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Automated computerized image analysis for the user-independent evaluation of disease severity in preclinical models of NAFLD/NASH.

De Rudder M, Bouzin C, Nachit M, Louvegny H, Vande Velde G, Julé Y, Leclercq IA.

Lab Invest. 2019 Sep 10. doi: 10.1038/s41374-019-0315-9. [Epub ahead of print]


Deficient IL-6/Stat3 Signaling, High TLR7, and Type I Interferons in Early Human Alcoholic Liver Disease: A Triad for Liver Damage and Fibrosis.

Stärkel P, Schnabl B, Leclercq S, Komuta M, Bataller R, Argemi J, Palma E, Chokshi S, Hellerbrand C, Maccioni L, Lanthier N, Leclercq I.

Hepatol Commun. 2019 May 10;3(7):867-882. doi: 10.1002/hep4.1364. eCollection 2019 Jul.


Kras and Lkb1 mutations synergistically induce intraductal papillary mucinous neoplasm derived from pancreatic duct cells.

Collet L, Ghurburrun E, Meyers N, Assi M, Pirlot B, Leclercq IA, Couvelard A, Komuta M, Cros J, Demetter P, Lemaigre FP, Borbath I, Jacquemin P.

Gut. 2019 Jun 1. pii: gutjnl-2018-318059. doi: 10.1136/gutjnl-2018-318059. [Epub ahead of print]


Invasive Ductular Reaction Operates Hepatobiliary Junctions upon Hepatocellular Injury in Rodents and Humans.

Clerbaux LA, Manco R, Van Hul N, Bouzin C, Sciarra A, Sempoux C, Theise ND, Leclercq IA.

Am J Pathol. 2019 Aug;189(8):1569-1581. doi: 10.1016/j.ajpath.2019.04.011. Epub 2019 May 18.


Hypoxia protects the liver from Small For Size Syndrome: A lesson learned from the associated liver partition and portal vein ligation for staged hepatectomy (ALPPS) procedure in rats.

Dili A, Bertrand C, Lebrun V, Pirlot B, Leclercq IA.

Am J Transplant. 2019 May 7. doi: 10.1111/ajt.15420. [Epub ahead of print]


Comparison of the Opn-CreER and Ck19-CreER Drivers in Bile Ducts of Normal and Injured Mouse Livers.

Lesaffer B, Verboven E, Van Huffel L, Moya IM, van Grunsven LA, Leclercq IA, Lemaigre FP, Halder G.

Cells. 2019 Apr 25;8(4). pii: E380. doi: 10.3390/cells8040380.


Reactive cholangiocytes differentiate into proliferative hepatocytes with efficient DNA repair in mice with chronic liver injury.

Manco R, Clerbaux LA, Verhulst S, Bou Nader M, Sempoux C, Ambroise J, Bearzatto B, Gala JL, Horsmans Y, van Grunsven L, Desdouets C, Leclercq I.

J Hepatol. 2019 Jun;70(6):1180-1191. doi: 10.1016/j.jhep.2019.02.003. Epub 2019 Feb 20.


Emerging awareness on the importance of skeletal muscle in liver diseases: time to dig deeper into mechanisms!

Nachit M, Leclercq IA.

Clin Sci (Lond). 2019 Feb 12;133(3):465-481. doi: 10.1042/CS20180421. Print 2019 Feb 14. Review.


Associating liver partition and portal vein ligation for staged hepatectomy: establishment of an animal model with insufficient liver remnant.

Dili A, Lebrun V, Bertrand C, Leclercq IA.

Lab Invest. 2019 May;99(5):698-707. doi: 10.1038/s41374-018-0155-z. Epub 2019 Jan 21.


Liver Regeneration: Different Sub-Populations of Parenchymal Cells at Play Choreographed by an Injury-Specific Microenvironment.

Manco R, Leclercq IA, Clerbaux LA.

Int J Mol Sci. 2018 Dec 18;19(12). pii: E4115. doi: 10.3390/ijms19124115. Review.


Does haemophilia slow down the development of liver fibrosis?

van Dievoet MA, Leclercq I, Hermans C, Lambert C, Horsmans Y, Jacquemin M, Eeckhoudt S.

Haemophilia. 2019 Jan;25(1):e32-e35. doi: 10.1111/hae.13630. Epub 2018 Nov 14. No abstract available.


Tumoral response and tumoral phenotypic changes in a rat model of diethylnitrosamine-induced hepatocellular carcinoma after salirasib and sorafenib administration.

Ciccarelli O, Colson A, De Saeger C, Reding R, Sempoux C, Leclercq IA, Stärkel P.

Onco Targets Ther. 2018 Oct 17;11:7143-7153. doi: 10.2147/OTT.S176903. eCollection 2018.


Mouse Models of Nonalcoholic Steatohepatitis: Toward Optimization of Their Relevance to Human Nonalcoholic Steatohepatitis.

Farrell G, Schattenberg JM, Leclercq I, Yeh MM, Goldin R, Teoh N, Schuppan D.

Hepatology. 2019 May;69(5):2241-2257. doi: 10.1002/hep.30333. Review.


Activation of brown adipose tissue enhances the efficacy of caloric restriction for treatment of nonalcoholic steatohepatitis.

Poekes L, Gillard J, Farrell GC, Horsmans Y, Leclercq IA.

Lab Invest. 2019 Jan;99(1):4-16. doi: 10.1038/s41374-018-0120-x. Epub 2018 Sep 26.


Influenza Virus Segment Composition Influences Viral Stability in the Environment.

Labadie T, Batéjat C, Manuguerra JC, Leclercq I.

Front Microbiol. 2018 Jul 9;9:1496. doi: 10.3389/fmicb.2018.01496. eCollection 2018.


Avian Influenza Virus Surveillance in High Arctic Breeding Geese, Greenland.

Gaidet N, Leclercq I, Batéjat C, Grassin Q, Daufresne T, Manuguerra JC.

Avian Dis. 2018 Jun;62(2):237-240. doi: 10.1637/11793-010418-ResNote.1.


Chronic liver injury promotes hepatocarcinoma cell seeding and growth, associated with infiltration by macrophages.

Delire B, Henriet P, Lemoine P, Leclercq IA, Stärkel P.

Cancer Sci. 2018 Jul;109(7):2141-2152. doi: 10.1111/cas.13628. Epub 2018 Jun 9.


TAT-Gap19 and Carbenoxolone Alleviate Liver Fibrosis in Mice.

Crespo Yanguas S, da Silva TC, Pereira IVA, Willebrords J, Maes M, Sayuri Nogueira M, Alves de Castro I, Leclercq I, Romualdo GR, Barbisan LF, Leybaert L, Cogliati B, Vinken M.

Int J Mol Sci. 2018 Mar 12;19(3). pii: E817. doi: 10.3390/ijms19030817.


Mouse models of non-alcoholic steatohepatitis: A reflection on recent literature.

Haczeyni F, Yeh MM, Ioannou GN, Leclercq IA, Goldin R, Dan YY, Yu J, Teoh NC, Farrell GC.

J Gastroenterol Hepatol. 2018 Jul;33(7):1312-1320. doi: 10.1111/jgh.14122. Epub 2018 Mar 24. Review.


The new-generation pan-peroxisome proliferator-activated receptor agonist IVA337 protects the liver from metabolic disorders and fibrosis.

Wettstein G, Luccarini JM, Poekes L, Faye P, Kupkowski F, Adarbes V, Defrêne E, Estivalet C, Gawronski X, Jantzen I, Philippot A, Tessier J, Tuyaa-Boustugue P, Oakley F, Mann DA, Leclercq I, Francque S, Konstantinova I, Broqua P, Junien JL.

Hepatol Commun. 2017 Jun 19;1(6):524-537. doi: 10.1002/hep4.1057. eCollection 2017 Aug.


Liver and systemic hemodynamics in children with cirrhosis: Impact on the surgical management in pediatric living donor liver transplantation.

de Magnée C, Veyckemans F, Pirotte T, Menten R, Dumitriu D, Clapuyt P, Carbonez K, Barrea C, Sluysmans T, Sempoux C, Leclercq I, Zech F, Stephenne X, Reding R.

Liver Transpl. 2017 Nov;23(11):1440-1450. doi: 10.1002/lt.24850.


Inhibition of connexin hemichannels alleviates non-alcoholic steatohepatitis in mice.

Willebrords J, Cogliati B, Pereira IVA, da Silva TC, Crespo Yanguas S, Maes M, Govoni VM, Lima A, Felisbino DA, Decrock E, Nogueira MS, de Castro IA, Leclercq I, Leybaert L, Rodrigues RM, Vinken M.

Sci Rep. 2017 Aug 15;7(1):8268. doi: 10.1038/s41598-017-08583-w.


Aging enhances liver fibrotic response in mice through hampering extracellular matrix remodeling.

Delire B, Lebrun V, Selvais C, Henriet P, Bertrand A, Horsmans Y, Leclercq IA.

Aging (Albany NY). 2016 Dec 9;9(1):98-113. doi: 10.18632/aging.101124.


Obeticholic acid improves adipose morphometry and inflammation and reduces steatosis in dietary but not metabolic obesity in mice.

Haczeyni F, Poekes L, Wang H, Mridha AR, Barn V, Geoffrey Haigh W, Ioannou GN, Yeh MM, Leclercq IA, Teoh NC, Farrell GC.

Obesity (Silver Spring). 2017 Jan;25(1):155-165. doi: 10.1002/oby.21701. Epub 2016 Nov 2.


Defective adaptive thermogenesis contributes to metabolic syndrome and liver steatosis in obese mice.

Poekes L, Legry V, Schakman O, Detrembleur C, Bol A, Horsmans Y, Farrell GC, Leclercq IA.

Clin Sci (Lond). 2017 Feb 1;131(4):285-296. doi: 10.1042/CS20160469. Epub 2016 Nov 1.


Colonic acetate in obesity: location matters!

Bindels LB, Leclercq I.

Clin Sci (Lond). 2016 Nov 1;130(22):2083-2086.


Macrophage Depletion Attenuates Extracellular Matrix Deposition and Ductular Reaction in a Mouse Model of Chronic Cholangiopathies.

Best J, Verhulst S, Syn WK, Lagaisse K, van Hul N, Heindryckx F, Sowa JP, Peeters L, Van Vlierberghe H, Leclercq IA, Canbay A, Dollé L, van Grunsven LA.

PLoS One. 2016 Sep 12;11(9):e0162286. doi: 10.1371/journal.pone.0162286. eCollection 2016.


Upstream regulators of hepatic Wnt/β-catenin activity control liver metabolic zonation, development, and regeneration.

Clerbaux LA, Manco R, Leclercq I.

Hepatology. 2016 Oct;64(4):1361-3. doi: 10.1002/hep.28763. Epub 2016 Aug 25. No abstract available.


Brown adipose tissue: a potential target in the fight against obesity and the metabolic syndrome.

Poekes L, Lanthier N, Leclercq IA.

Clin Sci (Lond). 2015 Dec;129(11):933-49. doi: 10.1042/CS20150339. Review.


Animal Models for Fibrotic Liver Diseases: What We Have, What We Need, and What Is under Development.

Delire B, Stärkel P, Leclercq I.

J Clin Transl Hepatol. 2015 Mar;3(1):53-66. doi: 10.14218/JCTH.2014.00035. Epub 2015 Mar 15. Review.


Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment.

Mu X, Español-Suñer R, Mederacke I, Affò S, Manco R, Sempoux C, Lemaigre FP, Adili A, Yuan D, Weber A, Unger K, Heikenwälder M, Leclercq IA, Schwabe RF.

J Clin Invest. 2015 Oct 1;125(10):3891-903. doi: 10.1172/JCI77995. Epub 2015 Sep 8.


Hepatic regeneration in a rat model is impaired by chemotherapy agents used in metastatic colorectal cancer.

Hubert C, Dahrenmoller C, Marique L, Jabbour N, Gianello P, Leclercq I.

Eur J Surg Oncol. 2015 Nov;41(11):1471-8. doi: 10.1016/j.ejso.2015.08.152. Epub 2015 Aug 21.


Experimental models of liver fibrosis.

Yanguas SC, Cogliati B, Willebrords J, Maes M, Colle I, van den Bossche B, de Oliveira CPMS, Andraus W, Alves VAF, Leclercq I, Vinken M.

Arch Toxicol. 2016 May;90(5):1025-1048. doi: 10.1007/s00204-015-1543-4. Epub 2015 Jun 6. Review.


Hepatic Stellate Cells Improve Engraftment of Human Primary Hepatocytes: A Preclinical Transplantation Study in an Animal Model.

Dusabineza AC, Najimi M, van Hul N, Legry V, Khuu DN, van Grunsven LA, Sokal E, Leclercq IA.

Cell Transplant. 2015;24(12):2557-71. doi: 10.3727/096368915X686788. Epub 2015 Feb 20.


Next generation of ALDH substrates and their potential to study maturational lineage biology in stem and progenitor cells.

Dollé L, Boulter L, Leclercq IA, van Grunsven LA.

Am J Physiol Gastrointest Liver Physiol. 2015 Apr 1;308(7):G573-8. doi: 10.1152/ajpgi.00420.2014. Epub 2015 Feb 5. Review.


Adipose tissues as endocrine target organs.

Lanthier N, Leclercq IA.

Best Pract Res Clin Gastroenterol. 2014 Aug;28(4):545-58. doi: 10.1016/j.bpg.2014.07.002. Epub 2014 Jul 11. Review.


Cleavage of hemagglutinin-bearing lentiviral pseudotypes and their use in the study of influenza virus persistence.

Sawoo O, Dublineau A, Batéjat C, Zhou P, Manuguerra JC, Leclercq I.

PLoS One. 2014 Aug 28;9(8):e106192. doi: 10.1371/journal.pone.0106192. eCollection 2014.


Heat inactivation of the Middle East respiratory syndrome coronavirus.

Leclercq I, Batéjat C, Burguière AM, Manuguerra JC.

Influenza Other Respir Viruses. 2014 Sep;8(5):585-6. doi: 10.1111/irv.12261. Epub 2014 Jul 29.


Association of endothelial lipase Thr111Ile polymorphism with proliferative retinopathy in type 2 diabetes patients.

Arndt C, Leclercq I, Nazeyrollas P, Durlach A, Ducasse A, Movesayan I, Socquard E, Clavel C, Malloy MM, Pullinger CR, Kane JP, Durlach V.

Diabetes Metab. 2014 Dec;40(6):452-8. doi: 10.1016/j.diabet.2014.04.004. Epub 2014 May 19.


Endoplasmic reticulum stress does not contribute to steatohepatitis in obese and insulin-resistant high-fat-diet-fed foz/foz mice.

Legry V, Van Rooyen DM, Lambert B, Sempoux C, Poekes L, Español-Suñer R, Molendi-Coste O, Horsmans Y, Farrell GC, Leclercq IA.

Clin Sci (Lond). 2014 Oct;127(7):507-18. doi: 10.1042/CS20140026.


The IGF2 mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis.

Laggai S, Kessler SM, Boettcher S, Lebrun V, Gemperlein K, Lederer E, Leclercq IA, Mueller R, Hartmann RW, Haybaeck J, Kiemer AK.

J Lipid Res. 2014 Jun;55(6):1087-97. doi: 10.1194/jlr.M045500. Epub 2014 Apr 22. Erratum in: J Lipid Res. 2016 Jul;57(7):1323.


Liver and systemic insulin resistance.

Lanthier N, Leclercq IA.

Hepatology. 2014 Sep;60(3):1113-4. doi: 10.1002/hep.27017. Epub 2014 Jul 28. No abstract available.


Influenza A virus survival in water is influenced by the origin species of the host cell.

Shigematsu S, Dublineau A, Sawoo O, Batéjat C, Matsuyama T, Leclercq I, Manuguerra JC.

Influenza Other Respir Viruses. 2014 Jan;8(1):123-30. doi: 10.1111/irv.12179. Epub 2013 Sep 23.


Prometheus' little helper, a novel role for fibroblast growth factor 15 in compensatory liver growth.

Schaap FG, Leclercq IA, Jansen PL, Olde Damink SW.

J Hepatol. 2013 Nov;59(5):1121-3. doi: 10.1016/j.jhep.2013.07.013. Epub 2013 Jul 16. No abstract available.


Impact of PPAR-α induction on glucose homoeostasis in alcohol-fed mice.

Lebrun V, Molendi-Coste O, Lanthier N, Sempoux C, Cani PD, van Rooijen N, Stärkel P, Horsmans Y, Leclercq IA.

Clin Sci (Lond). 2013 Dec;125(11):501-11. doi: 10.1042/CS20130064.


Reply: To PMID 22922013.

Español-Suñer R, Lemaigre FP, Leclercq IA.

Gastroenterology. 2013 Jul;145(1):255-256. doi: 10.1053/j.gastro.2013.05.037. Epub 2013 May 31. No abstract available.


Yin Yang 1 and farnesoid X receptor: a balancing act in non-alcoholic fatty liver disease?

Legry V, Schaap FG, Delire B, Horsmans Y, Leclercq IA.

Gut. 2014 Jan;63(1):1-2. doi: 10.1136/gutjnl-2012-304338. Epub 2013 Mar 8. No abstract available.


Sinusoidal obstruction syndrome (SOS) related to chemotherapy for colorectal liver metastases: factors predictive of severe SOS lesions and protective effect of bevacizumab.

Hubert C, Sempoux C, Humblet Y, van den Eynde M, Zech F, Leclercq I, Gigot JF.

HPB (Oxford). 2013 Nov;15(11):858-64. doi: 10.1111/hpb.12047. Epub 2013 Jan 18.


Salirasib sensitizes hepatocarcinoma cells to TRAIL-induced apoptosis through DR5 and survivin-dependent mechanisms.

Charette N, De Saeger C, Horsmans Y, Leclercq I, Stärkel P.

Cell Death Dis. 2013 Jan 24;4:e471. doi: 10.1038/cddis.2012.200.


Role of vascular endothelial growth factor in the pathophysiology of nonalcoholic steatohepatitis in two rodent models.

Coulon S, Legry V, Heindryckx F, Van Steenkiste C, Casteleyn C, Olievier K, Libbrecht L, Carmeliet P, Jonckx B, Stassen JM, Van Vlierberghe H, Leclercq I, Colle I, Geerts A.

Hepatology. 2013 May;57(5):1793-805. doi: 10.1002/hep.26219. Epub 2013 Mar 14.


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