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Items: 26

1.

A phase I window, dose escalating and safety trial of metformin in combination with induction chemotherapy in relapsed refractory acute lymphoblastic leukemia: Metformin with induction chemotherapy of vincristine, dexamethasone, PEG-asparaginase, and doxorubicin.

Trucco M, Barredo JC, Goldberg J, Leclerc GM, Hale GA, Gill J, Setty B, Smith T, Lush R, Lee JK, Reed DR.

Pediatr Blood Cancer. 2018 Sep;65(9):e27224. doi: 10.1002/pbc.27224. Epub 2018 Jun 1.

PMID:
29856514
2.

Inhibition of the NEDD8 conjugation pathway induces calcium-dependent compensatory activation of the pro-survival MEK/ERK pathway in acute lymphoblastic leukemia.

Zheng S, Leclerc GM, Li B, Swords RT, Barredo JC.

Oncotarget. 2017 Dec 31;9(5):5529-5544. doi: 10.18632/oncotarget.23797. eCollection 2018 Jan 19.

3.

The NEDD8-activating enzyme inhibitor pevonedistat activates the eIF2α and mTOR pathways inducing UPR-mediated cell death in acute lymphoblastic leukemia.

Leclerc GM, Zheng S, Leclerc GJ, DeSalvo J, Swords RT, Barredo JC.

Leuk Res. 2016 Nov;50:1-10. doi: 10.1016/j.leukres.2016.09.007. Epub 2016 Sep 5.

PMID:
27626202
4.

Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress.

Leclerc GJ, DeSalvo J, Du J, Gao N, Leclerc GM, Lehrman MA, Lampidis TJ, Barredo JC.

Leuk Res. 2015 Aug 20. pii: S0145-2126(15)30360-X. doi: 10.1016/j.leukres.2015.08.007. [Epub ahead of print]

5.

Metformin induces apoptosis through AMPK-dependent inhibition of UPR signaling in ALL lymphoblasts.

Leclerc GM, Leclerc GJ, Kuznetsov JN, DeSalvo J, Barredo JC.

PLoS One. 2013 Aug 23;8(8):e74420. doi: 10.1371/journal.pone.0074420. eCollection 2013.

6.

Inhibition of Akt potentiates 2-DG-induced apoptosis via downregulation of UPR in acute lymphoblastic leukemia.

DeSalvo J, Kuznetsov JN, Du J, Leclerc GM, Leclerc GJ, Lampidis TJ, Barredo JC.

Mol Cancer Res. 2012 Jul;10(7):969-78. doi: 10.1158/1541-7786.MCR-12-0125. Epub 2012 Jun 12.

7.

AMPK and Akt determine apoptotic cell death following perturbations of one-carbon metabolism by regulating ER stress in acute lymphoblastic leukemia.

Kuznetsov JN, Leclerc GJ, Leclerc GM, Barredo JC.

Mol Cancer Ther. 2011 Mar;10(3):437-47. doi: 10.1158/1535-7163.MCT-10-0777. Epub 2011 Jan 24.

8.

AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia.

Leclerc GM, Leclerc GJ, Fu G, Barredo JC.

J Mol Signal. 2010 Sep 23;5:15. doi: 10.1186/1750-2187-5-15.

9.
10.

Administration of connexin43 siRNA abolishes secretory pulse synchronization in GnRH clonal cell populations.

Bose S, Leclerc GM, Vasquez-Martinez R, Boockfor FR.

Mol Cell Endocrinol. 2010 Jan 15;314(1):75-83. doi: 10.1016/j.mce.2009.08.016. Epub 2009 Aug 28.

11.

Specific GATA-binding elements in the GnRH promoter are required for gene expression pulse activity: role of GATA-4 and GATA-5 in this intermittent process.

Leclerc GM, Bose SK, Boockfor FR.

Neuroendocrinology. 2008;88(1):1-16. doi: 10.1159/000115952. Epub 2008 Feb 6.

PMID:
18259093
12.
13.

Calcium influx and DREAM protein are required for GnRH gene expression pulse activity.

Leclerc GM, Boockfor FR.

Mol Cell Endocrinol. 2007 Mar 15;267(1-2):70-9. Epub 2006 Dec 27.

14.
15.

Identification of a novel OCT1 binding site that is necessary for the elaboration of pulses of rat GnRH promoter activity.

Leclerc GM, Boockfor FR.

Mol Cell Endocrinol. 2005 Dec 21;245(1-2):86-92. Epub 2005 Dec 7.

PMID:
16337733
16.

Pulses of prolactin promoter activity depend on a noncanonical E-box that can bind the circadian proteins CLOCK and BMAL1.

Leclerc GM, Boockfor FR.

Endocrinology. 2005 Jun;146(6):2782-90. Epub 2005 Mar 17.

PMID:
15774559
17.

Cloning and mRNA expression of the Ca2+-binding DREAM protein in the pituitary.

Leclerc GM, Leclerc GJ, Shorte SL, Stephen Frawley L, Boockfor FR.

Gen Comp Endocrinol. 2002 Oct 15;129(1):45-55.

PMID:
12409095
18.

Episodic activation of the rat GnRH promoter: role of the homeoprotein oct-1.

Vazquez-Martinez R, Leclerc GM, Wierman ME, Boockfor FR.

Mol Endocrinol. 2002 Sep;16(9):2093-100.

PMID:
12198245
19.
20.

PRL gene expression in individual living mammotropes displays distinct functional pulses that oscillate in a noncircadian temporal pattern.

Shorte SL, Leclerc GM, Vazquez-Martinez R, Leaumont DC, Faught WJ, Frawley LS, Boockfor FR.

Endocrinology. 2002 Mar;143(3):1126-33.

PMID:
11861540
21.

Zinc-thiolate intermediate in catalysis of methyl group transfer in Methanosarcina barkeri.

Gencic S, LeClerc GM, Gorlatova N, Peariso K, Penner-Hahn JE, Grahame DA.

Biochemistry. 2001 Oct 30;40(43):13068-78.

PMID:
11669645
22.

Isolation and Characterization of Microsatellite Loci for Striped Bass (Morone saxatilis).

Han K, Li L, Leclerc GM, Hays AM, Ely B.

Mar Biotechnol (NY). 2000 Sep;2(5):405-408.

PMID:
11246406
23.

Development of a destabilized firefly luciferase enzyme for measurement of gene expression.

Leclerc GM, Boockfor FR, Faught WJ, Frawley LS.

Biotechniques. 2000 Sep;29(3):590-1, 594-6, 598 passim.

24.

Characterization of a Highly Repetitive Sequence Conserved Among the North American Morone Species.

Leclerc GM, Han K, Leclerc GJ, Ely B.

Mar Biotechnol (NY). 1999 Mar;1(2):122-130.

PMID:
10373620
26.

Use of PCR-RFLP assays to detect genetic variation at single-copy nuclear loci in striped bass (Morone saxatilis).

Leclerc GM, Diaz M, Ely B.

Mol Mar Biol Biotechnol. 1996 Jun;5(2):138-44.

PMID:
8680526

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