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Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.

Mainolfi N, Ehara T, Karki RG, Anderson K, Mac Sweeney A, Liao SM, Argikar UA, Jendza K, Zhang C, Powers J, Klosowski DW, Crowley M, Kawanami T, Ding J, April M, Forster C, Serrano-Wu M, Capparelli M, Ramqaj R, Solovay C, Cumin F, Smith TM, Ferrara L, Lee W, Long D, Prentiss M, De Erkenez A, Yang L, Liu F, Sellner H, Sirockin F, Valeur E, Erbel P, Ostermeier D, Ramage P, Gerhartz B, Schubart A, Flohr S, Gradoux N, Feifel R, Vogg B, Wiesmann C, Maibaum J, Eder J, Sedrani R, Harrison RA, Mogi M, Jaffee BD, Adams CM.

J Med Chem. 2020 Feb 19. doi: 10.1021/acs.jmedchem.9b01870. [Epub ahead of print]


Predicting abdominal aortic aneurysm growth using patient-oriented growth models with two-step Bayesian inference.

Akkoyun E, Kwon ST, Acar AC, Lee W, Baek S.

Comput Biol Med. 2020 Feb;117:103620. doi: 10.1016/j.compbiomed.2020.103620. Epub 2020 Jan 13.


Colorectal cancer diagnostic model utilizing metagenomic and metabolomic data of stool microbial extracellular vesicles.

Kim DJ, Yang J, Seo H, Lee WH, Ho Lee D, Kym S, Park YS, Kim JG, Jang IJ, Kim YK, Cho JY.

Sci Rep. 2020 Feb 18;10(1):2860. doi: 10.1038/s41598-020-59529-8.


Correction to: Biomarkers associating endothelial dysregulation in pediatric-onset systemic lupus erythematous.

Lee WF, Wu CY, Yang HY, Lee WI, Chen LC, Ou LS, Huang JL.

Pediatr Rheumatol Online J. 2020 Feb 18;18(1):18. doi: 10.1186/s12969-020-0405-7.


Delivery of pDNA to lung epithelial cells using PLGA nanoparticles formulated with a cell-penetrating peptide: understanding the intracellular fate.

Gomes Dos Reis L, Lee WH, Svolos M, Moir LM, Jaber R, Engel A, Windhab N, Young PM, Traini D.

Drug Dev Ind Pharm. 2020 Feb 18:1-16. doi: 10.1080/03639045.2020.1724134. [Epub ahead of print]


Spatiotemporally Controlled Plasticity and Elasticity in 3D Multi-Shape Memory Structures Enabled by Elemental Sulfur-Derived Polysulfide Networks with Intrinsic NIR Responsiveness.

Lee JM, Choi YS, Noh GY, Lee W, Yoo Y, Kim DG, Yoon HG, Kim YS.

Macromol Rapid Commun. 2020 Feb 18:e2000013. doi: 10.1002/marc.202000013. [Epub ahead of print]


A 73-gene proliferative transcriptomic signature predicts uterine serous carcinoma patient survival and response to primary therapy.

Tran LKH, Tran PMH, Mysona DP, Purohit SB, Myers E, Lee WS, Dun B, Xu D, Liu H, Hopkins D, Nechtman J, Scelsi CL, Mittal PK, Kleven D, Wallbillich JJ, Rungruang B, Ghamande S, She JX.

Gynecol Oncol. 2020 Feb 14. pii: S0090-8258(20)30151-7. doi: 10.1016/j.ygyno.2020.02.015. [Epub ahead of print]


Identification of a Novel Splice Variant (c.423-8A>G) of APC by RNA Sequencing.

Kim A, Kim HK, Ahn S, Hong YS, Lim SB, Byeon JS, Chun S, Min WK, Lee W.

Ann Lab Med. 2020 Jul;40(4):345-347. doi: 10.3343/alm.2020.40.4.345. No abstract available.


Breast Arterial Calcification is Associated with the Progression of Coronary Atherosclerosis in Asymptomatic Women: A Preliminary Retrospective Cohort Study.

Yoon YE, Kim KM, Lee W, Han JS, Chun EJ, Ahn S, Choi SI, Yun B, Suh JW.

Sci Rep. 2020 Feb 17;10(1):2755. doi: 10.1038/s41598-020-59606-y.


Plasmodium-infected erythrocytes induce secretion of IGFBP7 to form type II rosettes and escape phagocytosis.

Lee WC, Russell B, Sobota RM, Ghaffar K, Howland SW, Wong ZX, Maier AG, Dorin-Semblat D, Biswas S, Gamain B, Lau YL, Malleret B, Chu C, Nosten F, Renia L.

Elife. 2020 Feb 18;9. pii: e51546. doi: 10.7554/eLife.51546. [Epub ahead of print]


Comparison of the Efficacy and Safety of Rosuvastatin/Ezetimibe Combination Therapy and Rosuvastatin Monotherapy on Lipoprotein in Patients With Type 2 Diabetes: Multicenter Randomized Controlled Study.

Lee J, Hwang YC, Lee WJ, Won JC, Song KH, Park CY, Ahn KJ, Park JY.

Diabetes Ther. 2020 Feb 17. doi: 10.1007/s13300-020-00778-1. [Epub ahead of print]


Phase II Trial of Enzalutamide and Androgen Deprivation Therapy with Salvage Radiation in Men with High-risk Prostate-specific Antigen Recurrent Prostate Cancer: The STREAM Trial.

Bitting RL, Healy P, George DJ, Anand M, Kim S, Mayer T, Winters C, Riggan C, Rasmussen J, Wilder R, Stein M, Frizzell B, Harrison MR, Zhang T, Lee WR, Wu Y, Koontz BF, Armstrong AJ.

Eur Urol Oncol. 2020 Feb 13. pii: S2588-9311(20)30020-1. doi: 10.1016/j.euo.2020.01.005. [Epub ahead of print]


Nitrogen-doped carbon quantum dots-decorated 2D graphitic carbon nitride as a promising photocatalyst for environmental remediation: A study on the importance of hybridization approach.

Seng RX, Tan LL, Lee WPC, Ong WJ, Chai SP.

J Environ Manage. 2020 Feb 1;255:109936. doi: 10.1016/j.jenvman.2019.109936. Epub 2019 Dec 3.


Quantitative analysis of retinal nerve fiber layer defect in early open-angle glaucoma with normal intraocular pressure.

Ha A, Kim TJ, Lee WJ, Kim DM, Jeoung JW, Kim YK, Park KH.

Jpn J Ophthalmol. 2020 Feb 15. doi: 10.1007/s10384-019-00704-4. [Epub ahead of print]


Fabrication of Colorimetric Textile Sensor Based on Rhodamine Dye for Acidic Gas Detection.

Park YK, Oh BM, Jo AR, Han JH, Lim JY, Oh HJ, Lim SJ, Kim JH, Lee WS.

Polymers (Basel). 2020 Feb 12;12(2). pii: E431. doi: 10.3390/polym12020431.


Relationship between occupational dust exposure levels and mental health symptoms among Korean workers.

Lee W, Lee JG, Yoon JH, Lee JH.

PLoS One. 2020 Feb 14;15(2):e0228853. doi: 10.1371/journal.pone.0228853. eCollection 2020.


A 3-year observation of excessive daytime sleepiness after subthalamic deep brain stimulation in patients with Parkinson's disease.

Jung YJ, Kim HJ, Lee WW, Ehm G, Jeon B.

Clin Neurol Neurosurg. 2020 Feb 4;192:105721. doi: 10.1016/j.clineuro.2020.105721. [Epub ahead of print]


Clinical outcomes of patients undergoing a cardiac implantable electronic device implantation following a recent non-device-related infection.

Chen HC, Chen YL, Lee WC, Tsai TH, Pan KL, Lin YS, Chen MC.

J Hosp Infect. 2020 Feb 11. pii: S0195-6701(20)30049-9. doi: 10.1016/j.jhin.2020.02.003. [Epub ahead of print]


Case of the Index Patient Who Caused Tertiary Transmission of COVID-19 Infection in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Infected Pneumonia Monitored by Quantitative RT-PCR.

Lim J, Jeon S, Shin HY, Kim MJ, Seong YM, Lee WJ, Choe KW, Kang YM, Lee B, Park SJ.

J Korean Med Sci. 2020 Feb 17;35(6):e79. doi: 10.3346/jkms.2020.35.e79.


Inhibition of phosphodiesterase suppresses allergic lung inflammation by regulating MCP-1 in an OVA-induced asthma murine model with co-exposure to lipopolysaccharide.

Lee CD, Choi WS, Choi YG, Kang HS, Lee WT, Kim HJ, Lee JY.

J Int Med Res. 2020 Feb;48(2):300060520903663. doi: 10.1177/0300060520903663. No abstract available.


Current Status of "Watch-and-Wait" Rectal Cancer Treatment in Asia-Pacific Countries.

Huh JW, Maeda K, Liu Z, Wang X, Roslani AC, Lee WY.

Ann Coloproctol. 2020 Jan 31. doi: 10.3393/ac.2020.01.19. [Epub ahead of print]


Estimation of carcass weight of Hanwoo (Korean native cattle) as a function of body measurements using statistical models and a neural network.

Lee DH, Lee SH, Cho BK, Wakholi C, Seo YW, Cho SH, Kang TH, Lee WH.

Asian-Australas J Anim Sci. 2019 Dec 24. doi: 10.5713/ajas.19.0748. [Epub ahead of print]


Myocardial Positron Emission Tomography for Evaluation of Cardiac Sarcoidosis: Specialized Protocols for Better Diagnosis.

Hwang IC, Bang JI, Yoon YE, Lee WW.

J Cardiovasc Imaging. 2020 Jan 13. doi: 10.4250/jcvi.2019.0103. [Epub ahead of print] Review.


Prenylflavonoid Icariin Induces Estrogen Response Element-Independent Estrogenic Responses in a Tissue-Selective Manner.

Zhou L, Poon CC, Wong KY, Cao S, Yu W, Dong X, Lee WY, Zhang Y, Wong MS.

J Endocr Soc. 2019 Nov 25;4(2):bvz025. doi: 10.1210/jendso/bvz025. eCollection 2020 Feb 1.


Patient preferences regarding bariatric/metabolic procedures: a survey of Korean obese candidates for surgery.

Roh SY, Park YH, Lee WK, Kim SM.

Ann Surg Treat Res. 2020 Feb;98(2):82-88. doi: 10.4174/astr.2020.98.2.82. Epub 2020 Jan 31.


Huge Anterior Skull Base Defect Reconstruction on Communicating Between Cranium and Nasal Cavity: Combination Flap of Galeal Flap and Reverse Temporalis Flap.

Shin D, Yang CE, Kim YO, Hong JW, Lee WJ, Lew DH, Chang JH, Kim CH.

J Craniofac Surg. 2020 Feb 7. doi: 10.1097/SCS.0000000000006221. [Epub ahead of print]


Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP.

Zhou Y, Fei M, Zhang G, Liang WC, Lin W, Wu Y, Piskol R, Ridgway J, McNamara E, Huang H, Zhang J, Oh J, Patel JM, Jakubiak D, Lau J, Blackwood B, Bravo DD, Shi Y, Wang J, Hu HM, Lee WP, Jesudason R, Sangaraju D, Modrusan Z, Anderson KR, Warming S, Roose-Girma M, Yan M.

Immunity. 2020 Feb 4. pii: S1074-7613(20)30042-X. doi: 10.1016/j.immuni.2020.01.014. [Epub ahead of print]


Effects of MACC1 polymorphisms on hepatocellular carcinoma development and clinical characteristics.

Lin CH, Hsieh MJ, Lee HL, Yang SF, Su SC, Lee WJ, Chou YE.

J Cancer. 2020 Jan 14;11(6):1641-1647. doi: 10.7150/jca.38856. eCollection 2020.


The mTOR Inhibitor Rapamycin Prevents General Anesthesia-Induced Changes in Synaptic Transmission and Mitochondrial Respiration in Late Postnatal Mice.

Ju X, Ryu MJ, Cui J, Lee Y, Park S, Hong B, Yoo S, Lee WH, Shin YS, Yoon SH, Kweon GR, Kim YH, Ko Y, Heo JY, Chung W.

Front Cell Neurosci. 2020 Jan 28;14:4. doi: 10.3389/fncel.2020.00004. eCollection 2020.


Association of miR-27aA>G, miR-423C>a, miR-449bA>G, and miR-604A>G Polymorphisms with Risk of Recurrent Implantation Failure.

Kim JO, Ahn EH, Sakong JH, An HJ, Park HS, Kim YR, Lee JR, Lee WS, Kim NK.

Reprod Sci. 2020 Jan;27(1):29-38. doi: 10.1007/s43032-019-00031-6. Epub 2020 Jan 1. Review.


Redox reactions between chromium(VI) and hydroquinone: Alternative pathways for polymerization of organic molecules.

Tzou YM, Chen KY, Cheng CY, Lee WZ, Teah HY, Liu YT.

Environ Pollut. 2020 Jan 23;261:114024. doi: 10.1016/j.envpol.2020.114024. [Epub ahead of print]


Exploring the Impact of ACA on Rural-Urban Disparity in Oral Health Services Among US Noninstitutionalized Adults.

Lee WC, Li CY, Serag H, Tabrizi M, Kuo YF.

J Rural Health. 2020 Feb 11. doi: 10.1111/jrh.12418. [Epub ahead of print]


Prognostic Significance of CD200 Protein Expression and its Correlation with COX-2 in Cutaneous Melanoma.

Lee MH, Kim YJ, Yun KA, Won CH, Lee MW, Choi JH, Chang SE, Lee WJ.

J Am Acad Dermatol. 2020 Feb 7. pii: S0190-9622(20)30210-3. doi: 10.1016/j.jaad.2020.02.006. [Epub ahead of print] No abstract available.


Cigarette smoking and knee osteoarthritis in the elderly: Data from the Korean National Health and Nutritional Examination Survey.

Kwon HM, Yang IH, Park KK, Cho BW, Byun J, Lee WS.

Exp Gerontol. 2020 Feb 7:110873. doi: 10.1016/j.exger.2020.110873. [Epub ahead of print]


Direct observation of glucose fingerprint using in vivo Raman spectroscopy.

Kang JW, Park YS, Chang H, Lee W, Singh SP, Choi W, Galindo LH, Dasari RR, Nam SH, Park J, So PTC.

Sci Adv. 2020 Jan 24;6(4):eaay5206. doi: 10.1126/sciadv.aay5206. eCollection 2020 Jan.


Near-field sub-diffraction photolithography with an elastomeric photomask.

Paik S, Kim G, Chang S, Lee S, Jin D, Jeong KY, Lee IS, Lee J, Moon H, Lee J, Chang K, Choi SS, Moon J, Jung S, Kang S, Lee W, Choi HJ, Choi H, Kim HJ, Lee JH, Cheon J, Kim M, Myoung J, Park HG, Shim W.

Nat Commun. 2020 Feb 10;11(1):805. doi: 10.1038/s41467-020-14439-1.


An integrated microfluidic system for rapid, automatic and high-throughput staining of clinical tissue samples for diagnosis of ovarian cancer.

Huang SP, Chuang YJ, Lee WB, Tsai YC, Lin CN, Hsu KF, Lee GB.

Lab Chip. 2020 Feb 10. doi: 10.1039/c9lc00979e. [Epub ahead of print]


Comparing the Quality of Cardiopulmonary Resuscitation Performed at the Over-the-Head Position and Lateral Position of Neonatal Manikin.

Cheung PY, Huang H, Xu C, Liu JQ, Ting JY, Wong R, Lee W, Xue Y, Yi Y.

Front Pediatr. 2020 Jan 20;7:559. doi: 10.3389/fped.2019.00559. eCollection 2019.


Serosal surface small vessel vasculitis in Henoch-Schonlein purpura.

Lee WS, Koh CT.

Pediatr Neonatol. 2020 Jan 25. pii: S1875-9572(20)30002-4. doi: 10.1016/j.pedneo.2020.01.002. [Epub ahead of print] No abstract available.


Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment.

Chen LK, Woo J, Assantachai P, Auyeung TW, Chou MY, Iijima K, Jang HC, Kang L, Kim M, Kim S, Kojima T, Kuzuya M, Lee JSW, Lee SY, Lee WJ, Lee Y, Liang CK, Lim JY, Lim WS, Peng LN, Sugimoto K, Tanaka T, Won CW, Yamada M, Zhang T, Akishita M, Arai H.

J Am Med Dir Assoc. 2020 Feb 4. pii: S1525-8610(19)30872-2. doi: 10.1016/j.jamda.2019.12.012. [Epub ahead of print]


Prognosis-Predicting Model Based on [18F]fluorodeoxyglucose PET Metabolic Parameters in Locally Advanced Cervical Cancer Patients Treated with Concurrent Chemoradiotherapy: Multi-Center Retrospective Study.

Lee WK, Chong GO, Jeong SY, Lee HJ, Park SH, Ryu JM, Choi YS, Kang S, Koo YJ, Lee DH, Kong E, Lee SW.

J Clin Med. 2020 Feb 5;9(2). pii: E427. doi: 10.3390/jcm9020427.


Determinants and indicators of successful ageing associated with mortality: a 4-year population-based study.

Lee WJ, Peng LN, Lin MH, Loh CH, Chen LK.

Aging (Albany NY). 2020 Feb 6;12(3):2670-2679. doi: 10.18632/aging.102769. Epub 2020 Feb 6.


Altered balance control in thoracic adolescent idiopathic scoliosis during obstructed gait.

Wu KW, Lu TW, Lee WC, Ho YT, Huang TC, Wang JH, Wang TM.

PLoS One. 2020 Feb 6;15(2):e0228752. doi: 10.1371/journal.pone.0228752. eCollection 2020.


Mental health in UK Biobank - development, implementation and results from an online questionnaire completed by 157 366 participants: a reanalysis.

Davis KAS, Coleman JRI, Adams M, Allen N, Breen G, Cullen B, Dickens C, Fox E, Graham N, Holliday J, Howard LM, John A, Lee W, McCabe R, McIntosh A, Pearsall R, Smith DJ, Sudlow C, Ward J, Zammit S, Hotopf M.

BJPsych Open. 2020 Feb 6;6(2):e18. doi: 10.1192/bjo.2019.100.


Association Between Functional Activity of Mitochondria and Actin Cytoskeleton Instability in Oocytes from Advanced Age Mice.

Kim MJ, Choi KH, Seo DW, Lee HR, Kong HS, Lee CH, Lee WS, Lee HT, Ko JJ, Kim JH, Lee SJ, Lee JH.

Reprod Sci. 2020 Feb 5. doi: 10.1007/s43032-020-00145-2. [Epub ahead of print]


Deep tissue space-gated microscopy via acousto-optic interaction.

Jang M, Ko H, Hong JH, Lee WK, Lee JS, Choi W.

Nat Commun. 2020 Feb 5;11(1):710. doi: 10.1038/s41467-020-14514-7.


Metabolomic Analysis of the Liver of a Dextran Sodium Sulfate-Induced Acute Colitis Mouse Model: Implications of the Gut-Liver Connection.

Kim SH, Lee W, Kwon D, Lee S, Son SW, Seo MS, Kim KS, Lee YH, Kim S, Jung YS.

Cells. 2020 Feb 1;9(2). pii: E341. doi: 10.3390/cells9020341.


Herb-Drug Interaction of Red Ginseng Extract and Ginsenoside Rc with Valsartan in Rats.

Jeon JH, Lee S, Lee W, Jin S, Kwon M, Shin CH, Choi MK, Song IS.

Molecules. 2020 Jan 31;25(3). pii: E622. doi: 10.3390/molecules25030622.


Fetal Weight Estimation Using Automated Fractional Limb Volume With 2-Dimensional Size Parameters: A Multicenter Study.

Lee W, Mack LM, Sangi-Haghpeykar H, Gandhi R, Wu Q, Kang L, Canavan TP, Gatina R, Schild RL.

J Ultrasound Med. 2020 Feb 5. doi: 10.1002/jum.15224. [Epub ahead of print]


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