Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 864

1.

Establishment of a murine culture system for modeling the temporal progression of cranial and trunk neural crest cell differentiation.

Replogle MR, Sreevidya VS, Lee VM, Laiosa MD, Svoboda KR, Udvadia AJ.

Dis Model Mech. 2018 Nov 8. pii: dmm.035097. doi: 10.1242/dmm.035097. [Epub ahead of print]

2.

A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model.

Zhang B, Yao Y, Cornec AS, Oukoloff K, James MJ, Koivula P, Trojanowski JQ, Smith AB 3rd, Lee VM, Ballatore C, Brunden KR.

Mol Neurodegener. 2018 Nov 7;13(1):59. doi: 10.1186/s13024-018-0291-3.

3.

UNC13A polymorphism contributes to frontotemporal disease in sporadic amyotrophic lateral sclerosis.

Placek K, Baer GM, Elman L, McCluskey L, Hennessy L, Ferraro PM, Lee EB, Lee VMY, Trojanowski JQ, Van Deerlin VM, Grossman M, Irwin DJ, McMillan CT.

Neurobiol Aging. 2018 Sep 27;73:190-199. doi: 10.1016/j.neurobiolaging.2018.09.031. [Epub ahead of print]

PMID:
30368160
4.

Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity.

Chung CY, Berson A, Kennerdell JR, Sartoris A, Unger T, Porta S, Kim HJ, Smith ER, Shilatifard A, Van Deerlin V, Lee VM, Chen-Plotkin A, Bonini NM.

Nat Commun. 2018 Oct 23;9(1):4406. doi: 10.1038/s41467-018-06543-0.

5.

Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology.

Sandelius Å, Portelius E, Källén Å, Zetterberg H, Rot U, Olsson B, Toledo JB, Shaw LM, Lee VMY, Irwin DJ, Grossman M, Weintraub D, Chen-Plotkin A, Wolk DA, McCluskey L, Elman L, Kostanjevecki V, Vandijck M, McBride J, Trojanowski JQ, Blennow K.

Alzheimers Dement. 2018 Oct 12. pii: S1552-5260(18)33515-5. doi: 10.1016/j.jalz.2018.08.006. [Epub ahead of print]

6.

Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo.

Porta S, Xu Y, Restrepo CR, Kwong LK, Zhang B, Brown HJ, Lee EB, Trojanowski JQ, Lee VM.

Nat Commun. 2018 Oct 11;9(1):4220. doi: 10.1038/s41467-018-06548-9.

7.

Converging Patterns of α-Synuclein Pathology in Multiple System Atrophy.

Brettschneider J, Suh E, Robinson JL, Fang L, Lee EB, Irwin DJ, Grossman M, Van Deerlin VM, Lee VM, Trojanowski JQ.

J Neuropathol Exp Neurol. 2018 Nov 1;77(11):1005-1016. doi: 10.1093/jnen/nly080.

PMID:
30203094
8.

Mechanisms of Cell-to-Cell Transmission of Pathological Tau: A Review.

Gibbons GS, Lee VMY, Trojanowski JQ.

JAMA Neurol. 2018 Sep 4. doi: 10.1001/jamaneurol.2018.2505. [Epub ahead of print]

PMID:
30193298
9.

The adult patient with headache.

Lee VME, Ang LL, Soon DTL, Ong JJY, Loh VWK.

Singapore Med J. 2018 Aug;59(8):399-406. doi: 10.11622/smedj.2018094.

10.

Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis.

McGurk L, Mojsilovic-Petrovic J, Van Deerlin VM, Shorter J, Kalb RG, Lee VM, Trojanowski JQ, Lee EB, Bonini NM.

Acta Neuropathol Commun. 2018 Aug 29;6(1):84. doi: 10.1186/s40478-018-0586-1.

11.

Cerebrospinal Fluid Total and Phosphorylated α-Synuclein in Patients with Creutzfeldt-Jakob Disease and Synucleinopathy.

Schmitz M, Villar-Piqué A, Llorens F, Gmitterová K, Hermann P, Varges D, Zafar S, Lingor P, Vanderstichele H, Demeyer L, Stoops E, Trojanowski JQ, Lee VM, Zerr I.

Mol Neurobiol. 2018 Aug 22. doi: 10.1007/s12035-018-1313-4. [Epub ahead of print]

PMID:
30136097
12.

White Matter Status of Participants in Altitude Chamber Research and Training.

Connolly DM, Lee VM, Hodkinson PD.

Aerosp Med Hum Perform. 2018 Sep 1;89(9):777-786. doi: 10.3357/AMHP.5090.2018.

PMID:
30126509
13.

TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading.

Martini-Stoica H, Cole AL, Swartzlander DB, Chen F, Wan YW, Bajaj L, Bader DA, Lee VMY, Trojanowski JQ, Liu Z, Sardiello M, Zheng H.

J Exp Med. 2018 Sep 3;215(9):2355-2377. doi: 10.1084/jem.20172158. Epub 2018 Aug 14.

PMID:
30108137
14.

Sex-specific genetic predictors of Alzheimer's disease biomarkers.

Deming Y, Dumitrescu L, Barnes LL, Thambisetty M, Kunkle B, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Huentelman M, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, Moghekar A, Del Aguila JL, Fernandez MV, Budde J, Hassenstab J, Fagan AM, Riemenschneider M, Petersen RC, Minthon L, Chao MJ, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Peskind ER, Li G, Davis LK, Sealock JM, Cox NJ; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Alzheimer Disease Genetics Consortium (ADGC), Goate AM, Bennett DA, Schneider JA, Jefferson AL, Cruchaga C, Hohman TJ.

Acta Neuropathol. 2018 Jul 2. doi: 10.1007/s00401-018-1881-4. [Epub ahead of print]

PMID:
29967939
15.

Non-Alzheimer's contributions to dementia and cognitive resilience in The 90+ Study.

Robinson JL, Corrada MM, Kovacs GG, Dominique M, Caswell C, Xie SX, Lee VM, Kawas CH, Trojanowski JQ.

Acta Neuropathol. 2018 Jun 18. doi: 10.1007/s00401-018-1872-5. [Epub ahead of print]

PMID:
29916037
16.

Sequential stages and distribution patterns of aging-related tau astrogliopathy (ARTAG) in the human brain.

Kovacs GG, Xie SX, Robinson JL, Lee EB, Smith DH, Schuck T, Lee VM, Trojanowski JQ.

Acta Neuropathol Commun. 2018 Jun 11;6(1):50. doi: 10.1186/s40478-018-0552-y.

17.

Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated.

Robinson JL, Lee EB, Xie SX, Rennert L, Suh E, Bredenberg C, Caswell C, Van Deerlin VM, Yan N, Yousef A, Hurtig HI, Siderowf A, Grossman M, McMillan CT, Miller B, Duda JE, Irwin DJ, Wolk D, Elman L, McCluskey L, Chen-Plotkin A, Weintraub D, Arnold SE, Brettschneider J, Lee VM, Trojanowski JQ.

Brain. 2018 Jul 1;141(7):2181-2193. doi: 10.1093/brain/awy146.

PMID:
29878075
18.

LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons.

Henderson MX, Peng C, Trojanowski JQ, Lee VMY.

Acta Neuropathol Commun. 2018 May 31;6(1):45. doi: 10.1186/s40478-018-0550-0.

19.

Design, synthesis and evaluation of photoactivatable derivatives of microtubule (MT)-active [1,2,4]triazolo[1,5-a]pyrimidines.

Oukoloff K, Kovalevich J, Cornec AS, Yao Y, Owyang ZA, James M, Trojanowski JQ, Lee VM, Smith AB 3rd, Brunden KR, Ballatore C.

Bioorg Med Chem Lett. 2018 Jul 1;28(12):2180-2183. doi: 10.1016/j.bmcl.2018.05.010. Epub 2018 May 5.

PMID:
29764743
20.

Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies.

Peng C, Gathagan RJ, Covell DJ, Medellin C, Stieber A, Robinson JL, Zhang B, Pitkin RM, Olufemi MF, Luk KC, Trojanowski JQ, Lee VM.

Nature. 2018 May;557(7706):558-563. doi: 10.1038/s41586-018-0104-4. Epub 2018 May 9.

21.

Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology.

Portelius E, Olsson B, Höglund K, Cullen NC, Kvartsberg H, Andreasson U, Zetterberg H, Sandelius Å, Shaw LM, Lee VMY, Irwin DJ, Grossman M, Weintraub D, Chen-Plotkin A, Wolk DA, McCluskey L, Elman L, McBride J, Toledo JB, Trojanowski JQ, Blennow K.

Acta Neuropathol. 2018 Sep;136(3):363-376. doi: 10.1007/s00401-018-1851-x. Epub 2018 Apr 26.

22.

Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity.

Luna E, Decker SC, Riddle DM, Caputo A, Zhang B, Cole T, Caswell C, Xie SX, Lee VMY, Luk KC.

Acta Neuropathol. 2018 Jun;135(6):855-875. doi: 10.1007/s00401-018-1829-8. Epub 2018 Mar 3.

PMID:
29502200
23.

Measurements of auto-antibodies to α-synuclein in the serum and cerebral spinal fluids of patients with Parkinson's disease.

Akhtar RS, Licata JP, Luk KC, Shaw LM, Trojanowski JQ, Lee VM.

J Neurochem. 2018 Jun;145(6):489-503. doi: 10.1111/jnc.14330. Epub 2018 Jun 10.

PMID:
29500813
24.

Activation of RhoA, Smad2, c-Src, PKC-βII/δ and JNK in atopic dermatitis.

Lu J, Yin R, Fu Z, Lee VM, Nelson JS, Tan W.

Australas J Dermatol. 2018 Nov;59(4):e258-e261. doi: 10.1111/ajd.12801. Epub 2018 Mar 2.

PMID:
29498756
25.

Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy.

Spiller KJ, Restrepo CR, Khan T, Dominique MA, Fang TC, Canter RG, Roberts CJ, Miller KR, Ransohoff RM, Trojanowski JQ, Lee VM.

Nat Neurosci. 2018 Mar;21(3):329-340. doi: 10.1038/s41593-018-0083-7. Epub 2018 Feb 20.

26.

Screen for Slit/Robo signaling in trunk neural cells reveals new players.

Martinez D, Zuhdi N, Reyes M, Ortega B, Giovannone D, Lee VM, de Bellard ME.

Gene Expr Patterns. 2018 Jun;28:22-33. doi: 10.1016/j.gep.2018.01.002. Epub 2018 Feb 7.

27.

Detection of Alzheimer Disease (AD)-Specific Tau Pathology in AD and NonAD Tauopathies by Immunohistochemistry With Novel Conformation-Selective Tau Antibodies.

Gibbons GS, Banks RA, Kim B, Changolkar L, Riddle DM, Leight SN, Irwin DJ, Trojanowski JQ, Lee VMY.

J Neuropathol Exp Neurol. 2018 Mar 1;77(3):216-228. doi: 10.1093/jnen/nly010.

PMID:
29415231
28.

Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson's Disease in Rodents.

Polinski NK, Volpicelli-Daley LA, Sortwell CE, Luk KC, Cremades N, Gottler LM, Froula J, Duffy MF, Lee VMY, Martinez TN, Dave KD.

J Parkinsons Dis. 2018;8(2):303-322. doi: 10.3233/JPD-171248.

29.

Asymmetry of post-mortem neuropathology in behavioural-variant frontotemporal dementia.

Irwin DJ, McMillan CT, Xie SX, Rascovsky K, Van Deerlin VM, Coslett HB, Hamilton R, Aguirre GK, Lee EB, Lee VMY, Trojanowski JQ, Grossman M.

Brain. 2018 Jan 1;141(1):288-301. doi: 10.1093/brain/awx319.

PMID:
29228211
30.

Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term.

Rey NL, George S, Steiner JA, Madaj Z, Luk KC, Trojanowski JQ, Lee VM, Brundin P.

Acta Neuropathol. 2018 Jan;135(1):65-83. doi: 10.1007/s00401-017-1792-9. Epub 2017 Dec 5.

31.

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation.

He Z, Guo JL, McBride JD, Narasimhan S, Kim H, Changolkar L, Zhang B, Gathagan RJ, Yue C, Dengler C, Stieber A, Nitla M, Coulter DA, Abel T, Brunden KR, Trojanowski JQ, Lee VM.

Nat Med. 2018 Jan;24(1):29-38. doi: 10.1038/nm.4443. Epub 2017 Dec 4.

PMID:
29200205
32.

TDP-43 Promotes Neurodegeneration by Impairing Chromatin Remodeling.

Berson A, Sartoris A, Nativio R, Van Deerlin V, Toledo JB, Porta S, Liu S, Chung CY, Garcia BA, Lee VM, Trojanowski JQ, Johnson FB, Berger SL, Bonini NM.

Curr Biol. 2017 Dec 4;27(23):3579-3590.e6. doi: 10.1016/j.cub.2017.10.024. Epub 2017 Nov 16.

PMID:
29153328
33.

Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain.

Narasimhan S, Guo JL, Changolkar L, Stieber A, McBride JD, Silva LV, He Z, Zhang B, Gathagan RJ, Trojanowski JQ, Lee VMY.

J Neurosci. 2017 Nov 22;37(47):11406-11423. doi: 10.1523/JNEUROSCI.1230-17.2017. Epub 2017 Oct 20.

34.

GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils.

Gibbons GS, Banks RA, Kim B, Xu H, Changolkar L, Leight SN, Riddle DM, Li C, Gathagan RJ, Brown HJ, Zhang B, Trojanowski JQ, Lee VM.

J Neurosci. 2017 Nov 22;37(47):11485-11494. doi: 10.1523/JNEUROSCI.2393-17.2017. Epub 2017 Oct 6.

35.

Protein arginylation targets alpha synuclein, facilitates normal brain health, and prevents neurodegeneration.

Wang J, Han X, Leu NA, Sterling S, Kurosaka S, Fina M, Lee VM, Dong DW, Yates JR 3rd, Kashina A.

Sci Rep. 2017 Sep 12;7(1):11323. doi: 10.1038/s41598-017-11713-z.

36.

Modeling Parkinson's disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain.

Thakur P, Breger LS, Lundblad M, Wan OW, Mattsson B, Luk KC, Lee VMY, Trojanowski JQ, Björklund A.

Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):E8284-E8293. doi: 10.1073/pnas.1710442114. Epub 2017 Sep 12.

37.

The use of mouse models to study cell-to-cell transmission of pathological tau.

Narasimhan S, Lee VMY.

Methods Cell Biol. 2017;141:287-305. doi: 10.1016/bs.mcb.2017.06.009. Epub 2017 Jul 14.

38.

Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration.

Yousef A, Robinson JL, Irwin DJ, Byrne MD, Kwong LK, Lee EB, Xu Y, Xie SX, Rennert L, Suh E, Van Deerlin VM, Grossman M, Lee VM, Trojanowski JQ.

Acta Neuropathol Commun. 2017 Sep 6;5(1):68. doi: 10.1186/s40478-017-0471-3.

39.

Evaluation of Oxetan-3-ol, Thietan-3-ol, and Derivatives Thereof as Bioisosteres of the Carboxylic Acid Functional Group.

Lassalas P, Oukoloff K, Makani V, James M, Tran V, Yao Y, Huang L, Vijayendran K, Monti L, Trojanowski JQ, Lee VM, Kozlowski MC, Smith AB 3rd, Brunden KR, Ballatore C.

ACS Med Chem Lett. 2017 Jul 5;8(8):864-868. doi: 10.1021/acsmedchemlett.7b00212. eCollection 2017 Aug 10.

40.

Protein astrogliopathies in human neurodegenerative diseases and aging.

Kovacs GG, Lee VM, Trojanowski JQ.

Brain Pathol. 2017 Sep;27(5):675-690. doi: 10.1111/bpa.12536. Review.

41.

Connexin-43 and aquaporin-4 are markers of ageing-related tau astrogliopathy (ARTAG)-related astroglial response.

Kovacs GG, Yousef A, Kaindl S, Lee VM, Trojanowski JQ.

Neuropathol Appl Neurobiol. 2017 Jul 29. doi: 10.1111/nan.12427. [Epub ahead of print]

PMID:
28755467
42.

Distinct α-Synuclein strains and implications for heterogeneity among α-Synucleinopathies.

Peng C, Gathagan RJ, Lee VM.

Neurobiol Dis. 2018 Jan;109(Pt B):209-218. doi: 10.1016/j.nbd.2017.07.018. Epub 2017 Jul 24. Review.

PMID:
28751258
43.

TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss.

Paolicelli RC, Jawaid A, Henstridge CM, Valeri A, Merlini M, Robinson JL, Lee EB, Rose J, Appel S, Lee VM, Trojanowski JQ, Spires-Jones T, Schulz PE, Rajendran L.

Neuron. 2017 Jul 19;95(2):297-308.e6. doi: 10.1016/j.neuron.2017.05.037. Epub 2017 Jun 29.

44.

Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies.

Karpowicz RJ Jr, Haney CM, Mihaila TS, Sandler RM, Petersson EJ, Lee VM.

J Biol Chem. 2017 Aug 11;292(32):13482-13497. doi: 10.1074/jbc.M117.780296. Epub 2017 Jun 13.

45.

Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium.

McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor JP, Weintraub D, Aarsland D, Galvin J, Attems J, Ballard CG, Bayston A, Beach TG, Blanc F, Bohnen N, Bonanni L, Bras J, Brundin P, Burn D, Chen-Plotkin A, Duda JE, El-Agnaf O, Feldman H, Ferman TJ, Ffytche D, Fujishiro H, Galasko D, Goldman JG, Gomperts SN, Graff-Radford NR, Honig LS, Iranzo A, Kantarci K, Kaufer D, Kukull W, Lee VMY, Leverenz JB, Lewis S, Lippa C, Lunde A, Masellis M, Masliah E, McLean P, Mollenhauer B, Montine TJ, Moreno E, Mori E, Murray M, O'Brien JT, Orimo S, Postuma RB, Ramaswamy S, Ross OA, Salmon DP, Singleton A, Taylor A, Thomas A, Tiraboschi P, Toledo JB, Trojanowski JQ, Tsuang D, Walker Z, Yamada M, Kosaka K.

Neurology. 2017 Jul 4;89(1):88-100. doi: 10.1212/WNL.0000000000004058. Epub 2017 Jun 7. Review.

46.

Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production.

Tapias V, Hu X, Luk KC, Sanders LH, Lee VM, Greenamyre JT.

Cell Mol Life Sci. 2017 Aug;74(15):2851-2874. doi: 10.1007/s00018-017-2541-x. Epub 2017 May 22.

47.

Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer's and Other Neurodegenerative Diseases.

Cornec AS, Monti L, Kovalevich J, Makani V, James MJ, Vijayendran KG, Oukoloff K, Yao Y, Lee VM, Trojanowski JQ, Smith AB 3rd, Brunden KR, Ballatore C.

J Med Chem. 2017 Jun 22;60(12):5120-5145. doi: 10.1021/acs.jmedchem.7b00475. Epub 2017 Jun 8.

48.

Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies.

Henderson MX, Chung CH, Riddle DM, Zhang B, Gathagan RJ, Seeholzer SH, Trojanowski JQ, Lee VMY.

J Neurosci. 2017 Jun 14;37(24):5870-5884. doi: 10.1523/JNEUROSCI.2705-16.2017. Epub 2017 May 18.

49.

Novel conformation-selective alpha-synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson's disease.

Covell DJ, Robinson JL, Akhtar RS, Grossman M, Weintraub D, Bucklin HM, Pitkin RM, Riddle D, Yousef A, Trojanowski JQ, Lee VM.

Neuropathol Appl Neurobiol. 2017 Dec;43(7):604-620. doi: 10.1111/nan.12402. Epub 2017 May 15.

PMID:
28386933
50.

Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases.

Kovacs GG, Robinson JL, Xie SX, Lee EB, Grossman M, Wolk DA, Irwin DJ, Weintraub D, Kim CF, Schuck T, Yousef A, Wagner ST, Suh E, Van Deerlin VM, Lee VM, Trojanowski JQ.

J Neuropathol Exp Neurol. 2017 Apr 1;76(4):270-288. doi: 10.1093/jnen/nlx007.

PMID:
28340083

Supplemental Content

Support Center