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Items: 1 to 50 of 884

1.

Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples.

Prokop S, Miller KR, Labra SR, Pitkin RM, Hoxha K, Narasimhan S, Changolkar L, Rosenbloom A, Lee VM, Trojanowski JQ.

Acta Neuropathol. 2019 Jul 26. doi: 10.1007/s00401-019-02048-2. [Epub ahead of print]

PMID:
31350575
2.

Spread of α-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysis.

Henderson MX, Cornblath EJ, Darwich A, Zhang B, Brown H, Gathagan RJ, Sandler RM, Bassett DS, Trojanowski JQ, Lee VMY.

Nat Neurosci. 2019 Aug;22(8):1248-1257. doi: 10.1038/s41593-019-0457-5. Epub 2019 Jul 25.

PMID:
31346295
3.

C9orf72 intermediate repeats are associated with corticobasal degeneration, increased C9orf72 expression and disruption of autophagy.

Cali CP, Patino M, Tai YK, Ho WY, McLean CA, Morris CM, Seeley WW, Miller BL, Gaig C, Vonsattel JPG, White CL 3rd, Roeber S, Kretzschmar H, Troncoso JC, Troakes C, Gearing M, Ghetti B, Van Deerlin VM, Lee VM, Trojanowski JQ, Mok KY, Ling H, Dickson DW, Schellenberg GD, Ling SC, Lee EB.

Acta Neuropathol. 2019 Jul 20. doi: 10.1007/s00401-019-02045-5. [Epub ahead of print]

PMID:
31327044
4.

Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation.

Saito T, Mihira N, Matsuba Y, Sasaguri H, Hashimoto S, Narasimhan S, Zhang B, Murayama S, Higuchi M, Lee VMY, Trojanowski JQ, Saido TC.

J Biol Chem. 2019 Jul 4. pii: jbc.RA119.009487. doi: 10.1074/jbc.RA119.009487. [Epub ahead of print]

5.

TREM2 function impedes tau seeding in neuritic plaques.

Leyns CEG, Gratuze M, Narasimhan S, Jain N, Koscal LJ, Jiang H, Manis M, Colonna M, Lee VMY, Ulrich JD, Holtzman DM.

Nat Neurosci. 2019 Aug;22(8):1217-1222. doi: 10.1038/s41593-019-0433-0. Epub 2019 Jun 24.

PMID:
31235932
6.

α-Synuclein pathology in Parkinson's disease and related α-synucleinopathies.

Henderson MX, Trojanowski JQ, Lee VM.

Neurosci Lett. 2019 Jun 3;709:134316. doi: 10.1016/j.neulet.2019.134316. [Epub ahead of print] Review.

PMID:
31170426
7.

α-Synuclein (αSyn) Preformed Fibrils Induce Endogenous αSyn Aggregation, Compromise Synaptic Activity and Enhance Synapse Loss in Cultured Excitatory Hippocampal Neurons.

Wu Q, Takano H, Riddle DM, Trojanowski JQ, Coulter DA, Lee VM.

J Neurosci. 2019 Jun 26;39(26):5080-5094. doi: 10.1523/JNEUROSCI.0060-19.2019. Epub 2019 Apr 29.

PMID:
31036761
8.

Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies.

Berson A, Goodman LD, Sartoris AN, Otte CG, Aykit JA, Lee VM, Trojanowski JQ, Bonini NM.

Acta Neuropathol Commun. 2019 Apr 29;7(1):65. doi: 10.1186/s40478-019-0710-x.

9.

eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS.

Goodman LD, Prudencio M, Srinivasan AR, Rifai OM, Lee VM, Petrucelli L, Bonini NM.

Acta Neuropathol Commun. 2019 Apr 25;7(1):62. doi: 10.1186/s40478-019-0711-9.

10.

Detection of Alzheimer's disease (AD) specific tau pathology with conformation-selective anti-tau monoclonal antibody in co-morbid frontotemporal lobar degeneration-tau (FTLD-tau).

Gibbons GS, Kim SJ, Robinson JL, Changolkar L, Irwin DJ, Shaw LM, Lee VM, Trojanowski JQ.

Acta Neuropathol Commun. 2019 Mar 4;7(1):34. doi: 10.1186/s40478-019-0687-5.

11.

LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice.

Henderson MX, Sengupta M, McGeary I, Zhang B, Olufemi MF, Brown H, Trojanowski JQ, Lee VMY.

Acta Neuropathol Commun. 2019 Feb 26;7(1):28. doi: 10.1186/s40478-019-0679-5.

12.

Stereotaxic Targeting of Alpha-Synuclein Pathology in Mouse Brain Using Preformed Fibrils.

Zhang B, Kehm V, Gathagan R, Leight SN, Trojanowski JQ, Lee VM, Luk KC.

Methods Mol Biol. 2019;1948:45-57. doi: 10.1007/978-1-4939-9124-2_5.

13.

Transmission of α-synuclein seeds in neurodegenerative disease: recent developments.

Karpowicz RJ Jr, Trojanowski JQ, Lee VM.

Lab Invest. 2019 Jul;99(7):971-981. doi: 10.1038/s41374-019-0195-z. Epub 2019 Feb 13. Review.

14.

Author Correction: Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity.

Chung CY, Berson A, Kennerdell JR, Sartoris A, Unger T, Porta S, Kim HJ, Smith ER, Shilatifard A, Van Deerlin V, Lee VM, Chen-Plotkin A, Bonini NM.

Nat Commun. 2019 Jan 29;10(1):555. doi: 10.1038/s41467-019-08562-x.

15.

A "Clickable" Photoconvertible Small Fluorescent Molecule as a Minimalist Probe for Tracking Individual Biomolecule Complexes.

Jun JV, Haney CM, Karpowicz RJ Jr, Giannakoulias S, Lee VM, Petersson EJ, Chenoweth DM.

J Am Chem Soc. 2019 Feb 6;141(5):1893-1897. doi: 10.1021/jacs.8b13094. Epub 2019 Jan 28.

PMID:
30657670
16.

Expression of cancer stem cell markers in metastatic melanoma to the brain.

Wickremesekera AC, Brasch HD, Lee VM, Davis PF, Woon K, Johnson R, Tan ST, Itinteang T.

J Clin Neurosci. 2019 Feb;60:112-116. doi: 10.1016/j.jocn.2018.10.068. Epub 2018 Oct 24.

PMID:
30626524
17.

Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders.

Coughlin D, Xie SX, Liang M, Williams A, Peterson C, Weintraub D, McMillan CT, Wolk DA, Akhtar RS, Hurtig HI, Branch Coslett H, Hamilton RH, Siderowf AD, Duda JE, Rascovsky K, Lee EB, Lee VM, Grossman M, Trojanowski JQ, Irwin DJ.

Ann Neurol. 2019 Feb;85(2):259-271. doi: 10.1002/ana.25392. Epub 2019 Jan 7.

18.

Cancer stem cells within moderately differentiated head and neck cutaneous squamous cell carcinoma express components of the renin-angiotensin system.

Nallaiah S, Lee VMY, Brasch HD, de Jongh J, Schaijik BV, Marsh R, Tan ST, Itinteang T.

J Plast Reconstr Aesthet Surg. 2018 Nov 22. pii: S1748-6815(18)30424-8. doi: 10.1016/j.bjps.2018.11.013. [Epub ahead of print]

PMID:
30528285
19.

Association of Cerebrospinal Fluid Neurofilament Light Protein Levels With Cognition in Patients With Dementia, Motor Neuron Disease, and Movement Disorders.

Olsson B, Portelius E, Cullen NC, Sandelius Å, Zetterberg H, Andreasson U, Höglund K, Irwin DJ, Grossman M, Weintraub D, Chen-Plotkin A, Wolk D, McCluskey L, Elman L, Shaw LM, Toledo JB, McBride J, Hernandez-Con P, Lee VM, Trojanowski JQ, Blennow K.

JAMA Neurol. 2019 Mar 1;76(3):318-325. doi: 10.1001/jamaneurol.2018.3746.

20.

Reduction of matrix metalloproteinase 9 (MMP-9) protects motor neurons from TDP-43-triggered death in rNLS8 mice.

Spiller KJ, Khan T, Dominique MA, Restrepo CR, Cotton-Samuel D, Levitan M, Jafar-Nejad P, Zhang B, Soriano A, Rigo F, Trojanowski JQ, Lee VM.

Neurobiol Dis. 2019 Apr;124:133-140. doi: 10.1016/j.nbd.2018.11.013. Epub 2018 Nov 17.

PMID:
30458231
21.

Establishment of a murine culture system for modeling the temporal progression of cranial and trunk neural crest cell differentiation.

Replogle MR, Sreevidya VS, Lee VM, Laiosa MD, Svoboda KR, Udvadia AJ.

Dis Model Mech. 2018 Dec 12;11(12). pii: dmm035097. doi: 10.1242/dmm.035097.

22.

A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model.

Zhang B, Yao Y, Cornec AS, Oukoloff K, James MJ, Koivula P, Trojanowski JQ, Smith AB 3rd, Lee VM, Ballatore C, Brunden KR.

Mol Neurodegener. 2018 Nov 7;13(1):59. doi: 10.1186/s13024-018-0291-3.

23.

UNC13A polymorphism contributes to frontotemporal disease in sporadic amyotrophic lateral sclerosis.

Placek K, Baer GM, Elman L, McCluskey L, Hennessy L, Ferraro PM, Lee EB, Lee VMY, Trojanowski JQ, Van Deerlin VM, Grossman M, Irwin DJ, McMillan CT.

Neurobiol Aging. 2019 Jan;73:190-199. doi: 10.1016/j.neurobiolaging.2018.09.031. Epub 2018 Sep 27.

PMID:
30368160
24.

Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity.

Chung CY, Berson A, Kennerdell JR, Sartoris A, Unger T, Porta S, Kim HJ, Smith ER, Shilatifard A, Van Deerlin V, Lee VM, Chen-Plotkin A, Bonini NM.

Nat Commun. 2018 Oct 23;9(1):4406. doi: 10.1038/s41467-018-06543-0. Erratum in: Nat Commun. 2019 Jan 29;10(1):555.

25.

Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology.

Sandelius Å, Portelius E, Källén Å, Zetterberg H, Rot U, Olsson B, Toledo JB, Shaw LM, Lee VMY, Irwin DJ, Grossman M, Weintraub D, Chen-Plotkin A, Wolk DA, McCluskey L, Elman L, Kostanjevecki V, Vandijck M, McBride J, Trojanowski JQ, Blennow K.

Alzheimers Dement. 2019 Jan;15(1):55-64. doi: 10.1016/j.jalz.2018.08.006. Epub 2018 Oct 12.

26.

Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo.

Porta S, Xu Y, Restrepo CR, Kwong LK, Zhang B, Brown HJ, Lee EB, Trojanowski JQ, Lee VM.

Nat Commun. 2018 Oct 11;9(1):4220. doi: 10.1038/s41467-018-06548-9.

27.

Converging Patterns of α-Synuclein Pathology in Multiple System Atrophy.

Brettschneider J, Suh E, Robinson JL, Fang L, Lee EB, Irwin DJ, Grossman M, Van Deerlin VM, Lee VM, Trojanowski JQ.

J Neuropathol Exp Neurol. 2018 Nov 1;77(11):1005-1016. doi: 10.1093/jnen/nly080.

PMID:
30203094
28.

Mechanisms of Cell-to-Cell Transmission of Pathological Tau: A Review.

Gibbons GS, Lee VMY, Trojanowski JQ.

JAMA Neurol. 2019 Jan 1;76(1):101-108. doi: 10.1001/jamaneurol.2018.2505.

29.

The adult patient with headache.

Lee VME, Ang LL, Soon DTL, Ong JJY, Loh VWK.

Singapore Med J. 2018 Aug;59(8):399-406. doi: 10.11622/smedj.2018094.

30.

Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis.

McGurk L, Mojsilovic-Petrovic J, Van Deerlin VM, Shorter J, Kalb RG, Lee VM, Trojanowski JQ, Lee EB, Bonini NM.

Acta Neuropathol Commun. 2018 Aug 29;6(1):84. doi: 10.1186/s40478-018-0586-1.

31.

Cerebrospinal Fluid Total and Phosphorylated α-Synuclein in Patients with Creutzfeldt-Jakob Disease and Synucleinopathy.

Schmitz M, Villar-Piqué A, Llorens F, Gmitterová K, Hermann P, Varges D, Zafar S, Lingor P, Vanderstichele H, Demeyer L, Stoops E, Trojanowski JQ, Lee VM, Zerr I.

Mol Neurobiol. 2019 May;56(5):3476-3483. doi: 10.1007/s12035-018-1313-4. Epub 2018 Aug 22.

PMID:
30136097
32.

White Matter Status of Participants in Altitude Chamber Research and Training.

Connolly DM, Lee VM, Hodkinson PD.

Aerosp Med Hum Perform. 2018 Sep 1;89(9):777-786. doi: 10.3357/AMHP.5090.2018.

PMID:
30126509
33.

TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading.

Martini-Stoica H, Cole AL, Swartzlander DB, Chen F, Wan YW, Bajaj L, Bader DA, Lee VMY, Trojanowski JQ, Liu Z, Sardiello M, Zheng H.

J Exp Med. 2018 Sep 3;215(9):2355-2377. doi: 10.1084/jem.20172158. Epub 2018 Aug 14.

34.

Sex-specific genetic predictors of Alzheimer's disease biomarkers.

Deming Y, Dumitrescu L, Barnes LL, Thambisetty M, Kunkle B, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Huentelman M, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, Moghekar A, Del Aguila JL, Fernandez MV, Budde J, Hassenstab J, Fagan AM, Riemenschneider M, Petersen RC, Minthon L, Chao MJ, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Peskind ER, Li G, Davis LK, Sealock JM, Cox NJ; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Alzheimer Disease Genetics Consortium (ADGC), Goate AM, Bennett DA, Schneider JA, Jefferson AL, Cruchaga C, Hohman TJ.

Acta Neuropathol. 2018 Dec;136(6):857-872. doi: 10.1007/s00401-018-1881-4. Epub 2018 Jul 2.

PMID:
29967939
35.

Non-Alzheimer's contributions to dementia and cognitive resilience in The 90+ Study.

Robinson JL, Corrada MM, Kovacs GG, Dominique M, Caswell C, Xie SX, Lee VM, Kawas CH, Trojanowski JQ.

Acta Neuropathol. 2018 Sep;136(3):377-388. doi: 10.1007/s00401-018-1872-5. Epub 2018 Jun 18.

36.

Sequential stages and distribution patterns of aging-related tau astrogliopathy (ARTAG) in the human brain.

Kovacs GG, Xie SX, Robinson JL, Lee EB, Smith DH, Schuck T, Lee VM, Trojanowski JQ.

Acta Neuropathol Commun. 2018 Jun 11;6(1):50. doi: 10.1186/s40478-018-0552-y.

37.

Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated.

Robinson JL, Lee EB, Xie SX, Rennert L, Suh E, Bredenberg C, Caswell C, Van Deerlin VM, Yan N, Yousef A, Hurtig HI, Siderowf A, Grossman M, McMillan CT, Miller B, Duda JE, Irwin DJ, Wolk D, Elman L, McCluskey L, Chen-Plotkin A, Weintraub D, Arnold SE, Brettschneider J, Lee VM, Trojanowski JQ.

Brain. 2018 Jul 1;141(7):2181-2193. doi: 10.1093/brain/awy146.

38.

LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons.

Henderson MX, Peng C, Trojanowski JQ, Lee VMY.

Acta Neuropathol Commun. 2018 May 31;6(1):45. doi: 10.1186/s40478-018-0550-0.

39.

Design, synthesis and evaluation of photoactivatable derivatives of microtubule (MT)-active [1,2,4]triazolo[1,5-a]pyrimidines.

Oukoloff K, Kovalevich J, Cornec AS, Yao Y, Owyang ZA, James M, Trojanowski JQ, Lee VM, Smith AB 3rd, Brunden KR, Ballatore C.

Bioorg Med Chem Lett. 2018 Jul 1;28(12):2180-2183. doi: 10.1016/j.bmcl.2018.05.010. Epub 2018 May 5.

40.

Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies.

Peng C, Gathagan RJ, Covell DJ, Medellin C, Stieber A, Robinson JL, Zhang B, Pitkin RM, Olufemi MF, Luk KC, Trojanowski JQ, Lee VM.

Nature. 2018 May;557(7706):558-563. doi: 10.1038/s41586-018-0104-4. Epub 2018 May 9.

41.

Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology.

Portelius E, Olsson B, Höglund K, Cullen NC, Kvartsberg H, Andreasson U, Zetterberg H, Sandelius Å, Shaw LM, Lee VMY, Irwin DJ, Grossman M, Weintraub D, Chen-Plotkin A, Wolk DA, McCluskey L, Elman L, McBride J, Toledo JB, Trojanowski JQ, Blennow K.

Acta Neuropathol. 2018 Sep;136(3):363-376. doi: 10.1007/s00401-018-1851-x. Epub 2018 Apr 26.

42.

Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity.

Luna E, Decker SC, Riddle DM, Caputo A, Zhang B, Cole T, Caswell C, Xie SX, Lee VMY, Luk KC.

Acta Neuropathol. 2018 Jun;135(6):855-875. doi: 10.1007/s00401-018-1829-8. Epub 2018 Mar 3.

43.

Measurements of auto-antibodies to α-synuclein in the serum and cerebral spinal fluids of patients with Parkinson's disease.

Akhtar RS, Licata JP, Luk KC, Shaw LM, Trojanowski JQ, Lee VM.

J Neurochem. 2018 Jun;145(6):489-503. doi: 10.1111/jnc.14330. Epub 2018 Jun 10.

44.

Activation of RhoA, Smad2, c-Src, PKC-βII/δ and JNK in atopic dermatitis.

Lu J, Yin R, Fu Z, Lee VM, Nelson JS, Tan W.

Australas J Dermatol. 2018 Nov;59(4):e258-e261. doi: 10.1111/ajd.12801. Epub 2018 Mar 2.

PMID:
29498756
45.

Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy.

Spiller KJ, Restrepo CR, Khan T, Dominique MA, Fang TC, Canter RG, Roberts CJ, Miller KR, Ransohoff RM, Trojanowski JQ, Lee VM.

Nat Neurosci. 2018 Mar;21(3):329-340. doi: 10.1038/s41593-018-0083-7. Epub 2018 Feb 20.

46.

Screen for Slit/Robo signaling in trunk neural cells reveals new players.

Martinez D, Zuhdi N, Reyes M, Ortega B, Giovannone D, Lee VM, de Bellard ME.

Gene Expr Patterns. 2018 Jun;28:22-33. doi: 10.1016/j.gep.2018.01.002. Epub 2018 Feb 7.

47.

Detection of Alzheimer Disease (AD)-Specific Tau Pathology in AD and NonAD Tauopathies by Immunohistochemistry With Novel Conformation-Selective Tau Antibodies.

Gibbons GS, Banks RA, Kim B, Changolkar L, Riddle DM, Leight SN, Irwin DJ, Trojanowski JQ, Lee VMY.

J Neuropathol Exp Neurol. 2018 Mar 1;77(3):216-228. doi: 10.1093/jnen/nly010.

48.

Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson's Disease in Rodents.

Polinski NK, Volpicelli-Daley LA, Sortwell CE, Luk KC, Cremades N, Gottler LM, Froula J, Duffy MF, Lee VMY, Martinez TN, Dave KD.

J Parkinsons Dis. 2018;8(2):303-322. doi: 10.3233/JPD-171248.

49.

Asymmetry of post-mortem neuropathology in behavioural-variant frontotemporal dementia.

Irwin DJ, McMillan CT, Xie SX, Rascovsky K, Van Deerlin VM, Coslett HB, Hamilton R, Aguirre GK, Lee EB, Lee VMY, Trojanowski JQ, Grossman M.

Brain. 2018 Jan 1;141(1):288-301. doi: 10.1093/brain/awx319.

50.

Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term.

Rey NL, George S, Steiner JA, Madaj Z, Luk KC, Trojanowski JQ, Lee VM, Brundin P.

Acta Neuropathol. 2018 Jan;135(1):65-83. doi: 10.1007/s00401-017-1792-9. Epub 2017 Dec 5.

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