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Items: 1 to 50 of 249

1.

Dynamics of the mitochondrial permeability transition pore: Transient and permanent opening events.

Boyman L, Coleman AK, Zhao G, Wescott AP, Joca HC, Greiser BM, Karbowski M, Ward CW, Lederer WJ.

Arch Biochem Biophys. 2019 May 15;666:31-39. doi: 10.1016/j.abb.2019.03.016. Epub 2019 Mar 28.

PMID:
30930285
2.

Real-time local oxygen measurements for high resolution cellular imaging.

Boyman L, Williams GSB, Wescott AP, Leach JB, Kao JPY, Lederer WJ.

J Mol Cell Cardiol. 2019 Feb;127:97-104. doi: 10.1016/j.yjmcc.2018.11.021. Epub 2018 Dec 5.

PMID:
30528909
3.

Niels Voigt talks to W. Jonathan Lederer, keynote lecturer at the "Göttingen Channels" Symposium 2017.

Voigt N, Lederer WJ.

Cardiovasc Res. 2018 Feb 1;114(2):e14. doi: 10.1093/cvr/cvx241. No abstract available.

PMID:
29373724
4.

Ambiguous interactions between diastolic and SR Ca2+ in the regulation of cardiac Ca2+ release.

Sobie EA, Williams GSB, Lederer WJ.

J Gen Physiol. 2017 Sep 4;149(9):847-855. doi: 10.1085/jgp.201711814. Epub 2017 Aug 10. Review. No abstract available.

5.

IP3 receptors regulate vascular smooth muscle contractility and hypertension.

Lin Q, Zhao G, Fang X, Peng X, Tang H, Wang H, Jing R, Liu J, Lederer WJ, Chen J, Ouyang K.

JCI Insight. 2016 Oct 20;1(17):e89402. doi: 10.1172/jci.insight.89402.

6.

Axial tubule junctions control rapid calcium signaling in atria.

Brandenburg S, Kohl T, Williams GS, Gusev K, Wagner E, Rog-Zielinska EA, Hebisch E, Dura M, Didié M, Gotthardt M, Nikolaev VO, Hasenfuss G, Kohl P, Ward CW, Lederer WJ, Lehnart SE.

J Clin Invest. 2016 Oct 3;126(10):3999-4015. doi: 10.1172/JCI88241. Epub 2016 Sep 19.

7.

Ryanodine receptor sensitivity governs the stability and synchrony of local calcium release during cardiac excitation-contraction coupling.

Wescott AP, Jafri MS, Lederer WJ, Williams GS.

J Mol Cell Cardiol. 2016 Mar;92:82-92. doi: 10.1016/j.yjmcc.2016.01.024. Epub 2016 Jan 28.

8.

Modeling Local X-ROS and Calcium Signaling in the Heart.

Limbu S, Hoang-Trong TM, Prosser BL, Lederer WJ, Jafri MS.

Biophys J. 2015 Nov 17;109(10):2037-50. doi: 10.1016/j.bpj.2015.09.031.

9.

Mitochondrial E3 ubiquitin ligase MARCH5 controls mitochondrial fission and cell sensitivity to stress-induced apoptosis through regulation of MiD49 protein.

Xu S, Cherok E, Das S, Li S, Roelofs BA, Ge SX, Polster BM, Boyman L, Lederer WJ, Wang C, Karbowski M.

Mol Biol Cell. 2016 Jan 15;27(2):349-59. doi: 10.1091/mbc.E15-09-0678. Epub 2015 Nov 12.

10.

On the Adjacency Matrix of RyR2 Cluster Structures.

Walker MA, Kohl T, Lehnart SE, Greenstein JL, Lederer WJ, Winslow RL.

PLoS Comput Biol. 2015 Nov 6;11(11):e1004521. doi: 10.1371/journal.pcbi.1004521. eCollection 2015 Nov.

11.

STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node.

Zhang H, Sun AY, Kim JJ, Graham V, Finch EA, Nepliouev I, Zhao G, Li T, Lederer WJ, Stiber JA, Pitt GS, Bursac N, Rosenberg PB.

Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):E5618-27. doi: 10.1073/pnas.1503847112. Epub 2015 Sep 30.

12.

The growing importance of mitochondrial calcium in health and disease.

Boyman L, Williams GS, Lederer WJ.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11150-1. doi: 10.1073/pnas.1514284112. Epub 2015 Aug 26. No abstract available.

13.

STIM1 enhances SR Ca2+ content through binding phospholamban in rat ventricular myocytes.

Zhao G, Li T, Brochet DX, Rosenberg PB, Lederer WJ.

Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):E4792-801. doi: 10.1073/pnas.1423295112. Epub 2015 Aug 10.

14.

Contractile Function During Angiotensin-II Activation: Increased Nox2 Activity Modulates Cardiac Calcium Handling via Phospholamban Phosphorylation.

Zhang M, Prosser BL, Bamboye MA, Gondim ANS, Santos CX, Martin D, Ghigo A, Perino A, Brewer AC, Ward CW, Hirsch E, Lederer WJ, Shah AM.

J Am Coll Cardiol. 2015 Jul 21;66(3):261-272. doi: 10.1016/j.jacc.2015.05.020.

15.

Myosin-binding protein C corrects an intrinsic inhomogeneity in cardiac excitation-contraction coupling.

Previs MJ, Prosser BL, Mun JY, Previs SB, Gulick J, Lee K, Robbins J, Craig R, Lederer WJ, Warshaw DM.

Sci Adv. 2015;1(1). pii: e1400205.

16.

Deranged sodium to sudden death.

Clancy CE, Chen-Izu Y, Bers DM, Belardinelli L, Boyden PA, Csernoch L, Despa S, Fermini B, Hool LC, Izu L, Kass RS, Lederer WJ, Louch WE, Maack C, Matiazzi A, Qu Z, Rajamani S, Rippinger CM, Sejersted OM, O'Rourke B, Weiss JN, Varró A, Zaza A.

J Physiol. 2015 Mar 15;593(6):1331-45. doi: 10.1113/jphysiol.2014.281204. Review. Erratum in: J Physiol. 2016 Mar 15;594(6):1791.

17.

Transient assembly of F-actin on the outer mitochondrial membrane contributes to mitochondrial fission.

Li S, Xu S, Roelofs BA, Boyman L, Lederer WJ, Sesaki H, Karbowski M.

J Cell Biol. 2015 Jan 5;208(1):109-23. doi: 10.1083/jcb.201404050. Epub 2014 Dec 29.

18.

Superresolution modeling of calcium release in the heart.

Walker MA, Williams GSB, Kohl T, Lehnart SE, Jafri MS, Greenstein JL, Lederer WJ, Winslow RL.

Biophys J. 2014 Dec 16;107(12):3018-3029. doi: 10.1016/j.bpj.2014.11.003.

19.

Mitochondrial calcium and the regulation of metabolism in the heart.

Williams GS, Boyman L, Lederer WJ.

J Mol Cell Cardiol. 2015 Jan;78:35-45. doi: 10.1016/j.yjmcc.2014.10.019. Epub 2014 Nov 7. Review.

20.

Tachycardia-induced silencing of subcellular Ca2+ signaling in atrial myocytes.

Greiser M, Kerfant BG, Williams GS, Voigt N, Harks E, Dibb KM, Giese A, Meszaros J, Verheule S, Ravens U, Allessie MA, Gammie JS, van der Velden J, Lederer WJ, Dobrev D, Schotten U.

J Clin Invest. 2014 Nov;124(11):4759-72. doi: 10.1172/JCI70102. Epub 2014 Oct 20.

21.

Calcium movement in cardiac mitochondria.

Boyman L, Chikando AC, Williams GS, Khairallah RJ, Kettlewell S, Ward CW, Smith GL, Kao JP, Lederer WJ.

Biophys J. 2014 Sep 16;107(6):1289-301. doi: 10.1016/j.bpj.2014.07.045.

22.

Mechanical stretch-induced activation of ROS/RNS signaling in striated muscle.

Ward CW, Prosser BL, Lederer WJ.

Antioxid Redox Signal. 2014 Feb 20;20(6):929-36. doi: 10.1089/ars.2013.5517. Epub 2014 Jan 3. Review.

23.

Mitochondrial calcium uptake.

Williams GS, Boyman L, Chikando AC, Khairallah RJ, Lederer WJ.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10479-86. doi: 10.1073/pnas.1300410110. Epub 2013 Jun 12. Review.

24.

Superresolution imaging--caveolae, caveolins, mitochondria, and function in heart.

Lederer WJ.

Biophys J. 2013 Jun 4;104(11):2323. doi: 10.1016/j.bpj.2013.04.041. No abstract available.

25.

The connection between inner membrane topology and mitochondrial function.

Mannella CA, Lederer WJ, Jafri MS.

J Mol Cell Cardiol. 2013 Sep;62:51-7. doi: 10.1016/j.yjmcc.2013.05.001. Epub 2013 May 12. Review.

26.

NCLX: the mitochondrial sodium calcium exchanger.

Boyman L, Williams GS, Khananshvili D, Sekler I, Lederer WJ.

J Mol Cell Cardiol. 2013 Jun;59:205-13. doi: 10.1016/j.yjmcc.2013.03.012. Epub 2013 Mar 26.

27.

X-ROS signalling is enhanced and graded by cyclic cardiomyocyte stretch.

Prosser BL, Ward CW, Lederer WJ.

Cardiovasc Res. 2013 May 1;98(2):307-14. doi: 10.1093/cvr/cvt066. Epub 2013 Mar 21.

28.

Short-term mechanical unloading with left ventricular assist devices after acute myocardial infarction conserves calcium cycling and improves heart function.

Wei X, Li T, Hagen B, Zhang P, Sanchez PG, Williams K, Li S, Bianchi G, Son HS, Wu C, DeFilippi C, Xu K, Lederer WJ, Wu ZJ, Griffith BP.

JACC Cardiovasc Interv. 2013 Apr;6(4):406-15. doi: 10.1016/j.jcin.2012.12.122. Epub 2013 Mar 20. Erratum in: JACC Cardiovasc Interv. 2013 Sep;6(9):992.

29.

Calcium signaling in heart: multiscale, diverse, rapid, local, and remarkable.

Lederer WJ, Bers DM, Eisner DA.

J Mol Cell Cardiol. 2013 May;58:3-4. doi: 10.1016/j.yjmcc.2013.03.003. Epub 2013 Mar 13. No abstract available.

PMID:
23500389
30.

X-ROS signaling in the heart and skeletal muscle: stretch-dependent local ROS regulates [Ca²⁺]i.

Prosser BL, Khairallah RJ, Ziman AP, Ward CW, Lederer WJ.

J Mol Cell Cardiol. 2013 May;58:172-81. doi: 10.1016/j.yjmcc.2012.11.011. Epub 2012 Dec 6. Review.

31.

Mitofusin 2 joins the sarcoplasmic reticulum and mitochondria at the hip to sustain cardiac energetics.

Konstantinidis K, Lederer WJ, Rizzuto R, Kitsis RN.

Circ Res. 2012 Sep 14;111(7):821-3. doi: 10.1161/CIRCRESAHA.112.277269. No abstract available.

32.

Microtubules underlie dysfunction in duchenne muscular dystrophy.

Khairallah RJ, Shi G, Sbrana F, Prosser BL, Borroto C, Mazaitis MJ, Hoffman EP, Mahurkar A, Sachs F, Sun Y, Chen YW, Raiteri R, Lederer WJ, Dorsey SG, Ward CW.

Sci Signal. 2012 Aug 7;5(236):ra56. doi: 10.1126/scisignal.2002829.

33.

Stimulated emission depletion live-cell super-resolution imaging shows proliferative remodeling of T-tubule membrane structures after myocardial infarction.

Wagner E, Lauterbach MA, Kohl T, Westphal V, Williams GS, Steinbrecher JH, Streich JH, Korff B, Tuan HT, Hagen B, Luther S, Hasenfuss G, Parlitz U, Jafri MS, Hell SW, Lederer WJ, Lehnart SE.

Circ Res. 2012 Aug 3;111(4):402-14. doi: 10.1161/CIRCRESAHA.112.274530. Epub 2012 Jun 21.

34.

A comparative assessment of fluo Ca2+ indicators in rat ventricular myocytes.

Hagen BM, Boyman L, Kao JP, Lederer WJ.

Cell Calcium. 2012 Aug;52(2):170-81. doi: 10.1016/j.ceca.2012.05.010. Epub 2012 Jun 19.

35.

Cell biology. Superresolution subspace signaling.

Lederer WJ, Hagen BM, Zhao G.

Science. 2012 May 4;336(6081):546-7. doi: 10.1126/science.1222540. No abstract available.

36.

Elementary calcium release events from the sarcoplasmic reticulum in the heart.

Brochet DX, Yang D, Cheng H, Lederer WJ.

Adv Exp Med Biol. 2012;740:499-509. doi: 10.1007/978-94-007-2888-2_21. Review.

37.

Stochastic simulation of cardiac ventricular myocyte calcium dynamics and waves.

Tuan HT, Williams GS, Chikando AC, Sobie EA, Lederer WJ, Jafri MS.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:4677-80. doi: 10.1109/IEMBS.2011.6091158.

38.

Does the Goldilocks Principle apply to calcium release restitution in heart cells?

Liu OZ, Lederer WJ, Sobie EA.

J Mol Cell Cardiol. 2012 Jan;52(1):3-6. doi: 10.1016/j.yjmcc.2011.10.014. Epub 2011 Oct 28. No abstract available.

39.

Dynamics of calcium sparks and calcium leak in the heart.

Williams GS, Chikando AC, Tuan HT, Sobie EA, Lederer WJ, Jafri MS.

Biophys J. 2011 Sep 21;101(6):1287-96. doi: 10.1016/j.bpj.2011.07.021. Epub 2011 Sep 20.

40.

X-ROS signaling: rapid mechano-chemo transduction in heart.

Prosser BL, Ward CW, Lederer WJ.

Science. 2011 Sep 9;333(6048):1440-5. doi: 10.1126/science.1202768.

41.

Ca2+ dynamics in the mitochondria - state of the art.

Chikando AC, Kettlewell S, Williams GS, Smith G, Lederer WJ.

J Mol Cell Cardiol. 2011 Nov;51(5):627-31. doi: 10.1016/j.yjmcc.2011.08.003. Epub 2011 Aug 16. No abstract available.

42.

Dynamic local changes in sarcoplasmic reticulum calcium: physiological and pathophysiological roles.

Sobie EA, Lederer WJ.

J Mol Cell Cardiol. 2012 Feb;52(2):304-11. doi: 10.1016/j.yjmcc.2011.06.024. Epub 2011 Jul 13. Review.

43.

Golgi export of the Kir2.1 channel is driven by a trafficking signal located within its tertiary structure.

Ma D, Taneja TK, Hagen BM, Kim BY, Ortega B, Lederer WJ, Welling PA.

Cell. 2011 Jun 24;145(7):1102-15. doi: 10.1016/j.cell.2011.06.007.

44.

Proton-sensing Ca2+ binding domains regulate the cardiac Na+/Ca2+ exchanger.

Boyman L, Hagen BM, Giladi M, Hiller R, Lederer WJ, Khananshvili D.

J Biol Chem. 2011 Aug 19;286(33):28811-20. doi: 10.1074/jbc.M110.214106. Epub 2011 Jun 16.

45.

FKBP12 is a critical regulator of the heart rhythm and the cardiac voltage-gated sodium current in mice.

Maruyama M, Li BY, Chen H, Xu X, Song LS, Guatimosim S, Zhu W, Yong W, Zhang W, Bu G, Lin SF, Fishbein MC, Lederer WJ, Schild JH, Field LJ, Rubart M, Chen PS, Shou W.

Circ Res. 2011 Apr 29;108(9):1042-52. doi: 10.1161/CIRCRESAHA.110.237867. Epub 2011 Mar 3.

46.

Mitofusin-2 maintains mitochondrial structure and contributes to stress-induced permeability transition in cardiac myocytes.

Papanicolaou KN, Khairallah RJ, Ngoh GA, Chikando A, Luptak I, O'Shea KM, Riley DD, Lugus JJ, Colucci WS, Lederer WJ, Stanley WC, Walsh K.

Mol Cell Biol. 2011 Mar;31(6):1309-28. doi: 10.1128/MCB.00911-10. Epub 2011 Jan 18.

47.

Alterations of atrial Ca(2+) handling as cause and consequence of atrial fibrillation.

Greiser M, Lederer WJ, Schotten U.

Cardiovasc Res. 2011 Mar 1;89(4):722-33. doi: 10.1093/cvr/cvq389. Epub 2010 Dec 15. Review.

PMID:
21159669
48.

Quarky calcium release in the heart.

Brochet DX, Xie W, Yang D, Cheng H, Lederer WJ.

Circ Res. 2011 Jan 21;108(2):210-8. doi: 10.1161/CIRCRESAHA.110.231258. Epub 2010 Dec 9.

49.

Novel function of cardiac protein kinase D1 as a dynamic regulator of Ca2+ sensitivity of contraction.

Goodall MH, Wardlow RD 2nd, Goldblum RR, Ziman A, Lederer WJ, Randall W, Rogers TB.

J Biol Chem. 2010 Dec 31;285(53):41686-700. doi: 10.1074/jbc.M110.179648. Epub 2010 Nov 1.

50.

Quantitative measurement of Ca²(+) in the sarcoplasmic reticulum lumen of mammalian skeletal muscle.

Ziman AP, Ward CW, Rodney GG, Lederer WJ, Bloch RJ.

Biophys J. 2010 Oct 20;99(8):2705-14. doi: 10.1016/j.bpj.2010.08.032.

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