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Influenza A Virus Infection Induces Apical Redistribution of Na+, K+-ATPase in Lung Epithelial Cells In Vitro and In Vivo.

Peteranderl C, Kuznetsova I, Schulze J, Hardt M, Lecuona E, Sznajder JI, Vadász I, Morty RE, Pleschka S, Wolff T, Herold S.

Am J Respir Cell Mol Biol. 2019 Sep;61(3):395-398. doi: 10.1165/rcmb.2019-0096LE. No abstract available.


Clinical relevance of lung-restricted antibodies in lung transplantation.

Akbarpour M, Wu Q, Liu X, Sun H, Lecuona E, Tomic R, Bhorade S, Mohanakumar T, Bharat A.

Hum Immunol. 2019 Aug;80(8):595-601. doi: 10.1016/j.humimm.2019.04.016. Epub 2019 May 8. Review.


Cardiac glycosides decrease influenza virus replication by inhibiting cell protein translational machinery.

Amarelle L, Katzen J, Shigemura M, Welch LC, Cajigas H, Peteranderl C, Celli D, Herold S, Lecuona E, Sznajder JI.

Am J Physiol Lung Cell Mol Physiol. 2019 Jun 1;316(6):L1094-L1106. doi: 10.1152/ajplung.00173.2018. Epub 2019 Mar 20.


Influenza A Virus Infection Induces Muscle Wasting via IL-6 Regulation of the E3 Ubiquitin Ligase Atrogin-1.

Radigan KA, Nicholson TT, Welch LC, Chi M, Amarelle L, Angulo M, Shigemura M, Shigemura A, Runyan CE, Morales-Nebreda L, Perlman H, Ceco E, Lecuona E, Dada LA, Misharin AV, Mutlu GM, Sznajder JI, Budinger GRS.

J Immunol. 2019 Jan 15;202(2):484-493. doi: 10.4049/jimmunol.1701433. Epub 2018 Dec 7.


A Nonhospitable Host: Targeting Cellular Factors as an Antiviral Strategy for Respiratory Viruses.

Amarelle L, Lecuona E.

Am J Respir Cell Mol Biol. 2018 Dec;59(6):666-667. doi: 10.1165/rcmb.2018-0268ED. No abstract available.


Hypercapnia increases airway smooth muscle contractility via caspase-7-mediated miR-133a-RhoA signaling.

Shigemura M, Lecuona E, Angulo M, Homma T, Rodríguez DA, Gonzalez-Gonzalez FJ, Welch LC, Amarelle L, Kim SJ, Kaminski N, Budinger GRS, Solway J, Sznajder JI.

Sci Transl Med. 2018 Sep 5;10(457). pii: eaat1662. doi: 10.1126/scitranslmed.aat1662.


The Antiviral Effects of Na,K-ATPase Inhibition: A Minireview.

Amarelle L, Lecuona E.

Int J Mol Sci. 2018 Jul 24;19(8). pii: E2154. doi: 10.3390/ijms19082154. Review.


Sensory integration intervention and the development of the premature infant: A controlled trial.

Lecuona E, Van Jaarsveld A, Raubenheimer J, Van Heerden R.

S Afr Med J. 2017 Oct 31;107(11):976-982. doi: 10.7196/SAMJ.2017.v107i11.12393.


Stretching to Understand How Proteostasis and the Unfolded Protein Response Regulate Lung Injury.

Lecuona E, Sznajder JI.

Am J Respir Cell Mol Biol. 2017 Aug;57(2):143-144. doi: 10.1165/rcmb.2017-0170ED. No abstract available.


Inflammatory Responses Regulating Alveolar Ion Transport during Pulmonary Infections.

Peteranderl C, Sznajder JI, Herold S, Lecuona E.

Front Immunol. 2017 Apr 18;8:446. doi: 10.3389/fimmu.2017.00446. eCollection 2017. Review.


Effects of hypercapnia on the lung.

Shigemura M, Lecuona E, Sznajder JI.

J Physiol. 2017 Apr 15;595(8):2431-2437. doi: 10.1113/JP273781. Epub 2017 Feb 14. Review.


Anti-Influenza Treatment: Drugs Currently Used and Under Development.

Amarelle L, Lecuona E, Sznajder JI.

Arch Bronconeumol. 2017 Jan;53(1):19-26. doi: 10.1016/j.arbres.2016.07.004. Epub 2016 Aug 9. Review. English, Spanish.


Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia.

Selfridge AC, Cavadas MA, Scholz CC, Campbell EL, Welch LC, Lecuona E, Colgan SP, Barrett KE, Sporn PH, Sznajder JI, Cummins EP, Taylor CT.

J Biol Chem. 2016 May 27;291(22):11800-8. doi: 10.1074/jbc.M116.713941. Epub 2016 Apr 4.


Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection.

Peteranderl C, Morales-Nebreda L, Selvakumar B, Lecuona E, Vadász I, Morty RE, Schmoldt C, Bespalowa J, Wolff T, Pleschka S, Mayer K, Gattenloehner S, Fink L, Lohmeyer J, Seeger W, Sznajder JI, Mutlu GM, Budinger GR, Herold S.

J Clin Invest. 2016 Apr 1;126(4):1566-80. doi: 10.1172/JCI83931. Epub 2016 Mar 21.


Corrigendum to "Calcium release-activated calcium (CRAC) channels mediate the β2 -adrenergic regulation of Na,K-ATPase" [FEBS Lett. 588 (24) (2014) 4686-4693].

Keller MJ, Lecuona E, Prakriya M, Cheng Y, Soberanes S, Scott Budinger GR, Sznajder JI.

FEBS Lett. 2015 Jan 30;589(3):414. doi: 10.1016/j.febslet.2014.12.017. No abstract available.


High CO2 levels cause skeletal muscle atrophy via AMP-activated kinase (AMPK), FoxO3a protein, and muscle-specific Ring finger protein 1 (MuRF1).

Jaitovich A, Angulo M, Lecuona E, Dada LA, Welch LC, Cheng Y, Gusarova G, Ceco E, Liu C, Shigemura M, Barreiro E, Patterson C, Nader GA, Sznajder JI.

J Biol Chem. 2015 Apr 3;290(14):9183-94. doi: 10.1074/jbc.M114.625715. Epub 2015 Feb 17.


Calcium release-activated calcium (CRAC) channels mediate the β(2)-adrenergic regulation of Na,K-ATPase.

Keller MJ, Lecuona E, Prakriya M, Cheng Y, Soberanes S, Budinger GR, Sznajder JI.

FEBS Lett. 2014 Dec 20;588(24):4686-93. doi: 10.1016/j.febslet.2014.10.041. Epub 2014 Nov 11. Erratum in: FEBS Lett. 2015 Jan 30;589(3):414.


Intratracheal administration of influenza virus is superior to intranasal administration as a model of acute lung injury.

Morales-Nebreda L, Chi M, Lecuona E, Chandel NS, Dada LA, Ridge K, Soberanes S, Nigdelioglu R, Sznajder JI, Mutlu GM, Budinger GR, Radigan KA.

J Virol Methods. 2014 Dec;209:116-20. doi: 10.1016/j.jviromet.2014.09.004. Epub 2014 Sep 17.


Protein kinase A-Iα regulates Na,K-ATPase endocytosis in alveolar epithelial cells exposed to high CO(2) concentrations.

Lecuona E, Sun H, Chen J, Trejo HE, Baker MA, Sznajder JI.

Am J Respir Cell Mol Biol. 2013 May;48(5):626-34. doi: 10.1165/rcmb.2012-0373OC.


Lipid overload: trigger or consequence of mitochondrial oxidative stress in ventilator-induced diaphragmatic dysfunction?

Lecuona E, Sassoon CS, Barreiro E.

Am J Respir Crit Care Med. 2012 Dec 1;186(11):1074-6. doi: 10.1164/rccm.201209-1735ED. No abstract available.


Role of MicroRNAs in lung disease.

Angulo M, Lecuona E, Sznajder JI.

Arch Bronconeumol. 2012 Sep;48(9):325-30. Epub 2012 May 17. Review. English, Spanish.


Elevated CO(2) levels cause mitochondrial dysfunction and impair cell proliferation.

Vohwinkel CU, Lecuona E, Sun H, Sommer N, Vadász I, Chandel NS, Sznajder JI.

J Biol Chem. 2011 Oct 28;286(43):37067-76. doi: 10.1074/jbc.M111.290056. Epub 2011 Sep 8.


Extracellular signal-regulated kinase (ERK) participates in the hypercapnia-induced Na,K-ATPase downregulation.

Welch LC, Lecuona E, Briva A, Trejo HE, Dada LA, Sznajder JI.

FEBS Lett. 2010 Sep 24;584(18):3985-9. doi: 10.1016/j.febslet.2010.08.002. Epub 2010 Aug 6.


[Permissive and non-permissive hypercapnia: mechanisms of action and consequences of high carbon dioxide levels].

Briva A, Lecuona E, Sznajder JI.

Arch Bronconeumol. 2010 Jul;46(7):378-82. doi: 10.1016/j.arbres.2010.01.009. Epub 2010 Mar 19. Review. Spanish.


Sensing, physiological effects and molecular response to elevated CO2 levels in eukaryotes.

Sharabi K, Lecuona E, Helenius IT, Beitel GJ, Sznajder JI, Gruenbaum Y.

J Cell Mol Med. 2009 Nov-Dec;13(11-12):4304-18. doi: 10.1111/j.1582-4934.2009.00952.x. Epub 2009 Oct 23. Review.


Myosin-Va restrains the trafficking of Na+/K+-ATPase-containing vesicles in alveolar epithelial cells.

Lecuona E, Minin A, Trejo HE, Chen J, Comellas AP, Sun H, Grillo D, Nekrasova OE, Welch LC, Szleifer I, Gelfand VI, Sznajder JI.

J Cell Sci. 2009 Nov 1;122(Pt 21):3915-22. doi: 10.1242/jcs.046953. Epub 2009 Oct 6.


Role of kinesin light chain-2 of kinesin-1 in the traffic of Na,K-ATPase-containing vesicles in alveolar epithelial cells.

Trejo HE, Lecuona E, Grillo D, Szleifer I, Nekrasova OE, Gelfand VI, Sznajder JI.

FASEB J. 2010 Feb;24(2):374-82. doi: 10.1096/fj.09-137802. Epub 2009 Sep 22.


Ubiquitination participates in the lysosomal degradation of Na,K-ATPase in steady-state conditions.

Lecuona E, Sun H, Vohwinkel C, Ciechanover A, Sznajder JI.

Am J Respir Cell Mol Biol. 2009 Dec;41(6):671-9. doi: 10.1165/rcmb.2008-0365OC. Epub 2009 Mar 13.


Endothelin-1 impairs alveolar epithelial function via endothelial ETB receptor.

Comellas AP, Briva A, Dada LA, Butti ML, Trejo HE, Yshii C, Azzam ZS, Litvan J, Chen J, Lecuona E, Pesce LM, Yanagisawa M, Sznajder JI.

Am J Respir Crit Care Med. 2009 Jan 15;179(2):113-22. doi: 10.1164/rccm.200804-540OC. Epub 2008 Oct 23.


AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis.

Vadász I, Dada LA, Briva A, Trejo HE, Welch LC, Chen J, Tóth PT, Lecuona E, Witters LA, Schumacker PT, Chandel NS, Seeger W, Sznajder JI.

J Clin Invest. 2008 Feb;118(2):752-62. doi: 10.1172/JCI29723.


Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein.

Zhou G, Dada LA, Chandel NS, Iwai K, Lecuona E, Ciechanover A, Sznajder JI.

FASEB J. 2008 May;22(5):1335-42. Epub 2007 Dec 11.


High CO2 levels impair alveolar epithelial function independently of pH.

Briva A, Vadász I, Lecuona E, Welch LC, Chen J, Dada LA, Trejo HE, Dumasius V, Azzam ZS, Myrianthefs PM, Batlle D, Gruenbaum Y, Sznajder JI.

PLoS One. 2007 Nov 28;2(11):e1238.


Regulation of Na,K-ATPase during acute lung injury.

Lecuona E, Trejo HE, Sznajder JI.

J Bioenerg Biomembr. 2007 Dec;39(5-6):391-5. Review.


Carbonic anhydrase II and alveolar fluid reabsorption during hypercapnia.

Chen J, Lecuona E, Briva A, Welch LC, Sznajder JI.

Am J Respir Cell Mol Biol. 2008 Jan;38(1):32-7. Epub 2007 Aug 9.


Role of the small GTPase RhoA in the hypoxia-induced decrease of plasma membrane Na,K-ATPase in A549 cells.

Dada LA, Novoa E, Lecuona E, Sun H, Sznajder JI.

J Cell Sci. 2007 Jul 1;120(Pt 13):2214-22. Epub 2007 Jun 5.


Na,K-ATPase alpha1-subunit dephosphorylation by protein phosphatase 2A is necessary for its recruitment to the plasma membrane.

Lecuona E, Dada LA, Sun H, Butti ML, Zhou G, Chew TL, Sznajder JI.

FASEB J. 2006 Dec;20(14):2618-20. Epub 2006 Oct 25.


Hypoxia-mediated degradation of Na,K-ATPase via mitochondrial reactive oxygen species and the ubiquitin-conjugating system.

Comellas AP, Dada LA, Lecuona E, Pesce LM, Chandel NS, Quesada N, Budinger GR, Strous GJ, Ciechanover A, Sznajder JI.

Circ Res. 2006 May 26;98(10):1314-22. Epub 2006 Apr 13.


Laminin-6 assembles into multimolecular fibrillar complexes with perlecan and participates in mechanical-signal transduction via a dystroglycan-dependent, integrin-independent mechanism.

Jones JC, Lane K, Hopkinson SB, Lecuona E, Geiger RC, Dean DA, Correa-Meyer E, Gonzales M, Campbell K, Sznajder JI, Budinger S.

J Cell Sci. 2005 Jun 15;118(Pt 12):2557-66. Epub 2005 May 31.


Hypocapnic but not metabolic alkalosis impairs alveolar fluid reabsorption.

Myrianthefs PM, Briva A, Lecuona E, Dumasius V, Rutschman DH, Ridge KM, Baltopoulos GJ, Sznajder JI.

Am J Respir Crit Care Med. 2005 Jun 1;171(11):1267-71. Epub 2005 Mar 11.


Norepinephrine increases alveolar fluid reabsorption and Na,K-ATPase activity.

Azzam ZS, Adir Y, Crespo A, Comellas A, Lecuona E, Dada LA, Krivoy N, Rutschman DH, Sznajder JI, Ridge KM.

Am J Respir Crit Care Med. 2004 Oct 1;170(7):730-6. Epub 2004 Jul 15.


Augmentation of endogenous dopamine production increases lung liquid clearance.

Adir Y, Azzam ZS, Lecuona E, Leal S, Pesce L, Dumasius V, Bertorello AM, Factor P, Young JB, Ridge KM, Sznajder JI.

Am J Respir Crit Care Med. 2004 Mar 15;169(6):757-63. Epub 2003 Dec 30.


The GTP-binding protein RhoA mediates Na,K-ATPase exocytosis in alveolar epithelial cells.

Lecuona E, Ridge K, Pesce L, Batlle D, Sznajder JI.

Mol Biol Cell. 2003 Sep;14(9):3888-97. Epub 2003 Jul 11.


Fibroblast growth factor-10 upregulates Na,K-ATPase via the MAPK pathway.

Upadhyay D, Lecuona E, Comellas A, Kamp DW, Sznajder JI.

FEBS Lett. 2003 Jun 19;545(2-3):173-6.


Dopamine increases lung liquid clearance during mechanical ventilation.

Saldías FJ, Comellas AP, Pesce L, Lecuona E, Sznajder JI.

Am J Physiol Lung Cell Mol Physiol. 2002 Jul;283(1):L136-43.


Dopamine-induced exocytosis of Na,K-ATPase is dependent on activation of protein kinase C-epsilon and -delta.

Ridge KM, Dada L, Lecuona E, Bertorello AM, Katz AI, Mochly-Rosen D, Sznajder JI.

Mol Biol Cell. 2002 Apr;13(4):1381-9.


Dopamine activates ERKs in alveolar epithelial cells via Ras-PKC-dependent and Grb2/Sos-independent mechanisms.

Guerrero C, Pesce L, Lecuona E, Ridge KM, Sznajder JI.

Am J Physiol Lung Cell Mol Physiol. 2002 May;282(5):L1099-107.


Dopamine regulates Na-K-ATPase in alveolar epithelial cells via MAPK-ERK-dependent mechanisms.

Guerrero C, Lecuona E, Pesce L, Ridge KM, Sznajder JI.

Am J Physiol Lung Cell Mol Physiol. 2001 Jul;281(1):L79-85.


A novel role for protein phosphatase 2A in the dopaminergic regulation of Na,K-ATPase.

Lecuona E, Garcia A, Sznajder JI.

FEBS Lett. 2000 Sep 22;481(3):217-20.


beta-adrenergic stimulation restores rat lung ability to clear edema in ventilator-associated lung injury.

Saldías FJ, Lecuona E, Comellas AP, Ridge KM, Rutschman DH, Sznajder JI.

Am J Respir Crit Care Med. 2000 Jul;162(1):282-7.


Stimulation of the dopamine 1 receptor increases lung edema clearance.

Barnard ML, Ridge KM, Saldias F, Friedman E, Gare M, Guerrero C, Lecuona E, Bertorello AM, Katz AI, Sznajder JI.

Am J Respir Crit Care Med. 1999 Sep;160(3):982-6.


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