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Items: 35

1.

CXA-10, a Nitrated Fatty Acid, Is Renoprotective in Deoxycorticosterone Acetate-Salt Nephropathy.

Arbeeny CM, Ling H, Smith MM, O'Brien S, Wawersik S, Ledbetter SR, McAlexander A, Schopfer FJ, Willette RN, Jorkasky DK.

J Pharmacol Exp Ther. 2019 Jun;369(3):503-510. doi: 10.1124/jpet.118.254755. Epub 2019 Mar 20.

PMID:
30894457
2.

Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis.

Husson H, Moreno S, Smith LA, Smith MM, Russo RJ, Pitstick R, Sergeev M, Ledbetter SR, Bukanov NO, Lane M, Zhang K, Billot K, Carlson G, Shah J, Meijer L, Beier DR, Ibraghimov-Beskrovnaya O.

Hum Mol Genet. 2016 Jun 1;25(11):2245-2255. Epub 2016 Apr 5.

3.

Blocking TGF-β Signaling Pathway Preserves Mitochondrial Proteostasis and Reduces Early Activation of PDGFRβ+ Pericytes in Aristolochic Acid Induced Acute Kidney Injury in Wistar Male Rats.

Pozdzik AA, Giordano L, Li G, Antoine MH, Quellard N, Godet J, De Prez E, Husson C, Declèves AE, Arlt VM, Goujon JM, Brochériou-Spelle I, Ledbetter SR, Caron N, Nortier JL.

PLoS One. 2016 Jul 5;11(7):e0157288. doi: 10.1371/journal.pone.0157288. eCollection 2016.

4.

Differences in the timing and magnitude of Pkd1 gene deletion determine the severity of polycystic kidney disease in an orthologous mouse model of ADPKD.

Rogers KA, Moreno SE, Smith LA, Husson H, Bukanov NO, Ledbetter SR, Budman Y, Lu Y, Wang B, Ibraghimov-Beskrovnaya O, Natoli TA.

Physiol Rep. 2016 Jun;4(12). pii: e12846. doi: 10.14814/phy2.12846.

5.

CaMKII as a pathological mediator of ER stress, oxidative stress, and mitochondrial dysfunction in a murine model of nephronophthisis.

Bracken C, Beauverger P, Duclos O, Russo RJ, Rogers KA, Husson H, Natoli TA, Ledbetter SR, Janiak P, Ibraghimov-Beskrovnaya O, Bukanov NO.

Am J Physiol Renal Physiol. 2016 Jun 1;310(11):F1414-22. doi: 10.1152/ajprenal.00426.2015. Epub 2016 Apr 13.

6.

Role of TGF-β in a mouse model of high turnover renal osteodystrophy.

Liu S, Song W, Boulanger JH, Tang W, Sabbagh Y, Kelley B, Gotschall R, Ryan S, Phillips L, Malley K, Cao X, Xia TH, Zhen G, Cao X, Ling H, Dechow PC, Bellido TM, Ledbetter SR, Schiavi SC.

J Bone Miner Res. 2014;29(5):1141-57. doi: 10.1002/jbmr.2120.

7.

Increased cellular senescence and vascular rarefaction exacerbate the progression of kidney fibrosis in aged mice following transient ischemic injury.

Clements ME, Chaber CJ, Ledbetter SR, Zuk A.

PLoS One. 2013 Aug 5;8(8):e70464. doi: 10.1371/journal.pone.0070464. Print 2013.

8.

CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD.

Bukanov NO, Moreno SE, Natoli TA, Rogers KA, Smith LA, Ledbetter SR, Oumata N, Galons H, Meijer L, Ibraghimov-Beskrovnaya O.

Cell Cycle. 2012 Nov 1;11(21):4040-6. doi: 10.4161/cc.22375. Epub 2012 Oct 3.

9.

Loss of GM3 synthase gene, but not sphingosine kinase 1, is protective against murine nephronophthisis-related polycystic kidney disease.

Natoli TA, Husson H, Rogers KA, Smith LA, Wang B, Budman Y, Bukanov NO, Ledbetter SR, Klinger KW, Leonard JP, Ibraghimov-Beskrovnaya O.

Hum Mol Genet. 2012 Aug 1;21(15):3397-407. doi: 10.1093/hmg/dds172. Epub 2012 May 4.

10.

Renoprotective effects of anti-TGF-β antibody and antihypertensive therapies in Dahl S rats.

Murphy SR, Dahly-Vernon AJ, Dunn KM, Chen CC, Ledbetter SR, Williams JM, Roman RJ.

Am J Physiol Regul Integr Comp Physiol. 2012 Jul 1;303(1):R57-69. doi: 10.1152/ajpregu.00263.2011. Epub 2012 Apr 25.

11.

A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis.

Trachtman H, Fervenza FC, Gipson DS, Heering P, Jayne DR, Peters H, Rota S, Remuzzi G, Rump LC, Sellin LK, Heaton JP, Streisand JB, Hard ML, Ledbetter SR, Vincenti F.

Kidney Int. 2011 Jun;79(11):1236-43. doi: 10.1038/ki.2011.33. Epub 2011 Mar 2.

12.

Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models.

Natoli TA, Smith LA, Rogers KA, Wang B, Komarnitsky S, Budman Y, Belenky A, Bukanov NO, Dackowski WR, Husson H, Russo RJ, Shayman JA, Ledbetter SR, Leonard JP, Ibraghimov-Beskrovnaya O.

Nat Med. 2010 Jul;16(7):788-92. doi: 10.1038/nm.2171. Epub 2010 Jun 20.

13.

Protective effect of 20-HETE analogues in experimental renal ischemia reperfusion injury.

Regner KR, Zuk A, Van Why SK, Shames BD, Ryan RP, Falck JR, Manthati VL, McMullen ME, Ledbetter SR, Roman RJ.

Kidney Int. 2009 Mar;75(5):511-7. doi: 10.1038/ki.2008.600. Epub 2008 Dec 3.

14.

Effect of combination therapy with enalapril and the TGF-beta antagonist 1D11 in unilateral ureteral obstruction.

El Chaar M, Chen J, Seshan SV, Jha S, Richardson I, Ledbetter SR, Vaughan ED Jr, Poppas DP, Felsen D.

Am J Physiol Renal Physiol. 2007 Apr;292(4):F1291-301. Epub 2006 Dec 12.

15.

Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine.

Bukanov NO, Smith LA, Klinger KW, Ledbetter SR, Ibraghimov-Beskrovnaya O.

Nature. 2006 Dec 14;444(7121):949-52. Epub 2006 Nov 22.

PMID:
17122773
16.

Transforming growth factor-beta, 20-HETE interaction, and glomerular injury in Dahl salt-sensitive rats.

Dahly-Vernon AJ, Sharma M, McCarthy ET, Savin VJ, Ledbetter SR, Roman RJ.

Hypertension. 2005 Apr;45(4):643-8. Epub 2005 Feb 21.

PMID:
15723968
17.

Antihypertensive effects of chronic anti-TGF-beta antibody therapy in Dahl S rats.

Dahly AJ, Hoagland KM, Flasch AK, Jha S, Ledbetter SR, Roman RJ.

Am J Physiol Regul Integr Comp Physiol. 2002 Sep;283(3):R757-67.

18.

Acute and chronic renal effects of recombinant human TGF-beta2 in the rat.

Kelly FJ, Anderson S, Thompson MM, Oyama TT, Kennefick TM, Corless CL, Roman RJ, Kurtzberg L, Pratt BM, Ledbetter SR.

J Am Soc Nephrol. 1999 Jun;10(6):1264-73.

19.

Solution structures of stromelysin complexed to thiadiazole inhibitors.

Stockman BJ, Waldon DJ, Gates JA, Scahill TA, Kloosterman DA, Mizsak SA, Jacobsen EJ, Belonga KL, Mitchell MA, Mao B, Petke JD, Goodman L, Powers EA, Ledbetter SR, Kaytes PS, Vogeli G, Marshall VP, Petzold GL, Poorman RA.

Protein Sci. 1998 Nov;7(11):2281-6.

20.
21.

CXC chemokines connective tissue activating peptide-III and neutrophil activating peptide-2 are heparin/heparan sulfate-degrading enzymes.

Hoogewerf AJ, Leone JW, Reardon IM, Howe WJ, Asa D, Heinrikson RL, Ledbetter SR.

J Biol Chem. 1995 Feb 17;270(7):3268-77.

22.

Vascular permeability factor (vascular endothelial growth factor) in guinea pig and human tumor and inflammatory effusions.

Yeo KT, Wang HH, Nagy JA, Sioussat TM, Ledbetter SR, Hoogewerf AJ, Zhou Y, Masse EM, Senger DR, Dvorak HF, et al.

Cancer Res. 1993 Jun 15;53(12):2912-8.

24.

Glucose transporters are abundant in cells with "occluding" junctions at the blood-eye barriers.

Harik SI, Kalaria RN, Whitney PM, Andersson L, Lundahl P, Ledbetter SR, Perry G.

Proc Natl Acad Sci U S A. 1990 Jun;87(11):4261-4.

25.

Identification of cDNA clones encoding different domains of the basement membrane heparan sulfate proteoglycan.

Noonan DM, Horigan EA, Ledbetter SR, Vogeli G, Sasaki M, Yamada Y, Hassell JR.

J Biol Chem. 1988 Nov 5;263(31):16379-87.

26.

Response of diabetic basement membrane--producing cells to glucose and insulin.

Ledbetter SR, Wagner CW, Martin GR, Rohrbach DH, Hassell JR.

Diabetes. 1987 Sep;36(9):1029-34.

PMID:
3301472
27.

Domain structure of the basement membrane heparan sulfate proteoglycan.

Ledbetter SR, Fisher LW, Hassell JR.

Biochemistry. 1987 Feb 24;26(4):988-95.

PMID:
2952166
28.

beta-D-xyloside-mediated alteration in the synthesis of basement membrane proteoglycan.

Ledbetter SR, Hassell JR.

Arch Biochem Biophys. 1986 Apr;246(1):403-10.

PMID:
3963827
29.

Biosynthesis and structure of the basement membrane proteoglycan containing heparan sulphate side-chains.

Hassell JM, Noonan DM, Ledbetter SR, Laurie GW.

Ciba Found Symp. 1986;124:204-22.

PMID:
2949947
30.

Identification of the precursor protein to basement membrane heparan sulfate proteoglycans.

Ledbetter SR, Tyree B, Hassell JR, Horigan EA.

J Biol Chem. 1985 Jul 5;260(13):8106-113.

31.

Isolation of two forms of basement membrane proteoglycans.

Hassell JR, Leyshon WC, Ledbetter SR, Tyree B, Suzuki S, Kato M, Kimata K, Kleinman HK.

J Biol Chem. 1985 Jul 5;260(13):8098-105.

32.

Appearance of basement membrane components during the differentiation of limb bud mesenchyme cells in culture.

Hassell JR, Horigan EA, Mosley GL, Ledbetter SR, Kleinman HK, Chandrasekhar S.

Prog Clin Biol Res. 1985;171:75-86. No abstract available.

PMID:
3983188
33.

Secondary aqueous humor stimulates the proliferation of cultured bovine corneal endothelial cells.

Ledbetter SR, Hatchell DL, O'Brien WJ.

Invest Ophthalmol Vis Sci. 1983 May;24(5):557-62.

PMID:
6841001
34.

Bovine corneal endothelium in vitro. Elaboration and organization and of a basement membrane.

MacCallum DK, Lillie JH, Scaletta LJ, Occhino JC, Frederick WG, Ledbetter SR.

Exp Cell Res. 1982 May;139(1):1-13. No abstract available.

35.

Differential effect of secondary aqueous humor from rabbit and cat on DNA synthesis of cultured bovine corneal endothelial cells.

Ledbetter SR, Hatchell DL, O'Brien WJ.

Curr Eye Res. 1981-1982;1(12):723-6. No abstract available.

PMID:
7347639

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