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Items: 24

1.

The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension.

Morikawa M, Mitani Y, Holmborn K, Kato T, Koinuma D, Maruyama J, Vasilaki E, Sawada H, Kobayashi M, Ozawa T, Morishita Y, Bessho Y, Maeda S, Ledin J, Aburatani H, Kageyama R, Maruyama K, Heldin CH, Miyazono K.

Sci Signal. 2019 Nov 12;12(607). pii: eaay4430. doi: 10.1126/scisignal.aay4430.

PMID:
31719172
2.

Zebrafish embryo as a replacement model for initial biocompatibility studies of biomaterials and drug delivery systems.

Rothenbücher TSP, Ledin J, Gibbs D, Engqvist H, Persson C, Hulsart-Billström G.

Acta Biomater. 2019 Oct 1. pii: S1742-7061(19)30659-2. doi: 10.1016/j.actbio.2019.09.038. [Epub ahead of print]

PMID:
31585201
3.

TAF1, associated with intellectual disability in humans, is essential for embryogenesis and regulates neurodevelopmental processes in zebrafish.

Gudmundsson S, Wilbe M, Filipek-Górniok B, Molin AM, Ekvall S, Johansson J, Allalou A, Gylje H, Kalscheuer VM, Ledin J, Annerén G, Bondeson ML.

Sci Rep. 2019 Jul 24;9(1):10730. doi: 10.1038/s41598-019-46632-8.

4.

The Nordic Zebrafish and Husbandry Meeting 2018.

Filipek-Górniok B, Ledin J, Aleström P, Braeutigam L.

Zebrafish. 2019 Jun;16(3):329-330. doi: 10.1089/zeb.2019.1732. Epub 2019 Mar 5.

PMID:
30835163
5.

A high-throughput functional genomics workflow based on CRISPR/Cas9-mediated targeted mutagenesis in zebrafish.

Varshney GK, Carrington B, Pei W, Bishop K, Chen Z, Fan C, Xu L, Jones M, LaFave MC, Ledin J, Sood R, Burgess SM.

Nat Protoc. 2016 Dec;11(12):2357-2375. doi: 10.1038/nprot.2016.141. Epub 2016 Oct 27.

6.

Fish from Head to Tail: The 9th European Zebrafish Meeting in Oslo.

Griffiths G, Müller F, Ledin J, Patton EE, Gjøen T, Lobert VH, Winther-Larsen HC, Mullins M, Joly JS, Weltzien FA, Press CM, Aleström P.

Zebrafish. 2016 Apr;13(2):132-7. doi: 10.1089/zeb.2015.1212. Epub 2016 Feb 9.

7.

CRISPRz: a database of zebrafish validated sgRNAs.

Varshney GK, Zhang S, Pei W, Adomako-Ankomah A, Fohtung J, Schaffer K, Carrington B, Maskeri A, Slevin C, Wolfsberg T, Ledin J, Sood R, Burgess SM.

Nucleic Acids Res. 2016 Jan 4;44(D1):D822-6. doi: 10.1093/nar/gkv998. Epub 2015 Oct 4.

8.

High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9.

Varshney GK, Pei W, LaFave MC, Idol J, Xu L, Gallardo V, Carrington B, Bishop K, Jones M, Li M, Harper U, Huang SC, Prakash A, Chen W, Sood R, Ledin J, Burgess SM.

Genome Res. 2015 Jul;25(7):1030-42. doi: 10.1101/gr.186379.114. Epub 2015 Jun 5.

9.

Chondroitin / dermatan sulfate modification enzymes in zebrafish development.

Habicher J, Haitina T, Eriksson I, Holmborn K, Dierker T, Ahlberg PE, Ledin J.

PLoS One. 2015 Mar 20;10(3):e0121957. doi: 10.1371/journal.pone.0121957. eCollection 2015.

10.

The NDST gene family in zebrafish: role of NDST1B in pharyngeal arch formation.

Filipek-Górniok B, Carlsson P, Haitina T, Habicher J, Ledin J, Kjellén L.

PLoS One. 2015 Mar 13;10(3):e0119040. doi: 10.1371/journal.pone.0119040. eCollection 2015.

11.

Spinal deformity in aged zebrafish is accompanied by degenerative changes to their vertebrae that resemble osteoarthritis.

Hayes AJ, Reynolds S, Nowell MA, Meakin LB, Habicher J, Ledin J, Bashford A, Caterson B, Hammond CL.

PLoS One. 2013 Sep 24;8(9):e75787. doi: 10.1371/journal.pone.0075787. eCollection 2013.

12.

Expression of chondroitin/dermatan sulfate glycosyltransferases during early zebrafish development.

Filipek-Górniok B, Holmborn K, Haitina T, Habicher J, Oliveira MB, Hellgren C, Eriksson I, Kjellén L, Kreuger J, Ledin J.

Dev Dyn. 2013 Aug;242(8):964-75. doi: 10.1002/dvdy.23981. Epub 2013 Jun 18.

13.

On the roles and regulation of chondroitin sulfate and heparan sulfate in zebrafish pharyngeal cartilage morphogenesis.

Holmborn K, Habicher J, Kasza Z, Eriksson AS, Filipek-Gorniok B, Gopal S, Couchman JR, Ahlberg PE, Wiweger M, Spillmann D, Kreuger J, Ledin J.

J Biol Chem. 2012 Sep 28;287(40):33905-16. Epub 2012 Aug 6.

14.

Zebrafish Ext2 is necessary for Fgf and Wnt signaling, but not for Hh signaling.

Fischer S, Filipek-Gorniok B, Ledin J.

BMC Dev Biol. 2011 Sep 5;11:53. doi: 10.1186/1471-213X-11-53.

15.

Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development.

Abramsson A, Kurup S, Busse M, Yamada S, Lindblom P, Schallmeiner E, Stenzel D, Sauvaget D, Ledin J, Ringvall M, Landegren U, Kjellén L, Bondjers G, Li JP, Lindahl U, Spillmann D, Betsholtz C, Gerhardt H.

Genes Dev. 2007 Feb 1;21(3):316-31.

16.

Enzymatically active N-deacetylase/N-sulfotransferase-2 is present in liver but does not contribute to heparan sulfate N-sulfation.

Ledin J, Ringvall M, Thuveson M, Eriksson I, Wilén M, Kusche-Gullberg M, Forsberg E, Kjellén L.

J Biol Chem. 2006 Nov 24;281(47):35727-34. Epub 2006 Sep 19.

17.

HSPG synthesis by zebrafish Ext2 and Extl3 is required for Fgf10 signalling during limb development.

Norton WH, Ledin J, Grandel H, Neumann CJ.

Development. 2005 Nov;132(22):4963-73. Epub 2005 Oct 12.

18.

Heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 is 6-O-sulfated but contains no N-sulfate groups.

Holmborn K, Ledin J, Smeds E, Eriksson I, Kusche-Gullberg M, Kjellén L.

J Biol Chem. 2004 Oct 8;279(41):42355-8. Epub 2004 Aug 19.

19.

Heparan sulfate structure in mice with genetically modified heparan sulfate production.

Ledin J, Staatz W, Li JP, Götte M, Selleck S, Kjellén L, Spillmann D.

J Biol Chem. 2004 Oct 8;279(41):42732-41. Epub 2004 Jul 29.

20.

Disturbed Ca2+ kinetics in N-deacetylase/N-sulfotransferase-1 defective myotubes.

Jenniskens GJ, Ringvall M, Koopman WJ, Ledin J, Kjellén L, Willems PH, Forsberg E, Veerkamp JH, van Kuppevelt TH.

J Cell Sci. 2003 Jun 1;116(Pt 11):2187-93. Epub 2003 Apr 8.

21.

Heparan sulfate and development: differential roles of the N-acetylglucosamine N-deacetylase/N-sulfotransferase isozymes.

Grobe K, Ledin J, Ringvall M, Holmborn K, Forsberg E, Esko JD, Kjellén L.

Biochim Biophys Acta. 2002 Dec 19;1573(3):209-15. Review.

PMID:
12417402
22.

Altered storage of proteases in mast cells from mice lacking heparin: a possible role for heparin in carboxypeptidase A processing.

Henningsson F, Ledin J, Lunderius C, Wilén M, Hellman L, Pejler G.

Biol Chem. 2002 May;383(5):793-801.

PMID:
12108544
23.

Defective heparan sulfate biosynthesis and neonatal lethality in mice lacking N-deacetylase/N-sulfotransferase-1.

Ringvall M, Ledin J, Holmborn K, van Kuppevelt T, Ellin F, Eriksson I, Olofsson AM, Kjellen L, Forsberg E.

J Biol Chem. 2000 Aug 25;275(34):25926-30.

24.

Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme.

Forsberg E, Pejler G, Ringvall M, Lunderius C, Tomasini-Johansson B, Kusche-Gullberg M, Eriksson I, Ledin J, Hellman L, Kjellén L.

Nature. 1999 Aug 19;400(6746):773-6.

PMID:
10466727

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