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Items: 1 to 50 of 126

1.

Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions.

Ishiyama N, Sarpal R, Wood MN, Barrick SK, Nishikawa T, Hayashi H, Kobb AB, Flozak AS, Yemelyanov A, Fernandez-Gonzalez R, Yonemura S, Leckband DE, Gottardi CJ, Tepass U, Ikura M.

Nat Commun. 2018 Nov 30;9(1):5121. doi: 10.1038/s41467-018-07481-7.

2.

N-cadherin signaling via Trio assembles adherens junctions to restrict endothelial permeability.

Kruse K, Lee QS, Sun Y, Klomp J, Yang X, Huang F, Sun MY, Zhao S, Hong Z, Vogel SM, Shin JW, Leckband DE, Tai LM, Malik AB, Komarova YA.

J Cell Biol. 2019 Jan 7;218(1):299-316. doi: 10.1083/jcb.201802076. Epub 2018 Nov 21.

PMID:
30463880
3.

Soluble Zwitterionic Poly(sulfobetaine) Destabilizes Proteins.

Kisley L, Serrano KA, Davis CM, Guin D, Murphy EA, Gruebele M, Leckband DE.

Biomacromolecules. 2018 Sep 10;19(9):3894-3901. doi: 10.1021/acs.biomac.8b01120. Epub 2018 Aug 17.

PMID:
30064224
4.

Epidermal growth factor receptor and integrins control force-dependent vinculin recruitment to E-cadherin junctions.

Sehgal P, Kong X, Wu J, Sunyer R, Trepat X, Leckband D.

J Cell Sci. 2018 Mar 20;131(6). pii: jcs206656. doi: 10.1242/jcs.206656.

5.

Salt bridges gate α-catenin activation at intercellular junctions.

Barrick S, Li J, Kong X, Ray A, Tajkhorshid E, Leckband D.

Mol Biol Cell. 2018 Jan 15;29(2):111-122. doi: 10.1091/mbc.E17-03-0168. Epub 2017 Nov 15.

6.

Substrate stiffness and VE-cadherin mechano-transduction coordinate to regulate endothelial monolayer integrity.

Andresen Eguiluz RC, Kaylan KB, Underhill GH, Leckband DE.

Biomaterials. 2017 Sep;140:45-57. doi: 10.1016/j.biomaterials.2017.06.010. Epub 2017 Jun 9.

7.

Direct Imaging of Protein Stability and Folding Kinetics in Hydrogels.

Kisley L, Serrano KA, Guin D, Kong X, Gruebele M, Leckband DE.

ACS Appl Mater Interfaces. 2017 Jul 5;9(26):21606-21617. doi: 10.1021/acsami.7b01371. Epub 2017 Jun 23.

PMID:
28553706
8.

Three Dimensional Conjugation of Recombinant N-Cadherin to a Hydrogel for In Vitro Anisotropic Neural Growth.

Vega L JCM, Lee MK, Qin EC, Rich M, Lee KY, Kim DH, Chung HJ, Leckband DE, Kong H.

J Mater Chem B. 2016 Nov 14;4(42):6803-6811. doi: 10.1039/C6TB01814A. Epub 2016 Sep 21.

9.

Corrigendum: Kinetic Measurements Reveal Enhanced Protein-Protein Interactions at Intercellular Junctions.

Shashikanth N, Kisting MA, Leckband DE.

Sci Rep. 2017 Feb 9;7:41469. doi: 10.1038/srep41469. No abstract available.

10.

Cadherin Diffusion in Supported Lipid Bilayers Exhibits Calcium-Dependent Dynamic Heterogeneity.

Cai Y, Shashikanth N, Leckband DE, Schwartz DK.

Biophys J. 2016 Dec 20;111(12):2658-2665. doi: 10.1016/j.bpj.2016.10.037.

11.

Correction: Nanoscale mechanics guides cellular decision making.

Rahil Z, Pedron S, Wang X, Ha T, Harley B, Leckband D.

Integr Biol (Camb). 2016 Sep 12;8(9):1002.

12.

A Computational Model for Kinetic Studies of Cadherin Binding and Clustering.

Chen J, Newhall J, Xie ZR, Leckband D, Wu Y.

Biophys J. 2016 Oct 4;111(7):1507-1518. doi: 10.1016/j.bpj.2016.08.038.

13.

Nanoscale mechanics guides cellular decision making.

Rahil Z, Pedron S, Wang X, Ha T, Harley B, Leckband D.

Integr Biol (Camb). 2016 Sep 12;8(9):929-35. doi: 10.1039/c6ib00113k. Epub 2016 Aug 1.

14.

Dynamic Imaging Reveals Coordinate Effects of Cyclic Stretch and Substrate Stiffness on Endothelial Integrity.

Dan A, Huang RB, Leckband DE.

Ann Biomed Eng. 2016 Dec;44(12):3655-3667. Epub 2016 Jun 17.

15.

Kinetic Measurements Reveal Enhanced Protein-Protein Interactions at Intercellular Junctions.

Shashikanth N, Kisting MA, Leckband DE.

Sci Rep. 2016 Mar 24;6:23623. doi: 10.1038/srep23623. Erratum in: Sci Rep. 2017 Feb 09;7:41469.

16.

E-cadherin-mediated force transduction signals regulate global cell mechanics.

Muhamed I, Wu J, Sehgal P, Kong X, Tajik A, Wang N, Leckband DE.

J Cell Sci. 2016 May 1;129(9):1843-54. doi: 10.1242/jcs.185447. Epub 2016 Mar 10.

17.

Constructing modular and universal single molecule tension sensor using protein G to study mechano-sensitive receptors.

Wang X, Rahil Z, Li IT, Chowdhury F, Leckband DE, Chemla YR, Ha T.

Sci Rep. 2016 Feb 15;6:21584. doi: 10.1038/srep21584.

18.

A genetic variant of cortactin linked to acute lung injury impairs lamellipodia dynamics and endothelial wound healing.

Choi S, Camp SM, Dan A, Garcia JG, Dudek SM, Leckband DE.

Am J Physiol Lung Cell Mol Physiol. 2015 Nov 1;309(9):L983-94. doi: 10.1152/ajplung.00062.2015. Epub 2015 Sep 11.

19.

Allosteric Regulation of E-Cadherin Adhesion.

Shashikanth N, Petrova YI, Park S, Chekan J, Maiden S, Spano M, Ha T, Gumbiner BM, Leckband DE.

J Biol Chem. 2015 Aug 28;290(35):21749-61. doi: 10.1074/jbc.M115.657098. Epub 2015 Jul 14.

20.

Structural Determinants of the Mechanical Stability of α-Catenin.

Li J, Newhall J, Ishiyama N, Gottardi C, Ikura M, Leckband DE, Tajkhorshid E.

J Biol Chem. 2015 Jul 31;290(31):18890-903. doi: 10.1074/jbc.M115.647941. Epub 2015 Jun 12.

21.

Local VE-cadherin mechanotransduction triggers long-ranged remodeling of endothelial monolayers.

Barry AK, Wang N, Leckband DE.

J Cell Sci. 2015 Apr 1;128(7):1341-51. doi: 10.1242/jcs.159954. Epub 2015 Feb 6.

22.

α-Catenin phosphorylation promotes intercellular adhesion through a dual-kinase mechanism.

Escobar DJ, Desai R, Ishiyama N, Folmsbee SS, Novak MN, Flozak AS, Daugherty RL, Mo R, Nanavati D, Sarpal R, Leckband D, Ikura M, Tepass U, Gottardi CJ.

J Cell Sci. 2015 Mar 15;128(6):1150-65. doi: 10.1242/jcs.163824. Epub 2015 Feb 4.

23.

Dynamic visualization of α-catenin reveals rapid, reversible conformation switching between tension states.

Kim TJ, Zheng S, Sun J, Muhamed I, Wu J, Lei L, Kong X, Leckband DE, Wang Y.

Curr Biol. 2015 Jan 19;25(2):218-224. doi: 10.1016/j.cub.2014.11.017. Epub 2014 Dec 24.

24.

Atomic force microscopy measurements reveal multiple bonds between Helicobacter pylori blood group antigen binding adhesin and Lewis b ligand.

Parreira P, Shi Q, Magalhaes A, Reis CA, Bugaytsova J, Borén T, Leckband D, Martins MC.

J R Soc Interface. 2014 Dec 6;11(101):20141040. doi: 10.1098/rsif.2014.1040.

25.

Cadherin adhesion and mechanotransduction.

Leckband DE, de Rooij J.

Annu Rev Cell Dev Biol. 2014;30:291-315. doi: 10.1146/annurev-cellbio-100913-013212. Epub 2014 Jul 9. Review.

PMID:
25062360
26.

Recapitulating cell-cell adhesion using N-cadherin biologically tethered to substrates.

Vega L JC, Lee MK, Jeong JH, Smith CE, Lee KY, Chung HJ, Leckband DE, Kong H.

Biomacromolecules. 2014 Jun 9;15(6):2172-9. doi: 10.1021/bm500335w. Epub 2014 May 15.

PMID:
24773064
27.

α-catenin cytomechanics--role in cadherin-dependent adhesion and mechanotransduction.

Barry AK, Tabdili H, Muhamed I, Wu J, Shashikanth N, Gomez GA, Yap AS, Gottardi CJ, de Rooij J, Wang N, Leckband DE.

J Cell Sci. 2014 Apr 15;127(Pt 8):1779-91. doi: 10.1242/jcs.139014. Epub 2014 Feb 12.

28.

Cell adhesion: sizing up a sticky situation.

Leckband D.

Curr Biol. 2013 Nov 18;23(22):R1008-R1011. doi: 10.1016/j.cub.2013.10.018.

29.

Bioengineered surfaces promote specific protein-glycan mediated binding of the gastric pathogen Helicobacter pylori.

Parreira P, Magalhães A, Reis CA, Borén T, Leckband D, Martins MC.

Acta Biomater. 2013 Nov;9(11):8885-93. doi: 10.1016/j.actbio.2013.06.042. Epub 2013 Jul 4.

PMID:
23831721
30.

Poly(N-isopropyl acrylamide) brush topography: dependence on grafting conditions and temperature.

Choi BC, Choi S, Leckband DE.

Langmuir. 2013 May 14;29(19):5841-50. doi: 10.1021/la400066d. Epub 2013 May 2.

PMID:
23600842
31.

Formin' cables under stress.

Leckband D.

Nat Cell Biol. 2013 Apr;15(4):345-6. doi: 10.1038/ncb2715.

PMID:
23548927
32.

N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathways.

Ouyang M, Lu S, Kim T, Chen CE, Seong J, Leckband DE, Wang F, Reynolds AB, Schwartz MA, Wang Y.

Nat Commun. 2013;4:1589. doi: 10.1038/ncomms2560.

33.

Protein adsorption mechanisms determine the efficiency of thermally controlled cell adhesion on poly(N-isopropyl acrylamide) brushes.

Choi S, Choi BC, Xue C, Leckband D.

Biomacromolecules. 2013 Jan 14;14(1):92-100. doi: 10.1021/bm301390q. Epub 2012 Dec 20.

PMID:
23214990
34.

Vinculin-dependent Cadherin mechanosensing regulates efficient epithelial barrier formation.

Twiss F, Le Duc Q, Van Der Horst S, Tabdili H, Van Der Krogt G, Wang N, Rehmann H, Huveneers S, Leckband DE, De Rooij J.

Biol Open. 2012 Nov 15;1(11):1128-40. doi: 10.1242/bio.20122428. Epub 2012 Sep 11.

35.

Cadherin recognition and adhesion.

Leckband D, Sivasankar S.

Curr Opin Cell Biol. 2012 Oct;24(5):620-7. doi: 10.1016/j.ceb.2012.05.014. Epub 2012 Jul 6. Review.

36.

Cadherin-dependent mechanotransduction depends on ligand identity but not affinity.

Tabdili H, Langer M, Shi Q, Poh YC, Wang N, Leckband D.

J Cell Sci. 2012 Sep 15;125(Pt 18):4362-71. doi: 10.1242/jcs.105775. Epub 2012 Jun 20.

37.

Biophysics of cadherin adhesion.

Leckband D, Sivasankar S.

Subcell Biochem. 2012;60:63-88. doi: 10.1007/978-94-007-4186-7_4. Review.

PMID:
22674068
38.

Cadherin point mutations alter cell sorting and modulate GTPase signaling.

Tabdili H, Barry AK, Langer MD, Chien YH, Shi Q, Lee KJ, Lu S, Leckband DE.

J Cell Sci. 2012 Jul 15;125(Pt 14):3299-309. doi: 10.1242/jcs.087395. Epub 2012 Apr 14.

39.

N-glycosylation alters cadherin-mediated intercellular binding kinetics.

Langer MD, Guo H, Shashikanth N, Pierce JM, Leckband DE.

J Cell Sci. 2012 May 15;125(Pt 10):2478-85. doi: 10.1242/jcs.101147. Epub 2012 Feb 17.

40.

Novel functions and binding mechanisms of carbohydrate-binding proteins determined by force measurements.

Leckband DE.

Curr Protein Pept Sci. 2011 Dec;12(8):743-59. Review.

PMID:
22044144
41.

Effect of surface chemistry on bacterial adhesion, viability, and morphology.

Parreira P, Magalhães A, Gonçalves IC, Gomes J, Vidal R, Reis CA, Leckband DE, Martins MC.

J Biomed Mater Res A. 2011 Dec 1;99(3):344-53. doi: 10.1002/jbm.a.33178. Epub 2011 Aug 23.

PMID:
22021182
42.

Mechanotransduction at cadherin-mediated adhesions.

Leckband DE, le Duc Q, Wang N, de Rooij J.

Curr Opin Cell Biol. 2011 Oct;23(5):523-30. doi: 10.1016/j.ceb.2011.08.003. Epub 2011 Sep 2. Review.

PMID:
21890337
43.

Single cell 3-D platform to study ligand mobility in cell-cell contact.

Andreasson-Ochsner M, Romano G, Håkanson M, Smith ML, Leckband DE, Textor M, Reimhult E.

Lab Chip. 2011 Sep 7;11(17):2876-83. doi: 10.1039/c1lc20067d. Epub 2011 Jul 20.

PMID:
21773619
44.

Acid-Sensitive Magnetic Nanoparticles as Potential Drug Depots.

Wuang SC, Neoh KG, Kang ET, Leckband DE, Pack DW.

AIChE J. 2011 Jun;57(6):1638-1645.

45.

Protein adsorption on poly(N-isopropylacrylamide) brushes: dependence on grafting density and chain collapse.

Xue C, Yonet-Tanyeri N, Brouette N, Sferrazza M, Braun PV, Leckband DE.

Langmuir. 2011 Jul 19;27(14):8810-8. doi: 10.1021/la2001909. Epub 2011 Jun 24.

46.

Geometry and adhesion of extracellular domains of DC-SIGNR neck length variants analyzed by force-distance measurements.

Leckband DE, Menon S, Rosenberg K, Graham SA, Taylor ME, Drickamer K.

Biochemistry. 2011 Jul 12;50(27):6125-32. doi: 10.1021/bi2003444. Epub 2011 Jun 16.

47.

Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation.

Niessen CM, Leckband D, Yap AS.

Physiol Rev. 2011 Apr;91(2):691-731. doi: 10.1152/physrev.00004.2010. Review.

48.

Integrated biochemical and mechanical signals regulate multifaceted human embryonic stem cell functions.

Li D, Zhou J, Wang L, Shin ME, Su P, Lei X, Kuang H, Guo W, Yang H, Cheng L, Tanaka TS, Leckband DE, Reynolds AB, Duan E, Wang F.

J Cell Biol. 2010 Nov 1;191(3):631-44. doi: 10.1083/jcb.201006094. Epub 2010 Oct 25.

49.

Allosteric cross talk between cadherin extracellular domains.

Shi Q, Maruthamuthu V, Li F, Leckband D.

Biophys J. 2010 Jul 7;99(1):95-104. doi: 10.1016/j.bpj.2010.03.062.

50.

Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner.

le Duc Q, Shi Q, Blonk I, Sonnenberg A, Wang N, Leckband D, de Rooij J.

J Cell Biol. 2010 Jun 28;189(7):1107-15. doi: 10.1083/jcb.201001149. Erratum in: J Cell Biol. 2010 Nov 15;191(4):891.

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