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Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy.

Oshima N, Ishida R, Kishimoto S, Beebe K, Brender JR, Yamamoto K, Urban D, Rai G, Johnson MS, Benavides G, Squadrito GL, Crooks D, Jackson J, Joshi A, Mott BT, Shrimp JH, Moses MA, Lee MJ, Yuno A, Lee TD, Hu X, Anderson T, Kusewitt D, Hathaway HH, Jadhav A, Picard D, Trepel JB, Mitchell JB, Stott GM, Moore W, Simeonov A, Sklar LA, Norenberg JP, Linehan WM, Maloney DJ, Dang CV, Waterson AG, Hall M, Darley-Usmar VM, Krishna MC, Neckers LM.

Cell Rep. 2020 Feb 11;30(6):1798-1810.e4. doi: 10.1016/j.celrep.2020.01.039.


Pulsed resource availability changes dietary niche breadth and partitioning between generalist rodent consumers.

Stephens RB, Hobbie EA, Lee TD, Rowe RJ.

Ecol Evol. 2019 Aug 20;9(18):10681-10693. doi: 10.1002/ece3.5587. eCollection 2019 Sep.


A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.

Lee TD, Lee OW, Brimacombe KR, Chen L, Guha R, Lusvarghi S, Tebase BG, Klumpp-Thomas C, Robey RW, Ambudkar SV, Shen M, Gottesman MM, Hall MD.

Mol Pharmacol. 2019 Nov;96(5):629-640. doi: 10.1124/mol.119.115964. Epub 2019 Sep 12.


Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.

Lee OW, Austin S, Gamma M, Cheff DM, Lee TD, Wilson KM, Johnson J, Travers J, Braisted JC, Guha R, Klumpp-Thomas C, Shen M, Hall MD.

SLAS Discov. 2020 Jan;25(1):9-20. doi: 10.1177/2472555219873068. Epub 2019 Sep 9.


An open-label trial of cryopreserved human umbilical cord in the treatment of complex diabetic foot ulcers complicated by osteomyelitis.

Marston WA, Lantis JC 2nd, Wu SC, Nouvong A, Lee TD, McCoy ND, Slade HB, Tseng SC.

Wound Repair Regen. 2019 Nov;27(6):680-686. doi: 10.1111/wrr.12754. Epub 2019 Aug 19.


Strong photosynthetic acclimation and enhanced water-use efficiency in grassland functional groups persist over 21 years of CO2 enrichment, independent of nitrogen supply.

Pastore MA, Lee TD, Hobbie SE, Reich PB.

Glob Chang Biol. 2019 Sep;25(9):3031-3044. doi: 10.1111/gcb.14714. Epub 2019 Jun 24.


Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.

Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang R, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA Jr, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu Z, Shen B, Shi W, Stephenson CRJ, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang Y, Ren T, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia M, Guha R, Rohde JM.

ACS Cent Sci. 2018 Dec 26;4(12):1727-1741. doi: 10.1021/acscentsci.8b00747. Epub 2018 Dec 5.


Allosteric Inhibition of Ubiquitin-like Modifications by a Class of Inhibitor of SUMO-Activating Enzyme.

Li YJ, Du L, Wang J, Vega R, Lee TD, Miao Y, Aldana-Masangkay G, Samuels ER, Li B, Ouyang SX, Colayco SA, Bobkova EV, Divlianska DB, Sergienko E, Chung TDY, Fakih M, Chen Y.

Cell Chem Biol. 2019 Feb 21;26(2):278-288.e6. doi: 10.1016/j.chembiol.2018.10.026. Epub 2018 Dec 20.


Response to Comment on "Unexpected reversal of C3 versus C4 grass response to elevated CO2 during a 20-year field experiment".

Reich PB, Hobbie SE, Lee TD, Pastore MA.

Science. 2018 Sep 14;361(6407). pii: eaau8982. doi: 10.1126/science.aau8982.


Adoption of E-Government Applications for Public Health Risk Communication: Government Trust and Social Media Competence as Primary Drivers.

Park H, Lee TD.

J Health Commun. 2018;23(8):712-723. doi: 10.1080/10810730.2018.1511013. Epub 2018 Aug 29.


Response to Comment on "Unexpected reversal of C3 versus C4 grass response to elevated CO2 during a 20-year field experiment".

Reich PB, Hobbie SE, Lee TD, Pastore MA.

Science. 2018 Aug 10;361(6402). pii: eaau1300. doi: 10.1126/science.aau1300.


Unexpected reversal of C3 versus C4 grass response to elevated CO2 during a 20-year field experiment.

Reich PB, Hobbie SE, Lee TD, Pastore MA.

Science. 2018 Apr 20;360(6386):317-320. doi: 10.1126/science.aas9313.


Use of genomics to design a diagnostic assay to discriminate between Streptococcus pneumoniae and Streptococcus pseudopneumoniae.

Croxen MA, Lee TD, Azana R, Hoang LM.

Microb Genom. 2018 Jul;4(7). doi: 10.1099/mgen.0.000175. Epub 2018 Apr 9.


Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.

Rohde JM, Brimacombe KR, Liu L, Pacold ME, Yasgar A, Cheff DM, Lee TD, Rai G, Baljinnyam B, Li Z, Simeonov A, Hall MD, Shen M, Sabatini DM, Boxer MB.

Bioorg Med Chem. 2018 May 1;26(8):1727-1739. doi: 10.1016/j.bmc.2018.02.016. Epub 2018 Feb 27.


The nasal microbiome in asthma.

Fazlollahi M, Lee TD, Andrade J, Oguntuyo K, Chun Y, Grishina G, Grishin A, Bunyavanich S.

J Allergy Clin Immunol. 2018 Sep;142(3):834-843.e2. doi: 10.1016/j.jaci.2018.02.020. Epub 2018 Mar 5.


Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).

Rai G, Brimacombe KR, Mott BT, Urban DJ, Hu X, Yang SM, Lee TD, Cheff DM, Kouznetsova J, Benavides GA, Pohida K, Kuenstner EJ, Luci DK, Lukacs CM, Davies DR, Dranow DM, Zhu H, Sulikowski G, Moore WJ, Stott GM, Flint AJ, Hall MD, Darley-Usmar VM, Neckers LM, Dang CV, Waterson AG, Simeonov A, Jadhav A, Maloney DJ.

J Med Chem. 2017 Nov 22;60(22):9184-9204. doi: 10.1021/acs.jmedchem.7b00941. Epub 2017 Nov 9.


Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays.

Urban DJ, Martinez NJ, Davis MI, Brimacombe KR, Cheff DM, Lee TD, Henderson MJ, Titus SA, Pragani R, Rohde JM, Liu L, Fang Y, Karavadhi S, Shah P, Lee OW, Wang A, McIver A, Zheng H, Wang X, Xu X, Jadhav A, Simeonov A, Shen M, Boxer MB, Hall MD.

Sci Rep. 2017 Oct 6;7(1):12758. doi: 10.1038/s41598-017-12630-x.


Development and validation of a real-time, reverse transcription PCR assay for rapid and low-cost genotyping of hepatitis C virus genotypes 1a, 1b, 2, and 3a.

Olmstead AD, Lee TD, Chow R, Gunadasa K, Auk B, Krajden M, Jassem AN.

J Virol Methods. 2017 Jun;244:17-22. doi: 10.1016/j.jviromet.2017.02.009. Epub 2017 Feb 20.


mcr-1-Positive Colistin-Resistant Escherichia coli in Traveler Returning to Canada from China.

Payne M, Croxen MA, Lee TD, Mayson B, Champagne S, Leung V, Bariso S, Hoang L, Lowe C.

Emerg Infect Dis. 2016 Sep;22(9):1673-5. doi: 10.3201/eid2209.160177. No abstract available.


Donor-Specific Antibodies Are Produced Locally in Ectopic Lymphoid Structures in Cardiac Allografts.

Huibers MM, Gareau AJ, Beerthuijzen JM, Siera-de Koning E, van Kuik J, Kamburova EG, Vink A, de Jonge N, Lee TD, Otten HG, de Weger RA.

Am J Transplant. 2017 Jan;17(1):246-254. doi: 10.1111/ajt.13969. Epub 2016 Aug 18.


Using a Manipulation Check to Uncover Age-Related Difference in Focus of Attention Instruction During a Balance Task.

Yeh TT, Cinelli ME, Lyons J, Lee TD.

Exp Aging Res. 2016;42(3):307-13. doi: 10.1080/0361073X.2016.1156977.


In Memoriam: Richard Allen Schmidt (1941 - 2015).

Lee TD, Wulf G, Winstein CJ, Zelaznik HN.

J Mot Behav. 2016;48(1):1-4. doi: 10.1080/00222895.2016.1124687. Epub 2015 Dec 23. No abstract available.


Age-related changes in postural control to the demands of a precision task.

Yeh TT, Cinelli ME, Lyons JL, Lee TD.

Hum Mov Sci. 2015 Dec;44:134-42. doi: 10.1016/j.humov.2015.08.021. Epub 2015 Sep 2.


On the Role of Error in Motor Learning.

Lee TD, Eliasz KL, Gonzalez D, Alguire K, Ding K, Dhaliwal C.

J Mot Behav. 2016;48(2):99-115. doi: 10.1080/00222895.2015.1046545. Epub 2015 Jun 5.


Rapid Detection of KPC, NDM, and OXA-48-Like Carbapenemases by Real-Time PCR from Rectal Swab Surveillance Samples.

Lee TD, Adie K, McNabb A, Purych D, Mannan K, Azana R, Ng C, Tang P, Hoang LM.

J Clin Microbiol. 2015 Aug;53(8):2731-3. doi: 10.1128/JCM.01237-15. Epub 2015 May 27.


Nominal and functional task difficulty in skill acquisition: Effects on performance in two tests of transfer.

Sanli EA, Lee TD.

Hum Mov Sci. 2015 Jun;41:218-29. doi: 10.1016/j.humov.2015.03.006. Epub 2015 Apr 4.


Nonclassical resident macrophages are important determinants in the development of myocardial fibrosis.

Falkenham A, de Antueno R, Rosin N, Betsch D, Lee TD, Duncan R, Légaré JF.

Am J Pathol. 2015 Apr;185(4):927-42. doi: 10.1016/j.ajpath.2014.11.027.


Disruption of collagen homeostasis can reverse established age-related myocardial fibrosis.

Rosin NL, Sopel MJ, Falkenham A, Lee TD, Légaré JF.

Am J Pathol. 2015 Mar;185(3):631-42. doi: 10.1016/j.ajpath.2014.11.009.


The composition of ectopic lymphoid structures suggests involvement of a local immune response in cardiac allograft vasculopathy.

Huibers MM, Gareau AJ, Vink A, Kruit R, Feringa H, Beerthuijzen JM, Siera-de Koning E, Peeters T, de Jonge N, de Weger RA, Lee TD.

J Heart Lung Transplant. 2015 May;34(5):734-45. doi: 10.1016/j.healun.2014.11.022. Epub 2014 Dec 8.


Profile of a milk-allergic patient who tolerated partially hydrolyzed whey formula.

Lee TD, Gimenez G, Grishina G, Mishoe M, Sampson HA, Bunyavanich S.

J Allergy Clin Immunol Pract. 2015 Jan-Feb;3(1):116-8. doi: 10.1016/j.jaip.2014.06.021. Epub 2014 Aug 29. No abstract available.


Functional analysis of rhomboid proteases during Toxoplasma invasion.

Shen B, Buguliskis JS, Lee TD, Sibley LD.

mBio. 2014 Oct 21;5(5):e01795-14. doi: 10.1128/mBio.01795-14.


De novo alloreactive memory CD8+ T cells develop following allogeneic challenge when CNI immunosuppression is delayed.

Hart-Matyas M, Gareau AJ, Hirsch GM, Lee TD.

Transpl Immunol. 2015 Jan;32(1):23-8. doi: 10.1016/j.trim.2014.10.001. Epub 2014 Oct 12.


Varied overground walking training versus body-weight-supported treadmill training in adults within 1 year of stroke: a randomized controlled trial.

DePaul VG, Wishart LR, Richardson J, Thabane L, Ma J, Lee TD.

Neurorehabil Neural Repair. 2015 May;29(4):329-40. doi: 10.1177/1545968314546135. Epub 2014 Aug 12.


Sequence analysis and feeding responses evoked by the large molecular form of gastrin releasing peptide (GRP) in the rat GRP-29.

Reeve JR Jr, Washington MC, Park KH, Johnson T, Hunt J, Shively JE, Ronk M, Lee TD, Goto Y, Chew P, Ho FJ, Sayegh AI.

Peptides. 2014 Sep;59:1-8. doi: 10.1016/j.peptides.2014.06.013. Epub 2014 Jun 30.


Fosmidomycin decreases membrane hopanoids and potentiates the effects of colistin on Burkholderia multivorans clinical isolates.

Malott RJ, Wu CH, Lee TD, Hird TJ, Dalleska NF, Zlosnik JE, Newman DK, Speert DP.

Antimicrob Agents Chemother. 2014 Sep;58(9):5211-9. doi: 10.1128/AAC.02705-14. Epub 2014 Jun 23.


What roles do errors serve in motor skill learning? An examination of two theoretical predictions.

Sanli EA, Lee TD.

J Mot Behav. 2014;46(5):329-37. doi: 10.1080/00222895.2014.913544. Epub 2014 May 23.


The impact and specificity of nerve perturbation on novel vibrotactile sensory letter learning.

Passmore SR, Bosse J, Murphy B, Lee TD.

Somatosens Mot Res. 2014 Dec;31(4):167-77. doi: 10.3109/08990220.2014.908837. Epub 2014 May 20.


Efficient gene disruption in diverse strains of Toxoplasma gondii using CRISPR/CAS9.

Shen B, Brown KM, Lee TD, Sibley LD.

mBio. 2014 May 13;5(3):e01114-14. doi: 10.1128/mBio.01114-14.


Say no to DMSO: dimethylsulfoxide inactivates cisplatin, carboplatin, and other platinum complexes.

Hall MD, Telma KA, Chang KE, Lee TD, Madigan JP, Lloyd JR, Goldlust IS, Hoeschele JD, Gottesman MM.

Cancer Res. 2014 Jul 15;74(14):3913-22. doi: 10.1158/0008-5472.CAN-14-0247. Epub 2014 May 8.


Sympathetic nerve fibers in human cervical and thoracic vagus nerves.

Seki A, Green HR, Lee TD, Hong L, Tan J, Vinters HV, Chen PS, Fishbein MC.

Heart Rhythm. 2014 Aug;11(8):1411-7. doi: 10.1016/j.hrthm.2014.04.032. Epub 2014 Apr 24.


Antibody therapy can enhance AngiotensinII-induced myocardial fibrosis.

Rosin NL, Gareau AJ, Betsch D, Falkenham A, Sopel MJ, Lee TD, Légaré JF.

Fibrogenesis Tissue Repair. 2014 Apr 10;7:6. doi: 10.1186/1755-1536-7-6. eCollection 2014.


Introducing samples directly into electrospray ionization mass spectrometers by direct infusion using a nanoelectrospray interface.

Lee TD, Moore RE, Keen D.

Curr Protoc Protein Sci. 2013 Nov 5;74:16.8.1-16.8.7. doi: 10.1002/0471140864.ps1608s74.


Effects of Invasive Winter Moth Defoliation on Tree Radial Growth in Eastern Massachusetts, USA.

Simmons MJ, Lee TD, Ducey MJ, Elkinton JS, Boettner GH, Dodds KJ.

Insects. 2014 Apr 9;5(2):301-18. doi: 10.3390/insects5020301.


Durability of healing from spray-applied cell therapy with human allogeneic fibroblasts and keratinocytes for the treatment of chronic venous leg ulcers: a 6-month follow-up.

Kirsner RS, Marston WA, Snyder RJ, Lee TD, Cargill DI, Zhang Y, Dickerson JE Jr, Slade HB.

Wound Repair Regen. 2013 Sep-Oct;21(5):682-7. doi: 10.1111/wrr.12076. Epub 2013 Aug 8.


Early fibroblast progenitor cell migration to the AngII-exposed myocardium is not CXCL12 or CCL2 dependent as previously thought.

Falkenham A, Sopel M, Rosin N, Lee TD, Issekutz T, Légaré JF.

Am J Pathol. 2013 Aug;183(2):459-69. doi: 10.1016/j.ajpath.2013.04.011. Epub 2013 Jun 1.


The influence of patient and wound variables on healing of venous leg ulcers in a randomized controlled trial of growth-arrested allogeneic keratinocytes and fibroblasts.

Lantis JC 2nd, Marston WA, Farber A, Kirsner RS, Zhang Y, Lee TD, Cargill DI, Slade HB.

J Vasc Surg. 2013 Aug;58(2):433-9. doi: 10.1016/j.jvs.2012.12.055. Epub 2013 Apr 12.


Impact of donor benign intimal thickening on cardiac allograft vasculopathy.

Devitt JJ, Rice A, McLean D, Murray SK, Hirsch GM, Lee TD.

J Heart Lung Transplant. 2013 Apr;32(4):454-60. doi: 10.1016/j.healun.2013.01.1044.


The gunslinger effect: why are movements made faster when responding to versus initiating an action?

La Delfa NJ, Garcia DB, Cappelletto JA, McDonald AC, Lyons JL, Lee TD.

J Mot Behav. 2013;45(2):85-90. doi: 10.1080/00222895.2012.746283. Epub 2013 Feb 26.


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