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Items: 31


USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages.

Ruuth M, Soronen J, Kaiharju E, Merikanto K, Perttilä J, Metso J, Lee-Rueckert M, Taskinen MR, Kovanen PT, Öörni K, Olkkonen VM, Jauhiainen MS, Laurila PP.

Lipids Health Dis. 2018 Dec 13;17(1):285. doi: 10.1186/s12944-018-0930-2.


Chymase released from hypoxia-activated cardiac mast cells cleaves human apoA-I at Tyr192 and compromises its cardioprotective activity.

Kareinen I, Baumann M, Nguyen SD, Maaninka K, Anisimov A, Tozuka M, Jauhiainen M, Lee-Rueckert M, Kovanen PT.

J Lipid Res. 2018 Jun;59(6):945-957. doi: 10.1194/jlr.M077503. Epub 2018 Mar 26.


Altered HDL Remodeling and Functionality in Familial Hypercholesterolemia.

Cedó L, Plana N, Metso J, Lee-Rueckert M, Sanchez-Quesada JL, Kovanen PT, Jauhiainen M, Masana L, Escolà-Gil JC, Blanco-Vaca F.

J Am Coll Cardiol. 2018 Jan 30;71(4):466-468. doi: 10.1016/j.jacc.2017.11.035. No abstract available.


Phytosterol-mediated inhibition of intestinal cholesterol absorption in mice is independent of liver X receptor.

Cedó L, Santos D, Ludwig IA, Silvennoinen R, García-León A, Kaipiainen L, Carbó JM, Valledor AF, Gylling H, Motilva MJ, Kovanen PT, Lee-Rueckert M, Blanco-Vaca F, Escolà-Gil JC.

Mol Nutr Food Res. 2017 Sep;61(9). doi: 10.1002/mnfr.201700055. Epub 2017 Apr 5.


Smooth Muscle Cell Foam Cell Formation, Apolipoproteins, and ABCA1 in Intracranial Aneurysms: Implications for Lipid Accumulation as a Promoter of Aneurysm Wall Rupture.

Ollikainen E, Tulamo R, Lehti S, Lee-Rueckert M, Hernesniemi J, Niemelä M, Ylä-Herttuala S, Kovanen PT, Frösen J.

J Neuropathol Exp Neurol. 2016 Jul;75(7):689-99. doi: 10.1093/jnen/nlw041. Epub 2016 Jun 9.


Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation.

da Silva RF, Lappalainen J, Lee-Rueckert M, Kovanen PT.

Atherosclerosis. 2016 May;248:170-8. doi: 10.1016/j.atherosclerosis.2016.03.012. Epub 2016 Mar 10.


HDL functionality in reverse cholesterol transport--Challenges in translating data emerging from mouse models to human disease.

Lee-Rueckert M, Escola-Gil JC, Kovanen PT.

Biochim Biophys Acta. 2016 Jul;1861(7):566-83. doi: 10.1016/j.bbalip.2016.03.004. Epub 2016 Mar 9. Review.


USF1 deficiency activates brown adipose tissue and improves cardiometabolic health.

Laurila PP, Soronen J, Kooijman S, Forsström S, Boon MR, Surakka I, Kaiharju E, Coomans CP, Van Den Berg SA, Autio A, Sarin AP, Kettunen J, Tikkanen E, Manninen T, Metso J, Silvennoinen R, Merikanto K, Ruuth M, Perttilä J, Mäkelä A, Isomi A, Tuomainen AM, Tikka A, Ramadan UA, Seppälä I, Lehtimäki T, Eriksson J, Havulinna A, Jula A, Karhunen PJ, Salomaa V, Perola M, Ehnholm C, Lee-Rueckert M, Van Eck M, Roivainen A, Taskinen MR, Peltonen L, Mervaala E, Jalanko A, Hohtola E, Olkkonen VM, Ripatti S, Kovanen PT, Rensen PC, Suomalainen A, Jauhiainen M.

Sci Transl Med. 2016 Jan 27;8(323):323ra13. doi: 10.1126/scitranslmed.aad0015.


Carboxyl-Terminal Cleavage of Apolipoprotein A-I by Human Mast Cell Chymase Impairs Its Anti-Inflammatory Properties.

Nguyen SD, Maaninka K, Lappalainen J, Nurmi K, Metso J, Öörni K, Navab M, Fogelman AM, Jauhiainen M, Lee-Rueckert M, Kovanen PT.

Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):274-84. doi: 10.1161/ATVBAHA.115.306827. Epub 2015 Dec 17.


Quantification of In Vitro Macrophage Cholesterol Efflux and In Vivo Macrophage-Specific Reverse Cholesterol Transport.

Escolà-Gil JC, Lee-Rueckert M, Santos D, Cedó L, Blanco-Vaca F, Julve J.

Methods Mol Biol. 2015;1339:211-33. doi: 10.1007/978-1-4939-2929-0_15.


The mast cell as a pluripotent HDL-modifying effector in atherogenesis: from in vitro to in vivo significance.

Lee-Rueckert M, Kovanen PT.

Curr Opin Lipidol. 2015 Oct;26(5):362-8. doi: 10.1097/MOL.0000000000000224. Review.


Chronic intermittent psychological stress promotes macrophage reverse cholesterol transport by impairing bile acid absorption in mice.

Silvennoinen R, Quesada H, Kareinen I, Julve J, Kaipiainen L, Gylling H, Blanco-Vaca F, Escola-Gil JC, Kovanen PT, Lee-Rueckert M.

Physiol Rep. 2015 May 11;3(5). pii: e12402. doi: 10.14814/phy2.12402.


Enhanced vascular permeability facilitates entry of plasma HDL and promotes macrophage-reverse cholesterol transport from skin in mice.

Kareinen I, Cedó L, Silvennoinen R, Laurila PP, Jauhiainen M, Julve J, Blanco-Vaca F, Escola-Gil JC, Kovanen PT, Lee-Rueckert M.

J Lipid Res. 2015 Feb;56(2):241-53. doi: 10.1194/jlr.M050948. Epub 2014 Dec 3.


Acidification of the intimal fluid: the perfect storm for atherogenesis.

Öörni K, Rajamäki K, Nguyen SD, Lähdesmäki K, Plihtari R, Lee-Rueckert M, Kovanen PT.

J Lipid Res. 2015 Feb;56(2):203-14. doi: 10.1194/jlr.R050252. Epub 2014 Nov 25. Review.


The role of the gut in reverse cholesterol transport--focus on the enterocyte.

Lee-Rueckert M, Blanco-Vaca F, Kovanen PT, Escola-Gil JC.

Prog Lipid Res. 2013 Jul;52(3):317-28. doi: 10.1016/j.plipres.2013.04.003. Epub 2013 Apr 20. Review.


The impact of gender and serum estradiol levels on HDL-mediated reverse cholesterol transport.

Badeau RM, Metso J, Kovanen PT, Lee-Rueckert M, Tikkanen MJ, Jauhiainen M.

Eur J Clin Invest. 2013 Apr;43(4):317-23. doi: 10.1111/eci.12044. Epub 2013 Feb 9.


Resveratrol administration or SIRT1 overexpression does not increase LXR signaling and macrophage-to-feces reverse cholesterol transport in vivo.

Escolà-Gil JC, Julve J, Llaverias G, Urpi-Sarda M, Silvennoinen R, Lee-Rueckert M, Andres-Lacueva C, Blanco-Vaca F.

Transl Res. 2013 Feb;161(2):110-7. doi: 10.1016/j.trsl.2012.10.008. Epub 2012 Nov 10.


Acute psychological stress accelerates reverse cholesterol transport via corticosterone-dependent inhibition of intestinal cholesterol absorption.

Silvennoinen R, Escola-Gil JC, Julve J, Rotllan N, Llaverias G, Metso J, Valledor AF, He J, Yu L, Jauhiainen M, Blanco-Vaca F, Kovanen PT, Lee-Rueckert M.

Circ Res. 2012 Nov 9;111(11):1459-69. doi: 10.1161/CIRCRESAHA.112.277962. Epub 2012 Aug 28.


Spontaneous remodeling of HDL particles at acidic pH enhances their capacity to induce cholesterol efflux from human macrophage foam cells.

Nguyen SD, Öörni K, Lee-Rueckert M, Pihlajamaa T, Metso J, Jauhiainen M, Kovanen PT.

J Lipid Res. 2012 Oct;53(10):2115-25. doi: 10.1194/jlr.M028118. Epub 2012 Aug 1.


High-density lipoproteins (HDL) are present in stenotic aortic valves and may interfere with the mechanisms of valvular calcification.

Lommi JI, Kovanen PT, Jauhiainen M, Lee-Rueckert M, Kupari M, Helske S.

Atherosclerosis. 2011 Dec;219(2):538-44. doi: 10.1016/j.atherosclerosis.2011.08.027. Epub 2011 Aug 22.


Extracellular modifications of HDL in vivo and the emerging concept of proteolytic inactivation of preβ-HDL.

Lee-Rueckert M, Kovanen PT.

Curr Opin Lipidol. 2011 Oct;22(5):394-402. doi: 10.1097/MOL.0b013e32834a3d24. Review.


Mast cell activation in vivo impairs the macrophage reverse cholesterol transport pathway in the mouse.

Lee-Rueckert M, Silvennoinen R, Rotllan N, Judström I, Blanco-Vaca F, Metso J, Jauhiainen M, Kovanen PT, Escola-Gil JC.

Arterioscler Thromb Vasc Biol. 2011 Mar;31(3):520-7. doi: 10.1161/ATVBAHA.110.221069. Epub 2011 Jan 6.


Acidic extracellular environments strongly impair ABCA1-mediated cholesterol efflux from human macrophage foam cells.

Lee-Rueckert M, Lappalainen J, Leinonen H, Pihlajamaa T, Jauhiainen M, Kovanen PT.

Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1766-72. doi: 10.1161/ATVBAHA.110.211276. Epub 2010 Aug 11.


Mast cell-dependent proteolytic modification of HDL particles during anaphylactic shock in the mouse reduces their ability to induce cholesterol efflux from macrophage foam cells ex vivo.

Judström I, Jukkola H, Metso J, Jauhiainen M, Kovanen PT, Lee-Rueckert M.

Atherosclerosis. 2010 Jan;208(1):148-54. doi: 10.1016/j.atherosclerosis.2009.07.027. Epub 2009 Jul 23.


Serum, but not monocyte macrophage foam cells derived from low HDL-C subjects, displays reduced cholesterol efflux capacity.

Nakanishi S, Vikstedt R, Söderlund S, Lee-Rueckert M, Hiukka A, Ehnholm C, Muilu M, Metso J, Naukkarinen J, Palotie L, Kovanen PT, Jauhiainen M, Taskinen MR.

J Lipid Res. 2009 Feb;50(2):183-92. doi: 10.1194/jlr.M800196-JLR200. Epub 2008 Sep 11.


The neutral protease chymase degrades apolipoprotein E from high-density lipoproteins.

Lee-Rueckert M, von Eckardstein A, Kovanen PT.

Clin Chem Lab Med. 2008;46(3):421-3. doi: 10.1515/CCLM.2008.072. No abstract available.


Association of cholesteryl ester transfer protein with HDL particles reduces its proteolytic inactivation by mast cell chymase.

Lee-Rueckert M, Vikstedt R, Metso J, Jauhiainen M, Kovanen PT.

J Lipid Res. 2008 Feb;49(2):358-68. Epub 2007 Nov 8.


Common ABCA1 variants, HDL levels, and cellular cholesterol efflux in subjects with familial low HDL.

Soro-Paavonen A, Naukkarinen J, Lee-Rueckert M, Watanabe H, Rantala E, Soderlund S, Hiukka A, Kovanen PT, Jauhiainen M, Peltonen L, Taskinen MR.

J Lipid Res. 2007 Jun;48(6):1409-16. Epub 2007 Mar 19.


A unique protease-sensitive high density lipoprotein particle containing the apolipoprotein A-I(Milano) dimer effectively promotes ATP-binding Cassette A1-mediated cell cholesterol efflux.

Favari E, Gomaraschi M, Zanotti I, Bernini F, Lee-Rueckert M, Kovanen PT, Sirtori CR, Franceschini G, Calabresi L.

J Biol Chem. 2007 Feb 23;282(8):5125-32. Epub 2006 Dec 12.


Absence of endogenous phospholipid transfer protein impairs ABCA1-dependent efflux of cholesterol from macrophage foam cells.

Lee-Rueckert M, Vikstedt R, Metso J, Ehnholm C, Kovanen PT, Jauhiainen M.

J Lipid Res. 2006 Aug;47(8):1725-32. Epub 2006 May 10.


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