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Items: 1 to 50 of 85

1.

Mixed-effects association of single cells identifies an expanded effector CD4+ T cell subset in rheumatoid arthritis.

Fonseka CY, Rao DA, Teslovich NC, Korsunsky I, Hannes SK, Slowikowski K, Gurish MF, Donlin LT, Lederer JA, Weinblatt ME, Massarotti EM, Coblyn JS, Helfgott SM, Todd DJ, Bykerk VP, Karlson EW, Ermann J, Lee YC, Brenner MB, Raychaudhuri S.

Sci Transl Med. 2018 Oct 17;10(463). pii: eaaq0305. doi: 10.1126/scitranslmed.aaq0305.

PMID:
30333237
2.

Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue.

Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F, Gutierrez-Arcelus M, Lieb DJ, Keegan J, Muskat K, Hillman J, Rozo C, Ricker E, Eisenhaure TM, Li S, Browne EP, Chicoine A, Sutherby D, Noma A; Accelerating Medicines Partnership RA/SLE Network, Nusbaum C, Kelly S, Pernis AB, Ivashkiv LB, Goodman SM, Robinson WH, Utz PJ, Lederer JA, Gravallese EM, Boyce BF, Hacohen N, Pitzalis C, Gregersen PK, Firestein GS, Raychaudhuri S, Moreland LW, Holers VM, Bykerk VP, Filer A, Boyle DL, Brenner MB, Anolik JH.

Arthritis Res Ther. 2018 Jul 11;20(1):139. doi: 10.1186/s13075-018-1631-y.

3.

Frontline Science: Targeted expression of a dominant-negative high mobility group A1 transgene improves outcome in sepsis.

Baron RM, Kwon MY, Castano AP, Ghanta S, Riascos-Bernal DF, Lopez-Guzman S, Macias AA, Ith B, Schissel SL, Lederer JA, Reeves R, Yet SF, Layne MD, Liu X, Perrella MA.

J Leukoc Biol. 2018 Oct;104(4):677-689. doi: 10.1002/JLB.4HI0817-333RR. Epub 2018 Jul 5.

PMID:
29975792
4.

Purinergic P2X4 receptors and mitochondrial ATP production regulate T cell migration.

Ledderose C, Liu K, Kondo Y, Slubowski CJ, Dertnig T, Denicoló S, Arbab M, Hubner J, Konrad K, Fakhari M, Lederer JA, Robson SC, Visner GA, Junger WG.

J Clin Invest. 2018 Aug 1;128(8):3583-3594. doi: 10.1172/JCI120972. Epub 2018 Jul 23.

5.

Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis.

Mizoguchi F, Slowikowski K, Wei K, Marshall JL, Rao DA, Chang SK, Nguyen HN, Noss EH, Turner JD, Earp BE, Blazar PE, Wright J, Simmons BP, Donlin LT, Kalliolias GD, Goodman SM, Bykerk VP, Ivashkiv LB, Lederer JA, Hacohen N, Nigrovic PA, Filer A, Buckley CD, Raychaudhuri S, Brenner MB.

Nat Commun. 2018 Feb 23;9(1):789. doi: 10.1038/s41467-018-02892-y.

6.

Phenotyping the Immune Response to Trauma: A Multiparametric Systems Immunology Approach.

Seshadri A, Brat GA, Yorkgitis BK, Keegan J, Dolan J, Salim A, Askari R, Lederer JA.

Crit Care Med. 2017 Sep;45(9):1523-1530. doi: 10.1097/CCM.0000000000002577.

PMID:
28671900
7.

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis.

Rao DA, Gurish MF, Marshall JL, Slowikowski K, Fonseka CY, Liu Y, Donlin LT, Henderson LA, Wei K, Mizoguchi F, Teslovich NC, Weinblatt ME, Massarotti EM, Coblyn JS, Helfgott SM, Lee YC, Todd DJ, Bykerk VP, Goodman SM, Pernis AB, Ivashkiv LB, Karlson EW, Nigrovic PA, Filer A, Buckley CD, Lederer JA, Raychaudhuri S, Brenner MB.

Nature. 2017 Feb 1;542(7639):110-114. doi: 10.1038/nature20810.

8.

Efficacy of Antibody to PNAG Against Keratitis Caused by Fungal Pathogens.

Zhao G, Zaidi TS, Bozkurt-Guzel C, Zaidi TH, Lederer JA, Priebe GP, Pier GB.

Invest Ophthalmol Vis Sci. 2016 Dec 1;57(15):6797-6804. doi: 10.1167/iovs.16-20358.

9.

The CD4/CD8 ratio is associated with coronary artery disease (CAD) in elderly Chinese patients.

Gao P, Rong HH, Lu T, Tang G, Si LY, Lederer JA, Xiong W.

Int Immunopharmacol. 2017 Jan;42:39-43. doi: 10.1016/j.intimp.2016.11.007. Epub 2016 Nov 17.

PMID:
27866071
10.

Beneficial Effects of CpG-Oligodeoxynucleotide Treatment on Trauma and Secondary Lung Infection.

Wanke-Jellinek L, Keegan JW, Dolan JW, Guo F, Chen J, Lederer JA.

J Immunol. 2016 Jan 15;196(2):767-77. doi: 10.4049/jimmunol.1500597. Epub 2015 Dec 16.

11.

Expansion of CD25+ Innate Lymphoid Cells Reduces Atherosclerosis.

Engelbertsen D, Foks AC, Alberts-Grill N, Kuperwaser F, Chen T, Lederer JA, Jarolim P, Grabie N, Lichtman AH.

Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2526-35. doi: 10.1161/ATVBAHA.115.306048. Epub 2015 Oct 22.

12.

Characterization of lung infection-induced TCRγδ T cell phenotypes by CyTOF mass cytometry.

Wanke-Jellinek L, Keegan JW, Dolan JW, Lederer JA.

J Leukoc Biol. 2016 Mar;99(3):483-93. doi: 10.1189/jlb.4A0315-115RR. Epub 2015 Oct 1.

PMID:
26428679
13.

Response to comment on "Radiation exposure induces inflammasome pathway activation in immune cells".

Lederer JA.

J Immunol. 2015 Jun 1;194(11):5039. doi: 10.4049/jimmunol.1500789. No abstract available.

14.

Genomic responses to inflammation in mouse models mimic humans: we concur, apples to oranges comparisons won't do.

Shay T, Lederer JA, Benoist C.

Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):E346. doi: 10.1073/pnas.1416629111. Epub 2014 Dec 24. No abstract available.

15.

Radiation exposure induces inflammasome pathway activation in immune cells.

Stoecklein VM, Osuka A, Ishikawa S, Lederer MR, Wanke-Jellinek L, Lederer JA.

J Immunol. 2015 Feb 1;194(3):1178-89. doi: 10.4049/jimmunol.1303051. Epub 2014 Dec 24.

16.

Circadian rhythm reprogramming during lung inflammation.

Haspel JA, Chettimada S, Shaik RS, Chu JH, Raby BA, Cernadas M, Carey V, Process V, Hunninghake GM, Ifedigbo E, Lederer JA, Englert J, Pelton A, Coronata A, Fredenburgh LE, Choi AM.

Nat Commun. 2014 Sep 11;5:4753. doi: 10.1038/ncomms5753.

17.

A roadmap to promote clinical and translational research in rheumatoid arthritis-associated interstitial lung disease.

Doyle TJ, Lee JS, Dellaripa PF, Lederer JA, Matteson EL, Fischer A, Ascherman DP, Glassberg MK, Ryu JH, Danoff SK, Brown KK, Collard HR, Rosas IO.

Chest. 2014 Mar 1;145(3):454-463. doi: 10.1378/chest.13-2408. Review.

18.

Abandon the mouse research ship? Not just yet!

Osuchowski MF, Remick DG, Lederer JA, Lang CH, Aasen AO, Aibiki M, Azevedo LC, Bahrami S, Boros M, Cooney R, Cuzzocrea S, Jiang Y, Junger WG, Hirasawa H, Hotchkiss RS, Li XA, Radermacher P, Redl H, Salomao R, Soebandrio A, Thiemermann C, Vincent JL, Ward P, Yao YM, Yu HP, Zingarelli B, Chaudry IH.

Shock. 2014 Jun;41(6):463-75. doi: 10.1097/SHK.0000000000000153.

19.

Immune response to traumatic injury: harmony and discordance of immune system homeostasis.

Osuka A, Ogura H, Ueyama M, Shimazu T, Lederer JA.

Acute Med Surg. 2014 Jan 28;1(2):63-69. doi: 10.1002/ams2.17. eCollection 2014 Apr. Review.

20.

Immune system phenotyping of radiation and radiation combined injury in outbred mice.

Tajima G, Delisle AJ, Hoang K, O'Leary FM, Ikeda K, Hanschen M, Stoecklein VM, Lederer JA.

Radiat Res. 2013 Jan;179(1):101-12. doi: 10.1667/RR3120.1. Epub 2012 Dec 5.

21.

Mesenchymal stromal cells improve survival during sepsis in the absence of heme oxygenase-1: the importance of neutrophils.

Hall SR, Tsoyi K, Ith B, Padera RF Jr, Lederer JA, Wang Z, Liu X, Perrella MA.

Stem Cells. 2013 Feb;31(2):397-407. doi: 10.1002/stem.1270.

22.

What's new in shock, November 2012?

Lederer JA.

Shock. 2012 Nov;38(5):447-9. doi: 10.1097/SHK.0b013e31827486cf. No abstract available.

PMID:
23076440
23.

Trauma equals danger--damage control by the immune system.

Stoecklein VM, Osuka A, Lederer JA.

J Leukoc Biol. 2012 Sep;92(3):539-51. doi: 10.1189/jlb.0212072. Epub 2012 May 31. Review.

24.

Chronic endotoxin exposure produces airflow obstruction and lung dendritic cell expansion.

Lai PS, Fresco JM, Pinilla MA, Macias AA, Brown RD, Englert JA, Hofmann O, Lederer JA, Hide W, Christiani DC, Cernadas M, Baron RM.

Am J Respir Cell Mol Biol. 2012 Aug;47(2):209-17. doi: 10.1165/rcmb.2011-0447OC. Epub 2012 Apr 19.

25.

Targeting regulatory T cells in cancer.

Byrne WL, Mills KH, Lederer JA, O'Sullivan GC.

Cancer Res. 2011 Nov 15;71(22):6915-20. doi: 10.1158/0008-5472.CAN-11-1156. Epub 2011 Nov 8. Review.

26.

Phospho-flow cytometry based analysis of differences in T cell receptor signaling between regulatory T cells and CD4+ T cells.

Hanschen M, Tajima G, O'Leary F, Hoang K, Ikeda K, Lederer JA.

J Immunol Methods. 2012 Feb 28;376(1-2):1-12. doi: 10.1016/j.jim.2011.08.023. Epub 2011 Sep 6.

27.

A protective role for inflammasome activation following injury.

Osuka A, Hanschen M, Stoecklein V, Lederer JA.

Shock. 2012 Jan;37(1):47-55. doi: 10.1097/SHK.0b013e318234f7ff.

28.

Injury-induced GR-1+ macrophage expansion and activation occurs independently of CD4 T-cell influence.

O'Leary FM, Tajima G, Delisle AJ, Ikeda K, Dolan SM, Hanschen M, Mannick JA, Lederer JA.

Shock. 2011 Aug;36(2):162-9. doi: 10.1097/SHK.0b013e31821af669.

29.

Regulatory T cells suppress antigen-driven CD4 T cell reactivity following injury.

MacConmara MP, Tajima G, O'Leary F, Delisle AJ, McKenna AM, Stallwood CG, Mannick JA, Lederer JA.

J Leukoc Biol. 2011 Jan;89(1):137-47. doi: 10.1189/jlb.0210082. Epub 2010 Sep 30.

30.

Injury induces early activation of T-cell receptor signaling pathways in CD4+ regulatory T cells.

Hanschen M, Tajima G, O'Leary F, Ikeda K, Lederer JA.

Shock. 2011 Mar;35(3):252-7. doi: 10.1097/SHK.0b013e3181f489c5.

31.

Analysis of factorial time-course microarrays with application to a clinical study of burn injury.

Zhou B, Xu W, Herndon D, Tompkins R, Davis R, Xiao W, Wong WH; Inflammation and Host Response to Injury Program, Toner M, Warren HS, Schoenfeld DA, Rahme L, McDonald-Smith GP, Hayden D, Mason P, Fagan S, Yu YM, Cobb JP, Remick DG, Mannick JA, Lederer JA, Gamelli RL, Silver GM, West MA, Shapiro MB, Smith R, Camp DG 2nd, Qian W, Storey J, Mindrinos M, Tibshirani R, Lowry S, Calvano S, Chaudry I, West MA, Cohen M, Moore EE, Johnson J, Moldawer LL, Baker HV, Efron PA, Balis UG, Billiar TR, Ochoa JB, Sperry JL, Miller-Graziano CL, De AK, Bankey PE, Finnerty CC, Jeschke MG, Minei JP, Arnoldo BD, Hunt JL, Horton J, Cobb JP, Brownstein B, Freeman B, Maier RV, Nathens AB, Cuschieri J, Gibran N, Klein M, O'Keefe G.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):9923-8. doi: 10.1073/pnas.1002757107. Epub 2010 May 17.

32.

Effective immunotherapy of weakly immunogenic solid tumours using a combined immunogene therapy and regulatory T-cell inactivation.

Whelan MC, Casey G, MacConmara M, Lederer JA, Soden D, Collins JK, Tangney M, O'Sullivan GC.

Cancer Gene Ther. 2010 Jul;17(7):501-11. doi: 10.1038/cgt.2010.8. Epub 2010 Feb 26.

PMID:
20186173
33.

Murine dendritic cell antigen-presenting cell function is not altered by burn injury.

Fujimi S, Lapchak PH, Zang Y, MacConmara MP, Maung AA, Delisle AJ, Mannick JA, Lederer JA.

J Leukoc Biol. 2009 May;85(5):862-70. doi: 10.1189/jlb.0408257. Epub 2009 Feb 19.

34.

Injury enhances resistance to Escherichia coli infection by boosting innate immune system function.

Maung AA, Fujimi S, MacConmara MP, Tajima G, McKenna AM, Delisle AJ, Stallwood C, Onderdonk AB, Mannick JA, Lederer JA.

J Immunol. 2008 Feb 15;180(4):2450-8.

35.

Trauma-hemorrhage inhibits splenic dendritic cell proinflammatory cytokine production via a mitogen-activated protein kinase process.

Kawasaki T, Choudhry MA, Schwacha MG, Fujimi S, Lederer JA, Bland KI, Chaudry IH.

Am J Physiol Cell Physiol. 2008 Mar;294(3):C754-64. doi: 10.1152/ajpcell.00494.2007. Epub 2008 Jan 16.

36.

Comparison of longitudinal leukocyte gene expression after burn injury or trauma-hemorrhage in mice.

Lederer JA, Brownstein BH, Lopez MC, Macmillan S, Delisle AJ, Macconmara MP, Choudhry MA, Xiao W, Lekousi S, Cobb JP, Baker HV, Mannick JA, Chaudry IH; Inflammation and the Host Response to Injury Collaborative Research Program Participants.

Physiol Genomics. 2008 Feb 19;32(3):299-310. Epub 2007 Nov 6.

PMID:
17986522
37.

Increased CD4+ CD25+ T regulatory cell activity in trauma patients depresses protective Th1 immunity.

MacConmara MP, Maung AA, Fujimi S, McKenna AM, Delisle A, Lapchak PH, Rogers S, Lederer JA, Mannick JA.

Ann Surg. 2006 Oct;244(4):514-23.

38.

Trauma-hemorrhage induces depressed splenic dendritic cell functions in mice.

Kawasaki T, Fujimi S, Lederer JA, Hubbard WJ, Choudhry MA, Schwacha MG, Bland KI, Chaudry IH.

J Immunol. 2006 Oct 1;177(7):4514-20. Erratum in: J Immunol. 2006 Dec 15;177(12):8877. Fujimi, Satoshi [added]; Lederer, James A [added].

39.

Burn injury induces an early activation response by lymph node CD4+ T cells.

Purcell EM, Dolan SM, Kriynovich S, Mannick JA, Lederer JA.

Shock. 2006 Feb;25(2):135-40.

PMID:
16525351
40.

Commonality and differences in leukocyte gene expression patterns among three models of inflammation and injury.

Brownstein BH, Logvinenko T, Lederer JA, Cobb JP, Hubbard WJ, Chaudry IH, Remick DG, Baker HV, Xiao W, Mannick JA.

Physiol Genomics. 2006 Feb 14;24(3):298-309. Epub 2005 Dec 20.

PMID:
16478828
41.

Platelet depletion in mice increases mortality after thermal injury.

Fujimi S, MacConmara MP, Maung AA, Zang Y, Mannick JA, Lederer JA, Lapchak PH.

Blood. 2006 Jun 1;107(11):4399-406. Epub 2006 Feb 7.

42.

Enhanced regulatory T cell activity is an element of the host response to injury.

Ni Choileain N, MacConmara M, Zang Y, Murphy TJ, Mannick JA, Lederer JA.

J Immunol. 2006 Jan 1;176(1):225-36.

43.

B cells.

MacConmara M, Lederer JA.

Crit Care Med. 2005 Dec;33(12 Suppl):S514-6. Review. No abstract available.

PMID:
16340437
44.

Enhanced TLR4 reactivity following injury is mediated by increased p38 activation.

Maung AA, Fujimi S, Miller ML, MacConmara MP, Mannick JA, Lederer JA.

J Leukoc Biol. 2005 Aug;78(2):565-73. Epub 2005 Apr 27.

PMID:
15857937
45.

Does nitric oxide control the counter-inflammatory response in endotoxic shock?

Lederer JA.

Crit Care Med. 2005 Apr;33(4):896-8. No abstract available.

PMID:
15818123
46.

CD4+CD25+ regulatory T cells control innate immune reactivity after injury.

Murphy TJ, Ni Choileain N, Zang Y, Mannick JA, Lederer JA.

J Immunol. 2005 Mar 1;174(5):2957-63.

47.

Linking the "two-hit" response following injury to enhanced TLR4 reactivity.

Murphy TJ, Paterson HM, Kriynovich S, Zang Y, Kurt-Jones EA, Mannick JA, Lederer JA.

J Leukoc Biol. 2005 Jan;77(1):16-23. Epub 2004 Oct 20.

PMID:
15496450
48.

Burn injury initiates a shift in superantigen-induced T cell responses and host survival.

Zang Y, Dolan SM, Ni Choileain N, Kriynovich SJ, Murphy TJ, Sayles P, Mannick JA, Lederer JA.

J Immunol. 2004 Apr 15;172(8):4883-92.

49.

Injury, sepsis, and the regulation of Toll-like receptor responses.

Murphy TJ, Paterson HM, Mannick JA, Lederer JA.

J Leukoc Biol. 2004 Mar;75(3):400-7. Epub 2003 Oct 13. Review.

PMID:
14557385
50.

Burn injury promotes antigen-driven Th2-type responses in vivo.

Guo Z, Kavanagh E, Zang Y, Dolan SM, Kriynovich SJ, Mannick JA, Lederer JA.

J Immunol. 2003 Oct 15;171(8):3983-90.

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