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Items: 31

1.

57Fe enrichment in mice for β-thalassaemia studies via Mössbauer spectroscopy of blood samples.

Charitou G, Tsertos C, Parpottas Y, Kleanthous M, Lederer CW, Phylactides M.

Eur Biophys J. 2019 Oct;48(7):635-643. doi: 10.1007/s00249-019-01389-w. Epub 2019 Jul 13.

PMID:
31302726
2.

Correction of IVS I-110(G>A) β-thalassemia by CRISPR/Cas-and TALEN-mediated disruption of aberrant regulatory elements in human hematopoietic stem and progenitor cells.

Patsali P, Turchiano G, Papasavva P, Romito M, Loucari CC, Stephanou C, Christou S, Sitarou M, Mussolino C, Cornu TI, Antoniou MN, Lederer CW, Cathomen T, Kleanthous M.

Haematologica. 2019 Nov;104(11):e497-e501. doi: 10.3324/haematol.2018.215178. Epub 2019 Apr 19. No abstract available.

3.

Disruptive Technology: CRISPR/Cas-Based Tools and Approaches.

Patsali P, Kleanthous M, Lederer CW.

Mol Diagn Ther. 2019 Apr;23(2):187-200. doi: 10.1007/s40291-019-00391-4. Review.

4.

Rare Opportunities: CRISPR/Cas-Based Therapy Development for Rare Genetic Diseases.

Papasavva P, Kleanthous M, Lederer CW.

Mol Diagn Ther. 2019 Apr;23(2):201-222. doi: 10.1007/s40291-019-00392-3. Review.

5.

A Novel BaEVRless-Pseudotyped γ-Globin Lentiviral Vector Drives High and Stable Fetal Hemoglobin Expression and Improves Thalassemic Erythropoiesis In Vitro.

Drakopoulou E, Georgomanoli M, Lederer CW, Kleanthous M, Costa C, Bernadin O, Cosset FL, Voskaridou E, Verhoeyen E, Papanikolaou E, Anagnou NP.

Hum Gene Ther. 2019 May;30(5):601-617. doi: 10.1089/hum.2018.022. Epub 2019 Mar 15.

PMID:
30324804
6.

Multiple Integrated Non-clinical Studies Predict the Safety of Lentivirus-Mediated Gene Therapy for β-Thalassemia.

Lidonnici MR, Paleari Y, Tiboni F, Mandelli G, Rossi C, Vezzoli M, Aprile A, Lederer CW, Ambrosi A, Chanut F, Sanvito F, Calabria A, Poletti V, Mavilio F, Montini E, Naldini L, Cristofori P, Ferrari G.

Mol Ther Methods Clin Dev. 2018 Sep 13;11:9-28. doi: 10.1016/j.omtm.2018.09.001. eCollection 2018 Dec 14.

7.

Short-hairpin RNA against aberrant HBBIVSI-110(G>A) mRNA restores β-globin levels in a novel cell model and acts as mono- and combination therapy for β-thalassemia in primary hematopoietic stem cells.

Patsali P, Papasavva P, Stephanou C, Christou S, Sitarou M, Antoniou MN, Lederer CW, Kleanthous M.

Haematologica. 2018 Sep;103(9):e419-e423. doi: 10.3324/haematol.2018.189357. Epub 2018 Apr 26. No abstract available.

8.

Selection and Identification of Skeletal-Muscle-Targeted RNA Aptamers.

Philippou S, Mastroyiannopoulos NP, Makrides N, Lederer CW, Kleanthous M, Phylactou LA.

Mol Ther Nucleic Acids. 2018 Mar 2;10:199-214. doi: 10.1016/j.omtn.2017.12.004. Epub 2017 Dec 9.

9.

Rapid and Sensitive Assessment of Globin Chains for Gene and Cell Therapy of Hemoglobinopathies.

Loucari CC, Patsali P, van Dijk TB, Stephanou C, Papasavva P, Zanti M, Kurita R, Nakamura Y, Christou S, Sitarou M, Philipsen S, Lederer CW, Kleanthous M.

Hum Gene Ther Methods. 2018 Feb;29(1):60-74. doi: 10.1089/hgtb.2017.190.

10.

Suitability of small diagnostic peripheral-blood samples for cell-therapy studies.

Stephanou C, Papasavva P, Zachariou M, Patsali P, Epitropou M, Ladas P, Al-Abdulla R, Christou S, Antoniou MN, Lederer CW, Kleanthous M.

Cytotherapy. 2017 Feb;19(2):311-326. doi: 10.1016/j.jcyt.2016.11.007.

PMID:
28088294
11.

Hb A2 Episkopi - a novel δ-globin chain variant [HBD:c.428C>T] in a family of mixed Cypriot-Lebanese descent.

Lederer CW, Pavlou E, Tanteles GA, Evangelidou P, Sismani C, Kolnagou A, Sitarou M, Christou S, Hadjigavriel M, Kleanthous M.

Hematology. 2017 Jun;22(5):304-309. doi: 10.1080/10245332.2016.1265043. Epub 2016 Dec 22.

PMID:
28007020
12.

The molecular spectrum and distribution of haemoglobinopathies in Cyprus: a 20-year retrospective study.

Kountouris P, Kousiappa I, Papasavva T, Christopoulos G, Pavlou E, Petrou M, Feleki X, Karitzie E, Phylactides M, Fanis P, Lederer CW, Kyrri AR, Kalogerou E, Makariou C, Ioannou C, Kythreotis L, Hadjilambi G, Andreou N, Pangalou E, Savvidou I, Angastiniotis M, Hadjigavriel M, Sitarou M, Kolnagou A, Kleanthous M, Christou S.

Sci Rep. 2016 May 20;6:26371. doi: 10.1038/srep26371.

13.

A Tribute to George Stamatoyannopoulos.

Srivastava A, Kay MA, Athanasopoulos T, Angastiniotis M, Anagnostopoulos A, Karponi G, Yannaki E, Zon LI, Lederer CW, Phylactides MS, Kleanthous M.

Hum Gene Ther. 2016 Apr;27(4):280-6. doi: 10.1089/hum.2016.29025.gst. No abstract available.

PMID:
27074151
14.

Measurement of lentiviral vector titre and copy number by cross-species duplex quantitative PCR.

Christodoulou I, Patsali P, Stephanou C, Antoniou M, Kleanthous M, Lederer CW.

Gene Ther. 2016 Jan;23(1):113-8. doi: 10.1038/gt.2015.60. Epub 2015 Jun 30.

15.

A novel family of katanin-like 2 protein isoforms (KATNAL2), interacting with nucleotide-binding proteins Nubp1 and Nubp2, are key regulators of different MT-based processes in mammalian cells.

Ververis A, Christodoulou A, Christoforou M, Kamilari C, Lederer CW, Santama N.

Cell Mol Life Sci. 2016 Jan;73(1):163-84. doi: 10.1007/s00018-015-1980-5. Epub 2015 Jul 8.

PMID:
26153462
16.

Plerixafor+G-CSF-mobilized CD34+ cells represent an optimal graft source for thalassemia gene therapy.

Karponi G, Psatha N, Lederer CW, Adair JE, Zervou F, Zogas N, Kleanthous M, Tsatalas C, Anagnostopoulos A, Sadelain M, Rivière I, Stamatoyannopoulos G, Yannaki E.

Blood. 2015 Jul 30;126(5):616-9. doi: 10.1182/blood-2015-03-629618. Epub 2015 Jun 18.

17.

Recent trends in the gene therapy of β-thalassemia.

Finotti A, Breda L, Lederer CW, Bianchi N, Zuccato C, Kleanthous M, Rivella S, Gambari R.

J Blood Med. 2015 Feb 19;6:69-85. doi: 10.2147/JBM.S46256. eCollection 2015. Review.

18.

IthaGenes: an interactive database for haemoglobin variations and epidemiology.

Kountouris P, Lederer CW, Fanis P, Feleki X, Old J, Kleanthous M.

PLoS One. 2014 Jul 24;9(7):e103020. doi: 10.1371/journal.pone.0103020. eCollection 2014.

19.

Hb Famagusta--analysis of a novel δ-globin chain variant [HBD:c.60C>A] in four families with diverse globin genotypes.

Lederer CW, Pavlou E, Makariou C, Hadjilambi G, Andreou N, Hadjigavriel M, Kolnagou A, Sitarou M, Christou S, Kleanthous M.

Ann Hematol. 2014 Sep;93(9):1625-7. doi: 10.1007/s00277-013-1996-6. Epub 2014 Jan 23. No abstract available.

PMID:
24452365
20.

The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis.

Kypri E, Christodoulou A, Maimaris G, Lethan M, Markaki M, Lysandrou C, Lederer CW, Tavernarakis N, Geimer S, Pedersen LB, Santama N.

Cell Mol Life Sci. 2014 Feb;71(3):517-38. doi: 10.1007/s00018-013-1401-6. Epub 2013 Jun 27.

PMID:
23807208
21.

A minimal set of SNPs for the noninvasive prenatal diagnosis of β-thalassaemia.

Papasavva TE, Lederer CW, Traeger-Synodinos J, Mavrou A, Kanavakis E, Ioannou C, Makariou C, Kleanthous M.

Ann Hum Genet. 2013 Mar;77(2):115-24. doi: 10.1111/ahg.12004. Epub 2013 Jan 31.

22.

hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: structural and functional studies.

Drakou CE, Malekkou A, Hayes JM, Lederer CW, Leonidas DD, Oikonomakos NG, Lamond AI, Santama N, Zographos SE.

Proteins. 2012 Jan;80(1):206-20. doi: 10.1002/prot.23186. Epub 2011 Oct 31.

23.

The nuclear ATPase/adenylate kinase hCINAP is recruited to perinucleolar caps generated upon RNA pol.II inhibition.

Malekkou A, Lederer CW, Lamond AI, Santama N.

FEBS Lett. 2010 Nov 19;584(22):4559-64. doi: 10.1016/j.febslet.2010.10.044. Epub 2010 Oct 26.

24.

Compounds of the anthracycline family of antibiotics elevate human gamma-globin expression both in erythroid cultures and in a transgenic mouse model.

Spyrou P, Phylactides M, Lederer CW, Kithreotis L, Kirri A, Christou S, Kkolou E, Kanavakis E, Anagnou NP, Stamatoyannopoulos G, Kleanthous M.

Blood Cells Mol Dis. 2010 Mar-Apr;44(2):100-6. doi: 10.1016/j.bcmd.2009.10.008. Epub 2009 Nov 14.

PMID:
19914848
25.

Bone marrow as an alternative site for islet transplantation.

Cantarelli E, Melzi R, Mercalli A, Sordi V, Ferrari G, Lederer CW, Mrak E, Rubinacci A, Ponzoni M, Sitia G, Guidotti LG, Bonifacio E, Piemonti L.

Blood. 2009 Nov 12;114(20):4566-74. doi: 10.1182/blood-2009-03-209973. Epub 2009 Sep 22.

PMID:
19773545
26.

An electronic infrastructure for research and treatment of the thalassemias and other hemoglobinopathies: the Euro-mediterranean ITHANET project.

Lederer CW, Basak AN, Aydinok Y, Christou S, El-Beshlawy A, Eleftheriou A, Fattoum S, Felice AE, Fibach E, Galanello R, Gambari R, Gavrila L, Giordano PC, Grosveld F, Hassapopoulou H, Hladka E, Kanavakis E, Locatelli F, Old J, Patrinos GP, Romeo G, Taher A, Traeger-Synodinos J, Vassiliou P, Villegas A, Voskaridou E, Wajcman H, Zafeiropoulos A, Kleanthous M.

Hemoglobin. 2009;33(3):163-76. doi: 10.1080/03630260903089177.

PMID:
19657830
27.

Neural stem cells: mechanisms of fate specification and nuclear reprogramming in regenerative medicine.

Lederer CW, Santama N.

Biotechnol J. 2008 Dec;3(12):1521-38. doi: 10.1002/biot.200800193. Review.

PMID:
19072908
28.

Differential expression of molecular motors in the motor cortex of sporadic ALS.

Pantelidou M, Zographos SE, Lederer CW, Kyriakides T, Pfaffl MW, Santama N.

Neurobiol Dis. 2007 Jun;26(3):577-89. Epub 2007 Feb 16.

PMID:
17418584
29.

Amyotrophic lateral sclerosis--the tools of the trait.

Lederer CW, Santama N.

Biotechnol J. 2007 May;2(5):608-21. Review.

PMID:
17345579
30.

Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis.

Lederer CW, Torrisi A, Pantelidou M, Santama N, Cavallaro S.

BMC Genomics. 2007 Jan 23;8:26.

31.

Motor protein KIFC5A interacts with Nubp1 and Nubp2, and is implicated in the regulation of centrosome duplication.

Christodoulou A, Lederer CW, Surrey T, Vernos I, Santama N.

J Cell Sci. 2006 May 15;119(Pt 10):2035-47. Epub 2006 Apr 25.

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