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Items: 1 to 50 of 81

1.

Rapid Aldosterone-Mediated Signaling in the DCT Increases Activity of the Thiazide-Sensitive NaCl Cotransporter.

Cheng L, Poulsen SB, Wu Q, Esteva-Font C, Olesen ETB, Peng L, Olde B, Leeb-Lundberg LMF, Pisitkun T, Rieg T, Dimke H, Fenton RA.

J Am Soc Nephrol. 2019 Aug;30(8):1454-1470. doi: 10.1681/ASN.2018101025. Epub 2019 Jun 28.

PMID:
31253651
2.

The estrogen receptor coactivator AIB1 is a new putative prognostic biomarker in ER-positive/HER2-negative invasive lobular carcinoma of the breast.

Narbe U, Sjöström M, Forsare C, Bendahl PO, Alkner S, Leeb-Lundberg LMF, Lövgren K, Rydén L, Ingvar C, Fernö M.

Breast Cancer Res Treat. 2019 Jun;175(2):305-316. doi: 10.1007/s10549-019-05138-7. Epub 2019 Feb 22.

3.

Human G protein-coupled receptor 30 is N-glycosylated and N-terminal domain asparagine 44 is required for receptor structure and activity.

Gonzalez de Valdivia E, Sandén C, Kahn R, Olde B, Leeb-Lundberg LMF.

Biosci Rep. 2019 Feb 26;39(2). pii: BSR20182436. doi: 10.1042/BSR20182436. Print 2019 Feb 28.

4.

G protein-coupled estrogen receptor 1 (GPER1)/GPR30 increases ERK1/2 activity through PDZ motif-dependent and -independent mechanisms.

Gonzalez de Valdivia E, Broselid S, Kahn R, Olde B, Leeb-Lundberg LMF.

J Biol Chem. 2017 Jun 16;292(24):9932-9943. doi: 10.1074/jbc.M116.765875. Epub 2017 Apr 27.

5.

C1-Inhibitor Decreases the Release of Vasculitis-Like Chemotactic Endothelial Microvesicles.

Mossberg M, Ståhl AL, Kahn R, Kristoffersson AC, Tati R, Heijl C, Segelmark M, Leeb-Lundberg LMF, Karpman D.

J Am Soc Nephrol. 2017 Aug;28(8):2472-2481. doi: 10.1681/ASN.2016060637. Epub 2017 Mar 13.

6.

Microvesicle transfer of kinin B1-receptors is a novel inflammatory mechanism in vasculitis.

Kahn R, Mossberg M, Ståhl AL, Johansson K, Lopatko Lindman I, Heijl C, Segelmark M, Mörgelin M, Leeb-Lundberg LM, Karpman D.

Kidney Int. 2017 Jan;91(1):96-105. doi: 10.1016/j.kint.2016.09.023. Epub 2016 Dec 1.

PMID:
27914700
7.

Bile Acids Protect Expanding Hematopoietic Stem Cells from Unfolded Protein Stress in Fetal Liver.

Sigurdsson V, Takei H, Soboleva S, Radulovic V, Galeev R, Siva K, Leeb-Lundberg LM, Iida T, Nittono H, Miharada K.

Cell Stem Cell. 2016 Apr 7;18(4):522-32. doi: 10.1016/j.stem.2016.01.002. Epub 2016 Jan 28.

8.

Acute hypothalamo-pituitary-adrenal axis response to LPS-induced endotoxemia: expression pattern of kinin type B1 and B2 receptors.

Qadri F, Rimmele F, Mallis L, Häuser W, Dendorfer A, Jöhren O, Dominiak P, Leeb-Lundberg LM, Bader M.

Biol Chem. 2016 Jan 1;397(2):97-109. doi: 10.1515/hsz-2015-0206.

PMID:
26468906
9.

G Protein-Coupled Estrogen Receptor 1 Mediates Acute Estrogen-Induced Cardioprotection via MEK/ERK/GSK-3β Pathway after Ischemia/Reperfusion.

Kabir ME, Singh H, Lu R, Olde B, Leeb-Lundberg LM, Bopassa JC.

PLoS One. 2015 Sep 10;10(9):e0135988. doi: 10.1371/journal.pone.0135988. eCollection 2015.

10.

G protein-coupled receptor 30 (GPR30) forms a plasma membrane complex with membrane-associated guanylate kinases (MAGUKs) and protein kinase A-anchoring protein 5 (AKAP5) that constitutively inhibits cAMP production.

Broselid S, Berg KA, Chavera TA, Kahn R, Clarke WP, Olde B, Leeb-Lundberg LM.

J Biol Chem. 2014 Aug 8;289(32):22117-27. doi: 10.1074/jbc.M114.566893. Epub 2014 Jun 24.

11.

Lack of G protein-coupled estrogen receptor (GPER) in the plasma membrane is associated with excellent long-term prognosis in breast cancer.

Sjöström M, Hartman L, Grabau D, Fornander T, Malmström P, Nordenskjöld B, Sgroi DC, Skoog L, Stål O, Leeb-Lundberg LM, Fernö M.

Breast Cancer Res Treat. 2014 May;145(1):61-71. doi: 10.1007/s10549-014-2936-4. Epub 2014 Apr 9.

PMID:
24715381
12.

The G protein-coupled estrogen receptor 1 (GPER1/GPR30) agonist G-1 regulates vascular smooth muscle cell Ca²⁺ handling.

Holm A, Hellstrand P, Olde B, Svensson D, Leeb-Lundberg LM, Nilsson BO.

J Vasc Res. 2013;50(5):421-9. doi: 10.1159/000354252. Epub 2013 Sep 25.

PMID:
24080531
13.

Kinin-stimulated B1 receptor signaling depends on receptor endocytosis whereas B2 receptor signaling does not.

Enquist J, Sandén C, Skröder C, Mathis SA, Leeb-Lundberg LM.

Neurochem Res. 2014 Jun;39(6):1037-47. doi: 10.1007/s11064-013-1126-9. Epub 2013 Aug 10.

PMID:
23934212
14.

G-protein-coupled receptor 30 interacts with receptor activity-modifying protein 3 and confers sex-dependent cardioprotection.

Lenhart PM, Broselid S, Barrick CJ, Leeb-Lundberg LM, Caron KM.

J Mol Endocrinol. 2013 Jul 3;51(1):191-202. doi: 10.1530/JME-13-0021. Print 2013.

15.

G protein-coupled estrogen receptor is apoptotic and correlates with increased distant disease-free survival of estrogen receptor-positive breast cancer patients.

Broselid S, Cheng B, Sjöström M, Lövgren K, Klug-De Santiago HL, Belting M, Jirström K, Malmström P, Olde B, Bendahl PO, Hartman L, Fernö M, Leeb-Lundberg LM.

Clin Cancer Res. 2013 Apr 1;19(7):1681-92. doi: 10.1158/1078-0432.CCR-12-2376.

16.

Kinin B1 receptor homo-oligomerization is required for receptor trafficking to the cell surface.

Sandén C, Leeb-Lundberg LM.

Int Immunopharmacol. 2013 Jan;15(1):121-8. doi: 10.1016/j.intimp.2012.11.012. Epub 2012 Nov 29.

PMID:
23201435
17.

The G protein-coupled oestrogen receptor 1 agonist G-1 disrupts endothelial cell microtubule structure in a receptor-independent manner.

Holm A, Grände PO, Ludueña RF, Olde B, Prasad V, Leeb-Lundberg LM, Nilsson BO.

Mol Cell Biochem. 2012 Jul;366(1-2):239-49. doi: 10.1007/s11010-012-1301-3. Epub 2012 Mar 27.

PMID:
22451019
18.

The GPER1 agonist G-1 attenuates endothelial cell proliferation by inhibiting DNA synthesis and accumulating cells in the S and G2 phases of the cell cycle.

Holm A, Baldetorp B, Olde B, Leeb-Lundberg LM, Nilsson BO.

J Vasc Res. 2011;48(4):327-35. doi: 10.1159/000322578. Epub 2011 Jan 27.

19.

G protein-coupled oestrogen receptor 1 (GPER1)/GPR30: a new player in cardiovascular and metabolic oestrogenic signalling.

Nilsson BO, Olde B, Leeb-Lundberg LM.

Br J Pharmacol. 2011 Jul;163(6):1131-9. doi: 10.1111/j.1476-5381.2011.01235.x. Review.

20.

G protein-coupled estrogen receptor 1/G protein-coupled receptor 30 localizes in the plasma membrane and traffics intracellularly on cytokeratin intermediate filaments.

Sandén C, Broselid S, Cornmark L, Andersson K, Daszkiewicz-Nilsson J, Mårtensson UE, Olde B, Leeb-Lundberg LM.

Mol Pharmacol. 2011 Mar;79(3):400-10. doi: 10.1124/mol.110.069500. Epub 2010 Dec 13.

PMID:
21149639
21.

GPR30/GPER1: searching for a role in estrogen physiology.

Olde B, Leeb-Lundberg LM.

Trends Endocrinol Metab. 2009 Oct;20(8):409-16. doi: 10.1016/j.tem.2009.04.006. Epub 2009 Sep 4. Review.

PMID:
19734054
22.

Neutrophil-derived proteinase 3 induces kallikrein-independent release of a novel vasoactive kinin.

Kahn R, Hellmark T, Leeb-Lundberg LM, Akbari N, Todiras M, Olofsson T, Wieslander J, Christensson A, Westman K, Bader M, Müller-Esterl W, Karpman D.

J Immunol. 2009 Jun 15;182(12):7906-15. doi: 10.4049/jimmunol.0803624.

23.

Activation of TAFI on the surface of Streptococcus pyogenes evokes inflammatory reactions by modulating the kallikrein/kinin system.

Bengtson SH, Sandén C, Mörgelin M, Marx PF, Olin AI, Leeb-Lundberg LM, Meijers JC, Herwald H.

J Innate Immun. 2009;1(1):18-28. doi: 10.1159/000145543. Epub 2008 Jul 12.

24.

The role of the G protein-coupled receptor GPR30 in the effects of estrogen in ovariectomized mice.

Windahl SH, Andersson N, Chagin AS, Mårtensson UE, Carlsten H, Olde B, Swanson C, Movérare-Skrtic S, Sävendahl L, Lagerquist MK, Leeb-Lundberg LM, Ohlsson C.

Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E490-6. doi: 10.1152/ajpendo.90691.2008. Epub 2008 Dec 16.

25.

Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice.

Mårtensson UE, Salehi SA, Windahl S, Gomez MF, Swärd K, Daszkiewicz-Nilsson J, Wendt A, Andersson N, Hellstrand P, Grände PO, Owman C, Rosen CJ, Adamo ML, Lundquist I, Rorsman P, Nilsson BO, Ohlsson C, Olde B, Leeb-Lundberg LM.

Endocrinology. 2009 Feb;150(2):687-98. doi: 10.1210/en.2008-0623. Epub 2008 Oct 9.

PMID:
18845638
26.

Kinin B2 receptor-mediated bradykinin internalization and metalloendopeptidase EP24.15-dependent intracellular bradykinin degradation.

Sandén C, Enquist J, Bengtson SH, Herwald H, Leeb-Lundberg LM.

J Pharmacol Exp Ther. 2008 Jul;326(1):24-32. doi: 10.1124/jpet.108.136911. Epub 2008 Apr 22.

PMID:
18430865
27.

Kinins promote B2 receptor endocytosis and delay constitutive B1 receptor endocytosis.

Enquist J, Skröder C, Whistler JL, Leeb-Lundberg LM.

Mol Pharmacol. 2007 Feb;71(2):494-507. Epub 2006 Nov 16.

PMID:
17110500
28.

Kinin receptor expression during Staphylococcus aureus infection.

Bengtson SH, Phagoo SB, Norrby-Teglund A, Påhlman L, Mörgelin M, Zuraw BL, Leeb-Lundberg LM, Herwald H.

Blood. 2006 Sep 15;108(6):2055-63. Epub 2006 May 30.

29.

Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes.

Kotarsky K, Boketoft A, Bristulf J, Nilsson NE, Norberg A, Hansson S, Owman C, Sillard R, Leeb-Lundberg LM, Olde B.

J Pharmacol Exp Ther. 2006 Aug;318(2):619-28. Epub 2006 May 1.

PMID:
16651401
30.

Exploring the future of local vascular and inflammatory mediators.

Leeb-Lundberg LM.

Biol Chem. 2006 Feb;387(2):117-8. No abstract available.

PMID:
16497142
31.

Infection-induced kinin B1 receptors in human pulmonary fibroblasts: role of intact pathogens and p38 mitogen-activated protein kinase-dependent signaling.

Phagoo SB, Reddi K, Silvallana BJ, Leeb-Lundberg LM, Warburton D.

J Pharmacol Exp Ther. 2005 Jun;313(3):1231-8. Epub 2005 Mar 2.

PMID:
15743925
32.

International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences.

Leeb-Lundberg LM, Marceau F, Müller-Esterl W, Pettibone DJ, Zuraw BL.

Pharmacol Rev. 2005 Mar;57(1):27-77. Review.

PMID:
15734727
33.

Bradykinin specificity and signaling at GPR100 and B2 kinin receptors.

Leeb-Lundberg LM.

Br J Pharmacol. 2004 Dec;143(8):931-2. Epub 2004 Nov 15. Review. No abstract available.

34.

B1 bradykinin receptor homo-oligomers in receptor cell surface expression and signaling: effects of receptor fragments.

Kang DS, Gustafsson C, Mörgelin M, Leeb-Lundberg LM.

Mol Pharmacol. 2005 Jan;67(1):309-18. Epub 2004 Oct 18.

PMID:
15492119
35.

Jak2 and Ca2+/calmodulin are key intermediates for bradykinin B2 receptor-mediated activation of Na+/H+ exchange in KNRK and CHO cells.

Lefler D, Mukhin YV, Pettus T, Leeb-Lundberg LM, Garnovskaya MN, Raymond JR.

Assay Drug Dev Technol. 2003 Apr;1(2):281-9.

PMID:
15090193
36.

Spontaneous formation of a proteolytic B1 and B2 bradykinin receptor complex with enhanced signaling capacity.

Kang DS, Ryberg K, Mörgelin M, Leeb-Lundberg LM.

J Biol Chem. 2004 May 21;279(21):22102-7. Epub 2004 Mar 19.

37.

Calcium-sensing receptor-mediated ERK1/2 activation requires Galphai2 coupling and dynamin-independent receptor internalization.

Holstein DM, Berg KA, Leeb-Lundberg LM, Olson MS, Saunders C.

J Biol Chem. 2004 Mar 12;279(11):10060-9. Epub 2003 Dec 30.

38.

Bradykinin receptor subtype 1 expression and function in prostate cancer.

Taub JS, Guo R, Leeb-Lundberg LM, Madden JF, Daaka Y.

Cancer Res. 2003 May 1;63(9):2037-41.

39.

Requirement for direct cross-talk between B1 and B2 kinin receptors for the proliferation of androgen-insensitive prostate cancer PC3 cells.

Barki-Harrington L, Bookout AL, Wang G, Lamb ME, Leeb-Lundberg LM, Daaka Y.

Biochem J. 2003 Apr 15;371(Pt 2):581-7.

40.

Human B1 and B2 bradykinin receptors and their agonists target caveolae-related lipid rafts to different degrees in HEK293 cells.

Lamb ME, Zhang C, Shea T, Kyle DJ, Leeb-Lundberg LM.

Biochemistry. 2002 Dec 3;41(48):14340-7.

PMID:
12450400
42.

PI 3-kinase regulation of dopamine uptake.

Carvelli L, Morón JA, Kahlig KM, Ferrer JV, Sen N, Lechleiter JD, Leeb-Lundberg LM, Merrill G, Lafer EM, Ballou LM, Shippenberg TS, Javitch JA, Lin RZ, Galli A.

J Neurochem. 2002 May;81(4):859-69.

43.
45.
46.

Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism.

Saunders C, Ferrer JV, Shi L, Chen J, Merrill G, Lamb ME, Leeb-Lundberg LM, Carvelli L, Javitch JA, Galli A.

Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6850-5.

48.

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