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Items: 28


Type VI Collagen Regulates Pericellular Matrix Properties, Chondrocyte Swelling, and Mechanotransduction in Mouse Articular Cartilage.

Zelenski NA, Leddy HA, Sanchez-Adams J, Zhang J, Bonaldo P, Liedtke W, Guilak F.

Arthritis Rheumatol. 2015 May;67(5):1286-94. doi: 10.1002/art.39034.


TRPV4 as a therapeutic target for joint diseases.

McNulty AL, Leddy HA, Liedtke W, Guilak F.

Naunyn Schmiedebergs Arch Pharmacol. 2015 Apr;388(4):437-50. doi: 10.1007/s00210-014-1078-x. Epub 2014 Dec 18. Review.


Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.

Lee W, Leddy HA, Chen Y, Lee SH, Zelenski NA, McNulty AL, Wu J, Beicker KN, Coles J, Zauscher S, Grandl J, Sachs F, Guilak F, Liedtke WB.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):E5114-22. doi: 10.1073/pnas.1414298111. Epub 2014 Nov 10.


The mechanobiology of articular cartilage: bearing the burden of osteoarthritis.

Sanchez-Adams J, Leddy HA, McNulty AL, O'Conor CJ, Guilak F.

Curr Rheumatol Rep. 2014 Oct;16(10):451. doi: 10.1007/s11926-014-0451-6. Review.


Follistatin in chondrocytes: the link between TRPV4 channelopathies and skeletal malformations.

Leddy HA, McNulty AL, Lee SH, Rothfusz NE, Gloss B, Kirby ML, Hutson MR, Cohn DH, Guilak F, Liedtke W.

FASEB J. 2014 Jun;28(6):2525-37. doi: 10.1096/fj.13-245936. Epub 2014 Feb 27.


TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading.

O'Conor CJ, Leddy HA, Benefield HC, Liedtke WB, Guilak F.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1316-21. doi: 10.1073/pnas.1319569111. Epub 2014 Jan 13.


Unraveling the mechanism by which TRPV4 mutations cause skeletal dysplasias.

Leddy HA, McNulty AL, Guilak F, Liedtke W.

Rare Dis. 2014 Oct 30;2(1):e962971. doi: 10.4161/2167549X.2014.962971. eCollection 2014.


High body mass index is associated with increased diurnal strains in the articular cartilage of the knee.

Widmyer MR, Utturkar GM, Leddy HA, Coleman JL, Spritzer CE, Moorman CT 3rd, DeFrate LE, Guilak F.

Arthritis Rheum. 2013 Oct;65(10):2615-22. doi: 10.1002/art.38062.


Synovial fluid concentrations and relative potency of interleukin-1 alpha and beta in cartilage and meniscus degradation.

McNulty AL, Rothfusz NE, Leddy HA, Guilak F.

J Orthop Res. 2013 Jul;31(7):1039-45. doi: 10.1002/jor.22334. Epub 2013 Mar 11.


Diurnal variations in articular cartilage thickness and strain in the human knee.

Coleman JL, Widmyer MR, Leddy HA, Utturkar GM, Spritzer CE, Moorman CT 3rd, Guilak F, DeFrate LE.

J Biomech. 2013 Feb 1;46(3):541-7. doi: 10.1016/j.jbiomech.2012.09.013. Epub 2012 Oct 24.


Effects of myocardial infarction on the distribution and transport of nutrients and oxygen in porcine myocardium.

Davis BH, Morimoto Y, Sample C, Olbrich K, Leddy HA, Guilak F, Taylor DA.

J Biomech Eng. 2012 Oct;134(10):101005. doi: 10.1115/1.4007455.


Altered trabecular bone structure and delayed cartilage degeneration in the knees of collagen VI null mice.

Christensen SE, Coles JM, Zelenski NA, Furman BD, Leddy HA, Zauscher S, Bonaldo P, Guilak F.

PLoS One. 2012;7(3):e33397. doi: 10.1371/journal.pone.0033397. Epub 2012 Mar 20.


Osmotic stress alters chromatin condensation and nucleocytoplasmic transport.

Finan JD, Leddy HA, Guilak F.

Biochem Biophys Res Commun. 2011 May 6;408(2):230-5. doi: 10.1016/j.bbrc.2011.03.131. Epub 2011 Apr 2.


Transient receptor potential vanilloid 4: The sixth sense of the musculoskeletal system?

Guilak F, Leddy HA, Liedtke W.

Ann N Y Acad Sci. 2010 Mar;1192:404-9. doi: 10.1111/j.1749-6632.2010.05389.x. Review.


Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes.

Phan MN, Leddy HA, Votta BJ, Kumar S, Levy DS, Lipshutz DB, Lee SH, Liedtke W, Guilak F.

Arthritis Rheum. 2009 Oct;60(10):3028-37. doi: 10.1002/art.24799.


Microscale diffusion properties of the cartilage pericellular matrix measured using 3D scanning microphotolysis.

Leddy HA, Christensen SE, Guilak F.

J Biomech Eng. 2008 Dec;130(6):061002. doi: 10.1115/1.2979876.


Site-specific effects of compression on macromolecular diffusion in articular cartilage.

Leddy HA, Guilak F.

Biophys J. 2008 Nov 15;95(10):4890-5. doi: 10.1529/biophysj.108.137752. Epub 2008 Aug 8.


Diffusional anisotropy in collagenous tissues: fluorescence imaging of continuous point photobleaching.

Leddy HA, Haider MA, Guilak F.

Biophys J. 2006 Jul 1;91(1):311-6. Epub 2006 Apr 7.


Composition and transport properties of human ankle and knee cartilage.

Fetter NL, Leddy HA, Guilak F, Nunley JA.

J Orthop Res. 2006 Feb;24(2):211-9.


Adjacent tissues (cartilage, bone) affect the functional integration of engineered calf cartilage in vitro.

Tognana E, Chen F, Padera RF, Leddy HA, Christensen SE, Guilak F, Vunjak-Novakovic G, Freed LE.

Osteoarthritis Cartilage. 2005 Feb;13(2):129-38.


Adipose-derived adult stem cells for cartilage tissue engineering.

Guilak F, Awad HA, Fermor B, Leddy HA, Gimble JM.

Biorheology. 2004;41(3-4):389-99. Review.


Molecular diffusion in tissue-engineered cartilage constructs: effects of scaffold material, time, and culture conditions.

Leddy HA, Awad HA, Guilak F.

J Biomed Mater Res B Appl Biomater. 2004 Aug 15;70(2):397-406.


Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds.

Awad HA, Wickham MQ, Leddy HA, Gimble JM, Guilak F.

Biomaterials. 2004 Jul;25(16):3211-22.


Sutural loosening and skeletal flexibility during growth: determination of drop-like shapes in sea urchins.

Johnson AS, Ellers O, Lemire J, Minor M, Leddy HA.

Proc Biol Sci. 2002 Feb 7;269(1488):215-20. Erratum in: Proc R Soc Lond B Biol Sci. 2002 Dec 22;269(1509):2603..


Surface protein characterization of human adipose tissue-derived stromal cells.

Gronthos S, Franklin DM, Leddy HA, Robey PG, Storms RW, Gimble JM.

J Cell Physiol. 2001 Oct;189(1):54-63.


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