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Physiological consequences of transient hyperleptinemia during discrete developmental periods on body weight in mice.

Skowronski AA, LeDuc CA, Foo KS, Goffer Y, Burnett LC, Egli D, Leibel RL.

Sci Transl Med. 2020 Jan 1;12(524). pii: eaax6629. doi: 10.1126/scitranslmed.aax6629.


Independent prognostic value of ultra-sensitive quantification of tumor pre-treatment T790M subclones in EGFR mutated non-small cell lung cancer (NSCLC) treated by first/second generation TKI, depends on variant allele frequency (VAF): Results of the French cooperative thoracic intergroup (IFCT) biomarkers France project.

Beau-Faller M, Pencreach E, Leduc C, Blons H, Merlio JP, Bringuier PP, de Fraipont F, Escande F, Lemoine A, Ouafik L, Denis M, Hofman P, Lacave R, Melaabi S, Langlais A, Missy P, Morin F, Moro-Sibilot D, Barlesi F, Cadranel J; French Cooperative Thoracic Intergroup (IFCT).

Lung Cancer. 2020 Feb;140:19-26. doi: 10.1016/j.lungcan.2019.10.013. Epub 2019 Nov 15.


Association Between Nitrate-Reducing Oral Bacteria and Cardiometabolic Outcomes: Results From ORIGINS.

Goh CE, Trinh P, Colombo PC, Genkinger JM, Mathema B, Uhlemann AC, LeDuc C, Leibel R, Rosenbaum M, Paster BJ, Desvarieux M, Papapanou PN, Jacobs DR Jr, Demmer RT.

J Am Heart Assoc. 2019 Dec 3;8(23):e013324. doi: 10.1161/JAHA.119.013324. Epub 2019 Nov 26.


The Quality, Quantity, and Intraindividual Variability of Sleep Among Students and Student-Athletes.

Leduc C, Tee J, Weakley J, Ramirez C, Jones B.

Sports Health. 2020 Jan/Feb;12(1):43-50. doi: 10.1177/1941738119887966. Epub 2019 Nov 15.


Subgingival Microbiota and Longitudinal Glucose Change: The Oral Infections, Glucose Intolerance and Insulin Resistance Study (ORIGINS).

Demmer RT, Trinh P, Rosenbaum M, Li G, LeDuc C, Leibel R, González A, Knight R, Paster B, Colombo PC, Desvarieux M, Papapanou PN, Jacobs DR Jr.

J Dent Res. 2019 Dec;98(13):1488-1496. doi: 10.1177/0022034519881978. Epub 2019 Oct 17.


Auto-Regulation of Leptin Neurobiology.

LeDuc CA, Leibel RL.

Cell Metab. 2019 Oct 1;30(4):614-616. doi: 10.1016/j.cmet.2019.09.006.


Deciphering the transport of elastic filaments by antagonistic motor proteins.

Portet S, Leduc C, Etienne-Manneville S, Dallon J.

Phys Rev E. 2019 Apr;99(4-1):042414. doi: 10.1103/PhysRevE.99.042414.


Activity of EGFR Tyrosine Kinase Inhibitors in NSCLC With Refractory Leptomeningeal Metastases.

Flippot R, Biondani P, Auclin E, Xiao D, Hendriks L, Le Rhun E, Leduc C, Beau-Faller M, Gervais R, Remon J, Adam J, Planchard D, Lavaud P, Naltet C, Caramella C, Le Pechoux C, Lacroix L, Gazzah A, Mezquita L, Besse B.

J Thorac Oncol. 2019 Aug;14(8):1400-1407. doi: 10.1016/j.jtho.2019.05.007. Epub 2019 May 18.


Developing a case definition for type 1 diabetes mellitus in a primary care electronic medical record database: an exploratory study.

Lethebe BC, Williamson T, Garies S, McBrien K, Leduc C, Butalia S, Soos B, Shaw M, Drummond N.

CMAJ Open. 2019 May 6;7(2):E246-E251. doi: 10.9778/cmajo.20180142. Print 2019 Apr-Jun.


Homozygous noncanonical splice variant in LSM1 in two siblings with multiple congenital anomalies and global developmental delay.

Okur V, LeDuc CA, Guzman E, Valivullah ZM, Anyane-Yeboa K, Chung WK.

Cold Spring Harb Mol Case Stud. 2019 Jun 3;5(3). pii: a004101. doi: 10.1101/mcs.a004101. Print 2019 Jun.


[Vaccines for the treatment of non-small cell lung cancer].

Leduc C, Quoix E.

Rev Mal Respir. 2019 Mar;36(3):415-425. doi: 10.1016/j.rmr.2018.12.003. Epub 2019 Mar 20. Review. French.


Transgenic substitution with Greater Amberjack Seriola dumerili fish insulin 2 in NOD mice reduces beta cell immunogenicity.

Foo KS, Skowronski AA, Baum D, Firdessa-Fite R, Thams S, Shang L, Creusot RJ, LeDuc CA, Egli D, Leibel RL.

Sci Rep. 2019 Mar 21;9(1):4965. doi: 10.1038/s41598-019-40768-3.


Microtubule acetylation but not detyrosination promotes focal adhesion dynamics and astrocyte migration.

Bance B, Seetharaman S, Leduc C, Boëda B, Etienne-Manneville S.

J Cell Sci. 2019 Apr 5;132(7). pii: jcs225805. doi: 10.1242/jcs.225805.


Effect of a Simulated Mine Rescue on Physiological Variables and Heat Strain of Mine Rescue Workers.

Konrad J, Gagnon D, Serresse O, Oddson B, Leduc C, Dorman SC.

J Occup Environ Med. 2019 Mar;61(3):251-261. doi: 10.1097/JOM.0000000000001530.


The Effects of Augmented Feedback on Sprint, Jump, and Strength Adaptations in Rugby Union Players After a 4-Week Training Program.

Weakley J, Till K, Sampson J, Banyard H, Leduc C, Wilson K, Roe G, Jones B.

Int J Sports Physiol Perform. 2019 Aug 29:1205-1211. doi: 10.1123/ijspp.2018-0523. [Epub ahead of print]


Sudden death in transposition of the great arteries with atrial switch surgery: Autopsy evidence of acute myocardial ischemia despite normal coronary arteries.

Chaix MA, Chergui M, Leduc C, Khairy P.

Int J Cardiol. 2019 Aug 1;288:65-67. doi: 10.1016/j.ijcard.2019.02.026. Epub 2019 Feb 14.


Sleep Quality and Quantity of International Rugby Sevens Players During Pre-season.

Leduc C, Jones B, Robineau J, Piscione J, Lacome M.

J Strength Cond Res. 2019 Jul;33(7):1878-1886. doi: 10.1519/JSC.0000000000002839.


Recessive Rare Variants in Deoxyhypusine Synthase, an Enzyme Involved in the Synthesis of Hypusine, Are Associated with a Neurodevelopmental Disorder.

Ganapathi M, Padgett LR, Yamada K, Devinsky O, Willaert R, Person R, Au PB, Tagoe J, McDonald M, Karlowicz D, Wolf B, Lee J, Shen Y, Okur V, Deng L, LeDuc CA, Wang J, Hanner A, Mirmira RG, Park MH, Mastracci TL, Chung WK.

Am J Hum Genet. 2019 Feb 7;104(2):287-298. doi: 10.1016/j.ajhg.2018.12.017. Epub 2019 Jan 17.


Stochastic modeling reveals how motor protein and filament properties affect intermediate filament transport.

Dallon JC, Leduc C, Etienne-Manneville S, Portet S.

J Theor Biol. 2019 Mar 7;464:132-148. doi: 10.1016/j.jtbi.2018.12.022. Epub 2018 Dec 27.


Haematological immune-related adverse events induced by anti-PD-1 or anti-PD-L1 immunotherapy: a descriptive observational study.

Delanoy N, Michot JM, Comont T, Kramkimel N, Lazarovici J, Dupont R, Champiat S, Chahine C, Robert C, Herbaux C, Besse B, Guillemin A, Mateus C, Pautier P, Saïag P, Madonna E, Maerevoet M, Bout JC, Leduc C, Biscay P, Quere G, Nardin C, Ebbo M, Albigès L, Marret G, Levrat V, Dujon C, Vargaftig J, Laghouati S, Croisille L, Voisin AL, Godeau B, Massard C, Ribrag V, Marabelle A, Michel M, Lambotte O.

Lancet Haematol. 2019 Jan;6(1):e48-e57. doi: 10.1016/S2352-3026(18)30175-3. Epub 2018 Dec 4.


Open staged repair of splenic and extensive superior mesenteric artery aneurysms.

Arghami A, Krajewski AC, Gloviczki P, Leduc C, Lin PT.

J Vasc Surg. 2019 Apr;69(4):1252-1256. doi: 10.1016/j.jvs.2018.08.168. Epub 2018 Oct 3.


Jump Training in Rugby Union Players: Barbell or Hexagonal Bar?

Weakley JJS, Till K, Read DB, Leduc C, Roe GAB, Phibbs PJ, Darrall-Jones J, Jones B.

J Strength Cond Res. 2018 Jul 4. doi: 10.1519/JSC.0000000000002742. [Epub ahead of print]


Intermediate filaments control collective migration by restricting traction forces and sustaining cell-cell contacts.

De Pascalis C, Pérez-González C, Seetharaman S, Boëda B, Vianay B, Burute M, Leduc C, Borghi N, Trepat X, Etienne-Manneville S.

J Cell Biol. 2018 Sep 3;217(9):3031-3044. doi: 10.1083/jcb.201801162. Epub 2018 Jul 6.


Bi-allelic Mutations in Phe-tRNA Synthetase Associated with a Multi-system Pulmonary Disease Support Non-translational Function.

Xu Z, Lo WS, Beck DB, Schuch LA, Oláhová M, Kopajtich R, Chong YE, Alston CL, Seidl E, Zhai L, Lau CF, Timchak D, LeDuc CA, Borczuk AC, Teich AF, Juusola J, Sofeso C, Müller C, Pierre G, Hilliard T, Turnpenny PD, Wagner M, Kappler M, Brasch F, Bouffard JP, Nangle LA, Yang XL, Zhang M, Taylor RW, Prokisch H, Griese M, Chung WK, Schimmel P.

Am J Hum Genet. 2018 Jul 5;103(1):100-114. doi: 10.1016/j.ajhg.2018.06.006.


Training Periodization Over an Elite Rugby Sevens Season: From Theory to Practice.

Marrier B, Le Meur Y, Leduc C, Piscione J, Lacome M, Igarza G, Hausswirth C, Morin JB, Robineau J.

Int J Sports Physiol Perform. 2018 Dec 18:1-9. doi: 10.1123/ijspp.2017-0839. [Epub ahead of print]


Evidence for a Non-leptin System that Defends against Weight Gain in Overfeeding.

Ravussin Y, Edwin E, Gallop M, Xu L, Bartolomé A, Kraakman MJ, LeDuc CA, Ferrante AW Jr.

Cell Metab. 2018 Aug 7;28(2):289-299.e5. doi: 10.1016/j.cmet.2018.05.029. Epub 2018 Jun 21.


FTO mediates cell-autonomous effects on adipogenesis and adipocyte lipid content by regulating gene expression via 6mA DNA modifications.

Martin Carli JF, LeDuc CA, Zhang Y, Stratigopoulos G, Leibel RL.

J Lipid Res. 2018 Aug;59(8):1446-1460. doi: 10.1194/jlr.M085555. Epub 2018 Jun 22.


DMSO increases efficiency of genome editing at two non-coding loci.

Stratigopoulos G, De Rosa MC, LeDuc CA, Leibel RL, Doege CA.

PLoS One. 2018 Jun 4;13(6):e0198637. doi: 10.1371/journal.pone.0198637. eCollection 2018.


ILDR2 has a negligible role in hepatic steatosis.

Millings EJ, De Rosa MC, Fleet S, Watanabe K, Rausch R, Egli D, Li G, Leduc CA, Zhang Y, Fischer SG, Leibel RL.

PLoS One. 2018 May 30;13(5):e0197548. doi: 10.1371/journal.pone.0197548. eCollection 2018.


SNAI2 and TWIST1 in lymph node progression in early stages of NSCLC patients.

Emprou C, Le Van Quyen P, Jégu J, Prim N, Weingertner N, Guérin E, Pencreach E, Legrain M, Voegeli AC, Leduc C, Mennecier B, Falcoz PE, Olland A, Santelmo N, Quoix E, Massard G, Guenot D, Chenard MP, Beau-Faller M.

Cancer Med. 2018 May 29. doi: 10.1002/cam4.1545. [Epub ahead of print]


Advancing Indigenous primary health care policy in Alberta, Canada.

Henderson R, Montesanti S, Crowshoe L, Leduc C.

Health Policy. 2018 Jun;122(6):638-644. doi: 10.1016/j.healthpol.2018.04.014. Epub 2018 May 7.


Spontaneous atopic dermatitis due to immune dysregulation in mice lacking Adamts2 and 14.

Dupont L, Ehx G, Chantry M, Monseur C, Leduc C, Janssen L, Cataldo D, Thiry M, Jerome C, Thomassin JM, Nusgens B, Dubail J, Baron F, Colige A.

Matrix Biol. 2018 Sep;70:140-157. doi: 10.1016/j.matbio.2018.04.002. Epub 2018 Apr 9.


Imaging Intermediate Filaments and Microtubules with 2-dimensional Direct Stochastic Optical Reconstruction Microscopy.

Leduc C, Salles A, Shorte SL, Etienne-Manneville S.

J Vis Exp. 2018 Mar 6;(133). doi: 10.3791/57087.


The role of Rpgrip1l, a component of the primary cilium, in adipocyte development and function.

Carli JFM, LeDuc CA, Zhang Y, Stratigopoulos G, Leibel RL.

FASEB J. 2018 Jul;32(7):3946-3956. doi: 10.1096/fj.201701216R. Epub 2018 Feb 21.


TPF induction chemotherapy increases PD-L1 expression in tumour cells and immune cells in head and neck squamous cell carcinoma.

Leduc C, Adam J, Louvet E, Sourisseau T, Dorvault N, Bernard M, Maingot E, Faivre L, Cassin-Kuo MS, Boissier E, Dessoliers MC, Robin A, Casiraghi O, Even C, Temam S, Olaussen KA, Soria JC, Postel-Vinay S.

ESMO Open. 2018 Jan 9;3(1):e000257. doi: 10.1136/esmoopen-2017-000257. eCollection 2018.


Outcome of EGFR-mutated NSCLC patients with MET-driven resistance to EGFR tyrosine kinase inhibitors.

Baldacci S, Mazieres J, Tomasini P, Girard N, Guisier F, Audigier-Valette C, Monnet I, Wislez M, Pérol M, Dô P, Dansin E, Leduc C, Giroux Leprieur E, Moro-Sibilot D, Tulasne D, Kherrouche Z, Labreuche J, Cortot AB.

Oncotarget. 2017 Oct 9;8(62):105103-105114. doi: 10.18632/oncotarget.21707. eCollection 2017 Dec 1.


Energy homeostasis in leptin deficient Lepob/ob mice.

Skowronski AA, Ravussin Y, Leibel RL, LeDuc CA.

PLoS One. 2017 Dec 20;12(12):e0189784. doi: 10.1371/journal.pone.0189784. eCollection 2017.


Technical Advances for the Clinical Genomic Evaluation of Sudden Cardiac Death: Verification of Next-Generation Sequencing Panels for Hereditary Cardiovascular Conditions Using Formalin-Fixed Paraffin-Embedded Tissues and Dried Blood Spots.

Baudhuin LM, Leduc C, Train LJ, Avula R, Kluge ML, Kotzer KE, Lin PT, Ackerman MJ, Maleszewski JJ.

Circ Cardiovasc Genet. 2017 Dec;10(6). pii: e001844. doi: 10.1161/CIRCGENETICS.117.001844.


Sleep Quantity and Quality of Ontario Wildland Firefighters Across a Low-Hazard Fire Season.

McGillis Z, Dorman SC, Robertson A, Larivière M, Leduc C, Eger T, Oddson BE, Larivière C.

J Occup Environ Med. 2017 Dec;59(12):1188-1196. doi: 10.1097/JOM.0000000000001175.


Combined targeting of Raf and Mek synergistically inhibits tumorigenesis in triple negative breast cancer model systems.

Nagaria TS, Shi C, Leduc C, Hoskin V, Sikdar S, Sangrar W, Greer PA.

Oncotarget. 2017 Aug 24;8(46):80804-80819. doi: 10.18632/oncotarget.20534. eCollection 2017 Oct 6.


Loss of the imprinted, non-coding Snord116 gene cluster in the interval deleted in the Prader Willi syndrome results in murine neuronal and endocrine pancreatic developmental phenotypes.

Burnett LC, Hubner G, LeDuc CA, Morabito MV, Carli JFM, Leibel RL.

Hum Mol Genet. 2017 Dec 1;26(23):4606-4616. doi: 10.1093/hmg/ddx342.


Clinical and molecular characteristics of non-small-cell lung cancer (NSCLC) harboring EGFR mutation: results of the nationwide French Cooperative Thoracic Intergroup (IFCT) program.

Leduc C, Merlio JP, Besse B, Blons H, Debieuvre D, Bringuier PP, Monnet I, Rouquette I, Fraboulet-Moreau S, Lemoine A, Pouessel D, Mosser J, Vaylet F, Langlais A, Missy P, Morin F, Moro-Sibilot D, Cadranel J, Barlesi F, Beau-Faller M; French Cooperative Thoracic Intergroup (IFCT).

Ann Oncol. 2017 Nov 1;28(11):2715-2724. doi: 10.1093/annonc/mdx404.


Case Study: Sleep and Injury in Elite Soccer-A Mixed Method Approach.

Nédélec M, Leduc C, Dawson B, Guilhem G, Dupont G.

J Strength Cond Res. 2019 Nov;33(11):3085-3091. doi: 10.1519/JSC.0000000000002251.


Intermediate filaments join the action.

Leduc C, Etienne-Manneville S.

Cell Cycle. 2017 Aug 3;16(15):1389-1390. doi: 10.1080/15384101.2017.1345230. Epub 2017 Jul 19. No abstract available.


Immune-related bone marrow failure following anti-PD1 therapy.

Michot JM, Vargaftig J, Leduc C, Quere G, Burroni B, Lazarovici J, Champiat S, Ribrag V, Lambotte O.

Eur J Cancer. 2017 Jul;80:1-4. doi: 10.1016/j.ejca.2017.04.004. Epub 2017 May 17. No abstract available.


Regulation of microtubule-associated motors drives intermediate filament network polarization.

Leduc C, Etienne-Manneville S.

J Cell Biol. 2017 Jun 5;216(6):1689-1703. doi: 10.1083/jcb.201607045. Epub 2017 Apr 21.


Comorbidities in the management of patients with lung cancer.

Leduc C, Antoni D, Charloux A, Falcoz PE, Quoix E.

Eur Respir J. 2017 Mar 29;49(3). pii: 1601721. doi: 10.1183/13993003.01721-2016. Print 2017 Mar. Review.


Curcumin and Piperine Supplementation and Recovery Following Exercise Induced Muscle Damage: A Randomized Controlled Trial.

Delecroix B, Abaïdia AE, Leduc C, Dawson B, Dupont G.

J Sports Sci Med. 2017 Mar 1;16(1):147-153. eCollection 2017 Mar.


Personal Exposimeter for Radiation Assessment in Real Environments in the 60-GHz Band.

Aminzadeh R, Thielens A, Li H, Leduc C, Zhadobov M, Torfs G, Bauwelinck J, Martens L, Joseph W.

Radiat Prot Dosimetry. 2017 Nov 1;176(3):316-321. doi: 10.1093/rpd/ncx012.


Novel Tools in Determining the Physiological Demands and Nutritional Practices of Ontario FireRangers during Fire Deployments.

Robertson AH, Larivière C, Leduc CR, McGillis Z, Eger T, Godwin A, Larivière M, Dorman SC.

PLoS One. 2017 Jan 20;12(1):e0169390. doi: 10.1371/journal.pone.0169390. eCollection 2017.

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