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Items: 37


Daratumumab is effective in the relapsed or refractory systemic light-chain amyloidosis but associated with high infection burden in a frail real-life population.

Van de Wyngaert Z, Carpentier B, Pascal L, Lionne-Huyghe P, Leduc I, Srour M, Vasseur M, Demarquette H, Terriou L, Herbaux C, Manier S, Bossard JB, Barbieux S, Chauvet P, Willaume A, Nudel M, Bories C, Gibier JB, Facon T, Boyle EM.

Br J Haematol. 2020 Feb;188(3):e24-e27. doi: 10.1111/bjh.16282. Epub 2019 Nov 19. No abstract available.


A Class I Haemophilus ducreyi Strain Containing a Class II hgbA Allele Is Partially Attenuated in Humans: Implications for HgbA Vaccine Efficacy Trials.

Leduc I, Fortney KR, Janowicz DM, Zwickl B, Ellinger S, Katz BP, Lin H, Dong Q, Spinola SM.

Infect Immun. 2019 Jun 20;87(7). pii: e00112-19. doi: 10.1128/IAI.00112-19. Print 2019 Jul.


Exome sequencing identifies germline variants in DIS3 in familial multiple myeloma.

Pertesi M, Vallée M, Wei X, Revuelta MV, Galia P, Demangel D, Oliver J, Foll M, Chen S, Perrial E, Garderet L, Corre J, Leleu X, Boyle EM, Decaux O, Rodon P, Kolb B, Slama B, Mineur P, Voog E, Le Bris C, Fontan J, Maigre M, Beaumont M, Azais I, Sobol H, Vignon M, Royer B, Perrot A, Fuzibet JG, Dorvaux V, Anglaret B, Cony-Makhoul P, Berthou C, Desquesnes F, Pegourie B, Leyvraz S, Mosser L, Frenkiel N, Augeul-Meunier K, Leduc I, Leyronnas C, Voillat L, Casassus P, Mathiot C, Cheron N, Paubelle E, Moreau P, Bignon YJ, Joly B, Bourquard P, Caillot D, Naman H, Rigaudeau S, Marit G, Macro M, Lambrecht I, Cliquennois M, Vincent L, Helias P, Avet-Loiseau H, Moreno V, Reis RM, Varkonyi J, Kruszewski M, Vangsted AJ, Jurczyszyn A, Zaucha JM, Sainz J, Krawczyk-Kulis M, Wątek M, Pelosini M, Iskierka-Jażdżewska E, Grząśko N, Martinez-Lopez J, Jerez A, Campa D, Buda G, Lesueur F, Dudziński M, García-Sanz R, Nagler A, Rymko M, Jamroziak K, Butrym A, Canzian F, Obazee O, Nilsson B, Klein RJ, Lipkin SM, McKay JD, Dumontet C.

Leukemia. 2019 Sep;33(9):2324-2330. doi: 10.1038/s41375-019-0452-6. Epub 2019 Apr 9. No abstract available.


Immunization with the Haemophilus ducreyi trimeric autotransporter adhesin DsrA with alum, CpG or imiquimod generates a persistent humoral immune response that recognizes the bacterial surface.

Samo M, Choudhary NR, Riebe KJ, Shterev I, Staats HF, Sempowski GD, Leduc I.

Vaccine. 2016 Feb 24;34(9):1193-200. doi: 10.1016/j.vaccine.2016.01.024. Epub 2016 Jan 24.


Defining Potential Vaccine Targets of Haemophilus ducreyi Trimeric Autotransporter Adhesin DsrA.

Fusco WG, Choudhary NR, Stewart SM, Alam SM, Sempowski GD, Elkins C, Leduc I.

Monoclon Antib Immunodiagn Immunother. 2015 Apr;34(2):73-82. doi: 10.1089/mab.2014.0054.


The Haemophilus ducreyi trimeric autotransporter adhesin DsrA protects against an experimental infection in the swine model of chancroid.

Fusco WG, Choudhary NR, Routh PA, Ventevogel MS, Smith VA, Koch GG, Almond GW, Orndorff PE, Sempowski GD, Leduc I.

Vaccine. 2014 Jun 24;32(30):3752-8. doi: 10.1016/j.vaccine.2014.05.031. Epub 2014 May 18.


Trimeric autotransporter DsrA is a major mediator of fibrinogen binding in Haemophilus ducreyi.

Fusco WG, Elkins C, Leduc I.

Infect Immun. 2013 Dec;81(12):4443-52. doi: 10.1128/IAI.00743-13. Epub 2013 Sep 16.


Mutational analysis of hemoglobin binding and heme utilization by a bacterial hemoglobin receptor.

Fusco WG, Choudhary NR, Council SE, Collins EJ, Leduc I.

J Bacteriol. 2013 Jul;195(13):3115-23. doi: 10.1128/JB.00199-13. Epub 2013 May 10.


Passive immunization with a polyclonal antiserum to the hemoglobin receptor of Haemophilus ducreyi confers protection against a homologous challenge in the experimental swine model of chancroid.

Leduc I, Fusco WG, Choudhary N, Routh PA, Cholon DM, Hobbs MM, Almond GW, Orndorff PE, Elkins C.

Infect Immun. 2011 Aug;79(8):3168-77. doi: 10.1128/IAI.00017-11. Epub 2011 Jun 6.


Immunization with the Haemophilus ducreyi hemoglobin receptor HgbA with adjuvant monophosphoryl lipid A protects swine from a homologous but not a heterologous challenge.

Fusco WG, Afonina G, Nepluev I, Cholon DM, Choudhary N, Routh PA, Almond GW, Orndorff PE, Staats H, Hobbs MM, Leduc I, Elkins C.

Infect Immun. 2010 Sep;78(9):3763-72. doi: 10.1128/IAI.00217-10. Epub 2010 Jun 28.


An immunogenic, surface-exposed domain of Haemophilus ducreyi outer membrane protein HgbA is involved in hemoglobin binding.

Nepluev I, Afonina G, Fusco WG, Leduc I, Olsen B, Temple B, Elkins C.

Infect Immun. 2009 Jul;77(7):3065-74. doi: 10.1128/IAI.00034-09. Epub 2009 May 18.


Evaluation of the repertoire of the TonB-dependent receptors of Haemophilus ducreyi for their role in virulence in humans.

Leduc I, Banks KE, Fortney KR, Patterson KB, Billings SD, Katz BP, Spinola SM, Elkins C.

J Infect Dis. 2008 Apr 15;197(8):1103-9. doi: 10.1086/586901.


Outer membrane protein DsrA is the major fibronectin-binding determinant of Haemophilus ducreyi.

Leduc I, White CD, Nepluev I, Throm RE, Spinola SM, Elkins C.

Infect Immun. 2008 Apr;76(4):1608-16. doi: 10.1128/IAI.00994-07. Epub 2008 Jan 22.


[Filling the thymic space after treatment of Hodgkin's disease: rebound or relapse].

Margery J, de Revel T, Magois E, Bonardel G, Leduc I, Saint-Blancard P, Bonnichon A, Vaylet F, Jancovici R, Nedellec G.

Rev Pneumol Clin. 2007 Feb;63(1):45-7. French.


Immunization with the Haemophilus ducreyi hemoglobin receptor HgbA protects against infection in the swine model of chancroid.

Afonina G, Leduc I, Nepluev I, Jeter C, Routh P, Almond G, Orndorff PE, Hobbs M, Elkins C.

Infect Immun. 2006 Apr;74(4):2224-32.


A DltA mutant of Haemophilus ducreyi Is partially attenuated in its ability to cause pustules in human volunteers.

Janowicz D, Leduc I, Fortney KR, Katz BP, Elkins C, Spinola SM.

Infect Immun. 2006 Feb;74(2):1394-7.


Attenuated Salmonella typhimurium SL3261 as a vaccine vector for recombinant antigen in rabbits.

Ashby D, Leduc I, Lauzon W, Lee BC, Singhal N, Cameron DW.

J Immunol Methods. 2005 Apr;299(1-2):153-64. Epub 2005 Mar 23.


Haemophilus ducreyi Outer membrane determinants, including DsrA, define two clonal populations.

White CD, Leduc I, Olsen B, Jeter C, Harris C, Elkins C.

Infect Immun. 2005 Apr;73(4):2387-99.


A novel lectin, DltA, is required for expression of a full serum resistance phenotype in Haemophilus ducreyi.

Leduc I, Richards P, Davis C, Schilling B, Elkins C.

Infect Immun. 2004 Jun;72(6):3418-28.


Dexamethasone inhibits apoptosis of eosinophils isolated from hypereosinophilic patients.

Debierre-Grockiego F, Leduc I, Prin L, Gouilleux-Gruart V.

Immunobiology. 2001 Dec;204(4):517-23.


Cloning, overexpression, purification, and immunobiology of an 85-kilodalton outer membrane protein from Haemophilus ducreyi.

Thomas KL, Leduc I, Olsen B, Thomas CE, Cameron DW, Elkins C.

Infect Immun. 2001 Jul;69(7):4438-46.


The Pim-1 kinase stimulates maturation of TCRbeta-deficient T cell progenitors: implications for the mechanism of Pim-1 action.

Leduc I, Karsunky H, Mathieu N, Schmidt T, Verthuy C, Ferrier P, Möröy T.

Int Immunol. 2000 Oct;12(10):1389-96.


Plasminogen activator inhibitor 1, transforming growth factor-beta1, and BMI are closely associated in human adipose tissue during morbid obesity.

Alessi MC, Bastelica D, Morange P, Berthet B, Leduc I, Verdier M, Geel O, Juhan-Vague I.

Diabetes. 2000 Aug;49(8):1374-80.


T cell development in TCR beta enhancer-deleted mice: implications for alpha beta T cell lineage commitment and differentiation.

Leduc I, Hempel WM, Mathieu N, Verthuy C, Bouvier G, Watrin F, Ferrier P.

J Immunol. 2000 Aug 1;165(3):1364-73.


[Exposure to blood accidents in a university hospital. Results of 1-year surveillance].

Smail A, Doutrellot C, Leduc I, Duche A, Masmoudi K, Lienard J.

Presse Med. 2000 Mar 25;29(11):596. French. No abstract available.


[Autoimmune hepatitis and lupus syndrome associated with minocycline].

Dadamessi I, Leduc I, Duché A, Tiev K, Barbieux D, Sevestre H, Andréjak M, Ducroix JP.

Rev Med Interne. 1999 Oct;20(10):930-3. French.


Polyarthritis following intravesical BCG immunotherapy. Report of a case and review of 26 cases in the literature.

Clavel G, Grados F, Cayrolle G, Bellony R, Leduc I, Lafont B, Ducroix JP, Fardellone P.

Rev Rhum Engl Ed. 1999 Feb;66(2):115-8. Review.


Accessibility control of V(D)J recombination: lessons from gene targeting.

Hempel WM, Leduc I, Mathieu N, Tripathi RK, Ferrier P.

Adv Immunol. 1998;69:309-52. Review. No abstract available.


Membrane isoforms of human immunoglobulins of the A1 and A2 isotypes: structural and functional study.

Leduc I, Drouet M, Bodinier MC, Helal A, Cogné M.

Immunology. 1997 Mar;90(3):330-6.


[Non-bacterial thrombosing endocarditis. Apropos of 2 cases].

Tribouilloy C, Mirode A, Leduc I, Peltier M, Trojette F, Tribout B, Lesbre JP.

Ann Cardiol Angeiol (Paris). 1997 Jan;46(1):29-32. French.


Involvement of a tyrosine kinase pathway in the growth-promoting effects of angiotensin II on aortic smooth muscle cells.

Leduc I, Haddad P, Giasson E, Meloche S.

Mol Pharmacol. 1995 Oct;48(4):582-92.


[Thrombopenia following treatment with omeprazole].

Rudelli A, Leduc I, Traulle C, Smail A, Ducroix JP, Andréjak M, Baillet J.

Presse Med. 1993 Jun 5;22(20):966. French. No abstract available.


A human myeloma IgA with a hybrid heavy chain resulting from putative somatic gene conversion.

Silvain C, Aucouturier P, Leduc I, Mihaesco E, Preud'homme JL, Cogné M.

Eur J Immunol. 1993 Feb;23(2):364-8.


Structure and expression of the mb-1 transcript in human lymphoid cells.

Leduc I, Preud'homme JL, Cogné M.

Clin Exp Immunol. 1992 Oct;90(1):141-6.

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