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Long-term remissions after stopping pembrolizumab for relapsed or refractory multiple myeloma.

Badros AZ, Ma N, Rapoport AP, Lederer E, Lesokhin AM.

Blood Adv. 2019 Jun 11;3(11):1658-1660. doi: 10.1182/bloodadvances.2019000191. No abstract available.


Loss of the Na+/H+ Exchange Regulatory Factor 1 Increases Susceptibility to Cisplatin-Induced Acute Kidney Injury.

Bushau-Sprinkle A, Barati M, Conklin C, Dupre T, Gagnon KB, Khundmiri SJ, Clark B, Siskind L, Doll MA, Rane M, Brier M, Coventry S, Lederer ED.

Am J Pathol. 2019 Jun;189(6):1190-1200. doi: 10.1016/j.ajpath.2019.02.010. Epub 2019 Mar 27.


Clinical aspects of the phosphate transporters NaPi-IIa and NaPi-IIb: mutations and disease associations.

Lederer E, Wagner CA.

Pflugers Arch. 2019 Jan;471(1):137-148. doi: 10.1007/s00424-018-2246-5. Epub 2018 Dec 13. Review.


Leadership as a Division Chief of Nephrology.

Lederer E.

Adv Chronic Kidney Dis. 2018 Nov;25(6):480-484. doi: 10.1053/j.ackd.2018.08.005. Review.


Women in Nephrology Today.

Lederer E.

Clin J Am Soc Nephrol. 2018 Nov 7;13(11):1755-1756. doi: 10.2215/CJN.07650618. Epub 2018 Oct 22. No abstract available.


Hyponatremia Complicating Esophageal Carcinoma: A Challenging Differential Diagnosis.

Mackelaite L, Lederer E.

Am J Med Sci. 2018 Dec;356(6):567-569. doi: 10.1016/j.amjms.2018.05.014. Epub 2018 Jun 6. Review.


IMP2/IGF2BP2 expression, but not IMP1 and IMP3, predicts poor outcome in patients and high tumor growth rate in xenograft models of gallbladder cancer.

Kessler SM, Lederer E, Laggai S, Golob-Schwarzl N, Hosseini K, Petzold J, Schweiger C, Reihs R, Keil M, Hoffmann J, Mayr C, Kiesslich T, Pichler M, Kim KS, Rhee H, Park YN, Lax S, Obrist P, Kiemer AK, Haybaeck J.

Oncotarget. 2017 Sep 21;8(52):89736-89745. doi: 10.18632/oncotarget.21116. eCollection 2017 Oct 27.


Corrigendum to "Low dose ouabain stimulates Na-K ATPase 〈alpha〉 1 subunit association with angiotensin II type 1 receptor in renal proximal tubule cells" [Biochim. Biophys. Acta 1863/11 (2016) 2624-2636].

Ketchem CJ, Conner CD, Murray RD, DuPlessis M, Lederer ED, Wilkey D, Merchant M, Khundmiri SJ.

Biochim Biophys Acta Mol Cell Res. 2017 Oct;1864(10):1922. doi: 10.1016/j.bbamcr.2017.06.002. Epub 2017 Jun 13. No abstract available.


Loss of NHERF-1 expression prevents dopamine-mediated Na-K-ATPase regulation in renal proximal tubule cells from rat models of hypertension: aged F344 rats and spontaneously hypertensive rats.

Barati MT, Ketchem CJ, Merchant ML, Kusiak WB, Jose PA, Weinman EJ, LeBlanc AJ, Lederer ED, Khundmiri SJ.

Am J Physiol Cell Physiol. 2017 Aug 1;313(2):C197-C206. doi: 10.1152/ajpcell.00219.2016. Epub 2017 May 17.


Pembrolizumab, pomalidomide, and low-dose dexamethasone for relapsed/refractory multiple myeloma.

Badros A, Hyjek E, Ma N, Lesokhin A, Dogan A, Rapoport AP, Kocoglu M, Lederer E, Philip S, Milliron T, Dell C, Goloubeva O, Singh Z.

Blood. 2017 Sep 7;130(10):1189-1197. doi: 10.1182/blood-2017-03-775122. Epub 2017 May 1.


Low dose ouabain stimulates NaK ATPase α1 subunit association with angiotensin II type 1 receptor in renal proximal tubule cells.

Ketchem CJ, Conner CD, Murray RD, DuPlessis M, Lederer ED, Wilkey D, Merchant M, Khundmiri SJ.

Biochim Biophys Acta. 2016 Nov;1863(11):2624-2636. doi: 10.1016/j.bbamcr.2016.07.008. Epub 2016 Aug 3. Erratum in: Biochim Biophys Acta. 2017 Oct;1864(10 ):1922.


Protein-DNA Interactions at the Opossum Npt2a Promoter are Dependent upon NHERF-1.

Clark BJ, Murray RD, Salyer SA, Tyagi SC, Arumugam C, Khundmiri SJ, Lederer ED.

Cell Physiol Biochem. 2016;39(1):1-12. doi: 10.1159/000445601. Epub 2016 Jun 20.


PTH and Vitamin D.

Khundmiri SJ, Murray RD, Lederer E.

Compr Physiol. 2016 Mar 15;6(2):561-601. doi: 10.1002/cphy.c140071. Review.


Identification of an RNA-binding protein that is phosphorylated by PTH and potentially mediates PTH-induced destabilization of Npt2a mRNA.

Murray RD, Merchant ML, Hardin E, Clark B, Khundmiri SJ, Lederer ED.

Am J Physiol Cell Physiol. 2016 Feb 1;310(3):C205-15. doi: 10.1152/ajpcell.00192.2015. Epub 2015 Nov 25.


IMP2/p62 induces genomic instability and an aggressive hepatocellular carcinoma phenotype.

Kessler SM, Laggai S, Barghash A, Schultheiss CS, Lederer E, Artl M, Helms V, Haybaeck J, Kiemer AK.

Cell Death Dis. 2015 Oct 1;6:e1894. doi: 10.1038/cddis.2015.241.


Role of Na+/H+ exchanger regulatory factor 1 in forward trafficking of the type IIa Na+-Pi cotransporter.

Ketchem CJ, Khundmiri SJ, Gaweda AE, Murray R, Clark BJ, Weinman EJ, Lederer ED.

Am J Physiol Renal Physiol. 2015 Jul 15;309(2):F109-19.


Baclofen, a GABABR agonist, ameliorates immune-complex mediated acute lung injury by modulating pro-inflammatory mediators.

Jin S, Merchant ML, Ritzenthaler JD, McLeish KR, Lederer ED, Torres-Gonzalez E, Fraig M, Barati MT, Lentsch AB, Roman J, Klein JB, Rane MJ.

PLoS One. 2015 Apr 7;10(4):e0121637. doi: 10.1371/journal.pone.0121637. eCollection 2015.


eIF3a is over-expressed in urinary bladder cancer and influences its phenotype independent of translation initiation.

Spilka R, Ernst C, Bergler H, Rainer J, Flechsig S, Vogetseder A, Lederer E, Benesch M, Brunner A, Geley S, Eger A, Bachmann F, Doppler W, Obrist P, Haybaeck J.

Cell Oncol (Dordr). 2014 Aug;37(4):253-67. doi: 10.1007/s13402-014-0181-9. Epub 2014 Jul 29.


Renal phosphate transporters.

Lederer E.

Curr Opin Nephrol Hypertens. 2014 Sep;23(5):502-6. doi: 10.1097/MNH.0000000000000053. Review.


Regulation of serum phosphate.

Lederer E.

J Physiol. 2014 Sep 15;592(18):3985-95. doi: 10.1113/jphysiol.2014.273979. Epub 2014 Jun 27. Review.


The IGF2 mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis.

Laggai S, Kessler SM, Boettcher S, Lebrun V, Gemperlein K, Lederer E, Leclercq IA, Mueller R, Hartmann RW, Haybaeck J, Kiemer AK.

J Lipid Res. 2014 Jun;55(6):1087-97. doi: 10.1194/jlr.M045500. Epub 2014 Apr 22. Erratum in: J Lipid Res. 2016 Jul;57(7):1323.


Structural determinants for the ouabain-stimulated increase in Na-K ATPase activity.

Khundmiri SJ, Salyer SA, Farmer B, Qipshidze-Kelm N, Murray RD, Clark BJ, Xie Z, Pressley TA, Lederer ED.

Biochim Biophys Acta. 2014 Jun;1843(6):1089-102. doi: 10.1016/j.bbamcr.2014.02.005. Epub 2014 Feb 22.


Angiotensin-II induced hypertension and renovascular remodelling in tissue inhibitor of metalloproteinase 2 knockout mice.

Pushpakumar S, Kundu S, Pryor T, Givvimani S, Lederer E, Tyagi SC, Sen U.

J Hypertens. 2013 Nov;31(11):2270-81; discussion 2281. doi: 10.1097/HJH.0b013e3283649b33.


Aldosterone regulates Na(+), K(+) ATPase activity in human renal proximal tubule cells through mineralocorticoid receptor.

Salyer SA, Parks J, Barati MT, Lederer ED, Clark BJ, Klein JD, Khundmiri SJ.

Biochim Biophys Acta. 2013 Oct;1833(10):2143-52. doi: 10.1016/j.bbamcr.2013.05.009. Epub 2013 May 16.


Vacuolar ATPase driven potassium transport in highly metastatic breast cancer cells.

Salyer SA, Olberding JR, Distler AA, Lederer ED, Clark BJ, Delamere NA, Khundmiri SJ.

Biochim Biophys Acta. 2013 Oct;1832(10):1734-43. doi: 10.1016/j.bbadis.2013.04.023. Epub 2013 Apr 29.


Parathyroid hormone (PTH) decreases sodium-phosphate cotransporter type IIa (NpT2a) mRNA stability.

Murray RD, Holthouser K, Clark BJ, Salyer SA, Barati MT, Khundmiri SJ, Lederer ED.

Am J Physiol Renal Physiol. 2013 Apr 15;304(8):F1076-85. doi: 10.1152/ajprenal.00632.2012. Epub 2013 Jan 23.


New treatments for CKD--new insights into pathogenesis.

Lederer ED, Klein JB.

J Am Soc Nephrol. 2012 Oct;23(10):1601-3. Epub 2012 Sep 13. No abstract available.


NHERF-1 and the regulation of renal phosphate reabsoption: a tale of three hormones.

Weinman EJ, Lederer ED.

Am J Physiol Renal Physiol. 2012 Aug 1;303(3):F321-7. doi: 10.1152/ajprenal.00093.2012. Epub 2012 Apr 25.


Clinical consequences of mutations in sodium phosphate cotransporters.

Lederer E, Miyamoto K.

Clin J Am Soc Nephrol. 2012 Jul;7(7):1179-87. doi: 10.2215/CJN.09090911. Epub 2012 Apr 19. Review.


PTH-mediated inhibition of the renal transport of phosphate.

Weinman EJ, Lederer ED.

Exp Cell Res. 2012 May 15;318(9):1027-32. doi: 10.1016/j.yexcr.2012.02.037. Epub 2012 Mar 5. Review. No abstract available.


Static and rotational step-and-shoot IMRT treatment plans for the prostate: a risk comparison study.

Blais AR, Lederer E, Oliver M, Leszczynski K.

Med Phys. 2012 Feb;39(2):1069-78. doi: 10.1118/1.3679338.


Role of vacuolar ATPase in the trafficking of renal type IIa sodium-phosphate cotransporter.

Ahmad A, Khundmiri SJ, Pribble F, Merchant ML, Ameen M, Klein JB, Levi M, Lederer ED.

Cell Physiol Biochem. 2011;27(6):703-14. doi: 10.1159/000330079. Epub 2011 Jun 17.


Real-time monitoring of cisplatin-induced cell death.

Alborzinia H, Can S, Holenya P, Scholl C, Lederer E, Kitanovic I, Wölfl S.

PLoS One. 2011;6(5):e19714. doi: 10.1371/journal.pone.0019714. Epub 2011 May 16.


The flux of phosphate: rapid evolution.

Lederer E, Levi M.

Adv Chronic Kidney Dis. 2011 Mar;18(2):61-2. doi: 10.1053/j.ackd.2011.02.001. No abstract available.


Dopamine regulation of Na+-K+-ATPase requires the PDZ-2 domain of sodium hydrogen regulatory factor-1 (NHERF-1) in opossum kidney cells.

Salyer S, Lesousky N, Weinman EJ, Clark BJ, Lederer ED, Khundmiri SJ.

Am J Physiol Cell Physiol. 2011 Mar;300(3):C425-34. doi: 10.1152/ajpcell.00357.2010. Epub 2010 Dec 15.


Cystathionine β-synthase and cystathionine γ-lyase double gene transfer ameliorate homocysteine-mediated mesangial inflammation through hydrogen sulfide generation.

Sen U, Givvimani S, Abe OA, Lederer ED, Tyagi SC.

Am J Physiol Cell Physiol. 2011 Jan;300(1):C155-63. doi: 10.1152/ajpcell.00143.2010. Epub 2010 Oct 13.


Computer controlled automated assay for comprehensive studies of enzyme kinetic parameters.

Bonowski F, Kitanovic A, Ruoff P, Holzwarth J, Kitanovic I, Bui VN, Lederer E, Wölfl S.

PLoS One. 2010 May 19;5(5):e10727. doi: 10.1371/journal.pone.0010727.


Ouabain stimulates Na-K-ATPase through a sodium/hydrogen exchanger-1 (NHE-1)-dependent mechanism in human kidney proximal tubule cells.

Holthouser KA, Mandal A, Merchant ML, Schelling JR, Delamere NA, Valdes RR Jr, Tyagi SC, Lederer ED, Khundmiri SJ.

Am J Physiol Renal Physiol. 2010 Jul;299(1):F77-90. doi: 10.1152/ajprenal.00581.2009. Epub 2010 Apr 28.


Development, implementation, and results of the ASN in-training examination for fellows.

Rosner MH, Berns JS, Parker M, Tolwani A, Bailey J, DiGiovanni S, Lederer E, Norby S, Plumb TJ, Qian Q, Yeun J, Hawley JL, Owens S; ASN In-Training Examination Committee.

Clin J Am Soc Nephrol. 2010 Feb;5(2):328-34. doi: 10.2215/CJN.06860909. Epub 2009 Dec 3.


Steroidogenic acute regulatory-related lipid transfer domain protein 5 localization and regulation in renal tubules.

Chen YC, Meier RK, Zheng S, Khundmiri SJ, Tseng MT, Lederer ED, Epstein PN, Clark BJ.

Am J Physiol Renal Physiol. 2009 Aug;297(2):F380-8. doi: 10.1152/ajprenal.90433.2008. Epub 2009 May 27.


Tartrate-resistant acid phosphatase isoform 5a as an inflammation marker in end-stage renal disease.

Janckila AJ, Lederer ED, Price BA, Yam LT.

Clin Nephrol. 2009 Apr;71(4):387-96.


[N,N'-Bis(salicylidene)-1,2-phenylenediamine]metal complexes with cell death promoting properties.

Hille A, Ott I, Kitanovic A, Kitanovic I, Alborzinia H, Lederer E, Wölfl S, Metzler-Nolte N, Schäfer S, Sheldrick WS, Bischof C, Schatzschneider U, Gust R.

J Biol Inorg Chem. 2009 Jun;14(5):711-25. doi: 10.1007/s00775-009-0485-9. Epub 2009 Mar 4.


Proteomic analysis of renal calculi indicates an important role for inflammatory processes in calcium stone formation.

Merchant ML, Cummins TD, Wilkey DW, Salyer SA, Powell DW, Klein JB, Lederer ED.

Am J Physiol Renal Physiol. 2008 Oct;295(4):F1254-8. doi: 10.1152/ajprenal.00134.2008. Epub 2008 Aug 13.


PTH-mediated regulation of Na+-K+-ATPase requires Src kinase-dependent ERK phosphorylation.

Khundmiri SJ, Ameen M, Delamere NA, Lederer ED.

Am J Physiol Renal Physiol. 2008 Aug;295(2):F426-37. doi: 10.1152/ajprenal.00516.2007. Epub 2008 Jun 11.


Novel regulatory function for NHERF-1 in Npt2a transcription.

Khundmiri SJ, Ahmad A, Bennett RE, Weinman EJ, Steplock D, Cole J, Baumann PD, Lewis J, Singh S, Clark BJ, Lederer ED.

Am J Physiol Renal Physiol. 2008 Apr;294(4):F840-9. doi: 10.1152/ajprenal.00180.2007. Epub 2008 Jan 23.


Under-recognition of chronic kidney disease in elderly outpatients.

Ouseph R, Hendricks P, Hollon JA, Bhimani BD, Lederer ED.

Clin Nephrol. 2007 Dec;68(6):373-8.


Development of clinical practice guidelines: are we defining the issues too narrowly?

Lederer ED.

Clin J Am Soc Nephrol. 2007 Mar;2(2):207. No abstract available.


Chronic kidney disease.

Lederer E, Ouseph R.

Am J Kidney Dis. 2007 Jan;49(1):162-71. Review. No abstract available.


Parathyroid hormone regulation of NA+,K+-ATPase requires the PDZ 1 domain of sodium hydrogen exchanger regulatory factor-1 in opossum kidney cells.

Khundmiri SJ, Weinman EJ, Steplock D, Cole J, Ahmad A, Baumann PD, Barati M, Rane MJ, Lederer E.

J Am Soc Nephrol. 2005 Sep;16(9):2598-607. Epub 2005 Jul 6.

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