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Sustained sensing in potassium homeostasis: Cyclic di-AMP controls potassium uptake by KimA at the levels of expression and activity.

Gundlach J, Krüger L, Herzberg C, Turdiev A, Poehlein A, Tascón I, Weiss M, Hertel D, Daniel R, Hänelt I, Lee VT, Stülke J.

J Biol Chem. 2019 Jun 14;294(24):9605-9614. doi: 10.1074/jbc.RA119.008774. Epub 2019 May 6.


The KupA and KupB Proteins of Lactococcus lactis IL1403 Are Novel c-di-AMP Receptor Proteins Responsible for Potassium Uptake.

Quintana IM, Gibhardt J, Turdiev A, Hammer E, Commichau FM, Lee VT, Magni C, Stülke J.

J Bacteriol. 2019 Apr 24;201(10). pii: e00028-19. doi: 10.1128/JB.00028-19. Print 2019 May 15.


Differential Radial Capillary Action of Ligand Assay (DRaCALA).

Seminara AB, Turdiev A, Turdiev H, Lee VT.

Curr Protoc Mol Biol. 2019 Apr;126(1):e84. doi: 10.1002/cpmb.84. Epub 2018 Dec 3.


Host suppression of quorum sensing during catheter-associated urinary tract infections.

Cole SJ, Hall CL, Schniederberend M, Farrow Iii JM, Goodson JR, Pesci EC, Kazmierczak BI, Lee VT.

Nat Commun. 2018 Oct 25;9(1):4436. doi: 10.1038/s41467-018-06882-y.


A Subset of Exoribonucleases Serve as Degradative Enzymes for pGpG in c-di-GMP Signaling.

Orr MW, Weiss CA, Severin GB, Turdiev H, Kim SK, Turdiev A, Liu K, Tu BP, Waters CM, Winkler WC, Lee VT.

J Bacteriol. 2018 Nov 26;200(24). pii: e00300-18. doi: 10.1128/JB.00300-18. Print 2018 Dec 15.


Comprehensive Evaluation of the MBT STAR-BL Module for Simultaneous Bacterial Identification and β-Lactamase-Mediated Resistance Detection in Gram-Negative Rods from Cultured Isolates and Positive Blood Cultures.

Lee AWT, Lam JKS, Lam RKW, Ng WH, Lee ENL, Lee VTY, Sze PP, Rajwani R, Fung KSC, To WK, Lee RA, Tsang DNC, Siu GKH.

Front Microbiol. 2018 Feb 23;9:334. doi: 10.3389/fmicb.2018.00334. eCollection 2018.


Prospective study to determine early hypertrophy of the contra-lateral liver lobe after unilobar, Yttrium-90, selective internal radiation therapy in patients with hepatocellular carcinoma.

Teo JY, Allen JC, Ng DCE, Abdul Latiff JB, Choo SP, Tai DW, Low ASC, Cheah FK, Chang JPE, Kam JH, Lee VTW, Chung AYF, Chan CY, Chow PKH, Goh BKP.

Surgery. 2018 May;163(5):1008-1013. doi: 10.1016/j.surg.2017.10.014. Epub 2018 Jan 3.


Thiol-benzo-triazolo-quinazolinone Inhibits Alg44 Binding to c-di-GMP and Reduces Alginate Production by Pseudomonas aeruginosa.

Zhou E, Seminara AB, Kim SK, Hall CL, Wang Y, Lee VT.

ACS Chem Biol. 2017 Dec 15;12(12):3076-3085. doi: 10.1021/acschembio.7b00826. Epub 2017 Nov 22.


Cyclic-di-GMP regulation of virulence in bacterial pathogens.

Hall CL, Lee VT.

Wiley Interdiscip Rev RNA. 2018 Jan;9(1). doi: 10.1002/wrna.1454. Epub 2017 Oct 8. Review.


Electron-shuttling antibiotics structure bacterial communities by modulating cellular levels of c-di-GMP.

Okegbe C, Fields BL, Cole SJ, Beierschmitt C, Morgan CJ, Price-Whelan A, Stewart RC, Lee VT, Dietrich LEP.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5236-E5245. doi: 10.1073/pnas.1700264114. Epub 2017 Jun 12.


Using a Concept Inventory to Reveal Student Thinking Associated with Common Misconceptions about Antibiotic Resistance.

Stevens AM, Smith AC, Marbach-Ad G, Balcom SA, Buchner J, Daniel SL, DeStefano JJ, El-Sayed NM, Frauwirth K, Lee VT, McIver KS, Melville SB, Mosser DM, Popham DL, Scharf BE, Schubot FD, Seyler RW Jr, Shields PA, Song W, Stein DC, Stewart RC, Thompson KV, Yang Z, Yarwood SA.

J Microbiol Biol Educ. 2017 Apr 21;18(1). pii: 18.1.10. doi: 10.1128/jmbe.v18i1.1281. eCollection 2017 Apr.


Cyclic Di-GMP Binding by an Assembly ATPase (PilB2) and Control of Type IV Pilin Polymerization in the Gram-Positive Pathogen Clostridium perfringens.

Hendrick WA, Orr MW, Murray SR, Lee VT, Melville SB.

J Bacteriol. 2017 Apr 25;199(10). pii: e00034-17. doi: 10.1128/JB.00034-17. Print 2017 May 15.


Sustained sensing as an emerging principle in second messenger signaling systems.

Orr MW, Galperin MY, Lee VT.

Curr Opin Microbiol. 2016 Dec;34:119-126. doi: 10.1016/j.mib.2016.08.010. Epub 2016 Oct 1. Review.


Old concepts, new molecules and current approaches applied to the bacterial nucleotide signalling field.

Gründling A, Lee VT.

Philos Trans R Soc Lond B Biol Sci. 2016 Nov 5;371(1707). pii: 20150503. doi: 10.1098/rstb.2015.0503. Review.


Discovering Protein Receptors for Signaling Nucleotides.

Lee VT.

PLoS Pathog. 2016 Aug 25;12(8):e1005569. doi: 10.1371/journal.ppat.1005569. eCollection 2016 Aug. No abstract available.


Laparoscopic Liver Resection for Tumors in the Left Lateral Liver Section.

Goh BK, Chan CY, Lee SY, Lee VT, Cheow PC, Chow PK, Ooi LL, Chung AY.

JSLS. 2016 Jan-Mar;20(1). pii: e2015.00112. doi: 10.4293/JSLS.2015.00112.


Laparoscopic liver resection for posterosuperior and anterolateral lesions-a comparison experience in an Asian centre.

Teo JY, Kam JH, Chan CY, Goh BK, Wong JS, Lee VT, Cheow PC, Chow PK, Ooi LL, Chung AY, Lee SY.

Hepatobiliary Surg Nutr. 2015 Dec;4(6):379-90. doi: 10.3978/j.issn.2304-3881.2015.06.06.


Systematic Identification of Cyclic-di-GMP Binding Proteins in Vibrio cholerae Reveals a Novel Class of Cyclic-di-GMP-Binding ATPases Associated with Type II Secretion Systems.

Roelofs KG, Jones CJ, Helman SR, Shang X, Orr MW, Goodson JR, Galperin MY, Yildiz FH, Lee VT.

PLoS Pathog. 2015 Oct 27;11(10):e1005232. doi: 10.1371/journal.ppat.1005232. eCollection 2015 Oct.


Oligoribonuclease is the primary degradative enzyme for pGpG in Pseudomonas aeruginosa that is required for cyclic-di-GMP turnover.

Orr MW, Donaldson GP, Severin GB, Wang J, Sintim HO, Waters CM, Lee VT.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):E5048-57. doi: 10.1073/pnas.1507245112. Epub 2015 Aug 24.


Are preoperative blood neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios useful in predicting malignancy in surgically-treated mucin-producing pancreatic cystic neoplasms?

Goh BK, Tan DM, Chan CY, Lee SY, Lee VT, Thng CH, Low AS, Tai DW, Cheow PC, Chow PK, Ooi LL, Chung AY.

J Surg Oncol. 2015 Sep;112(4):366-71. doi: 10.1002/jso.23997. Epub 2015 Aug 17.


Cyclic Di-GMP Signaling Contributes to Pseudomonas aeruginosa-Mediated Catheter-Associated Urinary Tract Infection.

Cole SJ, Lee VT.

J Bacteriol. 2015 Jul 20;198(1):91-7. doi: 10.1128/JB.00410-15. Print 2016 Jan 1.


Metal Iodate-Based Energetic Composites and Their Combustion and Biocidal Performance.

Wang H, Jian G, Zhou W, DeLisio JB, Lee VT, Zachariah MR.

ACS Appl Mater Interfaces. 2015 Aug 12;7(31):17363-70. doi: 10.1021/acsami.5b04589. Epub 2015 Aug 3.


Assessing RNA interactions with proteins by DRaCALA.

Patel DK, Gebbie MP, Lee VT.

Methods Enzymol. 2014;549:489-512. doi: 10.1016/B978-0-12-801122-5.00021-0.


Factors associated with and outcomes of open conversion after laparoscopic minor hepatectomy: initial experience at a single institution.

Goh BK, Chan CY, Wong JS, Lee SY, Lee VT, Cheow PC, Chow PK, Ooi LL, Chung AY.

Surg Endosc. 2015 Sep;29(9):2636-42. doi: 10.1007/s00464-014-3981-0. Epub 2014 Nov 27.


Surgical salvage of partial pancreatic allograft thrombosis presenting as ruptured pancreatic cyst: a case report.

Lee VT, Tiong HY, Vathsala A, Madhavan K.

Transplant Proc. 2014 Jul-Aug;46(6):2019-22. doi: 10.1016/j.transproceed.2014.05.082.


Catheter-associated urinary tract infection by Pseudomonas aeruginosa is mediated by exopolysaccharide-independent biofilms.

Cole SJ, Records AR, Orr MW, Linden SB, Lee VT.

Infect Immun. 2014 May;82(5):2048-58. doi: 10.1128/IAI.01652-14. Epub 2014 Mar 4.


Are the Sendai and Fukuoka consensus guidelines for cystic mucinous neoplasms of the pancreas useful in the initial triage of all suspected pancreatic cystic neoplasms? A single-institution experience with 317 surgically-treated patients.

Goh BK, Tan DM, Thng CH, Lee SY, Low AS, Chan CY, Wong JS, Lee VT, Cheow PC, Chow PK, Chung AY, Wong WK, Ooi LL.

Ann Surg Oncol. 2014 Jun;21(6):1919-26. doi: 10.1245/s10434-014-3501-4. Epub 2014 Feb 7.


High-throughput screening using the differential radial capillary action of ligand assay identifies ebselen as an inhibitor of diguanylate cyclases.

Lieberman OJ, Orr MW, Wang Y, Lee VT.

ACS Chem Biol. 2014 Jan 17;9(1):183-92. doi: 10.1021/cb400485k. Epub 2013 Nov 4.


Potent suppression of c-di-GMP synthesis via I-site allosteric inhibition of diguanylate cyclases with 2'-F-c-di-GMP.

Zhou J, Watt S, Wang J, Nakayama S, Sayre DA, Lam YF, Lee VT, Sintim HO.

Bioorg Med Chem. 2013 Jul 15;21(14):4396-404. doi: 10.1016/j.bmc.2013.04.050. Epub 2013 Apr 29.


Systematic identification of conserved bacterial c-di-AMP receptor proteins.

Corrigan RM, Campeotto I, Jeganathan T, Roelofs KG, Lee VT, Gründling A.

Proc Natl Acad Sci U S A. 2013 May 28;110(22):9084-9. doi: 10.1073/pnas.1300595110. Epub 2013 May 13.


Detection of cyclic diguanylate G-octaplex assembly and interaction with proteins.

Lieberman OJ, DeStefano JJ, Lee VT.

PLoS One. 2013;8(1):e53689. doi: 10.1371/journal.pone.0053689. Epub 2013 Jan 7. Erratum in: PLoS One. 2013;8(6). doi:10.1371/annotation/1e2e5c25-79ad-4cf2-b619-f6972eafbadc.


Quantitative attachment and detachment of bacterial spores from fine wires through continuous and pulsed DC electrophoretic deposition.

Zhou W, Watt SK, Tsai DH, Lee VT, Zachariah MR.

J Phys Chem B. 2013 Feb 14;117(6):1738-45. doi: 10.1021/jp307282q. Epub 2012 Nov 9.


A C-di-GMP-proflavine-hemin supramolecular complex has peroxidase activity--implication for a simple colorimetric detection.

Nakayama S, Roelofs K, Lee VT, Sintim HO.

Mol Biosyst. 2012 Mar;8(3):726-9. doi: 10.1039/c2mb05430b. Epub 2012 Jan 18.


Laparoendoscopic single-site minor hepatectomy for liver tumors.

Tan EK, Lee VT, Chang SK, Ganpathi IS, Madhavan K, Lomanto D.

Surg Endosc. 2012 Jul;26(7):2086-91. doi: 10.1007/s00464-011-2128-9. Epub 2012 Jan 11.


A rapid assay for affinity and kinetics of molecular interactions with nucleic acids.

Donaldson GP, Roelofs KG, Luo Y, Sintim HO, Lee VT.

Nucleic Acids Res. 2012 Apr;40(7):e48. doi: 10.1093/nar/gkr1299. Epub 2011 Dec 30.


Differential binding of 2'-biotinylated analogs of c-di-GMP with c-di-GMP riboswitches and binding proteins.

Luo Y, Zhou J, Watt SK, Lee VT, Dayie TK, Sintim HO.

Mol Biosyst. 2012 Mar;8(3):772-8. doi: 10.1039/c2mb05338a. Epub 2011 Dec 19.


Outer membrane targeting of Pseudomonas aeruginosa proteins shows variable dependence on the components of Bam and Lol machineries.

Hoang HH, Nickerson NN, Lee VT, Kazimirova A, Chami M, Pugsley AP, Lory S.

MBio. 2011 Dec 6;2(6). pii: e00246-11. doi: 10.1128/mBio.00246-11. Print 2011.


Highly sensitive amperometric detection of bilirubin using enzyme and gold nanoparticles on sol-gel film modified electrode.

Kannan P, Chen H, Lee VT, Kim DH.

Talanta. 2011 Oct 30;86:400-7. doi: 10.1016/j.talanta.2011.09.034. Epub 2011 Sep 28.


Differential radial capillary action of ligand assay for high-throughput detection of protein-metabolite interactions.

Roelofs KG, Wang J, Sintim HO, Lee VT.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15528-33. doi: 10.1073/pnas.1018949108. Epub 2011 Aug 29.


Conservative change to the phosphate moiety of cyclic diguanylic monophosphate remarkably affects its polymorphism and ability to bind DGC, PDE, and PilZ proteins.

Wang J, Zhou J, Donaldson GP, Nakayama S, Yan L, Lam YF, Lee VT, Sintim HO.

J Am Chem Soc. 2011 Jun 22;133(24):9320-30. doi: 10.1021/ja1112029. Epub 2011 May 25.


Thiazole orange-induced c-di-GMP quadruplex formation facilitates a simple fluorescent detection of this ubiquitous biofilm regulating molecule.

Nakayama S, Kelsey I, Wang J, Roelofs K, Stefane B, Luo Y, Lee VT, Sintim HO.

J Am Chem Soc. 2011 Apr 6;133(13):4856-64. doi: 10.1021/ja1091062. Epub 2011 Mar 8.


Minimally invasive retroperitoneal pancreatic necrosectomy in the management of infected pancreatitis.

Lakshmanan R, Iyer SG, Lee VT, Chang SK, Madhavan K.

Surg Laparosc Endosc Percutan Tech. 2010 Feb;20(1):e11-5. doi: 10.1097/SLE.0b013e3181c8f340.


Type III secretion systems as targets for novel therapeutics.

Lee VT, Kessler JL.

IDrugs. 2009 Oct;12(10):636-41. Review.


Expanding the donor pool for liver transplantation in the setting of an "opt-out" scheme: 3 years after new legislation.

Lee VT, Yip CC, Ganpathi IS, Chang S, Mak KS, Prabhakaran K, Madhavan K.

Ann Acad Med Singapore. 2009 Apr;38(4):315-7.


Laparoscopic cholecystectomy for acute cholecystitis: safe implementation of successful strategies to reduce conversion rates.

Low SW, Iyer SG, Chang SK, Mak KS, Lee VT, Madhavan K.

Surg Endosc. 2009 Nov;23(11):2424-9. doi: 10.1007/s00464-009-0374-x. Epub 2009 Mar 5.


Assessing student understanding of host pathogen interactions using a concept inventory.

Marbach-Ad G, Briken V, El-Sayed NM, Frauwirth K, Fredericksen B, Hutcheson S, Gao LY, Joseph S, Lee VT, McIver KS, Mosser D, Quimby BB, Shields P, Song W, Stein DC, Yuan RT, Smith AC.

J Microbiol Biol Educ. 2009 Dec 17;10(1):43-50. Print 2009.


Gene-boosted assembly of a novel bacterial genome from very short reads.

Salzberg SL, Sommer DD, Puiu D, Lee VT.

PLoS Comput Biol. 2008 Sep 26;4(9):e1000186. doi: 10.1371/journal.pcbi.1000186.


Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen.

Arnoldo A, Curak J, Kittanakom S, Chevelev I, Lee VT, Sahebol-Amri M, Koscik B, Ljuma L, Roy PJ, Bedalov A, Giaever G, Nislow C, Merrill AR, Lory S, Stagljar I.

PLoS Genet. 2008 Feb 29;4(2):e1000005. doi: 10.1371/journal.pgen.1000005. Erratum in: PLoS Genet. 2008 Apr;4(4). doi: 10.1371/annotation/76d35829-07a2-479f-bbc1-cce6755b6d8c. Merrill, Rod A [corrected to Merrill, A Rod].

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