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Items: 24


CUX1 stimulates APE1 enzymatic activity and increases the resistance of glioblastoma cells to the mono-alkylating agent temozolomide.

Kaur S, Ramdzan ZM, Guiot MC, Li L, Leduy L, Ramotar D, Sabri S, Abdulkarim B, Nepveu A.

Neuro Oncol. 2018 Mar 27;20(4):484-493. doi: 10.1093/neuonc/nox178.


The DNA repair function of CUX1 contributes to radioresistance.

Ramdzan ZM, Ginjala V, Pinder JB, Chung D, Donovan CM, Kaur S, Leduy L, Dellaire G, Ganesan S, Nepveu A.

Oncotarget. 2017 Mar 21;8(12):19021-19038. doi: 10.18632/oncotarget.14875.


Special AT-rich Sequence-binding Protein 1 (SATB1) Functions as an Accessory Factor in Base Excision Repair.

Kaur S, Coulombe Y, Ramdzan ZM, Leduy L, Masson JY, Nepveu A.

J Biol Chem. 2016 Oct 21;291(43):22769-22780. Epub 2016 Sep 2.


CUX2 protein functions as an accessory factor in the repair of oxidative DNA damage.

Pal R, Ramdzan ZM, Kaur S, Duquette PM, Marcotte R, Leduy L, Davoudi S, Lamarche-Vane N, Iulianella A, Nepveu A.

J Biol Chem. 2015 Sep 11;290(37):22520-31. doi: 10.1074/jbc.M115.651042. Epub 2015 Jul 28.


The function of CUX1 in oxidative DNA damage repair is needed to prevent premature senescence of mouse embryo fibroblasts.

Ramdzan ZM, Pal R, Kaur S, Leduy L, Bérubé G, Davoudi S, Vadnais C, Nepveu A.

Oncotarget. 2015 Feb 28;6(6):3613-26.


RAS transformation requires CUX1-dependent repair of oxidative DNA damage.

Ramdzan ZM, Vadnais C, Pal R, Vandal G, Cadieux C, Leduy L, Davoudi S, Hulea L, Yao L, Karnezis AN, Paquet M, Dankort D, Nepveu A.

PLoS Biol. 2014 Mar 11;12(3):e1001807. doi: 10.1371/journal.pbio.1001807. eCollection 2014 Mar.


Long-range transcriptional regulation by the p110 CUX1 homeodomain protein on the ENCODE array.

Vadnais C, Awan AA, Harada R, Clermont PL, Leduy L, Bérubé G, Nepveu A.

BMC Genomics. 2013 Apr 16;14:258. doi: 10.1186/1471-2164-14-258.


Cut homeobox 1 causes chromosomal instability by promoting bipolar division after cytokinesis failure.

Sansregret L, Vadnais C, Livingstone J, Kwiatkowski N, Awan A, Cadieux C, Leduy L, Hallett MT, Nepveu A.

Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1949-54. doi: 10.1073/pnas.1008403108. Epub 2011 Jan 18.


Hyperphosphorylation by cyclin B/CDK1 in mitosis resets CUX1 DNA binding clock at each cell cycle.

Sansregret L, Gallo D, Santaguida M, Leduy L, Harada R, Nepveu A.

J Biol Chem. 2010 Oct 22;285(43):32834-43. doi: 10.1074/jbc.M110.156406. Epub 2010 Aug 19.


CUX1 transcription factor is a downstream effector of the proteinase-activated receptor 2 (PAR2).

Wilson BJ, Harada R, LeDuy L, Hollenberg MD, Nepveu A.

J Biol Chem. 2009 Jan 2;284(1):36-45. doi: 10.1074/jbc.M803808200. Epub 2008 Oct 24.


Proteolytic processing of cut homeobox 1 by neutrophil elastase in the MV4;11 myeloid leukemia cell line.

Goulet B, Markovic Y, Leduy L, Nepveu A.

Mol Cancer Res. 2008 Apr;6(4):644-53. doi: 10.1158/1541-7786.MCR-07-0268.


Genome-wide location analysis and expression studies reveal a role for p110 CUX1 in the activation of DNA replication genes.

Harada R, Vadnais C, Sansregret L, Leduy L, Bérubé G, Robert F, Nepveu A.

Nucleic Acids Res. 2008 Jan;36(1):189-202. Epub 2007 Nov 14.


Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation.

Goulet B, Sansregret L, Leduy L, Bogyo M, Weber E, Chauhan SS, Nepveu A.

Mol Cancer Res. 2007 Sep;5(9):899-907.


Carboxyl-terminal proteolytic processing of CUX1 by a caspase enables transcriptional activation in proliferating cells.

Truscott M, Denault JB, Goulet B, Leduy L, Salvesen GS, Nepveu A.

J Biol Chem. 2007 Oct 12;282(41):30216-26. Epub 2007 Aug 6.


The p110 isoform of the CDP/Cux transcription factor accelerates entry into S phase.

Sansregret L, Goulet B, Harada R, Wilson B, Leduy L, Bertoglio J, Nepveu A.

Mol Cell Biol. 2006 Mar;26(6):2441-55.


The N-terminal region of the CCAAT displacement protein (CDP)/Cux transcription factor functions as an autoinhibitory domain that modulates DNA binding.

Truscott M, Raynal L, Wang Y, Bérubé G, Leduy L, Nepveu A.

J Biol Chem. 2004 Nov 26;279(48):49787-94. Epub 2004 Sep 17.


CDP/Cux stimulates transcription from the DNA polymerase alpha gene promoter.

Truscott M, Raynal L, Premdas P, Goulet B, Leduy L, Bérubé G, Nepveu A.

Mol Cell Biol. 2003 Apr;23(8):3013-28.


Characterization of a tissue-specific CDP/Cux isoform, p75, activated in breast tumor cells.

Goulet B, Watson P, Poirier M, Leduy L, Bérubé G, Meterissian S, Jolicoeur P, Nepveu A.

Cancer Res. 2002 Nov 15;62(22):6625-33.


S phase-specific proteolytic cleavage is required to activate stable DNA binding by the CDP/Cut homeodomain protein.

Moon NS, Premdas P, Truscott M, Leduy L, Bérubé G, Nepveu A.

Mol Cell Biol. 2001 Sep;21(18):6332-45.


Exon/intron structure and alternative transcripts of the CUTL1 gene.

Rong Zeng W, Soucie E, Sung Moon N, Martin-Soudant N, Bérubé G, Leduy L, Nepveu A.

Gene. 2000 Jan 4;241(1):75-85.


Changes in CD44 expression during carcinogenesis of the mouse colon.

Rudzki Z, LeDuy L, Jothy S.

Exp Mol Pathol. 1997 Apr;64(2):114-25.


Adhesion or anti-adhesion in cancer: what matters more?

Jothy S, Munro SB, LeDuy L, McClure D, Blaschuk OW.

Cancer Metastasis Rev. 1995 Dec;14(4):363-76. Review.


Turcot's syndrome of glioma and polyposis occurs in the absence of germ line mutations of exons 5 to 9 of the p53 gene.

Kikuchi T, Rempel SA, Rutz HP, de Tribolet N, Mulligan L, Cavenee WK, Jothy S, Leduy L, Van Meir EG.

Cancer Res. 1993 Mar 1;53(5):957-61.


Interleukin-6 and its receptor are expressed in human intestinal epithelial cells.

Shirota K, LeDuy L, Yuan SY, Jothy S.

Virchows Arch B Cell Pathol Incl Mol Pathol. 1990;58(4):303-8.


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