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Items: 1 to 50 of 196

1.

Systematic discovery of the functional impact of somatic genome alterations in individual tumors through tumor-specific causal inference.

Cai C, Cooper GF, Lu KN, Ma X, Xu S, Zhao Z, Chen X, Xue Y, Lee AV, Clark N, Chen V, Lu S, Chen L, Yu L, Hochheiser HS, Jiang X, Wang QJ, Lu X.

PLoS Comput Biol. 2019 Jul 5;15(7):e1007088. doi: 10.1371/journal.pcbi.1007088. eCollection 2019 Jul.

2.

FGFR4 overexpression and hotspot mutations in metastatic ER+ breast cancer are enriched in the lobular subtype.

Levine KM, Priedigkeit N, Basudan A, Tasdemir N, Sikora MJ, Sokol ES, Hartmaier RJ, Ding K, Ahmad NZ, Watters RJ, Weiss KR, Blohmer JU, Denkert C, Machleidt A, Karsten MM, Boisen MM, Elishaev E, Lucas PC, Lee AV, Oesterreich S.

NPJ Breast Cancer. 2019 Jun 27;5:19. doi: 10.1038/s41523-019-0114-x. eCollection 2019.

3.

Frequent amplifications of ESR1, ERBB2 and MDM4 in primary invasive lobular breast carcinoma.

Cao L, Basudan A, Sikora MJ, Bahreini A, Tasdemir N, Levine KM, Jankowitz RC, McAuliffe PF, Dabbs D, Haupt S, Haupt Y, Lucas PC, Lee AV, Oesterreich S, Atkinson JM.

Cancer Lett. 2019 Oct 1;461:21-30. doi: 10.1016/j.canlet.2019.06.011. Epub 2019 Jun 20.

PMID:
31229512
4.

Effect of lipopolysaccharide-induced immune stimulation and maternal fish oil and microalgae supplementation during late pregnancy on nursery pig hypothalamic-pituitary-adrenal function1.

You L, Lee AV, Oh SY, Fisher-Heffernan RE, Edwards M, de Lange K, Karrow NA.

J Anim Sci. 2019 Jul 2;97(7):2940-2951. doi: 10.1093/jas/skz166.

PMID:
31081510
5.

Molecular Biology Information Service: an innovative medical library-based bioinformatics support service for biomedical researchers.

Chattopadhyay A, Iwema CL, Epstein BA, Lee AV, Levine AS.

Brief Bioinform. 2019 Apr 5. pii: bbz035. doi: 10.1093/bib/bbz035. [Epub ahead of print]

PMID:
30949666
6.

Health Benefits of Supplementing Nursery Pig Diets with Microalgae or Fish Oil.

Lee AV, You L, Oh SY, Li Z, Code A, Zhu C, Fisher-Heffernan RE, Regnault TRH, De Lange CFM, Huber LA, Karrow NA.

Animals (Basel). 2019 Mar 5;9(3). pii: E80. doi: 10.3390/ani9030080.

7.

Bad to the Bone: The Role of the Insulin-Like Growth Factor Axis in Osseous Metastasis.

Rieunier G, Wu X, Macaulay VM, Lee AV, Weyer-Czernilofsky U, Bogenrieder T.

Clin Cancer Res. 2019 Jun 15;25(12):3479-3485. doi: 10.1158/1078-0432.CCR-18-2697. Epub 2019 Feb 11. Review.

PMID:
30745299
8.

Network-guided prediction of aromatase inhibitor response in breast cancer.

Ruffalo M, Thomas R, Chen J, Lee AV, Oesterreich S, Bar-Joseph Z.

PLoS Comput Biol. 2019 Feb 11;15(2):e1006730. doi: 10.1371/journal.pcbi.1006730. eCollection 2019 Feb.

9.

Targeted mutation detection in breast cancer using MammaSeq™.

Smith NG, Gyanchandani R, Shah OS, Gurda GT, Lucas PC, Hartmaier RJ, Brufsky AM, Puhalla S, Bahreini A, Kota K, Wald AI, Nikiforov YE, Nikiforova MN, Oesterreich S, Lee AV.

Breast Cancer Res. 2019 Feb 8;21(1):22. doi: 10.1186/s13058-019-1102-7.

10.

Integration of Cancer Registry Data into the Text Information Extraction System: Leveraging the Structured Data Import Tool.

Linkov F, Silverstein JC, Davis M, Crocker B, Hao D, Schneider A, Schwenk M, Winters S, Zelnis J, Lee AV, Becich MJ.

J Pathol Inform. 2018 Dec 24;9:47. doi: 10.4103/jpi.jpi_38_18. eCollection 2018.

11.

Whole genome amplification of cell-free DNA enables detection of circulating tumor DNA mutations from fingerstick capillary blood.

Gyanchandani R, Kvam E, Heller R, Finehout E, Smith N, Kota K, Nelson JR, Griffin W, Puhalla S, Brufsky AM, Davidson NE, Lee AV.

Sci Rep. 2018 Nov 23;8(1):17313. doi: 10.1038/s41598-018-35470-9.

12.

Loss of function of NF1 is a mechanism of acquired resistance to endocrine therapy in lobular breast cancer.

Sokol ES, Feng YX, Jin DX, Basudan A, Lee AV, Atkinson JM, Chen J, Stephens PJ, Frampton GM, Gupta PB, Ross JS, Chung JH, Oesterreich S, Ali SM, Hartmaier RJ.

Ann Oncol. 2019 Jan 1;30(1):115-123. doi: 10.1093/annonc/mdy497.

13.

Frequent ESR1 and CDK Pathway Copy-Number Alterations in Metastatic Breast Cancer.

Basudan A, Priedigkeit N, Hartmaier RJ, Sokol ES, Bahreini A, Watters RJ, Boisen MM, Bhargava R, Weiss KR, Karsten MM, Denkert C, Blohmer JU, Leone JP, Hamilton RL, Brufsky AM, Elishaev E, Lucas PC, Lee AV, Oesterreich S.

Mol Cancer Res. 2019 Feb;17(2):457-468. doi: 10.1158/1541-7786.MCR-18-0946. Epub 2018 Oct 24.

PMID:
30355675
14.

Circulating Tumor Cell Phenotyping via High-Throughput Acoustic Separation.

Wu M, Huang PH, Zhang R, Mao Z, Chen C, Kemeny G, Li P, Lee AV, Gyanchandani R, Armstrong AJ, Dao M, Suresh S, Huang TJ.

Small. 2018 Aug;14(32):e1801131. doi: 10.1002/smll.201801131. Epub 2018 Jul 3.

15.

Transcriptome Characterization of Matched Primary Breast and Brain Metastatic Tumors to Detect Novel Actionable Targets.

Varešlija D, Priedigkeit N, Fagan A, Purcell S, Cosgrove N, O'Halloran PJ, Ward E, Cocchiglia S, Hartmaier R, Castro CA, Zhu L, Tseng GC, Lucas PC, Puhalla SL, Brufsky AM, Hamilton RL, Mathew A, Leone JP, Basudan A, Hudson L, Dwyer R, Das S, O'Connor DP, Buckley PG, Farrell M, Hill ADK, Oesterreich S, Lee AV, Young LS.

J Natl Cancer Inst. 2019 Apr 1;111(4):388-398. doi: 10.1093/jnci/djy110.

16.

Loss of E-cadherin Enhances IGF1-IGF1R Pathway Activation and Sensitizes Breast Cancers to Anti-IGF1R/InsR Inhibitors.

Nagle AM, Levine KM, Tasdemir N, Scott JA, Burlbaugh K, Kehm J, Katz TA, Boone DN, Jacobsen BM, Atkinson JM, Oesterreich S, Lee AV.

Clin Cancer Res. 2018 Oct 15;24(20):5165-5177. doi: 10.1158/1078-0432.CCR-18-0279. Epub 2018 Jun 25.

PMID:
29941485
17.

Precision Medicine in Hormone Receptor-Positive Breast Cancer.

Nasrazadani A, Thomas RA, Oesterreich S, Lee AV.

Front Oncol. 2018 May 4;8:144. doi: 10.3389/fonc.2018.00144. eCollection 2018. Review.

18.

Invasive lobular and ductal breast carcinoma differ in immune response, protein translation efficiency and metabolism.

Du T, Zhu L, Levine KM, Tasdemir N, Lee AV, Vignali DAA, Houten BV, Tseng GC, Oesterreich S.

Sci Rep. 2018 May 8;8(1):7205. doi: 10.1038/s41598-018-25357-0.

19.

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics.

Liu J, Lichtenberg T, Hoadley KA, Poisson LM, Lazar AJ, Cherniack AD, Kovatich AJ, Benz CC, Levine DA, Lee AV, Omberg L, Wolf DM, Shriver CD, Thorsson V; Cancer Genome Atlas Research Network, Hu H.

Cell. 2018 Apr 5;173(2):400-416.e11. doi: 10.1016/j.cell.2018.02.052.

20.

Peptide vaccine immunotherapy biomarkers and response patterns in pediatric gliomas.

Müller S, Agnihotri S, Shoger KE, Myers MI, Smith N, Chaparala S, Villanueva CR, Chattopadhyay A, Lee AV, Butterfield LH, Diaz A, Okada H, Pollack IF, Kohanbash G.

JCI Insight. 2018 Apr 5;3(7). pii: 98791. doi: 10.1172/jci.insight.98791. eCollection 2018 Apr 5.

21.

Expression of reactive species related genes is associated with patient survival in luminal B breast cancer.

Luthra S, Chandran U, Diergaarde B, Becich M, Lee AV, Neumann CA.

Free Radic Biol Med. 2018 May 20;120:170-180. doi: 10.1016/j.freeradbiomed.2018.03.011. Epub 2018 Mar 12.

22.

Diastereoselective Palladium-Catalyzed (3 + 2)-Cycloadditions from Cyclic Imines and Vinyl Aziridines.

Spielmann K, Lee AV, de Figueiredo RM, Campagne JM.

Org Lett. 2018 Mar 2;20(5):1444-1447. doi: 10.1021/acs.orglett.8b00228. Epub 2018 Feb 13.

PMID:
29437402
23.

Recurrent hyperactive ESR1 fusion proteins in endocrine therapy-resistant breast cancer.

Hartmaier RJ, Trabucco SE, Priedigkeit N, Chung JH, Parachoniak CA, Vanden Borre P, Morley S, Rosenzweig M, Gay LM, Goldberg ME, Suh J, Ali SM, Ross J, Leyland-Jones B, Young B, Williams C, Park B, Tsai M, Haley B, Peguero J, Callahan RD, Sachelarie I, Cho J, Atkinson JM, Bahreini A, Nagle AM, Puhalla SL, Watters RJ, Erdogan-Yildirim Z, Cao L, Oesterreich S, Mathew A, Lucas PC, Davidson NE, Brufsky AM, Frampton GM, Stephens PJ, Chmielecki J, Lee AV.

Ann Oncol. 2018 Apr 1;29(4):872-880. doi: 10.1093/annonc/mdy025.

24.

Controlled dimerization of insulin-like growth factor-1 and insulin receptors reveals shared and distinct activities of holo and hybrid receptors.

Chen J, Nagle AM, Wang YF, Boone DN, Lee AV.

J Biol Chem. 2018 Mar 9;293(10):3700-3709. doi: 10.1074/jbc.M117.789503. Epub 2018 Jan 12.

25.

Clinically Observed Estrogen Receptor Alpha Mutations within the Ligand-Binding Domain Confer Distinguishable Phenotypes.

Jia S, Miedel MT, Ngo M, Hessenius R, Chen N, Wang P, Bahreini A, Li Z, Ding Z, Shun TY, Zuckerman DM, Taylor DL, Puhalla SL, Lee AV, Oesterreich S, Stern AM.

Oncology. 2018;94(3):176-189. doi: 10.1159/000485510. Epub 2018 Jan 6.

26.

Phospholyl(borane) Amino Acids and Peptides: Stereoselective Synthesis and Fluorescent Properties with Large Stokes Shift.

Arribat M, Rémond E, Clément S, Lee AV, Cavelier F.

J Am Chem Soc. 2018 Jan 24;140(3):1028-1034. doi: 10.1021/jacs.7b10954. Epub 2018 Jan 9.

PMID:
29262677
27.

The CARMA3-Bcl10-MALT1 Signalosome Drives NFκB Activation and Promotes Aggressiveness in Angiotensin II Receptor-Positive Breast Cancer.

Ekambaram P, Lee JL, Hubel NE, Hu D, Yerneni S, Campbell PG, Pollock N, Klei LR, Concel VJ, Delekta PC, Chinnaiyan AM, Tomlins SA, Rhodes DR, Priedigkeit N, Lee AV, Oesterreich S, McAllister-Lucas LM, Lucas PC.

Cancer Res. 2018 Mar 1;78(5):1225-1240. doi: 10.1158/0008-5472.CAN-17-1089. Epub 2017 Dec 19.

28.

Platform for Quantitative Evaluation of Spatial Intratumoral Heterogeneity in Multiplexed Fluorescence Images.

Spagnolo DM, Al-Kofahi Y, Zhu P, Lezon TR, Gough A, Stern AM, Lee AV, Ginty F, Sarachan B, Taylor DL, Chennubhotla SC.

Cancer Res. 2017 Nov 1;77(21):e71-e74. doi: 10.1158/0008-5472.CAN-17-0676.

29.

Upregulation of IRS1 Enhances IGF1 Response in Y537S and D538G ESR1 Mutant Breast Cancer Cells.

Li Z, Levine KM, Bahreini A, Wang P, Chu D, Park BH, Oesterreich S, Lee AV.

Endocrinology. 2018 Jan 1;159(1):285-296. doi: 10.1210/en.2017-00693.

30.

Exome-capture RNA sequencing of decade-old breast cancers and matched decalcified bone metastases.

Priedigkeit N, Watters RJ, Lucas PC, Basudan A, Bhargava R, Horne W, Kolls JK, Fang Z, Rosenzweig MQ, Brufsky AM, Weiss KR, Oesterreich S, Lee AV.

JCI Insight. 2017 Sep 7;2(17). pii: 95703. doi: 10.1172/jci.insight.95703. eCollection 2017 Sep 7.

31.

Restraint and Social Isolation Stressors Differentially Regulate Adaptive Immunity and Tumor Angiogenesis in a Breast Cancer Mouse Model.

Budiu RA, Vlad AM, Nazario L, Bathula C, Cooper KL, Edmed J, Thaker PH, Urban J, Kalinski P, Lee AV, Elishaev EL, Conrads TP, Flint MS.

Cancer Clin Oncol. 2017 May;6(1):12-24. doi: 10.5539/cco.v6n1p12. Epub 2016 Nov 11.

32.

Mutation site and context dependent effects of ESR1 mutation in genome-edited breast cancer cell models.

Bahreini A, Li Z, Wang P, Levine KM, Tasdemir N, Cao L, Weir HM, Puhalla SL, Davidson NE, Stern AM, Chu D, Park BH, Lee AV, Oesterreich S.

Breast Cancer Res. 2017 May 23;19(1):60. doi: 10.1186/s13058-017-0851-4.

33.

Spatial Statistics for Segmenting Histological Structures in H&E Stained Tissue Images.

Nguyen L, Tosun AB, Fine JL, Lee AV, Taylor DL, Chennubhotla SC.

IEEE Trans Med Imaging. 2017 Jul;36(7):1522-1532. doi: 10.1109/TMI.2017.2681519. Epub 2017 Mar 16.

34.

Ovine hippocampal mRNA expression in offspring from dams supplemented with fishmeal and stress challenged in late pregnancy with endotoxin.

Karrow NA, Lee AV, Quinton M, McBride BW, Fisher-Heffernan RE.

Anim Nutr. 2017 Mar;3(1):39-45. doi: 10.1016/j.aninu.2016.10.001. Epub 2016 Oct 28.

35.

THADA fusion is a mechanism of IGF2BP3 activation and IGF1R signaling in thyroid cancer.

Panebianco F, Kelly LM, Liu P, Zhong S, Dacic S, Wang X, Singhi AD, Dhir R, Chiosea SI, Kuan SF, Bhargava R, Dabbs D, Trivedi S, Gandhi M, Diaz R, Wald AI, Carty SE, Ferris RL, Lee AV, Nikiforova MN, Nikiforov YE.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2307-2312. doi: 10.1073/pnas.1614265114. Epub 2017 Feb 13.

36.

Active Estrogen Receptor-alpha Signaling in Ovarian Cancer Models and Clinical Specimens.

Andersen CL, Sikora MJ, Boisen MM, Ma T, Christie A, Tseng G, Park Y, Luthra S, Chandran U, Haluska P, Mantia-Smaldone GM, Odunsi K, McLean K, Lee AV, Elishaev E, Edwards RP, Oesterreich S.

Clin Cancer Res. 2017 Jul 15;23(14):3802-3812. doi: 10.1158/1078-0432.CCR-16-1501. Epub 2017 Jan 10.

37.

The Cellular Origin and Evolution of Breast Cancer.

Zhang M, Lee AV, Rosen JM.

Cold Spring Harb Perspect Med. 2017 Mar 1;7(3). pii: a027128. doi: 10.1101/cshperspect.a027128. Review.

38.

Pointwise mutual information quantifies intratumor heterogeneity in tissue sections labeled with multiple fluorescent biomarkers.

Spagnolo DM, Gyanchandani R, Al-Kofahi Y, Stern AM, Lezon TR, Gough A, Meyer DE, Ginty F, Sarachan B, Fine J, Lee AV, Taylor DL, Chennubhotla SC.

J Pathol Inform. 2016 Nov 29;7:47. eCollection 2016.

39.

New Strategies in Metastatic Hormone Receptor-Positive Breast Cancer: Searching for Biomarkers to Tailor Endocrine and Other Targeted Therapies.

Jankowitz RC, Oesterreich S, Lee AV, Davidson NE.

Clin Cancer Res. 2017 Mar 1;23(5):1126-1131. doi: 10.1158/1078-0432.CCR-16-0591. Epub 2016 Dec 15.

40.

Non-coding single nucleotide variants affecting estrogen receptor binding and activity.

Bahreini A, Levine K, Santana-Santos L, Benos PV, Wang P, Andersen C, Oesterreich S, Lee AV.

Genome Med. 2016 Dec 13;8(1):128.

41.

Intrinsic Subtype Switching and Acquired ERBB2/HER2 Amplifications and Mutations in Breast Cancer Brain Metastases.

Priedigkeit N, Hartmaier RJ, Chen Y, Vareslija D, Basudan A, Watters RJ, Thomas R, Leone JP, Lucas PC, Bhargava R, Hamilton RL, Chmielecki J, Puhalla SL, Davidson NE, Oesterreich S, Brufsky AM, Young L, Lee AV.

JAMA Oncol. 2017 May 1;3(5):666-671. doi: 10.1001/jamaoncol.2016.5630. Erratum in: JAMA Oncol. 2017 Mar 1;3(3):418.

42.

Epigenomic Deconvolution of Breast Tumors Reveals Metabolic Coupling between Constituent Cell Types.

Onuchic V, Hartmaier RJ, Boone DN, Samuels ML, Patel RY, White WM, Garovic VD, Oesterreich S, Roth ME, Lee AV, Milosavljevic A.

Cell Rep. 2016 Nov 15;17(8):2075-2086. doi: 10.1016/j.celrep.2016.10.057.

43.

Intratumor Heterogeneity Affects Gene Expression Profile Test Prognostic Risk Stratification in Early Breast Cancer.

Gyanchandani R, Lin Y, Lin HM, Cooper K, Normolle DP, Brufsky A, Fastuca M, Crosson W, Oesterreich S, Davidson NE, Bhargava R, Dabbs DJ, Lee AV.

Clin Cancer Res. 2016 Nov 1;22(21):5362-5369. Epub 2016 May 16.

44.

TCGA Expedition: A Data Acquisition and Management System for TCGA Data.

Chandran UR, Medvedeva OP, Barmada MM, Blood PD, Chakka A, Luthra S, Ferreira A, Wong KF, Lee AV, Zhang Z, Budden R, Scott JR, Berndt A, Berg JM, Jacobson RS.

PLoS One. 2016 Oct 27;11(10):e0165395. doi: 10.1371/journal.pone.0165395. eCollection 2016.

45.

Lack of interaction between ErbB2 and insulin receptor substrate signaling in breast cancer.

Farabaugh SM, Chan BT, Cui X, Dearth RK, Lee AV.

Cell Commun Signal. 2016 Oct 21;14(1):25.

46.

Signal-Oriented Pathway Analyses Reveal a Signaling Complex as a Synthetic Lethal Target for p53 Mutations.

Lu S, Cai C, Yan G, Zhou Z, Wan Y, Chen V, Chen L, Cooper GF, Obeid LM, Hannun YA, Lee AV, Lu X.

Cancer Res. 2016 Dec 1;76(23):6785-6794. Epub 2016 Oct 10.

47.

WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines.

Sikora MJ, Jacobsen BM, Levine K, Chen J, Davidson NE, Lee AV, Alexander CM, Oesterreich S.

Breast Cancer Res. 2016 Sep 20;18(1):92. doi: 10.1186/s13058-016-0748-7.

48.

The Endocrine Society Centennial: 40 Years of Aromatase Inhibitors as Targeted Therapy for Breast Cancer.

Lee AV.

Endocrinology. 2016 Oct;157(10):3697-3698. Epub 2016 Sep 6. No abstract available.

PMID:
27599035
49.

Detection of ESR1 mutations in circulating cell-free DNA from patients with metastatic breast cancer treated with palbociclib and letrozole.

Gyanchandani R, Kota KJ, Jonnalagadda AR, Minteer T, Knapick BA, Oesterreich S, Brufsky AM, Lee AV, Puhalla SL.

Oncotarget. 2016 Aug 19;8(40):66901-66911. doi: 10.18632/oncotarget.11383. eCollection 2017 Sep 15.

50.

Endocrine Response Phenotypes Are Altered by Charcoal-Stripped Serum Variability.

Sikora MJ, Johnson MD, Lee AV, Oesterreich S.

Endocrinology. 2016 Oct;157(10):3760-3766. Epub 2016 Jul 26.

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