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CXA-10, a Nitrated Fatty Acid, Is Renoprotective in Deoxycorticosterone Acetate-Salt Nephropathy.

Arbeeny CM, Ling H, Smith MM, O'Brien S, Wawersik S, Ledbetter SR, McAlexander A, Schopfer FJ, Willette RN, Jorkasky DK.

J Pharmacol Exp Ther. 2019 Jun;369(3):503-510. doi: 10.1124/jpet.118.254755. Epub 2019 Mar 20.


A Phase 2, Double-Blind, Placebo-Controlled, Randomized Study of Fresolimumab in Patients With Steroid-Resistant Primary Focal Segmental Glomerulosclerosis.

Vincenti F, Fervenza FC, Campbell KN, Diaz M, Gesualdo L, Nelson P, Praga M, Radhakrishnan J, Sellin L, Singh A, Thornley-Brown D, Veronese FV, Accomando B, Engstrand S, Ledbetter S, Lin J, Neylan J, Tumlin J; Focal Segmental Glomerulosclerosis Study Group.

Kidney Int Rep. 2017 Apr 7;2(5):800-810. doi: 10.1016/j.ekir.2017.03.011. eCollection 2017 Sep.


Metabolic reprogramming of the premalignant colonic mucosa is an early event in carcinogenesis.

Cruz MD, Ledbetter S, Chowdhury S, Tiwari AK, Momi N, Wali RK, Bliss C, Huang C, Lichtenstein D, Bhattacharya S, Varma-Wilson A, Backman V, Roy HK.

Oncotarget. 2017 Mar 28;8(13):20543-20557. doi: 10.18632/oncotarget.16129.


Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis.

Husson H, Moreno S, Smith LA, Smith MM, Russo RJ, Pitstick R, Sergeev M, Ledbetter SR, Bukanov NO, Lane M, Zhang K, Billot K, Carlson G, Shah J, Meijer L, Beier DR, Ibraghimov-Beskrovnaya O.

Hum Mol Genet. 2016 Jun 1;25(11):2245-2255. Epub 2016 Apr 5.


Blocking TGF-β Signaling Pathway Preserves Mitochondrial Proteostasis and Reduces Early Activation of PDGFRβ+ Pericytes in Aristolochic Acid Induced Acute Kidney Injury in Wistar Male Rats.

Pozdzik AA, Giordano L, Li G, Antoine MH, Quellard N, Godet J, De Prez E, Husson C, Declèves AE, Arlt VM, Goujon JM, Brochériou-Spelle I, Ledbetter SR, Caron N, Nortier JL.

PLoS One. 2016 Jul 5;11(7):e0157288. doi: 10.1371/journal.pone.0157288. eCollection 2016.


Differences in the timing and magnitude of Pkd1 gene deletion determine the severity of polycystic kidney disease in an orthologous mouse model of ADPKD.

Rogers KA, Moreno SE, Smith LA, Husson H, Bukanov NO, Ledbetter SR, Budman Y, Lu Y, Wang B, Ibraghimov-Beskrovnaya O, Natoli TA.

Physiol Rep. 2016 Jun;4(12). pii: e12846. doi: 10.14814/phy2.12846.


Anti-TGF-β Antibody, 1D11, Ameliorates Glomerular Fibrosis in Mouse Models after the Onset of Proteinuria.

Liang X, Schnaper HW, Matsusaka T, Pastan I, Ledbetter S, Hayashida T.

PLoS One. 2016 May 17;11(5):e0155534. doi: 10.1371/journal.pone.0155534. eCollection 2016.


CaMKII as a pathological mediator of ER stress, oxidative stress, and mitochondrial dysfunction in a murine model of nephronophthisis.

Bracken C, Beauverger P, Duclos O, Russo RJ, Rogers KA, Husson H, Natoli TA, Ledbetter SR, Janiak P, Ibraghimov-Beskrovnaya O, Bukanov NO.

Am J Physiol Renal Physiol. 2016 Jun 1;310(11):F1414-22. doi: 10.1152/ajprenal.00426.2015. Epub 2016 Apr 13.


Differential Ly6C Expression after Renal Ischemia-Reperfusion Identifies Unique Macrophage Populations.

Clements M, Gershenovich M, Chaber C, Campos-Rivera J, Du P, Zhang M, Ledbetter S, Zuk A.

J Am Soc Nephrol. 2016 Jan;27(1):159-70. doi: 10.1681/ASN.2014111138. Epub 2015 May 26.


Simple regression for correcting ΔCt bias in RT-qPCR low-density array data normalization.

Cui X, Yu S, Tamhane A, Causey ZL, Steg A, Danila MI, Reynolds RJ, Wang J, Wanzeck KC, Tang Q, Ledbetter SS, Redden DT, Johnson MR, Bridges SL Jr.

BMC Genomics. 2015 Feb 14;16:82. doi: 10.1186/s12864-015-1274-1.


CXCR₄antagonism as a therapeutic approach to prevent acute kidney injury.

Zuk A, Gershenovich M, Ivanova Y, MacFarland RT, Fricker SP, Ledbetter S.

Am J Physiol Renal Physiol. 2014 Oct 1;307(7):F783-97. doi: 10.1152/ajprenal.00685.2013. Epub 2014 Jul 30.


Management of pneumothoraces detected on chest computed tomography: can anatomical location identify patients who can be managed expectantly?

Agbo C, Hempel D, Studer M, Gulati K, Oliva I, Goldflam K, Ledbetter S, Platz E.

J Emerg Med. 2014 May;46(5):605-11. doi: 10.1016/j.jemermed.2013.11.079. Epub 2014 Feb 6.


Role of TGF-β in a mouse model of high turnover renal osteodystrophy.

Liu S, Song W, Boulanger JH, Tang W, Sabbagh Y, Kelley B, Gotschall R, Ryan S, Phillips L, Malley K, Cao X, Xia TH, Zhen G, Cao X, Ling H, Dechow PC, Bellido TM, Ledbetter SR, Schiavi SC.

J Bone Miner Res. 2014;29(5):1141-57. doi: 10.1002/jbmr.2120.


Implementation of speech recognition in a community-based radiology practice: effect on report turnaround times.

Prevedello LM, Ledbetter S, Farkas C, Khorasani R.

J Am Coll Radiol. 2014 Apr;11(4):402-6. doi: 10.1016/j.jacr.2013.07.008. Epub 2013 Oct 23.


Increased cellular senescence and vascular rarefaction exacerbate the progression of kidney fibrosis in aged mice following transient ischemic injury.

Clements ME, Chaber CJ, Ledbetter SR, Zuk A.

PLoS One. 2013 Aug 5;8(8):e70464. doi: 10.1371/journal.pone.0070464. Print 2013.


Glomerulopathy in the KK.Cg-A(y) /J mouse reflects the pathology of diabetic nephropathy.

O'Brien SP, Smith M, Ling H, Phillips L, Weber W, Lydon J, Maloney C, Ledbetter S, Arbeeny C, Wawersik S.

J Diabetes Res. 2013;2013:498925. doi: 10.1155/2013/498925. Epub 2013 Apr 24.


Transforming growth factor β neutralization ameliorates pre-existing hepatic fibrosis and reduces cholangiocarcinoma in thioacetamide-treated rats.

Ling H, Roux E, Hempel D, Tao J, Smith M, Lonning S, Zuk A, Arbeeny C, Ledbetter S.

PLoS One. 2013;8(1):e54499. doi: 10.1371/journal.pone.0054499. Epub 2013 Jan 17.


CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD.

Bukanov NO, Moreno SE, Natoli TA, Rogers KA, Smith LA, Ledbetter SR, Oumata N, Galons H, Meijer L, Ibraghimov-Beskrovnaya O.

Cell Cycle. 2012 Nov 1;11(21):4040-6. doi: 10.4161/cc.22375. Epub 2012 Oct 3.


Npt2b deletion attenuates hyperphosphatemia associated with CKD.

Schiavi SC, Tang W, Bracken C, O'Brien SP, Song W, Boulanger J, Ryan S, Phillips L, Liu S, Arbeeny C, Ledbetter S, Sabbagh Y.

J Am Soc Nephrol. 2012 Oct;23(10):1691-700. Epub 2012 Aug 2.


Diagnostic errors in the evaluation of nontraumatic aortic emergencies.

Souza D, Ledbetter S.

Semin Ultrasound CT MR. 2012 Aug;33(4):318-36. doi: 10.1053/j.sult.2012.02.001.


Abbreviated MRI for patients presenting to the emergency department with hip pain.

Khurana B, Okanobo H, Ossiani M, Ledbetter S, Al Dulaimy K, Sodickson A.

AJR Am J Roentgenol. 2012 Jun;198(6):W581-8. doi: 10.2214/AJR.11.7258.


Loss of GM3 synthase gene, but not sphingosine kinase 1, is protective against murine nephronophthisis-related polycystic kidney disease.

Natoli TA, Husson H, Rogers KA, Smith LA, Wang B, Budman Y, Bukanov NO, Ledbetter SR, Klinger KW, Leonard JP, Ibraghimov-Beskrovnaya O.

Hum Mol Genet. 2012 Aug 1;21(15):3397-407. doi: 10.1093/hmg/dds172. Epub 2012 May 4.


Renoprotective effects of anti-TGF-β antibody and antihypertensive therapies in Dahl S rats.

Murphy SR, Dahly-Vernon AJ, Dunn KM, Chen CC, Ledbetter SR, Williams JM, Roman RJ.

Am J Physiol Regul Integr Comp Physiol. 2012 Jul 1;303(1):R57-69. doi: 10.1152/ajpregu.00263.2011. Epub 2012 Apr 25.


Repression of osteocyte Wnt/β-catenin signaling is an early event in the progression of renal osteodystrophy.

Sabbagh Y, Graciolli FG, O'Brien S, Tang W, dos Reis LM, Ryan S, Phillips L, Boulanger J, Song W, Bracken C, Liu S, Ledbetter S, Dechow P, Canziani ME, Carvalho AB, Jorgetti V, Moyses RM, Schiavi SC.

J Bone Miner Res. 2012 Aug;27(8):1757-72. doi: 10.1002/jbmr.1630.


Simplified diagnostic algorithm for Lauge-Hansen classification of ankle injuries.

Okanobo H, Khurana B, Sheehan S, Duran-Mendicuti A, Arianjam A, Ledbetter S.

Radiographics. 2012 Mar-Apr;32(2):E71-84. doi: 10.1148/rg.322115017. Review.


Anatomical distribution of traumatic pneumothoraces on chest computed tomography: implications for ultrasound screening in the ED.

Mennicke M, Gulati K, Oliva I, Goldflam K, Skali H, Ledbetter S, Platz E.

Am J Emerg Med. 2012 Sep;30(7):1025-31. doi: 10.1016/j.ajem.2011.06.020. Epub 2011 Sep 9.


Outside imaging in emergency department transfer patients: CD import reduces rates of subsequent imaging utilization.

Sodickson A, Opraseuth J, Ledbetter S.

Radiology. 2011 Aug;260(2):408-13. doi: 10.1148/radiol.11101956. Epub 2011 Apr 19.


A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis.

Trachtman H, Fervenza FC, Gipson DS, Heering P, Jayne DR, Peters H, Rota S, Remuzzi G, Rump LC, Sellin LK, Heaton JP, Streisand JB, Hard ML, Ledbetter SR, Vincenti F.

Kidney Int. 2011 Jun;79(11):1236-43. doi: 10.1038/ki.2011.33. Epub 2011 Mar 2.


Spiral head CT in the evaluation of acute intracranial pathology: a pictorial essay.

Sodickson A, Okanobo H, Ledbetter S.

Emerg Radiol. 2011 Jan;18(1):81-91. doi: 10.1007/s10140-010-0914-7. Epub 2010 Oct 13.


Comparison of respiratory motion artifact from craniocaudal versus caudocranial scanning with 64-MDCT pulmonary angiography.

Wu C, Sodickson A, Cai T, Levit NA, Steigner ML, Rybicki FJ, Ledbetter SM.

AJR Am J Roentgenol. 2010 Jul;195(1):155-9. doi: 10.2214/AJR.09.3673.


Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models.

Natoli TA, Smith LA, Rogers KA, Wang B, Komarnitsky S, Budman Y, Belenky A, Bukanov NO, Dackowski WR, Husson H, Russo RJ, Shayman JA, Ledbetter SR, Leonard JP, Ibraghimov-Beskrovnaya O.

Nat Med. 2010 Jul;16(7):788-92. doi: 10.1038/nm.2171. Epub 2010 Jun 20.


Radiographic severity of rheumatoid arthritis in African Americans: results from a multicenter observational study.

Bridges SL Jr, Causey ZL, Burgos PI, Huynh BQ, Hughes LB, Danila MI, van Everdingen A, Ledbetter S, Conn DL, Tamhane A, Westfall AO, Jonas BL, Callahan LF, Smith EA, Brasington R, Moreland LW, Alarcón GS, van der Heijde DM.

Arthritis Care Res (Hoboken). 2010 May;62(5):624-31. doi: 10.1002/acr.20040.


Nonoperative management of patients with a diagnosis of high-grade small bowel obstruction by computed tomography.

Rocha FG, Theman TA, Matros E, Ledbetter SM, Zinner MJ, Ferzoco SJ.

Arch Surg. 2009 Nov;144(11):1000-4. doi: 10.1001/archsurg.2009.183.


Outside CT imaging among emergency department transfer patients.

Sung JC, Sodickson A, Ledbetter S.

J Am Coll Radiol. 2009 Sep;6(9):626-32. doi: 10.1016/j.jacr.2009.04.010.


Homeostatic role of transforming growth factor-beta in the oral cavity and esophagus of mice and its expression by mast cells in these tissues.

Vitsky A, Waire J, Pawliuk R, Bond A, Matthews D, Lacasse E, Hawes ML, Nelson C, Richards S, Piepenhagen PA, Garman RD, Andrews L, Thurberg BL, Lonning S, Ledbetter S, Ruzek MC.

Am J Pathol. 2009 Jun;174(6):2137-49. doi: 10.2353/ajpath.2009.080723. Epub 2009 Apr 30.


Protective effect of 20-HETE analogues in experimental renal ischemia reperfusion injury.

Regner KR, Zuk A, Van Why SK, Shames BD, Ryan RP, Falck JR, Manthati VL, McMullen ME, Ledbetter SR, Roman RJ.

Kidney Int. 2009 Mar;75(5):511-7. doi: 10.1038/ki.2008.600. Epub 2008 Dec 3.


Pneumomediastinum and subcutaneous emphysema after isolated blunt facial trauma.

Griffey RT, Ledbetter S.

J Trauma. 2008 Nov;65(5):1201. doi: 10.1097/01.ta.0000244374.14523.a6. No abstract available.


Yield and utility of radiographic "shunt series" in the evaluation of ventriculo-peritoneal shunt malfunction in adult emergency patients.

Griffey RT, Ledbetter S, Khorasani R.

Emerg Radiol. 2007 Mar;13(6):307-11. Epub 2007 Jan 10.


Recombinant human anti-transforming growth factor beta1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I/II trial of CAT-192.

Denton CP, Merkel PA, Furst DE, Khanna D, Emery P, Hsu VM, Silliman N, Streisand J, Powell J, Akesson A, Coppock J, Hoogen Fv, Herrick A, Mayes MD, Veale D, Haas J, Ledbetter S, Korn JH, Black CM, Seibold JR; Cat-192 Study Group; Scleroderma Clinical Trials Consortium.

Arthritis Rheum. 2007 Jan;56(1):323-33.


Effect of combination therapy with enalapril and the TGF-beta antagonist 1D11 in unilateral ureteral obstruction.

El Chaar M, Chen J, Seshan SV, Jha S, Richardson I, Ledbetter SR, Vaughan ED Jr, Poppas DP, Felsen D.

Am J Physiol Renal Physiol. 2007 Apr;292(4):F1291-301. Epub 2006 Dec 12.


Isoform-specific activation of latent transforming growth factor beta (LTGF-beta) by reactive oxygen species.

Jobling MF, Mott JD, Finnegan MT, Jurukovski V, Erickson AC, Walian PJ, Taylor SE, Ledbetter S, Lawrence CM, Rifkin DB, Barcellos-Hoff MH.

Radiat Res. 2006 Dec;166(6):839-48.


Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine.

Bukanov NO, Smith LA, Klinger KW, Ledbetter SR, Ibraghimov-Beskrovnaya O.

Nature. 2006 Dec 14;444(7121):949-52. Epub 2006 Nov 22.


Beneficial effect of TGFbeta antagonism in treating diabetic nephropathy depends on when treatment is started.

Benigni A, Zoja C, Campana M, Corna D, Sangalli F, Rottoli D, Gagliardini E, Conti S, Ledbetter S, Remuzzi G.

Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10.


Renal venous diversion: an unusual treatment for renal vein thrombosis.

Ho KJ, Owens CD, Ledbetter SM, Chew DK, Belkin M.

J Vasc Surg. 2006 Jun;43(6):1283-6.


Lowering the thyroid dose in screening examinations of the cervical spine.

Shu KM, MacKenzie JD, Smith JB, Blinder EM, Bourgeois LM, Ledbetter S, Castronovo FP, Judy PF, Rybicki F.

Emerg Radiol. 2006 Mar;12(3):133-6. Epub 2005 Dec 16.


An ovary with a twist: a case of interesting sonographic findings of ovarian torsion.

Villalba ML, Huynh B, So M, Mackenzie JD, Ledbetter S, Rybicki F.

J Emerg Med. 2005 Nov;29(4):443-6.


Neutralization of transforming growth factor-beta attenuates hypertension and prevents renal injury in uremic rats.

Lavoie P, Robitaille G, Agharazii M, Ledbetter S, Lebel M, Larivière R.

J Hypertens. 2005 Oct;23(10):1895-903.


Atlantoaxial instability associated with an orthotopic os odontoideum: a multimodality imaging assessment.

Vargas TM, Rybicki FJ, Ledbetter SM, MacKenzie JD.

Emerg Radiol. 2005 Jun;11(4):223-5.


The temporal effects of anti-TGF-beta1, 2, and 3 monoclonal antibody on wound healing and hypertrophic scar formation.

Lu L, Saulis AS, Liu WR, Roy NK, Chao JD, Ledbetter S, Mustoe TA.

J Am Coll Surg. 2005 Sep;201(3):391-7.


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