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Prospective multicenter randomized patient recruitment and sample collection to enable future measurements of sputum biomarkers of inflammation in an observational study of cystic fibrosis.

Liou TG, Adler FR, Argel N, Asfour F, Brown PS, Chatfield BA, Daines CL, Durham D, Francis JA, Glover B, Heynekamp T, Hoidal JR, Jensen JL, Keogh R, Kopecky CM, Lechtzin N, Li Y, Lysinger J, Molina O, Nakamura C, Packer KA, Poch KR, Quittner AL, Radford P, Redway AJ, Sagel SD, Sprandel S, Taylor-Cousar JL, Vroom JB, Yoshikawa R, Clancy JP, Elborn JS, Olivier KN, Cox DR.

BMC Med Res Methodol. 2019 Apr 26;19(1):88. doi: 10.1186/s12874-019-0705-0.


Predicting respiratory failure in amyotrophic lateral sclerosis: recruiting a few good pulmonologists.

Lechtzin N.

Eur Respir J. 2019 Apr 18;53(4). pii: 1900360. doi: 10.1183/13993003.00360-2019. Print 2019 Apr. No abstract available.


Cystic fibrosis: We see fungus among us, but should we care?

Hong G, Lechtzin N.

J Cyst Fibros. 2019 Mar;18(2):163-164. doi: 10.1016/j.jcf.2019.02.006. Epub 2019 Feb 21. No abstract available.


Inhaled antibiotic use is associated with Scedosporium/Lomentospora species isolation in cystic fibrosis.

Hong G, Lechtzin N, Hadjiliadis D, Kawut SM.

Pediatr Pulmonol. 2019 Feb;54(2):133-140. doi: 10.1002/ppul.24210. Epub 2018 Dec 14.


Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections.

Goss CH, Kaneko Y, Khuu L, Anderson GD, Ravishankar S, Aitken ML, Lechtzin N, Zhou G, Czyz DM, McLean K, Olakanmi O, Shuman HA, Teresi M, Wilhelm E, Caldwell E, Salipante SJ, Hornick DB, Siehnel RJ, Becker L, Britigan BE, Singh PK.

Sci Transl Med. 2018 Sep 26;10(460). pii: eaat7520. doi: 10.1126/scitranslmed.aat7520.


Amyotrophic Lateral Sclerosis and the Respiratory System.

Braun AT, Caballero-Eraso C, Lechtzin N.

Clin Chest Med. 2018 Jun;39(2):391-400. doi: 10.1016/j.ccm.2018.01.003. Review.


Reply to Martelli et al.: eHealth in Cystic Fibrosis: Promising, but Proof of Concept Is Still Needed.

Lechtzin N, Mayer-Hamblett N, Khan U, Goss CH.

Am J Respir Crit Care Med. 2018 Jul 15;198(2):285-286. doi: 10.1164/rccm.201803-0481LE. No abstract available.


Understanding the use of NIV in ALS: results of an international ALS specialist survey.

Heiman-Patterson TD, Cudkowicz ME, De Carvalho M, Genge A, Hardiman O, Jackson CE, Lechtzin N, Mitsumoto H, Silani V, Andrews JA, Chen D, Kulke S, Rudnicki SA, van den Berg LH.

Amyotroph Lateral Scler Frontotemporal Degener. 2018 Aug;19(5-6):331-341. doi: 10.1080/21678421.2018.1457058. Epub 2018 Apr 16.


Respiratory measures in amyotrophic lateral sclerosis.

Lechtzin N, Cudkowicz ME, de Carvalho M, Genge A, Hardiman O, Mitsumoto H, Mora JS, Shefner J, Van den Berg LH, Andrews JA.

Amyotroph Lateral Scler Frontotemporal Degener. 2018 Aug;19(5-6):321-330. doi: 10.1080/21678421.2018.1452945. Epub 2018 Mar 23. Erratum in: Amyotroph Lateral Scler Frontotemporal Degener. 2018 Aug;19(5-6):478.


Descriptions of the Pain Experience in Adults and Adolescents with Cystic Fibrosis.

Allgood SJ, Kozachik S, Alexander KA, Thaxton A, Vera M, Lechtzin N.

Pain Manag Nurs. 2018 Aug;19(4):340-347. doi: 10.1016/j.pmn.2017.11.011. Epub 2018 Mar 1.


Risk factors for persistent Aspergillus respiratory isolation in cystic fibrosis.

Hong G, Psoter KJ, Jennings MT, Merlo CA, Boyle MP, Hadjiliadis D, Kawut SM, Lechtzin N.

J Cyst Fibros. 2018 Sep;17(5):624-630. doi: 10.1016/j.jcf.2018.01.008. Epub 2018 Feb 12.


Hypertonic saline has a prolonged effect on mucociliary clearance in adults with cystic fibrosis.

Trimble AT, Whitney Brown A, Laube BL, Lechtzin N, Zeman KL, Wu J, Ceppe A, Waltz D, Bennett WD, Donaldson SH.

J Cyst Fibros. 2018 Sep;17(5):650-656. doi: 10.1016/j.jcf.2018.01.001. Epub 2018 Jan 20.


Bronchoscopy with endobronchial ultrasound guided transbronchial needle aspiration vs. transthoracic needle aspiration in lung cancer diagnosis and staging.

Munoz ML, Lechtzin N, Li QK, Wang K, Yarmus LB, Lee HJ, Feller-Kopman DJ.

J Thorac Dis. 2017 Jul;9(7):2178-2185. doi: 10.21037/jtd.2017.07.26.


Home Monitoring of Patients with Cystic Fibrosis to Identify and Treat Acute Pulmonary Exacerbations. eICE Study Results.

Lechtzin N, Mayer-Hamblett N, West NE, Allgood S, Wilhelm E, Khan U, Aitken ML, Ramsey BW, Boyle MP, Mogayzel PJ Jr, Gibson RL, Orenstein D, Milla C, Clancy JP, Antony V, Goss CH; eICE Study Team.

Am J Respir Crit Care Med. 2017 Nov 1;196(9):1144-1151. doi: 10.1164/rccm.201610-2172OC.


Risk factors for persistent methicillin-resistant Staphylococcus aureus infection in cystic fibrosis.

Jennings MT, Dasenbrook EC, Lechtzin N, Boyle MP, Merlo CA.

J Cyst Fibros. 2017 Nov;16(6):681-686. doi: 10.1016/j.jcf.2017.04.010. Epub 2017 Apr 23.


An Observational Study of Outcomes and Tolerances in Patients with Cystic Fibrosis Initiated on Lumacaftor/Ivacaftor.

Jennings MT, Dezube R, Paranjape S, West NE, Hong G, Braun A, Grant J, Merlo CA, Lechtzin N.

Ann Am Thorac Soc. 2017 Nov;14(11):1662-1666. doi: 10.1513/AnnalsATS.201701-058OC.


Fatal disseminated Rasamsonia infection in cystic fibrosis post-lung transplantation.

Hong G, White M, Lechtzin N, West NE, Avery R, Miller H, Lee R, Lovari RJ, Massire C, Blyn LB, Liang X, Sutton DA, Fu J, Wickes BL, Wiederhold NP, Zhang SX.

J Cyst Fibros. 2017 Mar;16(2):e3-e7. doi: 10.1016/j.jcf.2017.01.005. Epub 2017 Feb 6.


Use of Selective Fungal Culture Media Increases Rates of Detection of Fungi in the Respiratory Tract of Cystic Fibrosis Patients.

Hong G, Miller HB, Allgood S, Lee R, Lechtzin N, Zhang SX.

J Clin Microbiol. 2017 Apr;55(4):1122-1130. doi: 10.1128/JCM.02182-16. Epub 2017 Jan 18.


Exhaled nitric oxide in pulmonary arterial hypertension associated with systemic sclerosis.

Cao Z, Mathai SC, Hummers LK, Shah AA, Wigley FM, Lechtzin N, Hassoun PM, Girgis RE.

Pulm Circ. 2016 Dec;6(4):545-550. doi: 10.1086/688768.


Shifted focus of bronchoalveolar lavage in patients with suspected thoracic malignancy: an analysis of 224 patients.

Zhang X, Kuang Y, Zhang Y, He K, Lechtzin N, Zeng M, Yung RC, Xie C.

J Thorac Dis. 2016 Nov;8(11):3245-3254. doi: 10.21037/jtd.2016.11.06.


Digitoxin for Airway Inflammation in Cystic Fibrosis: Preliminary Assessment of Safety, Pharmacokinetics, and Dose Finding.

Zeitlin PL, Diener-West M, Callahan KA, Lee S, Talbot CC Jr, Pollard B, Boyle MP, Lechtzin N.

Ann Am Thorac Soc. 2017 Feb;14(2):220-229. doi: 10.1513/AnnalsATS.201608-649OC.


Long-Term Mechanical Ventilation.

Sahetya S, Allgood S, Gay PC, Lechtzin N.

Clin Chest Med. 2016 Dec;37(4):753-763. doi: 10.1016/j.ccm.2016.07.014. Epub 2016 Oct 14. Review.


The Association Between Pain and Clinical Outcomes in Adolescents With Cystic Fibrosis.

Lechtzin N, Allgood S, Hong G, Riekert K, Haythornthwaite JA, Mogayzel P, Hankinson J, Yaster M.

J Pain Symptom Manage. 2016 Nov;52(5):681-687. doi: 10.1016/j.jpainsymman.2016.03.023. Epub 2016 Sep 29.


The Impact of High-Frequency Chest Wall Oscillation on Healthcare Use in Patients with Neuromuscular Diseases.

Lechtzin N, Wolfe LF, Frick KD.

Ann Am Thorac Soc. 2016 Jun;13(6):904-9. doi: 10.1513/AnnalsATS.201509-597OC.


Ambrisentan and Tadalafil Up-front Combination Therapy in Scleroderma-associated Pulmonary Arterial Hypertension.

Hassoun PM, Zamanian RT, Damico R, Lechtzin N, Khair R, Kolb TM, Tedford RJ, Hulme OL, Housten T, Pisanello C, Sato T, Pullins EH, Corona-Villalobos CP, Zimmerman SL, Gashouta MA, Minai OA, Torres F, Girgis RE, Chin K, Mathai SC.

Am J Respir Crit Care Med. 2015 Nov 1;192(9):1102-10. doi: 10.1164/rccm.201507-1398OC.


Clinical and pathologic differences in interstitial lung disease based on antisynthetase antibody type.

Johnson C, Connors GR, Oaks J, Han S, Truong A, Richardson B, Lechtzin N, Mammen AL, Casciola-Rosen L, Christopher-Stine L, Danoff SK.

Respir Med. 2014 Oct;108(10):1542-8. doi: 10.1016/j.rmed.2014.09.003. Epub 2014 Sep 18.


TBNA with and without EBUS: a comparative efficacy study for the diagnosis and staging of lung cancer.

Jiang J, Browning R, Lechtzin N, Huang J, Terry P, Wang KP.

J Thorac Dis. 2014 May;6(5):416-20. doi: 10.3978/j.issn.2072-1439.2014.03.22.


Optimizing endobronchial ultrasound for molecular analysis. How many passes are needed?

Yarmus L, Akulian J, Gilbert C, Feller-Kopman D, Lee HJ, Zarogoulidis P, Lechtzin N, Ali SZ, Sathiyamoorthy V.

Ann Am Thorac Soc. 2013 Dec;10(6):636-43. doi: 10.1513/AnnalsATS.201305-130OC.


Rationale and design of a randomized trial of home electronic symptom and lung function monitoring to detect cystic fibrosis pulmonary exacerbations: the early intervention in cystic fibrosis exacerbation (eICE) trial.

Lechtzin N, West N, Allgood S, Wilhelm E, Khan U, Mayer-Hamblett N, Aitken ML, Ramsey BW, Boyle MP, Mogayzel PJ Jr, Goss CH.

Contemp Clin Trials. 2013 Nov;36(2):460-9. doi: 10.1016/j.cct.2013.09.004. Epub 2013 Sep 19.


ALS Untangled No. 20: the Deanna protocol.

ALSUntangled Group, Fournier C, Bedlack B, Hardiman O, Heiman-Patterson T, Gutmann L, Bromberg M, Ostrow L, Carter G, Kabashi E, Bertorini T, Mozaffar T, Andersen P, Dietz J, Gamez J, Dimachkie M, Wang Y, Wicks P, Heywood J, Novella S, Rowland LP, Pioro E, Kinsley L, Mitchell K, Glass J, Sathornsumetee S, Kwiecinski H, Baker J, Atassi N, Forshew D, Ravits J, Conwit R, Jackson C, Sherman A, Dalton K, Tindall K, Gonzalez G, Robertson J, Phillips L, Benatar M, Sorenson E, Shoesmith C, Nash S, Maragakis N, Moore D, Caress J, Boylan K, Armon C, Grosso M, Gerecke B, Wymer J, Oskarsson B, Bowser R, Drory V, Shefner J, Lechtzin N, Leitner M, Miller R, Mitsumoto H, Levine T, Russell J, Sharma K, Saperstein D, McClusky L, MacGowan D, Licht J, Verma A, Strong M, Lomen-Hoerth C, Tandan R, Rivner M, Kolb S, Polak M, Rudnicki S, Kittrell P, Quereshi M, Sachs G, Pattee G, Weiss M, Kissel J, Goldstein J, Rothstein J, Pastula D, Gleb L, Ogino M, Rosenfeld J, Carmi E, Oster C, Barkhaus P, Valor E.

Amyotroph Lateral Scler Frontotemporal Degener. 2013 May;14(4):319-23. doi: 10.3109/21678421.2013.788405. Epub 2013 May 2. Review. No abstract available.


Comparison of 21-gauge and 22-gauge aspiration needle in endobronchial ultrasound-guided transbronchial needle aspiration: results of the American College of Chest Physicians Quality Improvement Registry, Education, and Evaluation Registry.

Yarmus LB, Akulian J, Lechtzin N, Yasin F, Kamdar B, Ernst A, Ost DE, Ray C, Greenhill SR, Jimenez CA, Filner J, Feller-Kopman D; American College of Chest Physicians Quality Improvement Registry, Education, and Evaluation (AQuIRE) Participants.

Chest. 2013 Apr;143(4):1036-1043. doi: 10.1378/chest.12-1205.


Training perspective: the impact of starting an endobronchial ultrasound program at a major academic center on fellows training of transbronchial needle aspiration.

Feller-Kopman DJ, Brigham E, Lechtzin N, Gilbert C, Akulian J, Yarmus L.

Ann Am Thorac Soc. 2013 Apr;10(2):127-30. doi: 10.1513/AnnalsATS.201208-052OC.


Author reply: To PMID 22986377.

Lechtzin N, Horton MR.

Ann Intern Med. 2013 Mar 19;158(6):498-9. doi: 10.7326/0003-4819-158-6-201303190-00016. No abstract available.


Validation of the Cough Quality-of-Life Questionnaire in patients with idiopathic pulmonary fibrosis.

Lechtzin N, Hilliard ME, Horton MR.

Chest. 2013 Jun;143(6):1745-1749. doi: 10.1378/chest.12-2870.


Safety and feasibility of interventional pulmonologists performing bedside percutaneous endoscopic gastrostomy tube placement.

Yarmus L, Gilbert C, Lechtzin N, Imad M, Ernst A, Feller-Kopman D.

Chest. 2013 Aug;144(2):436-440. doi: 10.1378/chest.12-2550.


Regional and global biventricular function in pulmonary arterial hypertension: a cardiac MR imaging study.

Shehata ML, Harouni AA, Skrok J, Basha TA, Boyce D, Lechtzin N, Mathai SC, Girgis R, Osman NF, Lima JA, Bluemke DA, Hassoun PM, Vogel-Claussen J.

Radiology. 2013 Jan;266(1):114-22. doi: 10.1148/radiol.12111599. Epub 2012 Nov 14.


High-quality CMV-specific CD4+ memory is enriched in the lung allograft and is associated with mucosal viral control.

Akulian JA, Pipeling MR, John ER, Orens JB, Lechtzin N, McDyer JF.

Am J Transplant. 2013 Jan;13(1):146-56. doi: 10.1111/j.1600-6143.2012.04282.x. Epub 2012 Sep 27.


Thalidomide for the treatment of cough in idiopathic pulmonary fibrosis: a randomized trial.

Horton MR, Santopietro V, Mathew L, Horton KM, Polito AJ, Liu MC, Danoff SK, Lechtzin N.

Ann Intern Med. 2012 Sep 18;157(6):398-406. doi: 10.7326/0003-4819-157-6-201209180-00003.


Respiratory therapies for amyotrophic lateral sclerosis: a primer.

Gruis KL, Lechtzin N.

Muscle Nerve. 2012 Sep;46(3):313-31. doi: 10.1002/mus.23282. Review.


Pulmonary arterial hypertension: MR imaging-derived first-pass bolus kinetic parameters are biomarkers for pulmonary hemodynamics, cardiac function, and ventricular remodeling.

Skrok J, Shehata ML, Mathai S, Girgis RE, Zaiman A, Mudd JO, Boyce D, Lechtzin N, Lima JA, Bluemke DA, Hassoun PM, Vogel-Claussen J.

Radiology. 2012 Jun;263(3):678-87. doi: 10.1148/radiol.12111001. Epub 2012 Apr 16.


Primary cytomegalovirus phosphoprotein 65-specific CD8+ T-cell responses and T-bet levels predict immune control during early chronic infection in lung transplant recipients.

Pipeling MR, John ER, Orens JB, Lechtzin N, McDyer JF.

J Infect Dis. 2011 Dec 1;204(11):1663-71. doi: 10.1093/infdis/jir624. Epub 2011 Oct 21.


Tricuspid annular plane systolic excursion is a robust outcome measure in systemic sclerosis-associated pulmonary arterial hypertension.

Mathai SC, Sibley CT, Forfia PR, Mudd JO, Fisher MR, Tedford RJ, Lechtzin N, Boyce D, Hummers LK, Housten T, Zaiman AL, Girgis RE, Hassoun PM.

J Rheumatol. 2011 Nov;38(11):2410-8. doi: 10.3899/jrheum.110512. Epub 2011 Oct 1.


Pain is a common problem affecting clinical outcomes in adults with cystic fibrosis.

Hayes M, Yaster M, Haythornthwaite JA, Riekert KA, Nelson McMillan K, White E, Mogayzel PJ Jr, Lechtzin N.

Chest. 2011 Dec;140(6):1598-1603. doi: 10.1378/chest.11-0132. Epub 2011 Jun 9.


Increased right ventricular Septomarginal trabeculation mass is a novel marker for pulmonary hypertension: comparison with ventricular mass index and right ventricular mass.

Vogel-Claussen J, Shehata ML, Lossnitzer D, Skrok J, Singh S, Boyce D, Lechtzin N, Girgis RE, Mathai SC, Lima JA, Bluemke DA, Hassoun PM.

Invest Radiol. 2011 Sep;46(9):567-75. doi: 10.1097/RLI.0b013e31821b7041.


Systemic sclerosis-related pulmonary hypertension associated with interstitial lung disease: impact of pulmonary arterial hypertension therapies.

Le Pavec J, Girgis RE, Lechtzin N, Mathai SC, Launay D, Hummers LK, Zaiman A, Sitbon O, Simonneau G, Humbert M, Hassoun PM.

Arthritis Rheum. 2011 Aug;63(8):2456-64. doi: 10.1002/art.30423.


Statin therapy is associated with decreased pulmonary vascular pressures in severe COPD.

Reed RM, Iacono A, DeFilippis A, Jones S, Eberlein M, Lechtzin N, Girgis RE.

COPD. 2011 Apr;8(2):96-102. doi: 10.3109/15412555.2011.558545.


A randomized prospective trial of the utility of rapid on-site evaluation of transbronchial needle aspirate specimens.

Yarmus L, Van der Kloot T, Lechtzin N, Napier M, Dressel D, Feller-Kopman D.

J Bronchology Interv Pulmonol. 2011 Apr;18(2):121-7. doi: 10.1097/LBR.0b013e31821707ee.


Appropriate goal level for 25-hydroxyvitamin D in cystic fibrosis.

West NE, Lechtzin N, Merlo CA, Turowski JB, Davis ME, Ramsay MZ, Watts SL, Stenner SP, Boyle MP.

Chest. 2011 Aug;140(2):469-474. doi: 10.1378/chest.10-2114. Epub 2011 Mar 10.


Outcomes of hospitalisation for right heart failure in pulmonary arterial hypertension.

Campo A, Mathai SC, Le Pavec J, Zaiman AL, Hummers LK, Boyce D, Housten T, Lechtzin N, Chami H, Girgis RE, Hassoun PM.

Eur Respir J. 2011 Aug;38(2):359-67. doi: 10.1183/09031936.00148310. Epub 2011 Feb 10.


Myocardial delayed enhancement in pulmonary hypertension: pulmonary hemodynamics, right ventricular function, and remodeling.

Shehata ML, Lossnitzer D, Skrok J, Boyce D, Lechtzin N, Mathai SC, Girgis RE, Osman N, Lima JA, Bluemke DA, Hassoun PM, Vogel-Claussen J.

AJR Am J Roentgenol. 2011 Jan;196(1):87-94. doi: 10.2214/AJR.09.4114.

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