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Items: 1 to 50 of 67

1.

Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions.

Ishiyama N, Sarpal R, Wood MN, Barrick SK, Nishikawa T, Hayashi H, Kobb AB, Flozak AS, Yemelyanov A, Fernandez-Gonzalez R, Yonemura S, Leckband DE, Gottardi CJ, Tepass U, Ikura M.

Nat Commun. 2018 Nov 30;9(1):5121. doi: 10.1038/s41467-018-07481-7.

2.

N-cadherin signaling via Trio assembles adherens junctions to restrict endothelial permeability.

Kruse K, Lee QS, Sun Y, Klomp J, Yang X, Huang F, Sun MY, Zhao S, Hong Z, Vogel SM, Shin JW, Leckband DE, Tai LM, Malik AB, Komarova YA.

J Cell Biol. 2018 Nov 21. pii: jcb.201802076. doi: 10.1083/jcb.201802076. [Epub ahead of print]

PMID:
30463880
3.

Soluble Zwitterionic Poly(sulfobetaine) Destabilizes Proteins.

Kisley L, Serrano KA, Davis CM, Guin D, Murphy EA, Gruebele M, Leckband DE.

Biomacromolecules. 2018 Sep 10;19(9):3894-3901. doi: 10.1021/acs.biomac.8b01120. Epub 2018 Aug 17.

PMID:
30064224
4.

Substrate stiffness and VE-cadherin mechano-transduction coordinate to regulate endothelial monolayer integrity.

Andresen Eguiluz RC, Kaylan KB, Underhill GH, Leckband DE.

Biomaterials. 2017 Sep;140:45-57. doi: 10.1016/j.biomaterials.2017.06.010. Epub 2017 Jun 9.

5.

Direct Imaging of Protein Stability and Folding Kinetics in Hydrogels.

Kisley L, Serrano KA, Guin D, Kong X, Gruebele M, Leckband DE.

ACS Appl Mater Interfaces. 2017 Jul 5;9(26):21606-21617. doi: 10.1021/acsami.7b01371. Epub 2017 Jun 23.

PMID:
28553706
6.

Three Dimensional Conjugation of Recombinant N-Cadherin to a Hydrogel for In Vitro Anisotropic Neural Growth.

Vega L JCM, Lee MK, Qin EC, Rich M, Lee KY, Kim DH, Chung HJ, Leckband DE, Kong H.

J Mater Chem B. 2016 Nov 14;4(42):6803-6811. doi: 10.1039/C6TB01814A. Epub 2016 Sep 21.

7.

Corrigendum: Kinetic Measurements Reveal Enhanced Protein-Protein Interactions at Intercellular Junctions.

Shashikanth N, Kisting MA, Leckband DE.

Sci Rep. 2017 Feb 9;7:41469. doi: 10.1038/srep41469. No abstract available.

8.

Cadherin Diffusion in Supported Lipid Bilayers Exhibits Calcium-Dependent Dynamic Heterogeneity.

Cai Y, Shashikanth N, Leckband DE, Schwartz DK.

Biophys J. 2016 Dec 20;111(12):2658-2665. doi: 10.1016/j.bpj.2016.10.037.

9.

Dynamic Imaging Reveals Coordinate Effects of Cyclic Stretch and Substrate Stiffness on Endothelial Integrity.

Dan A, Huang RB, Leckband DE.

Ann Biomed Eng. 2016 Dec;44(12):3655-3667. Epub 2016 Jun 17.

10.

Kinetic Measurements Reveal Enhanced Protein-Protein Interactions at Intercellular Junctions.

Shashikanth N, Kisting MA, Leckband DE.

Sci Rep. 2016 Mar 24;6:23623. doi: 10.1038/srep23623. Erratum in: Sci Rep. 2017 Feb 09;7:41469.

11.

E-cadherin-mediated force transduction signals regulate global cell mechanics.

Muhamed I, Wu J, Sehgal P, Kong X, Tajik A, Wang N, Leckband DE.

J Cell Sci. 2016 May 1;129(9):1843-54. doi: 10.1242/jcs.185447. Epub 2016 Mar 10.

12.

Constructing modular and universal single molecule tension sensor using protein G to study mechano-sensitive receptors.

Wang X, Rahil Z, Li IT, Chowdhury F, Leckband DE, Chemla YR, Ha T.

Sci Rep. 2016 Feb 15;6:21584. doi: 10.1038/srep21584.

13.

A genetic variant of cortactin linked to acute lung injury impairs lamellipodia dynamics and endothelial wound healing.

Choi S, Camp SM, Dan A, Garcia JG, Dudek SM, Leckband DE.

Am J Physiol Lung Cell Mol Physiol. 2015 Nov 1;309(9):L983-94. doi: 10.1152/ajplung.00062.2015. Epub 2015 Sep 11.

14.

Allosteric Regulation of E-Cadherin Adhesion.

Shashikanth N, Petrova YI, Park S, Chekan J, Maiden S, Spano M, Ha T, Gumbiner BM, Leckband DE.

J Biol Chem. 2015 Aug 28;290(35):21749-61. doi: 10.1074/jbc.M115.657098. Epub 2015 Jul 14.

15.

Structural Determinants of the Mechanical Stability of α-Catenin.

Li J, Newhall J, Ishiyama N, Gottardi C, Ikura M, Leckband DE, Tajkhorshid E.

J Biol Chem. 2015 Jul 31;290(31):18890-903. doi: 10.1074/jbc.M115.647941. Epub 2015 Jun 12.

16.

Local VE-cadherin mechanotransduction triggers long-ranged remodeling of endothelial monolayers.

Barry AK, Wang N, Leckband DE.

J Cell Sci. 2015 Apr 1;128(7):1341-51. doi: 10.1242/jcs.159954. Epub 2015 Feb 6.

17.

Dynamic visualization of α-catenin reveals rapid, reversible conformation switching between tension states.

Kim TJ, Zheng S, Sun J, Muhamed I, Wu J, Lei L, Kong X, Leckband DE, Wang Y.

Curr Biol. 2015 Jan 19;25(2):218-224. doi: 10.1016/j.cub.2014.11.017. Epub 2014 Dec 24.

18.

Cadherin adhesion and mechanotransduction.

Leckband DE, de Rooij J.

Annu Rev Cell Dev Biol. 2014;30:291-315. doi: 10.1146/annurev-cellbio-100913-013212. Epub 2014 Jul 9. Review.

PMID:
25062360
19.

Recapitulating cell-cell adhesion using N-cadherin biologically tethered to substrates.

Vega L JC, Lee MK, Jeong JH, Smith CE, Lee KY, Chung HJ, Leckband DE, Kong H.

Biomacromolecules. 2014 Jun 9;15(6):2172-9. doi: 10.1021/bm500335w. Epub 2014 May 15.

PMID:
24773064
20.

α-catenin cytomechanics--role in cadherin-dependent adhesion and mechanotransduction.

Barry AK, Tabdili H, Muhamed I, Wu J, Shashikanth N, Gomez GA, Yap AS, Gottardi CJ, de Rooij J, Wang N, Leckband DE.

J Cell Sci. 2014 Apr 15;127(Pt 8):1779-91. doi: 10.1242/jcs.139014. Epub 2014 Feb 12.

21.

Poly(N-isopropyl acrylamide) brush topography: dependence on grafting conditions and temperature.

Choi BC, Choi S, Leckband DE.

Langmuir. 2013 May 14;29(19):5841-50. doi: 10.1021/la400066d. Epub 2013 May 2.

PMID:
23600842
22.

N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathways.

Ouyang M, Lu S, Kim T, Chen CE, Seong J, Leckband DE, Wang F, Reynolds AB, Schwartz MA, Wang Y.

Nat Commun. 2013;4:1589. doi: 10.1038/ncomms2560.

23.

Vinculin-dependent Cadherin mechanosensing regulates efficient epithelial barrier formation.

Twiss F, Le Duc Q, Van Der Horst S, Tabdili H, Van Der Krogt G, Wang N, Rehmann H, Huveneers S, Leckband DE, De Rooij J.

Biol Open. 2012 Nov 15;1(11):1128-40. doi: 10.1242/bio.20122428. Epub 2012 Sep 11.

24.

Cadherin point mutations alter cell sorting and modulate GTPase signaling.

Tabdili H, Barry AK, Langer MD, Chien YH, Shi Q, Lee KJ, Lu S, Leckband DE.

J Cell Sci. 2012 Jul 15;125(Pt 14):3299-309. doi: 10.1242/jcs.087395. Epub 2012 Apr 14.

25.

N-glycosylation alters cadherin-mediated intercellular binding kinetics.

Langer MD, Guo H, Shashikanth N, Pierce JM, Leckband DE.

J Cell Sci. 2012 May 15;125(Pt 10):2478-85. doi: 10.1242/jcs.101147. Epub 2012 Feb 17.

26.

Novel functions and binding mechanisms of carbohydrate-binding proteins determined by force measurements.

Leckband DE.

Curr Protein Pept Sci. 2011 Dec;12(8):743-59. Review.

PMID:
22044144
27.

Effect of surface chemistry on bacterial adhesion, viability, and morphology.

Parreira P, Magalhães A, Gonçalves IC, Gomes J, Vidal R, Reis CA, Leckband DE, Martins MC.

J Biomed Mater Res A. 2011 Dec 1;99(3):344-53. doi: 10.1002/jbm.a.33178. Epub 2011 Aug 23.

PMID:
22021182
28.

Mechanotransduction at cadherin-mediated adhesions.

Leckband DE, le Duc Q, Wang N, de Rooij J.

Curr Opin Cell Biol. 2011 Oct;23(5):523-30. doi: 10.1016/j.ceb.2011.08.003. Epub 2011 Sep 2. Review.

PMID:
21890337
29.

Single cell 3-D platform to study ligand mobility in cell-cell contact.

Andreasson-Ochsner M, Romano G, Håkanson M, Smith ML, Leckband DE, Textor M, Reimhult E.

Lab Chip. 2011 Sep 7;11(17):2876-83. doi: 10.1039/c1lc20067d. Epub 2011 Jul 20.

PMID:
21773619
30.

Acid-Sensitive Magnetic Nanoparticles as Potential Drug Depots.

Wuang SC, Neoh KG, Kang ET, Leckband DE, Pack DW.

AIChE J. 2011 Jun;57(6):1638-1645.

31.

Protein adsorption on poly(N-isopropylacrylamide) brushes: dependence on grafting density and chain collapse.

Xue C, Yonet-Tanyeri N, Brouette N, Sferrazza M, Braun PV, Leckband DE.

Langmuir. 2011 Jul 19;27(14):8810-8. doi: 10.1021/la2001909. Epub 2011 Jun 24.

32.

Geometry and adhesion of extracellular domains of DC-SIGNR neck length variants analyzed by force-distance measurements.

Leckband DE, Menon S, Rosenberg K, Graham SA, Taylor ME, Drickamer K.

Biochemistry. 2011 Jul 12;50(27):6125-32. doi: 10.1021/bi2003444. Epub 2011 Jun 16.

33.

Integrated biochemical and mechanical signals regulate multifaceted human embryonic stem cell functions.

Li D, Zhou J, Wang L, Shin ME, Su P, Lei X, Kuang H, Guo W, Yang H, Cheng L, Tanaka TS, Leckband DE, Reynolds AB, Duan E, Wang F.

J Cell Biol. 2010 Nov 1;191(3):631-44. doi: 10.1083/jcb.201006094. Epub 2010 Oct 25.

34.

Cadherin and integrin regulation of epithelial cell migration.

Silvestre J, Kenis PJ, Leckband DE.

Langmuir. 2009 Sep 1;25(17):10092-9. doi: 10.1021/la901109e.

35.

Binding-site geometry and flexibility in DC-SIGN demonstrated with surface force measurements.

Menon S, Rosenberg K, Graham SA, Ward EM, Taylor ME, Drickamer K, Leckband DE.

Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11524-9. doi: 10.1073/pnas.0901783106. Epub 2009 Jun 24.

36.

Is cell rheology governed by nonequilibrium-to-equilibrium transition of noncovalent bonds?

Chowdhury F, Na S, Collin O, Tay B, Li F, Tanaka T, Leckband DE, Wang N.

Biophys J. 2008 Dec 15;95(12):5719-27. doi: 10.1529/biophysj.108.139832. Epub 2008 Oct 3.

37.

HER-2-mediated endocytosis of magnetic nanospheres and the implications in cell targeting and particle magnetization.

Wuang SC, Neoh KG, Kang ET, Pack DW, Leckband DE.

Biomaterials. 2008 May;29(14):2270-9. doi: 10.1016/j.biomaterials.2008.01.028. Epub 2008 Mar 4.

38.

Variably elastic hydrogel patterned via capillary action in microchannels.

Dong R, Jensen TW, Engberg K, Nuzzo RG, Leckband DE.

Langmuir. 2007 Jan 30;23(3):1483-8.

PMID:
17241077
39.

Impact of salt bridges on the equilibrium binding and adhesion of human CD2 and CD58.

Bayas MV, Kearney A, Avramovic A, van der Merwe PA, Leckband DE.

J Biol Chem. 2007 Feb 23;282(8):5589-96. Epub 2006 Dec 15.

40.

WITHDRAWN: Horseshoe-shaped conformation of human L1 ectodomains identified by direct force measurements.

Kim S, Leckband DE.

Biopolymers. 2006 Dec 4. doi: 10.1002/bip.20647. Epub 2006 Dec 4. Retraction in: Biopolymers. 2014 Nov;101(11):1141.

PMID:
17146787
41.

Similarities between heterophilic and homophilic cadherin adhesion.

Prakasam AK, Maruthamuthu V, Leckband DE.

Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15434-9. Epub 2006 Oct 5.

42.

Single-molecule measurements of the impact of lipid phase behavior on anchor strengths.

Wieland JA, Gewirth AA, Leckband DE.

J Phys Chem B. 2005 Mar 31;109(12):5985-93.

PMID:
16851653
43.

Calcium site mutations in cadherin: impact on adhesion and evidence of cooperativity.

Prakasam A, Chien YH, Maruthamuthu V, Leckband DE.

Biochemistry. 2006 Jun 6;45(22):6930-9.

PMID:
16734428
44.

PNIPAM chain collapse depends on the molecular weight and grafting density.

Plunkett KN, Zhu X, Moore JS, Leckband DE.

Langmuir. 2006 Apr 25;22(9):4259-66.

PMID:
16618173
45.

Cell migration and polarity on microfabricated gradients of extracellular matrix proteins.

Gunawan RC, Silvestre J, Gaskins HR, Kenis PJ, Leckband DE.

Langmuir. 2006 Apr 25;22(9):4250-8.

PMID:
16618172
46.

Single molecule adhesion measurements reveal two homophilic neural cell adhesion molecule bonds with mechanically distinct properties.

Wieland JA, Gewirth AA, Leckband DE.

J Biol Chem. 2005 Dec 9;280(49):41037-46. Epub 2005 Sep 27.

47.

Synthesis and characterization of an electroactive surface that releases gamma-aminobutyric acid (GABA).

Yan C, Matsuda W, Pepperberg DR, Zimmerman SC, Leckband DE.

J Colloid Interface Sci. 2006 Apr 1;296(1):165-77. Epub 2005 Sep 15.

PMID:
16168426
48.

Multiple-bond kinetics from single-molecule pulling experiments: evidence for multiple NCAM bonds.

Hukkanen EJ, Wieland JA, Gewirth A, Leckband DE, Braatz RD.

Biophys J. 2005 Nov;89(5):3434-45. Epub 2005 Aug 12.

49.

Twists and turns in the development and maintenance of the mammalian small intestine epithelium.

Hauck AL, Swanson KS, Kenis PJ, Leckband DE, Gaskins HR, Schook LB.

Birth Defects Res C Embryo Today. 2005 Mar;75(1):58-71. Review.

PMID:
15838920
50.

Regiospecific control of protein expression in cells cultured on two-component counter gradients of extracellular matrix proteins.

Gunawan RC, Choban ER, Conour JE, Silvestre J, Schook LB, Gaskins HR, Leckband DE, Kenis PJ.

Langmuir. 2005 Mar 29;21(7):3061-8.

PMID:
15779985

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