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Items: 1 to 50 of 851

1.

TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading.

Martini-Stoica H, Cole AL, Swartzlander DB, Chen F, Wan YW, Bajaj L, Bader DA, Lee VMY, Trojanowski JQ, Liu Z, Sardiello M, Zheng H.

J Exp Med. 2018 Aug 14. pii: jem.20172158. doi: 10.1084/jem.20172158. [Epub ahead of print]

PMID:
30108137
2.

Sex-specific genetic predictors of Alzheimer's disease biomarkers.

Deming Y, Dumitrescu L, Barnes LL, Thambisetty M, Kunkle B, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Huentelman M, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, Moghekar A, Del Aguila JL, Fernandez MV, Budde J, Hassenstab J, Fagan AM, Riemenschneider M, Petersen RC, Minthon L, Chao MJ, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Peskind ER, Li G, Davis LK, Sealock JM, Cox NJ; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Alzheimer Disease Genetics Consortium (ADGC), Goate AM, Bennett DA, Schneider JA, Jefferson AL, Cruchaga C, Hohman TJ.

Acta Neuropathol. 2018 Jul 2. doi: 10.1007/s00401-018-1881-4. [Epub ahead of print]

PMID:
29967939
3.

Non-Alzheimer's contributions to dementia and cognitive resilience in The 90+ Study.

Robinson JL, Corrada MM, Kovacs GG, Dominique M, Caswell C, Xie SX, Lee VM, Kawas CH, Trojanowski JQ.

Acta Neuropathol. 2018 Jun 18. doi: 10.1007/s00401-018-1872-5. [Epub ahead of print]

PMID:
29916037
4.

Sequential stages and distribution patterns of aging-related tau astrogliopathy (ARTAG) in the human brain.

Kovacs GG, Xie SX, Robinson JL, Lee EB, Smith DH, Schuck T, Lee VM, Trojanowski JQ.

Acta Neuropathol Commun. 2018 Jun 11;6(1):50. doi: 10.1186/s40478-018-0552-y.

5.

Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated.

Robinson JL, Lee EB, Xie SX, Rennert L, Suh E, Bredenberg C, Caswell C, Van Deerlin VM, Yan N, Yousef A, Hurtig HI, Siderowf A, Grossman M, McMillan CT, Miller B, Duda JE, Irwin DJ, Wolk D, Elman L, McCluskey L, Chen-Plotkin A, Weintraub D, Arnold SE, Brettschneider J, Lee VM, Trojanowski JQ.

Brain. 2018 Jul 1;141(7):2181-2193. doi: 10.1093/brain/awy146.

PMID:
29878075
6.

LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons.

Henderson MX, Peng C, Trojanowski JQ, Lee VMY.

Acta Neuropathol Commun. 2018 May 31;6(1):45. doi: 10.1186/s40478-018-0550-0.

7.

Design, synthesis and evaluation of photoactivatable derivatives of microtubule (MT)-active [1,2,4]triazolo[1,5-a]pyrimidines.

Oukoloff K, Kovalevich J, Cornec AS, Yao Y, Owyang ZA, James M, Trojanowski JQ, Lee VM, Smith AB 3rd, Brunden KR, Ballatore C.

Bioorg Med Chem Lett. 2018 Jul 1;28(12):2180-2183. doi: 10.1016/j.bmcl.2018.05.010. Epub 2018 May 5.

PMID:
29764743
8.

Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies.

Peng C, Gathagan RJ, Covell DJ, Medellin C, Stieber A, Robinson JL, Zhang B, Pitkin RM, Olufemi MF, Luk KC, Trojanowski JQ, Lee VM.

Nature. 2018 May;557(7706):558-563. doi: 10.1038/s41586-018-0104-4. Epub 2018 May 9.

PMID:
29743672
9.

Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology.

Portelius E, Olsson B, Höglund K, Cullen NC, Kvartsberg H, Andreasson U, Zetterberg H, Sandelius Å, Shaw LM, Lee VMY, Irwin DJ, Grossman M, Weintraub D, Chen-Plotkin A, Wolk DA, McCluskey L, Elman L, McBride J, Toledo JB, Trojanowski JQ, Blennow K.

Acta Neuropathol. 2018 Apr 26. doi: 10.1007/s00401-018-1851-x. [Epub ahead of print]

PMID:
29700597
10.

Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity.

Luna E, Decker SC, Riddle DM, Caputo A, Zhang B, Cole T, Caswell C, Xie SX, Lee VMY, Luk KC.

Acta Neuropathol. 2018 Jun;135(6):855-875. doi: 10.1007/s00401-018-1829-8. Epub 2018 Mar 3.

PMID:
29502200
11.

Measurements of auto-antibodies to α-synuclein in the serum and cerebral spinal fluids of patients with Parkinson's disease.

Akhtar RS, Licata JP, Luk KC, Shaw LM, Trojanowski JQ, Lee VM.

J Neurochem. 2018 Jun;145(6):489-503. doi: 10.1111/jnc.14330. Epub 2018 Jun 10.

PMID:
29500813
12.

Activation of RhoA, Smad2, c-Src, PKC-βII/δ and JNK in atopic dermatitis.

Lu J, Yin R, Fu Z, Lee VM, Nelson JS, Tan W.

Australas J Dermatol. 2018 Mar 2. doi: 10.1111/ajd.12801. [Epub ahead of print]

PMID:
29498756
13.

Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy.

Spiller KJ, Restrepo CR, Khan T, Dominique MA, Fang TC, Canter RG, Roberts CJ, Miller KR, Ransohoff RM, Trojanowski JQ, Lee VM.

Nat Neurosci. 2018 Mar;21(3):329-340. doi: 10.1038/s41593-018-0083-7. Epub 2018 Feb 20.

PMID:
29463850
14.

Screen for Slit/Robo signaling in trunk neural cells reveals new players.

Martinez D, Zuhdi N, Reyes M, Ortega B, Giovannone D, Lee VM, de Bellard ME.

Gene Expr Patterns. 2018 Jun;28:22-33. doi: 10.1016/j.gep.2018.01.002. Epub 2018 Feb 7.

15.

Detection of Alzheimer Disease (AD)-Specific Tau Pathology in AD and NonAD Tauopathies by Immunohistochemistry With Novel Conformation-Selective Tau Antibodies.

Gibbons GS, Banks RA, Kim B, Changolkar L, Riddle DM, Leight SN, Irwin DJ, Trojanowski JQ, Lee VMY.

J Neuropathol Exp Neurol. 2018 Mar 1;77(3):216-228. doi: 10.1093/jnen/nly010.

PMID:
29415231
16.

Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson's Disease in Rodents.

Polinski NK, Volpicelli-Daley LA, Sortwell CE, Luk KC, Cremades N, Gottler LM, Froula J, Duffy MF, Lee VMY, Martinez TN, Dave KD.

J Parkinsons Dis. 2018;8(2):303-322. doi: 10.3233/JPD-171248.

17.

Asymmetry of post-mortem neuropathology in behavioural-variant frontotemporal dementia.

Irwin DJ, McMillan CT, Xie SX, Rascovsky K, Van Deerlin VM, Coslett HB, Hamilton R, Aguirre GK, Lee EB, Lee VMY, Trojanowski JQ, Grossman M.

Brain. 2018 Jan 1;141(1):288-301. doi: 10.1093/brain/awx319.

PMID:
29228211
18.

Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term.

Rey NL, George S, Steiner JA, Madaj Z, Luk KC, Trojanowski JQ, Lee VM, Brundin P.

Acta Neuropathol. 2018 Jan;135(1):65-83. doi: 10.1007/s00401-017-1792-9. Epub 2017 Dec 5.

19.

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation.

He Z, Guo JL, McBride JD, Narasimhan S, Kim H, Changolkar L, Zhang B, Gathagan RJ, Yue C, Dengler C, Stieber A, Nitla M, Coulter DA, Abel T, Brunden KR, Trojanowski JQ, Lee VM.

Nat Med. 2018 Jan;24(1):29-38. doi: 10.1038/nm.4443. Epub 2017 Dec 4.

PMID:
29200205
20.

TDP-43 Promotes Neurodegeneration by Impairing Chromatin Remodeling.

Berson A, Sartoris A, Nativio R, Van Deerlin V, Toledo JB, Porta S, Liu S, Chung CY, Garcia BA, Lee VM, Trojanowski JQ, Johnson FB, Berger SL, Bonini NM.

Curr Biol. 2017 Dec 4;27(23):3579-3590.e6. doi: 10.1016/j.cub.2017.10.024. Epub 2017 Nov 16.

PMID:
29153328
21.

Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain.

Narasimhan S, Guo JL, Changolkar L, Stieber A, McBride JD, Silva LV, He Z, Zhang B, Gathagan RJ, Trojanowski JQ, Lee VMY.

J Neurosci. 2017 Nov 22;37(47):11406-11423. doi: 10.1523/JNEUROSCI.1230-17.2017. Epub 2017 Oct 20.

22.

GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils.

Gibbons GS, Banks RA, Kim B, Xu H, Changolkar L, Leight SN, Riddle DM, Li C, Gathagan RJ, Brown HJ, Zhang B, Trojanowski JQ, Lee VM.

J Neurosci. 2017 Nov 22;37(47):11485-11494. doi: 10.1523/JNEUROSCI.2393-17.2017. Epub 2017 Oct 6.

23.

Protein arginylation targets alpha synuclein, facilitates normal brain health, and prevents neurodegeneration.

Wang J, Han X, Leu NA, Sterling S, Kurosaka S, Fina M, Lee VM, Dong DW, Yates JR 3rd, Kashina A.

Sci Rep. 2017 Sep 12;7(1):11323. doi: 10.1038/s41598-017-11713-z.

24.

Modeling Parkinson's disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain.

Thakur P, Breger LS, Lundblad M, Wan OW, Mattsson B, Luk KC, Lee VMY, Trojanowski JQ, Björklund A.

Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):E8284-E8293. doi: 10.1073/pnas.1710442114. Epub 2017 Sep 12.

25.

The use of mouse models to study cell-to-cell transmission of pathological tau.

Narasimhan S, Lee VMY.

Methods Cell Biol. 2017;141:287-305. doi: 10.1016/bs.mcb.2017.06.009. Epub 2017 Jul 14.

26.

Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration.

Yousef A, Robinson JL, Irwin DJ, Byrne MD, Kwong LK, Lee EB, Xu Y, Xie SX, Rennert L, Suh E, Van Deerlin VM, Grossman M, Lee VM, Trojanowski JQ.

Acta Neuropathol Commun. 2017 Sep 6;5(1):68. doi: 10.1186/s40478-017-0471-3.

27.

Evaluation of Oxetan-3-ol, Thietan-3-ol, and Derivatives Thereof as Bioisosteres of the Carboxylic Acid Functional Group.

Lassalas P, Oukoloff K, Makani V, James M, Tran V, Yao Y, Huang L, Vijayendran K, Monti L, Trojanowski JQ, Lee VM, Kozlowski MC, Smith AB 3rd, Brunden KR, Ballatore C.

ACS Med Chem Lett. 2017 Jul 5;8(8):864-868. doi: 10.1021/acsmedchemlett.7b00212. eCollection 2017 Aug 10.

28.

Protein astrogliopathies in human neurodegenerative diseases and aging.

Kovacs GG, Lee VM, Trojanowski JQ.

Brain Pathol. 2017 Sep;27(5):675-690. doi: 10.1111/bpa.12536.

PMID:
28805003
29.

Connexin-43 and aquaporin-4 are markers of ageing-related tau astrogliopathy (ARTAG)-related astroglial response.

Kovacs GG, Yousef A, Kaindl S, Lee VM, Trojanowski JQ.

Neuropathol Appl Neurobiol. 2017 Jul 29. doi: 10.1111/nan.12427. [Epub ahead of print]

PMID:
28755467
30.

Distinct α-Synuclein strains and implications for heterogeneity among α-Synucleinopathies.

Peng C, Gathagan RJ, Lee VM.

Neurobiol Dis. 2018 Jan;109(Pt B):209-218. doi: 10.1016/j.nbd.2017.07.018. Epub 2017 Jul 24. Review.

PMID:
28751258
31.

TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss.

Paolicelli RC, Jawaid A, Henstridge CM, Valeri A, Merlini M, Robinson JL, Lee EB, Rose J, Appel S, Lee VM, Trojanowski JQ, Spires-Jones T, Schulz PE, Rajendran L.

Neuron. 2017 Jul 19;95(2):297-308.e6. doi: 10.1016/j.neuron.2017.05.037. Epub 2017 Jun 29.

32.

Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies.

Karpowicz RJ Jr, Haney CM, Mihaila TS, Sandler RM, Petersson EJ, Lee VM.

J Biol Chem. 2017 Aug 11;292(32):13482-13497. doi: 10.1074/jbc.M117.780296. Epub 2017 Jun 13.

33.

Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium.

McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor JP, Weintraub D, Aarsland D, Galvin J, Attems J, Ballard CG, Bayston A, Beach TG, Blanc F, Bohnen N, Bonanni L, Bras J, Brundin P, Burn D, Chen-Plotkin A, Duda JE, El-Agnaf O, Feldman H, Ferman TJ, Ffytche D, Fujishiro H, Galasko D, Goldman JG, Gomperts SN, Graff-Radford NR, Honig LS, Iranzo A, Kantarci K, Kaufer D, Kukull W, Lee VMY, Leverenz JB, Lewis S, Lippa C, Lunde A, Masellis M, Masliah E, McLean P, Mollenhauer B, Montine TJ, Moreno E, Mori E, Murray M, O'Brien JT, Orimo S, Postuma RB, Ramaswamy S, Ross OA, Salmon DP, Singleton A, Taylor A, Thomas A, Tiraboschi P, Toledo JB, Trojanowski JQ, Tsuang D, Walker Z, Yamada M, Kosaka K.

Neurology. 2017 Jul 4;89(1):88-100. doi: 10.1212/WNL.0000000000004058. Epub 2017 Jun 7. Review.

34.

Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production.

Tapias V, Hu X, Luk KC, Sanders LH, Lee VM, Greenamyre JT.

Cell Mol Life Sci. 2017 Aug;74(15):2851-2874. doi: 10.1007/s00018-017-2541-x. Epub 2017 May 22.

35.

Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer's and Other Neurodegenerative Diseases.

Cornec AS, Monti L, Kovalevich J, Makani V, James MJ, Vijayendran KG, Oukoloff K, Yao Y, Lee VM, Trojanowski JQ, Smith AB 3rd, Brunden KR, Ballatore C.

J Med Chem. 2017 Jun 22;60(12):5120-5145. doi: 10.1021/acs.jmedchem.7b00475. Epub 2017 Jun 8.

36.

Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies.

Henderson MX, Chung CH, Riddle DM, Zhang B, Gathagan RJ, Seeholzer SH, Trojanowski JQ, Lee VMY.

J Neurosci. 2017 Jun 14;37(24):5870-5884. doi: 10.1523/JNEUROSCI.2705-16.2017. Epub 2017 May 18.

37.

Novel conformation-selective alpha-synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson's disease.

Covell DJ, Robinson JL, Akhtar RS, Grossman M, Weintraub D, Bucklin HM, Pitkin RM, Riddle D, Yousef A, Trojanowski JQ, Lee VM.

Neuropathol Appl Neurobiol. 2017 Dec;43(7):604-620. doi: 10.1111/nan.12402. Epub 2017 May 15.

PMID:
28386933
38.

Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases.

Kovacs GG, Robinson JL, Xie SX, Lee EB, Grossman M, Wolk DA, Irwin DJ, Weintraub D, Kim CF, Schuck T, Yousef A, Wagner ST, Suh E, Van Deerlin VM, Lee VM, Trojanowski JQ.

J Neuropathol Exp Neurol. 2017 Apr 1;76(4):270-288. doi: 10.1093/jnen/nlx007.

PMID:
28340083
39.

Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers.

Deming Y, Li Z, Kapoor M, Harari O, Del-Aguila JL, Black K, Carrell D, Cai Y, Fernandez MV, Budde J, Ma S, Saef B, Howells B, Huang KL, Bertelsen S, Fagan AM, Holtzman DM, Morris JC, Kim S, Saykin AJ, De Jager PL, Albert M, Moghekar A, O'Brien R, Riemenschneider M, Petersen RC, Blennow K, Zetterberg H, Minthon L, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Schellenberg G, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Peskind ER, Li G, Di Narzo AF; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Alzheimer Disease Genetic Consortium (ADGC), Kauwe JS, Goate AM, Cruchaga C.

Acta Neuropathol. 2017 May;133(5):839-856. doi: 10.1007/s00401-017-1685-y. Epub 2017 Feb 28.

40.

Expansion of the classification of FTLD-TDP: distinct pathology associated with rapidly progressive frontotemporal degeneration.

Lee EB, Porta S, Michael Baer G, Xu Y, Suh E, Kwong LK, Elman L, Grossman M, Lee VM, Irwin DJ, Van Deerlin VM, Trojanowski JQ.

Acta Neuropathol. 2017 Jul;134(1):65-78. doi: 10.1007/s00401-017-1679-9. Epub 2017 Jan 27.

41.

Non-Naturally Occurring Small Molecule Microtubule-Stabilizing Agents: A Potential Tactic for CNS-Directed Therapies.

Ballatore C, Brunden KR, Trojanowski JQ, Lee VM, Smith AB 3rd.

ACS Chem Neurosci. 2017 Jan 18;8(1):5-7. doi: 10.1021/acschemneuro.6b00384. Epub 2016 Nov 29. Review.

42.

Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies.

Ono M, Sahara N, Kumata K, Ji B, Ni R, Koga S, Dickson DW, Trojanowski JQ, Lee VM, Yoshida M, Hozumi I, Yoshiyama Y, van Swieten JC, Nordberg A, Suhara T, Zhang MR, Higuchi M.

Brain. 2017 Mar 1;140(3):764-780. doi: 10.1093/brain/aww339.

43.

Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases.

Kovacs GG, Kwong LK, Grossman M, Irwin DJ, Lee EB, Robinson JL, Suh E, Van Deerlin VM, Lee VM, Trojanowski JQ.

Brain Pathol. 2018 Mar;28(2):274-283. doi: 10.1111/bpa.12482. Epub 2017 Jan 19.

PMID:
28019685
44.

Altered microtubule dynamics in neurodegenerative disease: Therapeutic potential of microtubule-stabilizing drugs.

Brunden KR, Lee VM, Smith AB 3rd, Trojanowski JQ, Ballatore C.

Neurobiol Dis. 2017 Sep;105:328-335. doi: 10.1016/j.nbd.2016.12.021. Epub 2016 Dec 22. Review.

PMID:
28012891
45.

Conserved Lysine Acetylation within the Microtubule-Binding Domain Regulates MAP2/Tau Family Members.

Hwang AW, Trzeciakiewicz H, Friedmann D, Yuan CX, Marmorstein R, Lee VM, Cohen TJ.

PLoS One. 2016 Dec 21;11(12):e0168913. doi: 10.1371/journal.pone.0168913. eCollection 2016.

46.

Longitudinal imaging reveals subhippocampal dynamics in glutamate levels associated with histopathologic events in a mouse model of tauopathy and healthy mice.

Crescenzi R, DeBrosse C, Nanga RP, Byrne MD, Krishnamoorthy G, D'Aquilla K, Nath H, Morales KH, Iba M, Hariharan H, Lee VM, Detre JA, Reddy R.

Hippocampus. 2017 Mar;27(3):285-302. doi: 10.1002/hipo.22693. Epub 2017 Feb 3.

47.

Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism.

Chapuis J, Flaig A, Grenier-Boley B, Eysert F, Pottiez V, Deloison G, Vandeputte A, Ayral AM, Mendes T, Desai S, Goate AM, Kauwe JSK, Leroux F, Herledan A, Demiautte F, Bauer C, Checler F, Petersen RC, Blennow K, Zetterberg H, Minthon L, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Albert M, Moghekar A, O'Brien R, Peskind ER, Malmanche N, Schellenberg GD, Dourlen P, Song OR, Cruchaga C, Amouyel P, Deprez B, Brodin P, Lambert JC; ADGC, Alzheimer’s Disease Neuroimaging Initiative.

Acta Neuropathol. 2017 Jun;133(6):955-966. doi: 10.1007/s00401-016-1652-z. Epub 2016 Dec 8.

48.

Multimodal evaluation demonstrates in vivo 18F-AV-1451 uptake in autopsy-confirmed corticobasal degeneration.

McMillan CT, Irwin DJ, Nasrallah I, Phillips JS, Spindler M, Rascovsky K, Ternes K, Jester C, Wolk DA, Kwong LK, Lee VM, Lee EB, Trojanowski JQ, Grossman M.

Acta Neuropathol. 2016 Dec;132(6):935-937. Epub 2016 Nov 4. No abstract available.

49.

Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice.

Guo JL, Narasimhan S, Changolkar L, He Z, Stieber A, Zhang B, Gathagan RJ, Iba M, McBride JD, Trojanowski JQ, Lee VM.

J Exp Med. 2016 Nov 14;213(12):2635-2654. Epub 2016 Oct 17.

50.

Cognitive reserve in frontotemporal degeneration: Neuroanatomic and neuropsychological evidence.

Placek K, Massimo L, Olm C, Ternes K, Firn K, Van Deerlin V, Lee EB, Trojanowski JQ, Lee VM, Irwin D, Grossman M, McMillan CT.

Neurology. 2016 Oct 25;87(17):1813-1819. Epub 2016 Sep 28.

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