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Items: 9


Gene expression signature that predicts early molecular response failure in chronic-phase CML patients on frontline imatinib.

Kok CH, Yeung DT, Lu L, Watkins DB, Leclercq TM, Dang P, Saunders VA, Reynolds J, White DL, Hughes TP.

Blood Adv. 2019 May 28;3(10):1610-1621. doi: 10.1182/bloodadvances.2019000195.


Increased peroxisome proliferator-activated receptor γ activity reduces imatinib uptake and efficacy in chronic myeloid leukemia mononuclear cells.

Wang J, Lu L, Kok CH, Saunders VA, Goyne JM, Dang P, Leclercq TM, Hughes TP, White DL.

Haematologica. 2017 May;102(5):843-853. doi: 10.3324/haematol.2016.153270. Epub 2017 Feb 2.


An oncogenic role for sphingosine kinase 2.

Neubauer HA, Pham DH, Zebol JR, Moretti PA, Peterson AL, Leclercq TM, Chan H, Powell JA, Pitman MR, Samuel MS, Bonder CS, Creek DJ, Gliddon BL, Pitson SM.

Oncotarget. 2016 Oct 4;7(40):64886-64899. doi: 10.18632/oncotarget.11714.


Ponatinib is not transported by ABCB1, ABCG2 or OCT-1 in CML cells.

Lu L, Saunders VA, Leclercq TM, Hughes TP, White DL.

Leukemia. 2015 Aug;29(8):1792-4. doi: 10.1038/leu.2015.35. Epub 2015 Feb 13. No abstract available.


Clarithromycin enhances dasatinib-induced cell death in chronic myeloid leukemia cells, by inhibition of late stage autophagy.

Schafranek L, Leclercq TM, White DL, Hughes TP.

Leuk Lymphoma. 2013 Jan;54(1):198-201. doi: 10.3109/10428194.2012.698737. Epub 2012 Jul 9. No abstract available.


Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis.

Leclercq TM, Moretti PA, Pitson SM.

Oncogene. 2011 Jan 20;30(3):372-8. doi: 10.1038/onc.2010.420. Epub 2010 Sep 13.


Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity.

Leclercq TM, Moretti PA, Vadas MA, Pitson SM.

J Biol Chem. 2008 Apr 11;283(15):9606-14. doi: 10.1074/jbc.M708782200. Epub 2008 Feb 8.


Cellular signalling by sphingosine kinase and sphingosine 1-phosphate.

Leclercq TM, Pitson SM.

IUBMB Life. 2006 Aug;58(8):467-72. Review.


Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling.

Pitson SM, Xia P, Leclercq TM, Moretti PA, Zebol JR, Lynn HE, Wattenberg BW, Vadas MA.

J Exp Med. 2005 Jan 3;201(1):49-54. Epub 2004 Dec 28.

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