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Items: 16

1.

The NEDD8-activating enzyme inhibitor pevonedistat activates the eIF2α and mTOR pathways inducing UPR-mediated cell death in acute lymphoblastic leukemia.

Leclerc GM, Zheng S, Leclerc GJ, DeSalvo J, Swords RT, Barredo JC.

Leuk Res. 2016 Nov;50:1-10. doi: 10.1016/j.leukres.2016.09.007. Epub 2016 Sep 5.

PMID:
27626202
2.

Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress.

Leclerc GJ, DeSalvo J, Du J, Gao N, Leclerc GM, Lehrman MA, Lampidis TJ, Barredo JC.

Leuk Res. 2015 Aug 20. pii: S0145-2126(15)30360-X. doi: 10.1016/j.leukres.2015.08.007. [Epub ahead of print]

3.

Metformin induces apoptosis through AMPK-dependent inhibition of UPR signaling in ALL lymphoblasts.

Leclerc GM, Leclerc GJ, Kuznetsov JN, DeSalvo J, Barredo JC.

PLoS One. 2013 Aug 23;8(8):e74420. doi: 10.1371/journal.pone.0074420. eCollection 2013.

4.

Inhibition of Akt potentiates 2-DG-induced apoptosis via downregulation of UPR in acute lymphoblastic leukemia.

DeSalvo J, Kuznetsov JN, Du J, Leclerc GM, Leclerc GJ, Lampidis TJ, Barredo JC.

Mol Cancer Res. 2012 Jul;10(7):969-78. doi: 10.1158/1541-7786.MCR-12-0125. Epub 2012 Jun 12.

5.

AMPK and Akt determine apoptotic cell death following perturbations of one-carbon metabolism by regulating ER stress in acute lymphoblastic leukemia.

Kuznetsov JN, Leclerc GJ, Leclerc GM, Barredo JC.

Mol Cancer Ther. 2011 Mar;10(3):437-47. doi: 10.1158/1535-7163.MCT-10-0777. Epub 2011 Jan 24.

6.

AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia.

Leclerc GM, Leclerc GJ, Fu G, Barredo JC.

J Mol Signal. 2010 Sep 23;5:15. doi: 10.1186/1750-2187-5-15.

7.

Folylpolyglutamate synthetase gene transcription is regulated by a multiprotein complex that binds the TEL-AML1 fusion in acute lymphoblastic leukemia.

Leclerc GJ, Sanderson C, Hunger S, Devidas M, Barredo JC.

Leuk Res. 2010 Dec;34(12):1601-9. doi: 10.1016/j.leukres.2010.05.012. Epub 2010 Jun 9.

8.
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10.

Molecular basis for decreased folylpoly-gamma-glutamate synthetase expression in a methotrexate resistant CCRF-CEM mutant cell line.

Leclerc GJ, York TA, Hsieh-Kinser T, Barredo JC.

Leuk Res. 2007 Mar;31(3):293-9. Epub 2006 Aug 1.

PMID:
16884772
11.
12.

Cloning and mRNA expression of the Ca2+-binding DREAM protein in the pituitary.

Leclerc GM, Leclerc GJ, Shorte SL, Stephen Frawley L, Boockfor FR.

Gen Comp Endocrinol. 2002 Oct 15;129(1):45-55.

PMID:
12409095
13.
15.

Characterization of a Highly Repetitive Sequence Conserved Among the North American Morone Species.

Leclerc GM, Han K, Leclerc GJ, Ely B.

Mar Biotechnol (NY). 1999 Mar;1(2):122-130.

PMID:
10373620
16.

Environmental regulation of Salmonella typhi invasion-defective mutants.

Leclerc GJ, Tartera C, Metcalf ES.

Infect Immun. 1998 Feb;66(2):682-91.

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