Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 32

1.

OATP1A/1B, CYP3A, ABCB1, and ABCG2 limit oral availability of NTRK inhibitor larotrectinib, while ABCB1 and ABCG2 also restrict its brain accumulation.

Wang Y, Sparidans RW, Li W, Lebre MC, Beijnen JH, Schinkel AH.

Br J Pharmacol. 2020 Feb 22. doi: 10.1111/bph.15034. [Epub ahead of print]

PMID:
32087611
2.

P-glycoprotein (ABCB1/MDR1) limits brain accumulation and Cytochrome P450-3A (CYP3A) restricts oral availability of the novel FGFR4 inhibitor fisogatinib (BLU-554).

Li W, Sparidans R, El-Lari M, Wang Y, Lebre MC, Beijnen JH, Schinkel AH.

Int J Pharm. 2020 Jan 5;573:118842. doi: 10.1016/j.ijpharm.2019.118842. Epub 2019 Nov 20.

PMID:
31759109
3.

Myeloid Dendritic Cells Are Enriched in Lymph Node Tissue of Early Rheumatoid Arthritis Patients but not in At Risk Individuals.

Ramwadhdoebe TH, Ramos MI, Maijer KI, van Lienden KP, Maas M, Gerlag DM, Tak PP, Lebre MC, van Baarsen LGM.

Cells. 2019 Jul 20;8(7). pii: E756. doi: 10.3390/cells8070756.

4.

P-glycoprotein Limits Ribociclib Brain Exposure and CYP3A4 Restricts Its Oral Bioavailability.

Martínez-Chávez A, van Hoppe S, Rosing H, Lebre MC, Tibben M, Beijnen JH, Schinkel AH.

Mol Pharm. 2019 Sep 3;16(9):3842-3852. doi: 10.1021/acs.molpharmaceut.9b00475. Epub 2019 Aug 5.

PMID:
31329454
5.

P-glycoprotein (MDR1/ABCB1) controls brain accumulation and intestinal disposition of the novel TGF-β signaling pathway inhibitor galunisertib.

Li W, Tibben M, Wang Y, Lebre MC, Rosing H, Beijnen JH, Schinkel AH.

Int J Cancer. 2020 Mar 15;146(6):1631-1642. doi: 10.1002/ijc.32568. Epub 2019 Jul 15.

PMID:
31304590
6.

Oral coadministration of elacridar and ritonavir enhances brain accumulation and oral availability of the novel ALK/ROS1 inhibitor lorlatinib.

Li W, Sparidans RW, Wang Y, Lebre MC, Beijnen JH, Schinkel AH.

Eur J Pharm Biopharm. 2019 Mar;136:120-130. doi: 10.1016/j.ejpb.2019.01.016. Epub 2019 Jan 17.

PMID:
30660696
7.

P-glycoprotein (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) limit brain accumulation of the FLT3 inhibitor quizartinib in mice.

Wang J, Gan C, Retmana IA, Sparidans RW, Li W, Lebre MC, Beijnen JH, Schinkel AH.

Int J Pharm. 2019 Feb 10;556:172-180. doi: 10.1016/j.ijpharm.2018.12.014. Epub 2018 Dec 12.

PMID:
30553002
8.

P-glycoprotein and breast cancer resistance protein restrict brigatinib brain accumulation and toxicity, and, alongside CYP3A, limit its oral availability.

Li W, Sparidans RW, Wang Y, Lebre MC, Beijnen JH, Schinkel AH.

Pharmacol Res. 2018 Nov;137:47-55. doi: 10.1016/j.phrs.2018.09.020. Epub 2018 Sep 22.

PMID:
30253203
9.

P-glycoprotein (MDR1/ABCB1) restricts brain accumulation and cytochrome P450-3A (CYP3A) limits oral availability of the novel ALK/ROS1 inhibitor lorlatinib.

Li W, Sparidans RW, Wang Y, Lebre MC, Wagenaar E, Beijnen JH, Schinkel AH.

Int J Cancer. 2018 Oct 15;143(8):2029-2038. doi: 10.1002/ijc.31582. Epub 2018 Jul 10.

10.

CD40 signaling instructs chronic lymphocytic leukemia cells to attract monocytes via the CCR2 axis.

van Attekum MHA, van Bruggen JAC, Slinger E, Lebre MC, Reinen E, Kersting S, Eldering E, Kater AP.

Haematologica. 2017 Dec;102(12):2069-2076. doi: 10.3324/haematol.2016.157206. Epub 2017 Sep 29.

11.

Synovial IL-21/TNF-producing CD4+ T cells induce joint destruction in rheumatoid arthritis by inducing matrix metalloproteinase production by fibroblast-like synoviocytes.

Lebre MC, Vieira PL, Tang MW, Aarrass S, Helder B, Newsom-Davis T, Tak PP, Screaton GR.

J Leukoc Biol. 2017 Mar;101(3):775-783. doi: 10.1189/jlb.5A0516-217RR. Epub 2016 Oct 12.

PMID:
27733582
12.

Indoor pollutant hexabromocyclododecane enhances house dust mite-induced activation of human monocyte-derived dendritic cells.

Canbaz D, Lebre MC, Logiantara A, van Ree R, van Rijt LS.

J Immunotoxicol. 2016 Nov;13(6):810-816. Epub 2016 Jul 14.

PMID:
27414104
13.

Reduced CLEC9A expression in synovial tissue of psoriatic arthritis patients after adalimumab therapy.

Ramos MI, Teunissen MB, Helder B, Aarrass S, de Hair MJ, van Kuijk AW, Gerlag DM, Tak PP, Lebre MC.

Rheumatology (Oxford). 2016 Sep;55(9):1575-84. doi: 10.1093/rheumatology/kew204. Epub 2016 May 13.

PMID:
27179104
14.

Heterogeneous expression pattern of interleukin 17A (IL-17A), IL-17F and their receptors in synovium of rheumatoid arthritis, psoriatic arthritis and osteoarthritis: possible explanation for nonresponse to anti-IL-17 therapy?

van Baarsen LG, Lebre MC, van der Coelen D, Aarrass S, Tang MW, Ramwadhdoebe TH, Gerlag DM, Tak PP.

Arthritis Res Ther. 2014 Aug 22;16(4):426. doi: 10.1186/s13075-014-0426-z.

15.

FMS-related tyrosine kinase 3 ligand (Flt3L)/CD135 axis in rheumatoid arthritis.

Ramos MI, Perez SG, Aarrass S, Helder B, Broekstra P, Gerlag DM, Reedquist KA, Tak PP, Lebre MC.

Arthritis Res Ther. 2013;15(6):R209.

16.

Fms-like tyrosine kinase 3 ligand-dependent dendritic cells in autoimmune inflammation.

Ramos MI, Tak PP, Lebre MC.

Autoimmun Rev. 2014 Feb;13(2):117-24. doi: 10.1016/j.autrev.2013.09.010. Epub 2013 Oct 7. Review.

PMID:
24113138
17.

Absence of Fms-like tyrosine kinase 3 ligand (Flt3L) signalling protects against collagen-induced arthritis.

Ramos MI, Karpus ON, Broekstra P, Aarrass S, Jacobsen SE, Tak PP, Lebre MC.

Ann Rheum Dis. 2015 Jan;74(1):211-9. doi: 10.1136/annrheumdis-2013-203371. Epub 2013 Sep 24.

PMID:
24064002
18.

Anti-TNF therapy reduces serum levels of chemerin in rheumatoid arthritis: a new mechanism by which anti-TNF might reduce inflammation.

Herenius MM, Oliveira AS, Wijbrandts CA, Gerlag DM, Tak PP, Lebre MC.

PLoS One. 2013;8(2):e57802. doi: 10.1371/journal.pone.0057802. Epub 2013 Feb 27.

19.

Expression of IL-20 in synovium and lesional skin of patients with psoriatic arthritis: differential response to alefacept treatment.

Lebre MC, Jonckheere CL, Kraan MC, van Kuijk AW, Bos JD, de Rie M, Gerlag DM, Tak PP.

Arthritis Res Ther. 2012 Sep 24;14(5):R200. doi: 10.1186/ar4038.

20.

Why CCR2 and CCR5 blockade failed and why CCR1 blockade might still be effective in the treatment of rheumatoid arthritis.

Lebre MC, Vergunst CE, Choi IY, Aarrass S, Oliveira AS, Wyant T, Horuk R, Reedquist KA, Tak PP.

PLoS One. 2011;6(7):e21772. doi: 10.1371/journal.pone.0021772. Epub 2011 Jul 1.

21.

Dendritic cells in rheumatoid arthritis: Which subset should be used as a tool to induce tolerance?

Lebre MC, Tak PP.

Hum Immunol. 2009 May;70(5):321-4. doi: 10.1016/j.humimm.2009.02.006. Epub 2009 Feb 21. Review.

PMID:
19236901
22.

Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice.

van Maanen MA, Lebre MC, van der Poll T, LaRosa GJ, Elbaum D, Vervoordeldonk MJ, Tak PP.

Arthritis Rheum. 2009 Jan;60(1):114-22. doi: 10.1002/art.24177.

23.

Aberrant function of peripheral blood myeloid and plasmacytoid dendritic cells in atopic dermatitis patients.

Lebre MC, van Capel TM, Bos JD, Knol EF, Kapsenberg ML, de Jong EC.

J Allergy Clin Immunol. 2008 Nov;122(5):969-976.e5. doi: 10.1016/j.jaci.2008.08.028. Epub 2008 Oct 9.

PMID:
18845325
24.

Dendritic cell subsets: their roles in rheumatoid arthritis.

Lebre MC, Tak PP.

Acta Reumatol Port. 2008 Jan-Mar;33(1):35-45. Review.

25.

Rheumatoid arthritis synovium contains two subsets of CD83-DC-LAMP- dendritic cells with distinct cytokine profiles.

Lebre MC, Jongbloed SL, Tas SW, Smeets TJ, McInnes IB, Tak PP.

Am J Pathol. 2008 Apr;172(4):940-50. doi: 10.2353/ajpath.2008.070703. Epub 2008 Feb 21.

26.

Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9.

Lebre MC, van der Aar AM, van Baarsen L, van Capel TM, Schuitemaker JH, Kapsenberg ML, de Jong EC.

J Invest Dermatol. 2007 Feb;127(2):331-41. Epub 2006 Oct 26.

27.

Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis.

Jongbloed SL, Lebre MC, Fraser AR, Gracie JA, Sturrock RD, Tak PP, McInnes IB.

Arthritis Res Ther. 2006;8(1):R15.

28.

The role of chemokines in rheumatoid arthritis and osteoarthritis.

Vergunst CE, van de Sande MG, Lebre MC, Tak PP.

Scand J Rheumatol. 2005 Nov-Dec;34(6):415-25. Review.

PMID:
16393761
29.
30.

Analysis of the CD4+ T cell responses to house dust mite allergoid.

Kalinski P, Lebre MC, Kramer D, De Jong EC, Van Schijndel JW, Kapsenberg ML.

Allergy. 2003 Jul;58(7):648-56.

PMID:
12823126
32.

Inhibition of contact sensitizer-induced migration of human Langerhans cells by matrix metalloproteinase inhibitors.

Lebre MC, Kalinski P, Das PK, Everts V.

Arch Dermatol Res. 1999 Jul-Aug;291(7-8):447-52.

PMID:
10482016

Supplemental Content

Loading ...
Support Center