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Items: 1 to 50 of 270

1.

Early-onset Parkinson disease caused by a mutation in CHCHD2 and mitochondrial dysfunction.

Lee RG, Sedghi M, Salari M, Shearwood AJ, Stentenbach M, Kariminejad A, Goullee H, Rackham O, Laing NG, Tajsharghi H, Filipovska A.

Neurol Genet. 2018 Oct 5;4(5):e276. doi: 10.1212/NXG.0000000000000276. eCollection 2018 Oct.

PMID:
30338296
2.

Is mitochondrial gene expression coordinated or stochastic?

Lee RG, Rudler DL, Rackham O, Filipovska A.

Biochem Soc Trans. 2018 Oct 8. pii: BST20180174. doi: 10.1042/BST20180174. [Epub ahead of print] Review.

PMID:
30301847
3.

Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM.

Kummer E, Leibundgut M, Rackham O, Lee RG, Boehringer D, Filipovska A, Ban N.

Nature. 2018 Aug;560(7717):263-267. doi: 10.1038/s41586-018-0373-y. Epub 2018 Aug 8.

PMID:
30089917
4.

Therapeutic silencing of FSP27 reduces the progression of atherosclerosis in Ldlr-/- mice.

Rajamoorthi A, Lee RG, Baldán Á.

Atherosclerosis. 2018 Aug;275:43-49. doi: 10.1016/j.atherosclerosis.2018.05.045. Epub 2018 May 24.

5.

Δ-5 Fatty Acid Desaturase FADS1 Impacts Metabolic Disease by Balancing Proinflammatory and Proresolving Lipid Mediators.

Gromovsky AD, Schugar RC, Brown AL, Helsley RN, Burrows AC, Ferguson D, Zhang R, Sansbury BE, Lee RG, Morton RE, Allende DS, Parks JS, Spite M, Brown JM.

Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):218-231. doi: 10.1161/ATVBAHA.117.309660. Epub 2017 Oct 26.

PMID:
29074585
6.

Amelioration of diet-induced steatohepatitis in mice following combined therapy with ASO-Fsp27 and fenofibrate.

Rajamoorthi A, Arias N, Basta J, Lee RG, Baldán Á.

J Lipid Res. 2017 Nov;58(11):2127-2138. doi: 10.1194/jlr.M077941. Epub 2017 Sep 5.

7.

Adult-onset obesity is triggered by impaired mitochondrial gene expression.

Perks KL, Ferreira N, Richman TR, Ermer JA, Kuznetsova I, Shearwood AJ, Lee RG, Viola HM, Johnstone VPA, Matthews V, Hool LC, Rackham O, Filipovska A.

Sci Adv. 2017 Aug 16;3(8):e1700677. doi: 10.1126/sciadv.1700677. eCollection 2017 Aug.

8.

Targeting hepatic heparin-binding EGF-like growth factor (HB-EGF) induces anti-hyperlipidemia leading to reduction of angiotensin II-induced aneurysm development.

Kim S, Yang L, Kim S, Lee RG, Graham MJ, Berliner JA, Lusis AJ, Cai L, Temel RE, Rateri DL, Lee S.

PLoS One. 2017 Aug 9;12(8):e0182566. doi: 10.1371/journal.pone.0182566. eCollection 2017.

9.

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue.

Schugar RC, Shih DM, Warrier M, Helsley RN, Burrows A, Ferguson D, Brown AL, Gromovsky AD, Heine M, Chatterjee A, Li L, Li XS, Wang Z, Willard B, Meng Y, Kim H, Che N, Pan C, Lee RG, Crooke RM, Graham MJ, Morton RE, Langefeld CD, Das SK, Rudel LL, Zein N, McCullough AJ, Dasarathy S, Tang WHW, Erokwu BO, Flask CA, Laakso M, Civelek M, Naga Prasad SV, Heeren J, Lusis AJ, Hazen SL, Brown JM.

Cell Rep. 2017 Jul 5;20(1):279. doi: 10.1016/j.celrep.2017.06.053. No abstract available.

10.

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue.

Schugar RC, Shih DM, Warrier M, Helsley RN, Burrows A, Ferguson D, Brown AL, Gromovsky AD, Heine M, Chatterjee A, Li L, Li XS, Wang Z, Willard B, Meng Y, Kim H, Che N, Pan C, Lee RG, Crooke RM, Graham MJ, Morton RE, Langefeld CD, Das SK, Rudel LL, Zein N, McCullough AJ, Dasarathy S, Tang WHW, Erokwu BO, Flask CA, Laakso M, Civelek M, Naga Prasad SV, Heeren J, Lusis AJ, Hazen SL, Brown JM.

Cell Rep. 2017 Jun 20;19(12):2451-2461. doi: 10.1016/j.celrep.2017.05.077. Erratum in: Cell Rep. 2017 Jul 5;20(1):279.

11.

Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides.

Graham MJ, Lee RG, Brandt TA, Tai LJ, Fu W, Peralta R, Yu R, Hurh E, Paz E, McEvoy BW, Baker BF, Pham NC, Digenio A, Hughes SG, Geary RS, Witztum JL, Crooke RM, Tsimikas S.

N Engl J Med. 2017 Jul 20;377(3):222-232. doi: 10.1056/NEJMoa1701329. Epub 2017 May 24.

12.

The lipid droplet-associated protein perilipin 3 facilitates hepatitis C virus-driven hepatic steatosis.

Ferguson D, Zhang J, Davis MA, Helsley RN, Vedin LL, Lee RG, Crooke RM, Graham MJ, Allende DS, Parini P, Brown JM.

J Lipid Res. 2017 Feb;58(2):420-432. doi: 10.1194/jlr.M073734. Epub 2016 Dec 10.

13.

Therapeutic silencing of fat-specific protein 27 improves glycemic control in mouse models of obesity and insulin resistance.

Langhi C, Arias N, Rajamoorthi A, Basta J, Lee RG, Baldán Á.

J Lipid Res. 2017 Jan;58(1):81-91. doi: 10.1194/jlr.M069799. Epub 2016 Nov 24.

14.

ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors.

Gordts PL, Nock R, Son NH, Ramms B, Lew I, Gonzales JC, Thacker BE, Basu D, Lee RG, Mullick AE, Graham MJ, Goldberg IJ, Crooke RM, Witztum JL, Esko JD.

J Clin Invest. 2016 Aug 1;126(8):2855-66. doi: 10.1172/JCI86610. Epub 2016 Jul 11.

15.

Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation.

Lord CC, Ferguson D, Thomas G, Brown AL, Schugar RC, Burrows A, Gromovsky AD, Betters J, Neumann C, Sacks J, Marshall S, Watts R, Schweiger M, Lee RG, Crooke RM, Graham MJ, Lathia JD, Sakaguchi TF, Lehner R, Haemmerle G, Zechner R, Brown JM.

Cell Rep. 2016 Jul 26;16(4):939-949. doi: 10.1016/j.celrep.2016.06.049. Epub 2016 Jul 7.

16.

Antisense-Mediated Lowering of Plasma Apolipoprotein C-III by Volanesorsen Improves Dyslipidemia and Insulin Sensitivity in Type 2 Diabetes.

Digenio A, Dunbar RL, Alexander VJ, Hompesch M, Morrow L, Lee RG, Graham MJ, Hughes SG, Yu R, Singleton W, Baker BF, Bhanot S, Crooke RM.

Diabetes Care. 2016 Aug;39(8):1408-15. doi: 10.2337/dc16-0126. Epub 2016 Jun 6.

PMID:
27271183
17.

Development of Home-Based Frailty Detection Device Using Wireless Sensor Networks.

Lin CC, Chen CC, Lin PS, Lee RG, Huang JS, Tsai TH, Chang YC.

J Med Biol Eng. 2016;36:168-177. Epub 2016 Apr 16.

18.

Targeting IκB kinase β in Adipocyte Lineage Cells for Treatment of Obesity and Metabolic Dysfunctions.

Helsley RN, Sui Y, Park SH, Liu Z, Lee RG, Zhu B, Kern PA, Zhou C.

Stem Cells. 2016 Jul;34(7):1883-95. doi: 10.1002/stem.2358. Epub 2016 Mar 28.

19.

MAFG is a transcriptional repressor of bile acid synthesis and metabolism.

de Aguiar Vallim TQ, Tarling EJ, Ahn H, Hagey LR, Romanoski CE, Lee RG, Graham MJ, Motohashi H, Yamamoto M, Edwards PA.

Cell Metab. 2015 Feb 3;21(2):298-311. doi: 10.1016/j.cmet.2015.01.007. Erratum in: Cell Metab. 2016 Mar 8;23(3):563.

20.

The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance.

Warrier M, Shih DM, Burrows AC, Ferguson D, Gromovsky AD, Brown AL, Marshall S, McDaniel A, Schugar RC, Wang Z, Sacks J, Rong X, Vallim TA, Chou J, Ivanova PT, Myers DS, Brown HA, Lee RG, Crooke RM, Graham MJ, Liu X, Parini P, Tontonoz P, Lusis AJ, Hazen SL, Temel RE, Brown JM.

Cell Rep. 2015 Jan 14. pii: S2211-1247(14)01065-1. doi: 10.1016/j.celrep.2014.12.036. [Epub ahead of print]

21.

TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in mice.

Jiang S, Minter LC, Stratton SA, Yang P, Abbas HA, Akdemir ZC, Pant V, Post S, Gagea M, Lee RG, Lozano G, Barton MC.

J Hepatol. 2015 Feb;62(2):371-9. doi: 10.1016/j.jhep.2014.09.026. Epub 2014 Oct 2.

22.

Acute sterol o-acyltransferase 2 (SOAT2) knockdown rapidly mobilizes hepatic cholesterol for fecal excretion.

Marshall SM, Gromovsky AD, Kelley KL, Davis MA, Wilson MD, Lee RG, Crooke RM, Graham MJ, Rudel LL, Brown JM, Temel RE.

PLoS One. 2014 Jun 5;9(6):e98953. doi: 10.1371/journal.pone.0098953. eCollection 2014.

23.

Reduction of VLDL secretion decreases cholesterol excretion in niemann-pick C1-like 1 hepatic transgenic mice.

Marshall SM, Kelley KL, Davis MA, Wilson MD, McDaniel AL, Lee RG, Crooke RM, Graham MJ, Rudel LL, Brown JM, Temel RE.

PLoS One. 2014 Jan 3;9(1):e84418. doi: 10.1371/journal.pone.0084418. eCollection 2014.

24.

The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome.

Thomas G, Betters JL, Lord CC, Brown AL, Marshall S, Ferguson D, Sawyer J, Davis MA, Melchior JT, Blume LC, Howlett AC, Ivanova PT, Milne SB, Myers DS, Mrak I, Leber V, Heier C, Taschler U, Blankman JL, Cravatt BF, Lee RG, Crooke RM, Graham MJ, Zimmermann R, Brown HA, Brown JM.

Cell Rep. 2013 Oct 31;5(2):508-20. doi: 10.1016/j.celrep.2013.08.047. Epub 2013 Oct 3.

25.

Antisense technology: an emerging platform for cardiovascular disease therapeutics.

Lee RG, Crosby J, Baker BF, Graham MJ, Crooke RM.

J Cardiovasc Transl Res. 2013 Dec;6(6):969-80. doi: 10.1007/s12265-013-9495-7. Epub 2013 Jul 16. Review.

26.

Antisense oligonucleotide inhibition of cholesteryl ester transfer protein enhances RCT in hyperlipidemic, CETP transgenic, LDLr-/- mice.

Bell TA 3rd, Graham MJ, Lee RG, Mullick AE, Fu W, Norris D, Crooke RM.

J Lipid Res. 2013 Oct;54(10):2647-57. doi: 10.1194/jlr.M036509. Epub 2013 Jun 25.

27.

Antisense oligonucleotide inhibition of apolipoprotein C-III reduces plasma triglycerides in rodents, nonhuman primates, and humans.

Graham MJ, Lee RG, Bell TA 3rd, Fu W, Mullick AE, Alexander VJ, Singleton W, Viney N, Geary R, Su J, Baker BF, Burkey J, Crooke ST, Crooke RM.

Circ Res. 2013 May 24;112(11):1479-90. doi: 10.1161/CIRCRESAHA.111.300367. Epub 2013 Mar 29.

PMID:
23542898
28.

Comparison of the pharmacological profiles of murine antisense oligonucleotides targeting apolipoprotein B and microsomal triglyceride transfer protein.

Lee RG, Fu W, Graham MJ, Mullick AE, Sipe D, Gattis D, Bell TA, Booten S, Crooke RM.

J Lipid Res. 2013 Mar;54(3):602-14. doi: 10.1194/jlr.M029215. Epub 2012 Dec 6.

29.

CGI-58/ABHD5-derived signaling lipids regulate systemic inflammation and insulin action.

Lord CC, Betters JL, Ivanova PT, Milne SB, Myers DS, Madenspacher J, Thomas G, Chung S, Liu M, Davis MA, Lee RG, Crooke RM, Graham MJ, Parks JS, Brasaemle DL, Fessler MB, Brown HA, Brown JM.

Diabetes. 2012 Feb;61(2):355-63. doi: 10.2337/db11-0994. Epub 2012 Jan 6.

30.

Wireless sensor networks for indoor air quality monitoring.

Yu TC, Lin CC, Chen CC, Lee WL, Lee RG, Tseng CH, Liu SP.

Med Eng Phys. 2013 Feb;35(2):231-5. doi: 10.1016/j.medengphy.2011.10.011. Epub 2011 Nov 30.

PMID:
22133488
31.

eFurniture for home-based frailty detection using artificial neural networks and wireless sensors.

Chang YC, Lin CC, Lin PH, Chen CC, Lee RG, Huang JS, Tsai TH.

Med Eng Phys. 2013 Feb;35(2):263-8. doi: 10.1016/j.medengphy.2011.09.010. Epub 2011 Oct 5.

PMID:
21981806
32.

Antisense oligonucleotide reduction of apoB-ameliorated atherosclerosis in LDL receptor-deficient mice.

Mullick AE, Fu W, Graham MJ, Lee RG, Witchell D, Bell TA, Whipple CP, Crooke RM.

J Lipid Res. 2011 May;52(5):885-96. doi: 10.1194/jlr.M011791. Epub 2011 Feb 22.

33.

Photodynamic therapy of cottontail rabbit papillomavirus-induced papillomas in a severe combined immunodeficient mouse xenograft system.

Lee RG, Vecchiotti MA, Heaphy J, Panneerselvam A, Schluchter MD, Oleinick NL, Lavertu P, Alagramam KN, Arnold JE, Sprecher RC.

Laryngoscope. 2010 Mar;120(3):618-24. doi: 10.1002/lary.20709.

34.

Combination of microsatellite instability and lymphocytic infiltrate as a prognostic indicator for adjuvant therapy in colon cancer.

Kumar S, Chang EY, Frankhouse J, Dorsey PB, Lee RG, Johnson N.

Arch Surg. 2009 Sep;144(9):835-40. doi: 10.1001/archsurg.2009.162.

PMID:
19797108
35.

Combination of microsatellite instability and lymphocytic infiltrate as a prognostic indicator in colon cancer.

Chang EY, Dorsey PB, Frankhouse J, Lee RG, Walts D, Johnson W, Anadiotis G, Johnson N.

Arch Surg. 2009 Jun;144(6):511-5. doi: 10.1001/archsurg.2009.40.

PMID:
19528382
36.

A healthcare integration system for disease assessment and safety monitoring of dementia patients.

Lin CC, Lin PY, Lu PK, Hsieh GY, Lee WL, Lee RG.

IEEE Trans Inf Technol Biomed. 2008 Sep;12(5):579-86. doi: 10.1109/TITB.2008.917914.

PMID:
18779072
37.

Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss.

Brown JM, Bell TA 3rd, Alger HM, Sawyer JK, Smith TL, Kelley K, Shah R, Wilson MD, Davis MA, Lee RG, Graham MJ, Crooke RM, Rudel LL.

J Biol Chem. 2008 Apr 18;283(16):10522-34. doi: 10.1074/jbc.M707659200. Epub 2008 Feb 14.

38.

[High conjugated linoleic acid (CLA) content in milk and dairy products using a dietary supplementation of sunflower seed in cows. Thrombogenic/atherogenic risk issues].

Hernández ER, Jácome MM, Lee RG, Nakano T, Ozimek L, Guzmán IV.

Arch Latinoam Nutr. 2007 Jun;57(2):173-8. Spanish.

PMID:
17992982
39.

Inflammatory pseudotumor of the middle ear masquerading as Bell's palsy.

Lee RG, Weber DE, Ness AB, Wasman JK, Megerian CA.

Am J Otolaryngol. 2007 Nov-Dec;28(6):423-6.

PMID:
17980777
40.

Design and implementation of a mobile-care system over wireless sensor network for home healthcare applications.

Lee RG, Lai CC, Chiang SS, Liu HS, Chen CC, Hsieh GY.

Conf Proc IEEE Eng Med Biol Soc. 2006;1:6004-7.

PMID:
17945927
41.

A pervasive health monitoring service system based on ubiquitous network technology.

Lin CC, Lee RG, Hsiao CC.

Int J Med Inform. 2008 Jul;77(7):461-9. Epub 2007 Nov 1.

PMID:
17936065
42.

A mobile care system with alert mechanism.

Lee RG, Chen KC, Hsiao CC, Tseng CL.

IEEE Trans Inf Technol Biomed. 2007 Sep;11(5):507-17.

PMID:
17912967
43.

Quantitative kinematics of gait patterns during the recovery period after stroke.

Mah CD, Hulliger M, O'Callaghan IS, Lee RG.

J Stroke Cerebrovasc Dis. 1999 Sep-Oct;8(5):312-29.

PMID:
17895181
44.

An automatic analysis method for detecting and eliminating ECG artifacts in EEG.

Jiang JA, Chao CF, Chiu MJ, Lee RG, Tseng CL, Lin R.

Comput Biol Med. 2007 Nov;37(11):1660-71. Epub 2007 May 22.

PMID:
17517386
45.

Wireless health care service system for elderly with dementia.

Lin CC, Chiu MJ, Hsiao CC, Lee RG, Tsai YS.

IEEE Trans Inf Technol Biomed. 2006 Oct;10(4):696-704.

PMID:
17044403
46.

Improving outcomes of locoregional flaps: an emphasis on anatomy and basic science.

Lee RG, Baskin JZ.

Curr Opin Otolaryngol Head Neck Surg. 2006 Aug;14(4):260-4. Review.

PMID:
16832183
47.

Referrals for movement disorder surgery: under-representation of females and reasons for refusal.

Setiawan M, Kraft S, Doig K, Hunka K, Haffenden A, Trew M, Longman S, Ranawaya R, Furtado S, Lee RG, Suchowersky O, Kiss ZH.

Can J Neurol Sci. 2006 Feb;33(1):53-7.

PMID:
16583722
48.

Reductions and changing patterns of ambient PCDD/Fs in the UK: evidence and implications.

Hassanin A, Lee RG, Johnston AE, Jones KC.

Chemosphere. 2006 Oct;65(3):530-9. Epub 2006 Feb 28.

PMID:
16504246
49.

Verifying emission factors and national POPs emission inventories for the UK using measurements and modelling at two rural locations.

Lohmann R, Lee RG, Abbott J, Coleman P, Jones KC.

J Environ Monit. 2006 Jan;8(1):79-88. Epub 2005 Nov 24.

PMID:
16395463
50.

A profile of mental health crisis response in a rural setting.

Bonynge ER, Lee RG, Thurber S.

Community Ment Health J. 2005 Dec;41(6):675-85.

PMID:
16328582

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