Denny JC, Grenade L, Wheatley LM, Carrington MN, Chantratita W, Chung WH, Dalton AD, Hung SI, Lee MTM, Leeder JS, Lertora JJL, Mahasirimongkol S, McLeod HL, Mockenhaupt M, Pacanowski M, Phillips EJ, Pinheiro S, Pirmohamed M, Sung C, Suwankesawong W, Trepanier L, Tumminia SJ, Veenstra D, Yuliwulandari R, Shear NH.

Clin Pharmacol Ther. 2018 Mar;103(3):390-394. doi: 10.1002/cpt.890. Epub 2017 Nov 6. Review.


Early pregnancy intrauterine fetal exposure to maternal smoking and impact on fetal telomere length.

Mirzakhani H, De Vivo I, Leeder JS, Gaedigk R, Vyhlidal CA, Weiss ST, Tantisira K.

Eur J Obstet Gynecol Reprod Biol. 2017 Nov;218:27-32. doi: 10.1016/j.ejogrb.2017.09.013. Epub 2017 Sep 14.


Pharmacogenomic Variability of Oral Baclofen Clearance and Clinical Response in Children With Cerebral Palsy.

McLaughlin MJ, He Y, Brunstrom-Hernandez J, Thio LL, Carleton BC, Ross CJD, Gaedigk A, Lewandowski A, Dai H, Jusko WJ, Leeder JS.

PM R. 2018 Mar;10(3):235-243. doi: 10.1016/j.pmrj.2017.08.441. Epub 2017 Sep 1.


Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver.

Xu M, Bhatt DK, Yeung CK, Claw KG, Chaudhry AS, Gaedigk A, Pearce RE, Broeckel U, Gaedigk R, Nickerson DA, Schuetz E, Rettie AE, Leeder JS, Thummel KE, Prasad B.

J Pharmacol Exp Ther. 2017 Nov;363(2):265-274. doi: 10.1124/jpet.117.243113. Epub 2017 Aug 17.


Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver.

Bhatt DK, Gaedigk A, Pearce RE, Leeder JS, Prasad B.

Drug Metab Dispos. 2017 Sep;45(9):1044-1048. doi: 10.1124/dmd.117.076463. Epub 2017 Jun 12.


Aprepitant and fosaprepitant drug interactions: a systematic review.

Patel P, Leeder JS, Piquette-Miller M, Dupuis LL.

Br J Clin Pharmacol. 2017 Oct;83(10):2148-2162. doi: 10.1111/bcp.13322. Epub 2017 Jun 10. Review.


Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase.

Zhang LQ, Van Haandel L, Xiong M, Huang P, Heruth DP, Bi C, Gaedigk R, Jiang X, Li DY, Wyckoff G, Grigoryev DN, Gao L, Li L, Wu M, Leeder JS, Ye SQ.

Cell Death Dis. 2017 Mar 23;8(3):e2705. doi: 10.1038/cddis.2017.132.


Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future.

Darwich AS, Ogungbenro K, Vinks AA, Powell JR, Reny JL, Marsousi N, Daali Y, Fairman D, Cook J, Lesko LJ, McCune JS, Knibbe C, de Wildt SN, Leeder JS, Neely M, Zuppa AF, Vicini P, Aarons L, Johnson TN, Boiani J, Rostami-Hodjegan A.

Clin Pharmacol Ther. 2017 May;101(5):646-656. doi: 10.1002/cpt.659. Epub 2017 Apr 4. Review.


Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants.

Boberg M, Vrana M, Mehrotra A, Pearce RE, Gaedigk A, Bhatt DK, Leeder JS, Prasad B.

Drug Metab Dispos. 2017 Feb;45(2):216-223. doi: 10.1124/dmd.116.072652. Epub 2016 Nov 28.


Bioactivation of Trimethoprim to Protein-Reactive Metabolites in Human Liver Microsomes.

Goldman JL, Koen YM, Rogers SA, Li K, Leeder JS, Hanzlik RP.

Drug Metab Dispos. 2016 Oct;44(10):1603-7. doi: 10.1124/dmd.116.072041. Epub 2016 Jul 25.


Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation.

Wang LA, Gonzalez D, Leeder JS, Tyndale RF, Pearce RE, Benjamin DK Jr, Kearns GL, Cohen-Wolkowiez M; Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee.

J Clin Pharmacol. 2017 Feb;57(2):230-234. doi: 10.1002/jcph.797. Epub 2016 Aug 23. No abstract available.


Prediction of CYP2D6 phenotype from genotype across world populations.

Gaedigk A, Sangkuhl K, Whirl-Carrillo M, Klein T, Leeder JS.

Genet Med. 2017 Jan;19(1):69-76. doi: 10.1038/gim.2016.80. Epub 2016 Jul 7. Erratum in: Genet Med. 2016 Nov;18(11):1167.


Challenges and Opportunities for Increasing the Knowledge Base Related to Drug Biotransformation and Pharmacokinetics during Growth and Development.

Leeder JS, Meibohm B.

Drug Metab Dispos. 2016 Jul;44(7):916-23. doi: 10.1124/dmd.116.071159. Review.


Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics.

Prasad B, Gaedigk A, Vrana M, Gaedigk R, Leeder JS, Salphati L, Chu X, Xiao G, Hop C, Evers R, Gan L, Unadkat JD.

Clin Pharmacol Ther. 2016 Oct;100(4):362-70. doi: 10.1002/cpt.409. Epub 2016 Aug 13.


Nicotinamide Phosphoribosyltransferase Attenuates Methotrexate Response in Juvenile Idiopathic Arthritis and In Vitro.

Funk RS, Singh R, Pramann L, Gigliotti N, Islam S, Heruth DP, Ye SQ, Chan MA, Leeder JS, Becker ML.

Clin Transl Sci. 2016 Jun;9(3):149-57. doi: 10.1111/cts.12399. Epub 2016 May 11.


Design and Testing of an EHR-Integrated, Busulfan Pharmacokinetic Decision Support Tool for the Point-of-Care Clinician.

Abdel-Rahman SM, Breitkreutz ML, Bi C, Matzuka BJ, Dalal J, Casey KL, Garg U, Winkle S, Leeder JS, Breedlove J, Rivera B.

Front Pharmacol. 2016 Mar 30;7:65. doi: 10.3389/fphar.2016.00065. eCollection 2016.


Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children.

Dinh JC, Pearce RE, Van Haandel L, Gaedigk A, Leeder JS.

Drug Metab Dispos. 2016 Jul;44(7):1070-9. doi: 10.1124/dmd.116.069518. Epub 2016 Apr 6.


Decreased Pregnane X Receptor Expression in Children with Active Crohn's Disease.

Shakhnovich V, Vyhlidal C, Friesen C, Hildreth A, Singh V, Daniel J, Kearns GL, Leeder JS.

Drug Metab Dispos. 2016 Jul;44(7):1066-9. doi: 10.1124/dmd.115.068742. Epub 2016 Mar 24.


Quantification of pravastatin acid, lactone and isomers in human plasma by UHPLC-MS/MS and its application to a pediatric pharmacokinetic study.

van Haandel L, Gibson KT, Leeder JS, Wagner JB.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Feb 15;1012-1013:169-77. doi: 10.1016/j.jchromb.2016.01.038. Epub 2016 Jan 24.


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