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Physical Exercise Affects Adipose Tissue Profile and Prevents Arterial Thrombosis in BDNF Val66Met Mice.

Sandrini L, Ieraci A, Amadio P, Zarà M, Mitro N, Lee FS, Tremoli E, Barbieri SS.

Cells. 2019 Aug 11;8(8). pii: E875. doi: 10.3390/cells8080875.


Update on mutations in the HIF: EPO pathway and their role in erythrocytosis.

Lappin TR, Lee FS.

Blood Rev. 2019 Sep;37:100590. doi: 10.1016/j.blre.2019.100590. Epub 2019 Jul 16. Review.


Diminished Fear Extinction in Adolescents Is Associated With an Altered Somatostatin Interneuron-Mediated Inhibition in the Infralimbic Cortex.

Koppensteiner P, Von Itter R, Melani R, Galvin C, Lee FS, Ninan I.

Biol Psychiatry. 2019 May 13. pii: S0006-3223(19)31336-8. doi: 10.1016/j.biopsych.2019.04.035. [Epub ahead of print]


ARF GTPases and their GEFs and GAPs: concepts and challenges.

Sztul E, Chen PW, Casanova JE, Cherfils J, Dacks JB, Lambright DG, Lee FS, Randazzo PA, Santy LC, Schürmann A, Wilhelmi I, Yohe ME, Kahn RA.

Mol Biol Cell. 2019 May 15;30(11):1249-1271. doi: 10.1091/mbc.E18-12-0820.


Role of BDNF in the development of an OFC-amygdala circuit regulating sociability in mouse and human.

Li A, Jing D, Dellarco DV, Hall BS, Yang R, Heilberg RT, Huang C, Liston C, Casey BJ, Lee FS.

Mol Psychiatry. 2019 Apr 16. doi: 10.1038/s41380-019-0422-4. [Epub ahead of print]


Splice-Break: exploiting an RNA-seq splice junction algorithm to discover mitochondrial DNA deletion breakpoints and analyses of psychiatric disorders.

Hjelm BE, Rollins B, Morgan L, Sequeira A, Mamdani F, Pereira F, Damas J, Webb MG, Weber MD, Schatzberg AF, Barchas JD, Lee FS, Akil H, Watson SJ, Myers RM, Chao EC, Kimonis V, Thompson PM, Bunney WE, Vawter MP.

Nucleic Acids Res. 2019 Jun 4;47(10):e59. doi: 10.1093/nar/gkz164.


Author Correction: Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis.

Liu S, Zhang G, Guo J, Chen X, Lei J, Ze K, Dong L, Dai X, Gao Y, Song D, Ecker BL, Yang R, Feltcher C, Peng K, Feng C, Chen H, Lee RX, Kerestes H, Niu J, Kumar S, Xu W, Zhang J, Wei Z, Martin JS, Liu X, Mills G, Lu Y, Guo W, Sun L, Zhang L, Weeraratna A, Herlyn M, Wei W, Lee FS, Xu X.

Nat Commun. 2019 Mar 11;10(1):1211. doi: 10.1038/s41467-019-09195-w.


Translating Developmental Neuroscience to Understand Risk for Psychiatric Disorders.

Meyer HC, Lee FS.

Am J Psychiatry. 2019 Mar 1;176(3):179-185. doi: 10.1176/appi.ajp.2019.19010091.


Using a Developmental Ecology Framework to Align Fear Neurobiology Across Species.

Callaghan B, Meyer H, Opendak M, Van Tieghem M, Harmon C, Li A, Lee FS, Sullivan RM, Tottenham N.

Annu Rev Clin Psychol. 2019 May 7;15:345-369. doi: 10.1146/annurev-clinpsy-050718-095727. Epub 2019 Feb 20.


Action of Arl1 GTPase and golgin Imh1 in Ypt6-independent retrograde transport from endosomes to the trans-Golgi network.

Chen YT, Wang IH, Wang YH, Chiu WY, Hu JH, Chen WH, Lee FS.

Mol Biol Cell. 2019 Apr 1;30(8):1008-1019. doi: 10.1091/mbc.E18-09-0579. Epub 2019 Feb 6.


Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis.

Liu S, Zhang G, Guo J, Chen X, Lei J, Ze K, Dong L, Dai X, Gao Y, Song D, Ecker BL, Yang R, Feltcher C, Peng K, Feng C, Chen H, Lee RX, Kerestes H, Niu J, Kumar S, Xu W, Zhang J, Wei Z, Martin JS, Liu X, Mills G, Lu Y, Guo W, Sun L, Zhang L, Weeraratna A, Herlyn M, Wei W, Lee FS, Xu X.

Nat Commun. 2018 Dec 21;9(1):5426. doi: 10.1038/s41467-018-07126-9. Erratum in: Nat Commun. 2019 Mar 11;10(1):1211.


At the crossroads of oxygen and iron sensing: hepcidin control of HIF-2α.

Lee FS.

J Clin Invest. 2019 Jan 2;129(1):72-74. doi: 10.1172/JCI125509. Epub 2018 Dec 10.


ADP-ribosylation factor-like 4A interacts with Robo1 to promote cell migration by regulating Cdc42 activation.

Chiang TS, Lin MC, Tsai MC, Chen CH, Jang LT, Lee FS.

Mol Biol Cell. 2019 Jan 1;30(1):69-81. doi: 10.1091/mbc.E18-01-0001. Epub 2018 Nov 14.


Epigenetic intersection of BDNF Val66Met genotype with premenstrual dysphoric disorder transcriptome in a cross-species model of estradiol add-back.

Marrocco J, Einhorn NR, Petty GH, Li H, Dubey N, Hoffman J, Berman KF, Goldman D, Lee FS, Schmidt PJ, McEwen BS.

Mol Psychiatry. 2018 Oct 24. doi: 10.1038/s41380-018-0274-3. [Epub ahead of print]


Sub-Chronic Stress Exacerbates the Pro-Thrombotic Phenotype in BDNFVal/Met Mice: Gene-Environment Interaction in the Modulation of Arterial Thrombosis.

Sandrini L, Ieraci A, Amadio P, Veglia F, Popoli M, Lee FS, Tremoli E, Barbieri SS.

Int J Mol Sci. 2018 Oct 19;19(10). pii: E3235. doi: 10.3390/ijms19103235.


The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior.

Giza JI, Kim J, Meyer HC, Anastasia A, Dincheva I, Zheng CI, Lopez K, Bains H, Yang J, Bracken C, Liston C, Jing D, Hempstead BL, Lee FS.

Neuron. 2018 Sep 19;99(6):1356. doi: 10.1016/j.neuron.2018.08.041. No abstract available.


New Roles for an Ancient Factor.

Lee FS, Hempstead BL.

Trends Neurosci. 2018 Nov;41(11):765-767. doi: 10.1016/j.tins.2018.08.012. Epub 2018 Sep 12.


Protective effects of elevated anandamide on stress and fear-related behaviors: translational evidence from humans and mice.

Mayo LM, Asratian A, Lindé J, Holm L, Nätt D, Augier G, Stensson N, Vecchiarelli HA, Balsevich G, Aukema RJ, Ghafouri B, Spagnolo PA, Lee FS, Hill MN, Heilig M.

Mol Psychiatry. 2018 Aug 17. doi: 10.1038/s41380-018-0215-1. [Epub ahead of print]


Loss-of-function zinc finger mutation in the EGLN1 gene associated with erythrocytosis.

Sinnema M, Song D, Guan W, Janssen JWH, van Wijk R, Navalsky BE, Peng K, Donker AE, Stegmann APA, Lee FS.

Blood. 2018 Sep 27;132(13):1455-1458. doi: 10.1182/blood-2018-06-854711. Epub 2018 Aug 15. No abstract available.


Global epigenetic analysis of BDNF Val66Met mice hippocampus reveals changes in dendrite and spine remodeling genes.

Mallei A, Ieraci A, Corna S, Tardito D, Lee FS, Popoli M.

Hippocampus. 2018 Nov;28(11):783-795. doi: 10.1002/hipo.22991.


Acetyl-l-carnitine deficiency in patients with major depressive disorder.

Nasca C, Bigio B, Lee FS, Young SP, Kautz MM, Albright A, Beasley J, Millington DS, Mathé AA, Kocsis JH, Murrough JW, McEwen BS, Rasgon N.

Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):8627-8632. doi: 10.1073/pnas.1801609115. Epub 2018 Jul 30.


Role for fatty acid amide hydrolase (FAAH) in the leptin-mediated effects on feeding and energy balance.

Balsevich G, Sticht M, Bowles NP, Singh A, Lee TTY, Li Z, Chelikani PK, Lee FS, Borgland SL, Hillard CJ, McEwen BS, Hill MN.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):7605-7610. doi: 10.1073/pnas.1802251115. Epub 2018 Jul 2.


The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior.

Giza JI, Kim J, Meyer HC, Anastasia A, Dincheva I, Zheng CI, Lopez K, Bains H, Yang J, Bracken C, Liston C, Jing D, Hempstead BL, Lee FS.

Neuron. 2018 Jul 11;99(1):163-178.e6. doi: 10.1016/j.neuron.2018.05.024. Epub 2018 Jun 14. Erratum in: Neuron. 2018 Sep 19;99(6):1356.


Connective Tissue Growth Factor Is a Novel Prodepressant.

Turner CA, Sharma V, Hagenauer MH, Chaudhury S, O'Connor AM, Hebda-Bauer EK, Thompson RC, Myers RM, Bunney WE, Barchas JD, Lee FS, Schatzberg AF, Watson SJ Jr, Akil H.

Biol Psychiatry. 2018 Oct 15;84(8):555-562. doi: 10.1016/j.biopsych.2018.04.013. Epub 2018 May 3.


Functional Assays to Screen and Dissect Genomic Hits: Doubling Down on the National Investment in Genomic Research.

Musunuru K, Bernstein D, Cole FS, Khokha MK, Lee FS, Lin S, McDonald TV, Moskowitz IP, Quertermous T, Sankaran VG, Schwartz DA, Silverman EK, Zhou X, Hasan AAK, Luo XJ.

Circ Genom Precis Med. 2018 Apr;11(4):e002178. doi: 10.1161/CIRCGEN.118.002178. Review.


Mitochondrial Complex I Deficiency in Schizophrenia and Bipolar Disorder and Medication Influence.

Rollins BL, Morgan L, Hjelm BE, Sequeira A, Schatzberg AF, Barchas JD, Lee FS, Myers RM, Watson SJ, Akil H, Potkin SG, Bunney WE, Vawter MP.

Mol Neuropsychiatry. 2018 Feb;3(3):157-169. doi: 10.1159/000484348. Epub 2017 Nov 30.


The relationship between posttraumatic and depressive symptoms during virtual reality exposure therapy with a cognitive enhancer.

Peskin M, Wyka K, Cukor J, Olden M, Altemus M, Lee FS, Difede J.

J Anxiety Disord. 2019 Jan;61:82-88. doi: 10.1016/j.janxdis.2018.03.001. Epub 2018 Mar 10.


Quantitative validation of immunofluorescence and lectin staining using reduced CLARITY acrylamide formulations.

Krolewski DM, Kumar V, Martin B, Tomer R, Deisseroth K, Myers RM, Schatzberg AF, Lee FS, Barchas JD, Bunney WE, Akil H, Watson SJ Jr.

Brain Struct Funct. 2018 Mar;223(2):987-999. doi: 10.1007/s00429-017-1583-z. Epub 2017 Dec 14.


Effect of Early-Life Fluoxetine on Anxiety-Like Behaviors in BDNF Val66Met Mice.

Dincheva I, Yang J, Li A, Marinic T, Freilingsdorf H, Huang C, Casey BJ, Hempstead B, Glatt CE, Lee FS, Bath KG, Jing D.

Am J Psychiatry. 2017 Dec 1;174(12):1203-1213. doi: 10.1176/appi.ajp.2017.15121592. Epub 2017 Oct 31.


Role of the Astroglial Glutamate Exchanger xCT in Ventral Hippocampus in Resilience to Stress.

Nasca C, Bigio B, Zelli D, de Angelis P, Lau T, Okamoto M, Soya H, Ni J, Brichta L, Greengard P, Neve RL, Lee FS, McEwen BS.

Neuron. 2017 Oct 11;96(2):402-413.e5. doi: 10.1016/j.neuron.2017.09.020.


A sexually dimorphic pre-stressed translational signature in CA3 pyramidal neurons of BDNF Val66Met mice.

Marrocco J, Petty GH, Ríos MB, Gray JD, Kogan JF, Waters EM, Schmidt EF, Lee FS, McEwen BS.

Nat Commun. 2017 Oct 9;8(1):808. doi: 10.1038/s41467-017-01014-4.


BDNF at the synapse: why location matters.

Song M, Martinowich K, Lee FS.

Mol Psychiatry. 2017 Oct;22(10):1370-1375. doi: 10.1038/mp.2017.144. Epub 2017 Jul 25.


ADP-ribosylation factor-like 4C binding to filamin-A modulates filopodium formation and cell migration.

Chiang TS, Wu HF, Lee FS.

Mol Biol Cell. 2017 Nov 1;28(22):3013-3028. doi: 10.1091/mbc.E17-01-0059. Epub 2017 Aug 30.


Characterization and health risk assessment of PM2.5-bound organics inside and outside of Chinese smoking lounges.

Li L, Ho SSH, Chow JC, Watson JG, Lee FSC, Cui L, Gao Y, Dai W, Ho KF, Huang Y, Cao J.

Chemosphere. 2017 Nov;186:438-445. doi: 10.1016/j.chemosphere.2017.08.006. Epub 2017 Aug 4.


Blockade of alcohol escalation and "relapse" drinking by pharmacological FAAH inhibition in male and female C57BL/6J mice.

Zhou Y, Schwartz BI, Giza J, Gross SS, Lee FS, Kreek MJ.

Psychopharmacology (Berl). 2017 Oct;234(19):2955-2970. doi: 10.1007/s00213-017-4691-9. Epub 2017 Jul 20.


The Role of the Endocannabinoid System and Genetic Variation in Adolescent Brain Development.

Meyer HC, Lee FS, Gee DG.

Neuropsychopharmacology. 2018 Jan;43(1):21-33. doi: 10.1038/npp.2017.143. Epub 2017 Jul 7. Review.


D-Cycloserine Augmentation of Exposure-Based Cognitive Behavior Therapy for Anxiety, Obsessive-Compulsive, and Posttraumatic Stress Disorders: A Systematic Review and Meta-analysis of Individual Participant Data.

Mataix-Cols D, Fernández de la Cruz L, Monzani B, Rosenfield D, Andersson E, Pérez-Vigil A, Frumento P, de Kleine RA, Difede J, Dunlop BW, Farrell LJ, Geller D, Gerardi M, Guastella AJ, Hofmann SG, Hendriks GJ, Kushner MG, Lee FS, Lenze EJ, Levinson CA, McConnell H, Otto MW, Plag J, Pollack MH, Ressler KJ, Rodebaugh TL, Rothbaum BO, Scheeringa MS, Siewert-Siegmund A, Smits JAJ, Storch EA, Ströhle A, Tart CD, Tolin DF, van Minnen A, Waters AM, Weems CF, Wilhelm S, Wyka K, Davis M, Rück C; the DCS Anxiety Consortium, Altemus M, Anderson P, Cukor J, Finck C, Geffken GR, Golfels F, Goodman WK, Gutner C, Heyman I, Jovanovic T, Lewin AB, McNamara JP, Murphy TK, Norrholm S, Thuras P.

JAMA Psychiatry. 2017 May 1;74(5):501-510. doi: 10.1001/jamapsychiatry.2016.3955. Review. Erratum in: JAMA Psychiatry. 2017 May 1;74(5):542.


Rare Synaptogenesis-Impairing Mutations in SLITRK5 Are Associated with Obsessive Compulsive Disorder.

Song M, Mathews CA, Stewart SE, Shmelkov SV, Mezey JG, Rodriguez-Flores JL, Rasmussen SA, Britton JC, Oh YS, Walkup JT, Lee FS, Glatt CE.

PLoS One. 2017 Jan 13;12(1):e0169994. doi: 10.1371/journal.pone.0169994. eCollection 2017.


Translational profiling of stress-induced neuroplasticity in the CA3 pyramidal neurons of BDNF Val66Met mice.

Gray JD, Rubin TG, Kogan JF, Marrocco J, Weidmann J, Lindkvist S, Lee FS, Schmidt EF, McEwen BS.

Mol Psychiatry. 2018 Apr;23(4):904-913. doi: 10.1038/mp.2016.219. Epub 2016 Dec 13.


The BDNF Val66Met polymorphism enhances glutamatergic transmission but diminishes activity-dependent synaptic plasticity in the dorsolateral striatum.

Jing D, Lee FS, Ninan I.

Neuropharmacology. 2017 Jan;112(Pt A):84-93. doi: 10.1016/j.neuropharm.2016.06.030. Epub 2016 Jul 1.


Identification of Small-Molecule PHD2 Zinc Finger Inhibitors that Activate Hypoxia Inducible Factor.

Arsenault PR, Song D, Bergkamp M, Ravaschiere AM, Navalsky BE, Lieberman PM, Lee FS.

Chembiochem. 2016 Dec 14;17(24):2316-2323. doi: 10.1002/cbic.201600493. Epub 2016 Nov 11.


The Role of BDNF in the Development of Fear Learning.

Dincheva I, Lynch NB, Lee FS.

Depress Anxiety. 2016 Oct;33(10):907-916. doi: 10.1002/da.22497. Review.


Pilot Study of a Telehealth-Delivered Medication-Augmented Exposure Therapy Protocol for PTSD.

Olden M, Wyka K, Cukor J, Peskin M, Altemus M, Lee FS, Finkelstein-Fox L, Rabinowitz T, Difede J.

J Nerv Ment Dis. 2017 Feb;205(2):154-160. doi: 10.1097/NMD.0000000000000563.


Brain-Derived Neurotrophic Factor Val66Met Human Polymorphism Impairs the Beneficial Exercise-Induced Neurobiological Changes in Mice.

Ieraci A, Madaio AI, Mallei A, Lee FS, Popoli M.

Neuropsychopharmacology. 2016 Dec;41(13):3070-3079. doi: 10.1038/npp.2016.120. Epub 2016 Jul 8.


The Zinc Finger of Prolyl Hydroxylase Domain Protein 2 Is Essential for Efficient Hydroxylation of Hypoxia-Inducible Factor α.

Arsenault PR, Song D, Chung YJ, Khurana TS, Lee FS.

Mol Cell Biol. 2016 Aug 26;36(18):2328-43. doi: 10.1128/MCB.00090-16. Print 2016 Sep 15.


New Insights into the Biology of the BDNF Transcriptional 'Code'.

Song M, Lee FS.

Neuropsychopharmacology. 2016 Jul;41(8):1941-2. doi: 10.1038/npp.2016.29. No abstract available.


Differential effects of BDNF and neurotrophin 4 (NT4) on endocytic sorting of TrkB receptors.

Proenca CC, Song M, Lee FS.

J Neurochem. 2016 Aug;138(3):397-406. doi: 10.1111/jnc.13676. Epub 2016 Jun 18.


Dynamic changes in neural circuitry during adolescence are associated with persistent attenuation of fear memories.

Pattwell SS, Liston C, Jing D, Ninan I, Yang RR, Witztum J, Murdock MH, Dincheva I, Bath KG, Casey BJ, Deisseroth K, Lee FS.

Nat Commun. 2016 May 24;7:11475. doi: 10.1038/ncomms11475.


Endocannabinoids and Stress Resilience: Is Deficiency Sufficient to Promote Vulnerability?

Hill MN, Lee FS.

Biol Psychiatry. 2016 May 15;79(10):792-793. doi: 10.1016/j.biopsych.2016.03.2099. No abstract available.


Individual differences in frontolimbic circuitry and anxiety emerge with adolescent changes in endocannabinoid signaling across species.

Gee DG, Fetcho RN, Jing D, Li A, Glatt CE, Drysdale AT, Cohen AO, Dellarco DV, Yang RR, Dale AM, Jernigan TL, Lee FS, Casey BJ; PING Consortium.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4500-5. doi: 10.1073/pnas.1600013113. Epub 2016 Mar 21.

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