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Fenofibrate induces human hepatoma Hep3B cells apoptosis and necroptosis through inhibition of thioesterase domain of fatty acid synthase.

You BJ, Hour MJ, Chen LY, Luo SC, Hsu PH, Lee HZ.

Sci Rep. 2019 Mar 1;9(1):3306. doi: 10.1038/s41598-019-39778-y.


Orlistat Displays Antitumor Activity and Enhances the Efficacy of Paclitaxel in Human Hepatoma Hep3B Cells.

You BJ, Chen LY, Hsu PH, Sung PH, Hung YC, Lee HZ.

Chem Res Toxicol. 2019 Feb 18;32(2):255-264. doi: 10.1021/acs.chemrestox.8b00269. Epub 2019 Jan 22.


Intracellular Localization of an Osmocenyl-Tamoxifen Derivative in Breast Cancer Cells Revealed by Synchrotron Radiation X-ray Fluorescence Nanoimaging.

Fus F, Yang Y, Lee HZS, Top S, Carriere M, Bouron A, Pacureanu A, da Silva JC, Salmain M, Vessières A, Cloetens P, Jaouen G, Bohic S.

Angew Chem Int Ed Engl. 2019 Mar 11;58(11):3461-3465. doi: 10.1002/anie.201812336. Epub 2019 Feb 6.


The effect of low-level laser irradiation on hyperglycemia-induced inflammation in human gingival fibroblasts.

Lee KD, Chiang MH, Chen PH, Ho ML, Lee HZ, Lee HE, Wang YH.

Lasers Med Sci. 2019 Jul;34(5):913-920. doi: 10.1007/s10103-018-2675-6. Epub 2018 Nov 19.


Challenges in GC-MS analysis: Case studies on phenibut and ethylphenidate.

Lee HZS, Ong MC, Lim JLW, Yap TWA.

Forensic Sci Int. 2017 Aug;277:166-178. doi: 10.1016/j.forsciint.2017.06.002. Epub 2017 Jun 9.


Induction of apoptosis and ganoderic acid biosynthesis by cAMP signaling in Ganoderma lucidum.

You BJ, Tien N, Lee MH, Bao BY, Wu YS, Hu TC, Lee HZ.

Sci Rep. 2017 Mar 23;7(1):318. doi: 10.1038/s41598-017-00281-x.


Prognostic Value of Prostaglandin-endoperoxide Synthase 2 Polymorphisms in Prostate Cancer Recurrence after Radical Prostatectomy.

Lee CH, Pao JB, Lu TL, Lee HZ, Lee YC, Liu CC, Huang CY, Lin VC, Yu CC, Yin HL, Huang SP, Bao BY.

Int J Med Sci. 2016 Aug 11;13(9):696-700. doi: 10.7150/ijms.16259. eCollection 2016.


Osmocenyl-tamoxifen derivatives target the thioredoxin system leading to a redox imbalance in Jurkat cells.

Scalcon V, Top S, Lee HZ, Citta A, Folda A, Bindoli A, Leong WK, Salmain M, Vessières A, Jaouen G, Rigobello MP.

J Inorg Biochem. 2016 Jul;160:296-304. doi: 10.1016/j.jinorgbio.2016.04.005. Epub 2016 Apr 13.


The Roles of 4β-Hydroxywithanolide E from Physalis peruviana on the Nrf2-Anti-Oxidant System and the Cell Cycle in Breast Cancer Cells.

Peng CY, You BJ, Lee CL, Wu YC, Lin WH, Lu TL, Chang FC, Lee HZ.

Am J Chin Med. 2016;44(3):617-36. doi: 10.1142/S0192415X16500348. Epub 2016 Apr 24.


Lived experience of Korean nurses caring for patients on maintenance haemodialysis.

Kim S, Lee HZ, Hwang E, Song J, Kwon HJ, Choe K.

J Clin Nurs. 2016 May;25(9-10):1455-63. doi: 10.1111/jocn.13160. Epub 2016 Mar 16.


Genetic variants in ultraconserved regions associate with prostate cancer recurrence and survival.

Bao BY, Lin VC, Yu CC, Yin HL, Chang TY, Lu TL, Lee HZ, Pao JB, Huang CY, Huang SP.

Sci Rep. 2016 Feb 23;6:22124. doi: 10.1038/srep22124.


Raf/ERK/Nrf2 signaling pathway and MMP-7 expression involvement in the trigonelline-mediated inhibition of hepatocarcinoma cell migration.

Liao JC, Lee KT, You BJ, Lee CL, Chang WT, Wu YC, Lee HZ.

Food Nutr Res. 2015 Dec 22;59:29884. doi: 10.3402/fnr.v59.29884. eCollection 2015.


Oxidative metabolism of ferrocene analogues of tamoxifen: characterization and antiproliferative activities of the metabolites.

Richard MA, Hamels D, Pigeon P, Top S, Dansette PM, Lee HZ, Vessières A, Mansuy D, Jaouen G.

ChemMedChem. 2015 Jun;10(6):981-90. doi: 10.1002/cmdc.201500075. Epub 2015 Apr 16.


FDA Approval: Belinostat for the Treatment of Patients with Relapsed or Refractory Peripheral T-cell Lymphoma.

Lee HZ, Kwitkowski VE, Del Valle PL, Ricci MS, Saber H, Habtemariam BA, Bullock J, Bloomquist E, Li Shen Y, Chen XH, Brown J, Mehrotra N, Dorff S, Charlab R, Kane RC, Kaminskas E, Justice R, Farrell AT, Pazdur R.

Clin Cancer Res. 2015 Jun 15;21(12):2666-70. doi: 10.1158/1078-0432.CCR-14-3119. Epub 2015 Mar 23.


Suppression of the TNF-alpha level is mediated by Gan-Lu-Yin (traditional Chinese medicine) in human oral cancer cells through the NF-kappa B, AKT, and ERK-dependent pathways.

Yang JS, Wu CC, Lee HZ, Hsieh WT, Tang FY, Bau DT, Lai KC, Lien JC, Chung JG.

Environ Toxicol. 2016 Oct;31(10):1196-205. doi: 10.1002/tox.22127. Epub 2015 Feb 26.


Naphthoquinone derivative PPE8 induces endoplasmic reticulum stress in p53 null H1299 cells.

Lien JC, Huang CC, Lu TJ, Tseng CH, Sung PJ, Lee HZ, Bao BY, Kuo YH, Lu TL.

Oxid Med Cell Longev. 2015;2015:453679. doi: 10.1155/2015/453679. Epub 2015 Jan 18.


Combined versus monotherapy or concurrent therapy for treatment of thalassaemia.

Song TS, Hsieh YW, Peng CT, Chen TL, Lee HZ, Chung JG, Hour MJ.

In Vivo. 2014 Jul-Aug;28(4):645-9.


U.S. Food and drug administration approval: obinutuzumab in combination with chlorambucil for the treatment of previously untreated chronic lymphocytic leukemia.

Lee HZ, Miller BW, Kwitkowski VE, Ricci S, DelValle P, Saber H, Grillo J, Bullock J, Florian J, Mehrotra N, Ko CW, Nie L, Shapiro M, Tolnay M, Kane RC, Kaminskas E, Justice R, Farrell AT, Pazdur R.

Clin Cancer Res. 2014 Aug 1;20(15):3902-7. doi: 10.1158/1078-0432.CCR-14-0516. Epub 2014 May 13.


Genetic variants in microRNAs and microRNA target sites predict biochemical recurrence after radical prostatectomy in localized prostate cancer.

Huang SP, Lévesque E, Guillemette C, Yu CC, Huang CY, Lin VC, Chung IC, Chen LC, Laverdière I, Lacombe L, Fradet Y, Chang TY, Lee HZ, Juang SH, Bao BY.

Int J Cancer. 2014 Dec 1;135(11):2661-7. doi: 10.1002/ijc.28904. Epub 2014 Apr 22.


Cytotoxic triosmium carbonyl clusters: a structure-activity relationship study.

Lee HZ, Leong WK, Top S, Vessières A.

ChemMedChem. 2014 Jul;9(7):1453-7. doi: 10.1002/cmdc.201300394. Epub 2014 Jan 20.


Non-homologous end joining pathway is the major route of protection against 4β-hydroxywithanolide E-induced DNA damage in MCF-7 cells.

You BJ, Wu YC, Lee CL, Lee HZ.

Food Chem Toxicol. 2014 Mar;65:205-12. doi: 10.1016/j.fct.2013.12.026. Epub 2013 Dec 25.


Application of proteomics to identify the target molecules involved in Lonicera japonica-induced photokilling in human lung cancer CH27 cells.

Liao JC, Chang WT, Lan YH, Hour MJ, Lee HZ.

BMC Complement Altern Med. 2013 Oct 1;13:244. doi: 10.1186/1472-6882-13-244.


Impact of interleukin-10 gene polymorphisms on survival in patients with colorectal cancer.

Ting WC, Chen LM, Huang LC, Hour MJ, Lan YH, Lee HZ, You BJ, Chang TY, Bao BY.

J Korean Med Sci. 2013 Sep;28(9):1302-6. doi: 10.3346/jkms.2013.28.9.1302. Epub 2013 Aug 28.


Genetic variants in nuclear factor-kappa B binding sites are associated with clinical outcomes in prostate cancer patients.

Huang SP, Lin VC, Lee YC, Yu CC, Huang CY, Chang TY, Lee HZ, Juang SH, Lu TL, Bao BY.

Eur J Cancer. 2013 Nov;49(17):3729-37. doi: 10.1016/j.ejca.2013.07.012. Epub 2013 Aug 3.


Genetic polymorphisms of matrix metalloproteinases and clinical outcomes in colorectal cancer patients.

Ting WC, Chen LM, Pao JB, Yang YP, You BJ, Chang TY, Lan YH, Lee HZ, Bao BY.

Int J Med Sci. 2013 Jun 15;10(8):1022-7. doi: 10.7150/ijms.6686. Print 2013.


Anti-inflammatory components from the root of Solanum erianthum.

Chen YC, Lee HZ, Chen HC, Wen CL, Kuo YH, Wang GJ.

Int J Mol Sci. 2013 Jun 14;14(6):12581-92. doi: 10.3390/ijms140612581.


Molecular modelling, synthesis, cytotoxicity and anti-tumour mechanisms of 2-aryl-6-substituted quinazolinones as dual-targeted anti-cancer agents.

Hour MJ, Lee KH, Chen TL, Lee KT, Zhao Y, Lee HZ.

Br J Pharmacol. 2013 Aug;169(7):1574-86. doi: 10.1111/bph.12233.


Direct conversion of 1-(2-bromobenzoyl)isoquinolines to dibenzo[de,g]quinolin-7-ones via reductive photocyclization.

Chuang TH, Li CF, Lee HZ, Wen YC.

J Org Chem. 2013 May 17;78(10):4974-84. doi: 10.1021/jo400645g. Epub 2013 May 6.


Common genetic variants in Wnt signaling pathway genes as potential prognostic biomarkers for colorectal cancer.

Ting WC, Chen LM, Pao JB, Yang YP, You BJ, Chang TY, Lan YH, Lee HZ, Bao BY.

PLoS One. 2013;8(2):e56196. doi: 10.1371/journal.pone.0056196. Epub 2013 Feb 6.


Common variants in IGF1 pathway genes and clinical outcomes after radical prostatectomy.

Chang CF, Pao JB, Yu CC, Huang CY, Huang SP, Yang YP, Huang CN, Chang TY, You BJ, Lee HZ, Hour TC, Bao BY.

Ann Surg Oncol. 2013 Jul;20(7):2446-52. doi: 10.1245/s10434-013-2884-y. Epub 2013 Feb 10.


A novel approach to enhancing ganoderic acid production by Ganoderma lucidum using apoptosis induction.

You BJ, Lee MH, Tien N, Lee MS, Hsieh HC, Tseng LH, Chung YL, Lee HZ.

PLoS One. 2013;8(1):e53616. doi: 10.1371/journal.pone.0053616. Epub 2013 Jan 10.


A novel antitubulin agent, DPQZ, induces cell apoptosis in human oral cancer cells through Ras/Raf inhibition and MAP kinases activation.

Hour MJ, Lee KT, Wu YC, Wu CY, You BJ, Chen TL, Lee HZ.

Arch Toxicol. 2013 May;87(5):835-46. doi: 10.1007/s00204-012-0991-3. Epub 2012 Dec 5.


Induced apoptosis of Th2 lymphocytes and inhibition of airway hyperresponsiveness and inflammation by combined lactic acid bacteria treatment.

Lin WH, Wu CR, Lee HZ, Kuo YH, Wen HS, Lin TY, Lee CY, Huang SY, Lin CY.

Int Immunopharmacol. 2013 Apr;15(4):703-11. doi: 10.1016/j.intimp.2012.10.025. Epub 2012 Nov 8.


The role of XRCC6 T-991C functional polymorphism in renal cell carcinoma.

Chang WS, Ke HL, Tsai CW, Lien CS, Liao WL, Lin HH, Lee MH, Wu HC, Chang CH, Chen CC, Lee HZ, Bau DT.

Anticancer Res. 2012 Sep;32(9):3855-60.


The joint effect of smoking and hOGG1 genotype on oral cancer in Taiwan.

Tsai CW, Tsai MH, Tsou YA, Shih LC, Tseng HC, Chang WS, Ho CY, Lee HZ, Bau DT.

Anticancer Res. 2012 Sep;32(9):3799-803.


Protein kinase C delta-mediated cytoskeleton remodeling is involved in aloe-emodin-induced photokilling of human lung cancer cells.

Chang WT, You BJ, Yang WH, Wu CY, Bau DT, Lee HZ.

Anticancer Res. 2012 Sep;32(9):3707-13.


Enhanced production of ganoderic acids and cytotoxicity of Ganoderma lucidum using solid-medium culture.

You BJ, Lee HZ, Chung KR, Lee MH, Huang MJ, Tien N, Chan CW, Kuo YH.

Biosci Biotechnol Biochem. 2012;76(8):1529-34. Epub 2012 Aug 7.


Association of p53 and CDKN1A genotypes with endometriosis.

Ying TH, Tseng CJ, Tsai SJ, Hsieh SC, Lee HZ, Hsieh YH, Bau DT.

Anticancer Res. 2011 Dec;31(12):4301-6.


Vitamin D receptor gene variants and clinical outcomes after androgen-deprivation therapy for prostate cancer.

Pao JB, Yang YP, Huang CN, Huang SP, Hour TC, Chang TY, Lan YH, Lu TL, Lee HZ, Juang SH, Huang CY, Bao BY.

World J Urol. 2013 Apr;31(2):281-7. doi: 10.1007/s00345-011-0813-x. Epub 2011 Dec 23.


Interaction of CCND1 genotype and smoking habit in Taiwan lung cancer patients.

Hsia TC, Liu CJ, Lin CH, Chang WS, Chu CC, Hang LW, Lee HZ, Lo WC, Bau DT.

Anticancer Res. 2011 Oct;31(10):3601-5.


Genetic polymorphisms in oestrogen receptor-binding sites affect clinical outcomes in patients with prostate cancer receiving androgen-deprivation therapy.

Huang CN, Huang SP, Pao JB, Hour TC, Chang TY, Lan YH, Lu TL, Lee HZ, Juang SH, Wu PP, Huang CY, Hsieh CJ, Bao BY.

J Intern Med. 2012 May;271(5):499-509. doi: 10.1111/j.1365-2796.2011.02449.x. Epub 2011 Sep 29.


2-(Naphthalene-1-yl)-6-pyrrolidinyl-4-quinazolinone inhibits skin cancer M21 cell proliferation through aberrant expression of microtubules and the cell cycle.

Wu YC, Hour MJ, Leung WC, Wu CY, Liu WZ, Chang YH, Lee HZ.

J Pharmacol Exp Ther. 2011 Sep;338(3):942-51. doi: 10.1124/jpet.110.176115. Epub 2011 Jun 7.


Genetic polymorphisms in androgen receptor-binding sites predict survival in prostate cancer patients receiving androgen-deprivation therapy.

Huang CN, Huang SP, Pao JB, Chang TY, Lan YH, Lu TL, Lee HZ, Juang SH, Wu PP, Pu YS, Hsieh CJ, Bao BY.

Ann Oncol. 2012 Mar;23(3):707-13. doi: 10.1093/annonc/mdr264. Epub 2011 Jun 6.


Proteomics displays cytoskeletal proteins and chaperones involvement in Hedyotis corymbosa-induced photokilling in skin cancer cells.

You BJ, Wu YC, Wu CY, Bao BY, Chen MY, Chang YH, Lee HZ.

Exp Dermatol. 2011 Aug;20(8):653-8. doi: 10.1111/j.1600-0625.2011.01290.x. Epub 2011 May 16.


Inhibitory effects of Physalis angulata on tumor metastasis and angiogenesis.

Hseu YC, Wu CR, Chang HW, Kumar KJ, Lin MK, Chen CS, Cho HJ, Huang CY, Huang CY, Lee HZ, Hsieh WT, Chung JG, Wang HM, Yang HL.

J Ethnopharmacol. 2011 Jun 1;135(3):762-71. doi: 10.1016/j.jep.2011.04.016. Epub 2011 Apr 14.


Significant associations of prostate cancer susceptibility variants with survival in patients treated with androgen-deprivation therapy.

Bao BY, Pao JB, Huang CN, Pu YS, Chang TY, Lan YH, Lu TL, Lee HZ, Chen LM, Ting WC, Hsieh CJ, Huang SP.

Int J Cancer. 2012 Feb 15;130(4):876-84. doi: 10.1002/ijc.26091. Epub 2011 May 25.


Rottlerin Inhibits Lonicera japonica-Induced Photokilling in Human Lung Cancer Cells through Cytoskeleton-Related Signaling Cascade.

You BJ, Wu YC, Bao BY, Wu CY, Yang YW, Chang YH, Lee HZ.

Evid Based Complement Alternat Med. 2011;2011:193842. doi: 10.1155/2011/193842. Epub 2011 Feb 8.


Production and diagnostic application of a purified, E. coli-expressed, serological-specific chicken anaemia virus antigen VP3.

Lee MS, Chou YM, Lien YY, Lin MK, Chang WT, Lee HZ, Lee MS, Lai GH, Chen HJ, Huang CH, Lin WH.

Transbound Emerg Dis. 2011 Jun;58(3):232-9. doi: 10.1111/j.1865-1682.2010.01200.x. Epub 2011 Jan 30.


Clarification of the phenotypic characteristics and anti-tumor activity of Hedyotis diffusa.

Lee HZ, Bau DT, Kuo CL, Tsai RY, Chen YC, Chang YH.

Am J Chin Med. 2011;39(1):201-13.


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