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Items: 1 to 50 of 166

1.

Increased Immunogenicity of Full-Length Protein Antigens through Sortase-Mediated Coupling on the PapMV Vaccine Platform.

Laliberté-Gagné MÈ, Bolduc M, Thérien A, Garneau C, Casault P, Savard P, Estaquier J, Leclerc D.

Vaccines (Basel). 2019 Jun 12;7(2). pii: E49. doi: 10.3390/vaccines7020049.

2.

Consistency of Adolescents' Self-Report of Gambling Age of Onset: A Longitudinal Study.

Dussault F, Dufour M, Brunelle N, Tremblay J, Rousseau M, Leclerc D, Cousineau MM, Berbiche D.

J Gambl Stud. 2019 Jun;35(2):533-544. doi: 10.1007/s10899-019-09834-3.

PMID:
30778812
3.

Mild Methylenetetrahydrofolate Reductase Deficiency Alters Inflammatory and Lipid Pathways in Liver.

Leclerc D, Christensen KE, Cauvi O, Yang E, Fournelle F, Bahous RH, Malysheva OV, Deng L, Wu Q, Zhou Z, Gao ZH, Chaurand P, Caudill MA, Rozen R.

Mol Nutr Food Res. 2019 Feb;63(3):e1801001. doi: 10.1002/mnfr.201801001. Epub 2018 Nov 23.

PMID:
30408316
4.

Early Manifestations of Brain Aging in Mice Due to Low Dietary Folate and Mild MTHFR Deficiency.

Bahous RH, Cosín-Tomás M, Deng L, Leclerc D, Malysheva O, Ho MK, Pallàs M, Kaliman P, Bedell BJ, Caudill MA, Rozen R.

Mol Neurobiol. 2019 Jun;56(6):4175-4191. doi: 10.1007/s12035-018-1375-3. Epub 2018 Oct 4.

PMID:
30288696
5.

The quest for a nanoparticle-based vaccine inducing broad protection to influenza viruses.

Bolduc M, Baz M, Laliberté-Gagné MÈ, Carignan D, Garneau C, Russel A, Boivin G, Savard P, Leclerc D.

Nanomedicine. 2018 Nov;14(8):2563-2574. doi: 10.1016/j.nano.2018.08.010. Epub 2018 Sep 5.

PMID:
30193813
6.

Psychosocial Difficulties in Adolescents nine Months after a Railway Accident.

Hugron M, Dufour M, Guay S, Brunelle N, Tremblay J, Morvannou A, Leclerc D, Cousineau MM, Rousseau M, Berbiche D.

Psychiatr Q. 2018 Dec;89(4):829-840. doi: 10.1007/s11126-018-9583-6.

PMID:
29728960
7.

Plasma Biomarkers of Inflammation and Angiogenesis Predict Cerebral Cavernous Malformation Symptomatic Hemorrhage or Lesional Growth.

Girard R, Zeineddine HA, Koskimäki J, Fam MD, Cao Y, Shi C, Moore T, Lightle R, Stadnik A, Chaudagar K, Polster S, Shenkar R, Duggan R, Leclerc D, Whitehead KJ, Li DY, Awad IA.

Circ Res. 2018 Jun 8;122(12):1716-1721. doi: 10.1161/CIRCRESAHA.118.312680. Epub 2018 May 2.

8.

Testicular MTHFR deficiency may explain sperm DNA hypomethylation associated with high dose folic acid supplementation.

Aarabi M, Christensen KE, Chan D, Leclerc D, Landry M, Ly L, Rozen R, Trasler J.

Hum Mol Genet. 2018 Apr 1;27(7):1123-1135. doi: 10.1093/hmg/ddy021.

9.

Efficacy of a Virus-Like Nanoparticle As Treatment for a Chronic Viral Infection Is Hindered by IRAK1 Regulation and Antibody Interference.

Chartrand K, Lebel MÈ, Tarrab E, Savard P, Leclerc D, Lamarre A.

Front Immunol. 2018 Jan 4;8:1885. doi: 10.3389/fimmu.2017.01885. eCollection 2017.

10.

Activation of innate immunity in primary human cells using a plant virus derived nanoparticle TLR7/8 agonist.

Carignan D, Herblot S, Laliberté-Gagné MÈ, Bolduc M, Duval M, Savard P, Leclerc D.

Nanomedicine. 2018 Oct;14(7):2317-2327. doi: 10.1016/j.nano.2017.10.015. Epub 2017 Nov 8.

PMID:
29128662
11.

A versatile papaya mosaic virus (PapMV) vaccine platform based on sortase-mediated antigen coupling.

Thérien A, Bédard M, Carignan D, Rioux G, Gauthier-Landry L, Laliberté-Gagné MÈ, Bolduc M, Savard P, Leclerc D.

J Nanobiotechnology. 2017 Jul 18;15(1):54. doi: 10.1186/s12951-017-0289-y.

12.

Oncogenic role of PDK4 in human colon cancer cells.

Leclerc D, Pham DN, Lévesque N, Truongcao M, Foulkes WD, Sapienza C, Rozen R.

Br J Cancer. 2017 Mar 28;116(7):930-936. doi: 10.1038/bjc.2017.38. Epub 2017 Feb 16.

13.

Complement Component 3 Regulates IFN-α Production by Plasmacytoid Dendritic Cells following TLR7 Activation by a Plant Virus-like Nanoparticle.

Lebel MÈ, Langlois MP, Daudelin JF, Tarrab E, Savard P, Leclerc D, Lamarre A.

J Immunol. 2017 Jan 1;198(1):292-299. Epub 2016 Nov 18.

14.

Gender Difference in Internet Use and Internet Problems among Quebec High School Students.

Dufour M, Brunelle N, Tremblay J, Leclerc D, Cousineau MM, Khazaal Y, Légaré AA, Rousseau M, Berbiche D.

Can J Psychiatry. 2016 Oct;61(10):663-8. doi: 10.1177/0706743716640755. Epub 2016 Mar 24.

15.

Influence of PapMV nanoparticles on the kinetics of the antibody response to flu vaccine.

Rioux G, Carignan D, Russell A, Bolduc M, Gagné MÈ, Savard P, Leclerc D.

J Nanobiotechnology. 2016 Jun 10;14(1):43. doi: 10.1186/s12951-016-0200-2.

16.

Murine diet/tissue and human brain tumorigenesis alter Mthfr/MTHFR 5'-end methylation.

Lévesque N, Leclerc D, Gayden T, Lazaris A, De Jay N, Petrillo S, Metrakos P, Jabado N, Rozen R.

Mamm Genome. 2016 Apr;27(3-4):122-34. doi: 10.1007/s00335-016-9624-0. Epub 2016 Mar 7.

PMID:
26951114
17.

Potentiating Cancer Immunotherapy Using Papaya Mosaic Virus-Derived Nanoparticles.

Lebel MÈ, Chartrand K, Tarrab E, Savard P, Leclerc D, Lamarre A.

Nano Lett. 2016 Mar 9;16(3):1826-32. doi: 10.1021/acs.nanolett.5b04877. Epub 2016 Feb 22.

PMID:
26891174
18.

Engineering of the PapMV vaccine platform with a shortened M2e peptide leads to an effective one dose influenza vaccine.

Carignan D, Thérien A, Rioux G, Paquet G, Gagné ML, Bolduc M, Savard P, Leclerc D.

Vaccine. 2015 Dec 16;33(51):7245-7253. doi: 10.1016/j.vaccine.2015.10.123. Epub 2015 Nov 6.

PMID:
26549362
19.

Plant Viruses as Nanoparticle-Based Vaccines and Adjuvants.

Lebel MÈ, Chartrand K, Leclerc D, Lamarre A.

Vaccines (Basel). 2015 Aug 5;3(3):620-37. doi: 10.3390/vaccines3030620. Review.

20.

Quantitative proteomics reveals differentially expressed proteins in murine preneoplastic intestine in a model of intestinal tumorigenesis induced by low dietary folate and MTHFR deficiency.

Leclerc D, Dejgaard K, Mazur A, Deng L, Wu Q, Nilsson T, Rozen R.

Proteomics. 2014 Nov;14(21-22):2558-65. doi: 10.1002/pmic.201400280. Epub 2014 Sep 5.

PMID:
25081070
21.

Fludarabine downregulates indoleamine 2,3-dioxygenase in tumors via a proteasome-mediated degradation mechanism.

Hanafi LA, Gauchat D, Godin-Ethier J, Possamaï D, Duvignaud JB, Leclerc D, Grandvaux N, Lapointe R.

PLoS One. 2014 Jun 9;9(6):e99211. doi: 10.1371/journal.pone.0099211. eCollection 2014.

22.

PapMV nanoparticles improve mucosal immune responses to the trivalent inactivated flu vaccine.

Rioux G, Mathieu C, Russell A, Bolduc M, Laliberté-Gagné ME, Savard P, Leclerc D.

J Nanobiotechnology. 2014 May 3;12:19. doi: 10.1186/1477-3155-12-19.

23.

Severe methylenetetrahydrofolate reductase deficiency: clinical clues to a potentially treatable cause of adult-onset hereditary spastic paraplegia.

Lossos A, Teltsh O, Milman T, Meiner V, Rozen R, Leclerc D, Schwahn BC, Karp N, Rosenblatt DS, Watkins D, Shaag A, Korman SH, Heyman SN, Gal A, Newman JP, Steiner-Birmanns B, Abramsky O, Kohn Y.

JAMA Neurol. 2014 Jul 1;71(7):901-4. doi: 10.1001/jamaneurol.2014.116.

PMID:
24797679
24.

Nanoparticle adjuvant sensing by TLR7 enhances CD8+ T cell-mediated protection from Listeria monocytogenes infection.

Lebel MÈ, Daudelin JF, Chartrand K, Tarrab E, Kalinke U, Savard P, Labrecque N, Leclerc D, Lamarre A.

J Immunol. 2014 Feb 1;192(3):1071-8. doi: 10.4049/jimmunol.1302030. Epub 2013 Dec 27.

25.

Genes with aberrant expression in murine preneoplastic intestine show epigenetic and expression changes in normal mucosa of colon cancer patients.

Leclerc D, Lévesque N, Cao Y, Deng L, Wu Q, Powell J, Sapienza C, Rozen R.

Cancer Prev Res (Phila). 2013 Nov;6(11):1171-81. doi: 10.1158/1940-6207.CAPR-13-0198. Epub 2013 Oct 29.

26.

A novel M2e based flu vaccine formulation for dogs.

Leclerc D, Rivest M, Babin C, López-Macias C, Savard P.

PLoS One. 2013 Oct 2;8(10):e77084. doi: 10.1371/journal.pone.0077084. eCollection 2013.

27.

β,β-carotene 15,15'-monooxygenase and its substrate β-carotene modulate migration and invasion in colorectal carcinoma cells.

Pham DN, Leclerc D, Lévesque N, Deng L, Rozen R.

Am J Clin Nutr. 2013 Aug;98(2):413-22. doi: 10.3945/ajcn.113.060996. Epub 2013 Jun 26.

PMID:
23803888
28.

Engineering of papaya mosaic virus (PapMV) nanoparticles with a CTL epitope derived from influenza NP.

Babin C, Majeau N, Leclerc D.

J Nanobiotechnology. 2013 Apr 4;11:10. doi: 10.1186/1477-3155-11-10.

29.

Induction of innate immunity in lungs with virus-like nanoparticles leads to protection against influenza and Streptococcus pneumoniae challenge.

Mathieu C, Rioux G, Dumas MC, Leclerc D.

Nanomedicine. 2013 Oct;9(7):839-48. doi: 10.1016/j.nano.2013.02.009. Epub 2013 Mar 8.

PMID:
23499666
30.

Differential gene expression and methylation in the retinoid/PPARA pathway and of tumor suppressors may modify intestinal tumorigenesis induced by low folate in mice.

Leclerc D, Cao Y, Deng L, Mikael LG, Wu Q, Rozen R.

Mol Nutr Food Res. 2013 Apr;57(4):686-97. doi: 10.1002/mnfr.201200212. Epub 2012 Sep 24.

PMID:
23001810
31.

Crystal structure of the coat protein of the flexible filamentous papaya mosaic virus.

Yang S, Wang T, Bohon J, Gagné MÈ, Bolduc M, Leclerc D, Li H.

J Mol Biol. 2012 Sep 14;422(2):263-73. doi: 10.1016/j.jmb.2012.05.032. Epub 2012 May 30.

32.

Mapping the surface-exposed regions of papaya mosaic virus nanoparticles.

Rioux G, Majeau N, Leclerc D.

FEBS J. 2012 Jun;279(11):2004-11. doi: 10.1111/j.1742-4658.2012.08583.x. Epub 2012 Apr 24.

33.

Severe methylenetetrahydrofolate reductase deficiency in mice results in behavioral anomalies with morphological and biochemical changes in hippocampus.

Jadavji NM, Deng L, Leclerc D, Malysheva O, Bedell BJ, Caudill MA, Rozen R.

Mol Genet Metab. 2012 Jun;106(2):149-59. doi: 10.1016/j.ymgme.2012.03.020. Epub 2012 Apr 4.

PMID:
22521626
34.

Interfering with hepatitis C virus assembly in vitro using affinity peptides directed towards core protein.

Duvignaud JB, Majeau N, Delisle P, Voyer N, Gagné SM, Leclerc D.

Can J Microbiol. 2012 Apr;58(4):475-82. doi: 10.1139/w2012-009. Epub 2012 Mar 27.

PMID:
22452666
35.

Engineering of papaya mosaic virus (PapMV) nanoparticles through fusion of the HA11 peptide to several putative surface-exposed sites.

Rioux G, Babin C, Majeau N, Leclerc D.

PLoS One. 2012;7(2):e31925. doi: 10.1371/journal.pone.0031925. Epub 2012 Feb 21.

36.

Internet gambling, substance use, and delinquent behavior: an adolescent deviant behavior involvement pattern.

Brunelle N, Leclerc D, Cousineau MM, Dufour M, Gendron A, Martin I.

Psychol Addict Behav. 2012 Jun;26(2):364-70. doi: 10.1037/a0027079. Epub 2012 Feb 20.

PMID:
22352700
37.

Improvement of the PapMV nanoparticle adjuvant property through an increased of its avidity for the antigen [influenza NP].

Savard C, Laliberté-Gagné MÈ, Babin C, Bolduc M, Guérin A, Drouin K, Forget MA, Majeau N, Lapointe R, Leclerc D.

Vaccine. 2012 Mar 28;30(15):2535-42. doi: 10.1016/j.vaccine.2012.01.085. Epub 2012 Feb 8.

PMID:
22326774
38.

Effect of pepsin-treated bovine and goat caseinomacropeptide on Escherichia coli and Lactobacillus rhamnosus in acidic conditions.

Robitaille G, Lapointe C, Leclerc D, Britten M.

J Dairy Sci. 2012 Jan;95(1):1-8. doi: 10.3168/jds.2010-4142.

39.

Plant viral epitope display systems for vaccine development.

Leclerc D.

Curr Top Microbiol Immunol. 2014;375:47-59. doi: 10.1007/82_2011_183. Review.

PMID:
22021043
40.

IDO expression by human B lymphocytes in response to T lymphocyte stimuli and TLR engagement is biologically inactive.

Godin-Ethier J, Hanafi LA, Duvignaud JB, Leclerc D, Lapointe R.

Mol Immunol. 2011 Oct;49(1-2):253-9. doi: 10.1016/j.molimm.2011.08.017. Epub 2011 Sep 19.

PMID:
21937116
41.

Targeted insertion of two Mthfr promoters in mice reveals temporal- and tissue-specific regulation.

Pickell L, Wu Q, Wang XL, Leclerc D, Friedman H, Peterson AC, Rozen R.

Mamm Genome. 2011 Dec;22(11-12):635-47. doi: 10.1007/s00335-011-9351-5. Epub 2011 Jul 19.

PMID:
21769670
42.

Improvement of the trivalent inactivated flu vaccine using PapMV nanoparticles.

Savard C, Guérin A, Drouin K, Bolduc M, Laliberté-Gagné ME, Dumas MC, Majeau N, Leclerc D.

PLoS One. 2011;6(6):e21522. doi: 10.1371/journal.pone.0021522. Epub 2011 Jun 29.

43.

Susceptibility to intestinal tumorigenesis in folate-deficient mice may be influenced by variation in one-carbon metabolism and DNA repair.

Knock E, Deng L, Krupenko N, Mohan RD, Wu Q, Leclerc D, Gupta S, Elmore CL, Kruger W, Tini M, Rozen R.

J Nutr Biochem. 2011 Nov;22(11):1022-9. doi: 10.1016/j.jnutbio.2010.07.015. Epub 2010 Dec 28.

PMID:
21193302
44.

Developing registries of volunteers: key principles to manage issues regarding personal information protection.

Lévesque E, Leclerc D, Puymirat J, Knoppers BM.

J Med Ethics. 2010 Nov;36(11):712-4. doi: 10.1136/jme.2010.036715. Epub 2010 Sep 29.

PMID:
20880892
45.

Two distinct chimeric potexviruses share antigenic cross-presentation properties of MHC class I epitopes.

Hanafi LA, Bolduc M, Gagné ME, Dufour F, Langelier Y, Boulassel MR, Routy JP, Leclerc D, Lapointe R.

Vaccine. 2010 Aug 2;28(34):5617-26. doi: 10.1016/j.vaccine.2010.06.024. Epub 2010 Jun 25.

PMID:
20600515
46.

[Nurse consultants in the field of travel].

Leclerc D.

Rev Infirm. 2010 May;(160):31. French. No abstract available.

PMID:
20461984
47.

Structure and dynamics changes induced by 2,2,2-trifluoro-ethanol (TFE) on the N-terminal half of hepatitis C virus core protein.

Duvignaud JB, Leclerc D, Gagné SM.

Biochem Cell Biol. 2010 Apr;88(2):315-23. doi: 10.1139/o09-155.

PMID:
20453932
48.

[Taking blood, an everyday action performed with sense].

Leclerc D, Cosquer D, Bouchaud O, Courtois J, Miangu S.

Rev Infirm. 2009 Dec;(156):26-7. French. No abstract available.

PMID:
20085024
49.

Palmitoylation of hepatitis C virus core protein is important for virion production.

Majeau N, Fromentin R, Savard C, Duval M, Tremblay MJ, Leclerc D.

J Biol Chem. 2009 Dec 4;284(49):33915-25. doi: 10.1074/jbc.M109.018549. Epub 2009 Sep 16.

50.

Structure and dynamics of the N-terminal half of hepatitis C virus core protein: an intrinsically unstructured protein.

Duvignaud JB, Savard C, Fromentin R, Majeau N, Leclerc D, Gagné SM.

Biochem Biophys Res Commun. 2009 Jan 2;378(1):27-31. doi: 10.1016/j.bbrc.2008.10.141. Epub 2008 Nov 4.

PMID:
18992225

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