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Items: 1 to 50 of 110

1.

The integrity of the FOG-2 LXCXE pRb-binding motif is required for small intestine homeostasis.

Goupille O, Kadri Z, Langelé A, Luccantoni S, Badoual C, Leboulch P, Chrétien S.

Exp Physiol. 2019 Jul;104(7):1074-1089. doi: 10.1113/EP087369. Epub 2019 May 14.

PMID:
31012180
2.

Enhanced Transduction of Macaca fascicularis Hematopoietic Cells with Chimeric Lentiviral Vectors.

Sii-Felice K, Castillo Padilla J, Relouzat F, Cheuzeville J, Tantawet S, Maouche L, Le Grand R, Leboulch P, Payen E.

Hum Gene Ther. 2019 May 15. doi: 10.1089/hum.2018.179. [Epub ahead of print]

PMID:
30848170
3.

UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells.

Ngom M, Imren S, Maetzig T, Adair JE, Knapp DJHF, Chagraoui J, Fares I, Bordeleau ME, Sauvageau G, Leboulch P, Eaves C, Humphries RK.

Mol Ther Methods Clin Dev. 2018 Jul 5;10:156-164. doi: 10.1016/j.omtm.2018.06.009. eCollection 2018 Sep 21.

4.

Hemoglobin disorders: lentiviral gene therapy in the starting blocks to enter clinical practice.

Sii-Felice K, Giorgi M, Leboulch P, Payen E.

Exp Hematol. 2018 Aug;64:12-32. doi: 10.1016/j.exphem.2018.05.004. Epub 2018 May 26. Review.

PMID:
29807062
5.

Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia.

Thompson AA, Walters MC, Kwiatkowski J, Rasko JEJ, Ribeil JA, Hongeng S, Magrin E, Schiller GJ, Payen E, Semeraro M, Moshous D, Lefrere F, Puy H, Bourget P, Magnani A, Caccavelli L, Diana JS, Suarez F, Monpoux F, Brousse V, Poirot C, Brouzes C, Meritet JF, Pondarré C, Beuzard Y, Chrétien S, Lefebvre T, Teachey DT, Anurathapan U, Ho PJ, von Kalle C, Kletzel M, Vichinsky E, Soni S, Veres G, Negre O, Ross RW, Davidson D, Petrusich A, Sandler L, Asmal M, Hermine O, De Montalembert M, Hacein-Bey-Abina S, Blanche S, Leboulch P, Cavazzana M.

N Engl J Med. 2018 Apr 19;378(16):1479-1493. doi: 10.1056/NEJMoa1705342.

6.

The LXCXE Retinoblastoma Protein-Binding Motif of FOG-2 Regulates Adipogenesis.

Goupille O, Penglong T, Kadri Z, Granger-Locatelli M, Denis R, Luquet S, Badoual C, Fucharoen S, Maouche-Chrétien L, Leboulch P, Chrétien S.

Cell Rep. 2017 Dec 19;21(12):3524-3535. doi: 10.1016/j.celrep.2017.11.098.

7.

Ex Vivo Selection of Transduced Hematopoietic Stem Cells for Gene Therapy of β-Hemoglobinopathies.

Bhukhai K, de Dreuzy E, Giorgi M, Colomb C, Negre O, Denaro M, Gillet-Legrand B, Cheuzeville J, Paulard A, Trebeden-Negre H, Borwornpinyo S, Sii-Felice K, Maouche L, Down JD, Leboulch P, Payen E.

Mol Ther. 2018 Feb 7;26(2):480-495. doi: 10.1016/j.ymthe.2017.10.015. Epub 2017 Oct 24.

8.

Gene Therapy in a Patient with Sickle Cell Disease.

Leboulch P, Cavazzana M.

N Engl J Med. 2017 May 25;376(21):2094. doi: 10.1056/NEJMc1704009. No abstract available.

PMID:
28538131
9.

Gene Therapy in a Patient with Sickle Cell Disease.

Ribeil JA, Hacein-Bey-Abina S, Payen E, Magnani A, Semeraro M, Magrin E, Caccavelli L, Neven B, Bourget P, El Nemer W, Bartolucci P, Weber L, Puy H, Meritet JF, Grevent D, Beuzard Y, Chrétien S, Lefebvre T, Ross RW, Negre O, Veres G, Sandler L, Soni S, de Montalembert M, Blanche S, Leboulch P, Cavazzana M.

N Engl J Med. 2017 Mar 2;376(9):848-855. doi: 10.1056/NEJMoa1609677.

10.

Induced pluripotent stem cell generation from a man carrying a complex chromosomal rearrangement as a genetic model for infertility studies.

Mouka A, Izard V, Tachdjian G, Brisset S, Yates F, Mayeur A, Drévillon L, Jarray R, Leboulch P, Maouche-Chrétien L, Tosca L.

Sci Rep. 2017 Jan 3;7:39760. doi: 10.1038/srep39760.

11.

Pioglitazone together with imatinib in chronic myeloid leukemia: A proof of concept study.

Rousselot P, Prost S, Guilhot J, Roy L, Etienne G, Legros L, Charbonnier A, Coiteux V, Cony-Makhoul P, Huguet F, Cayssials E, Cayuela JM, Relouzat F, Delord M, Bruzzoni-Giovanelli H, Morisset L, Mahon FX, Guilhot F, Leboulch P; French CML Group.

Cancer. 2017 May 15;123(10):1791-1799. doi: 10.1002/cncr.30490. Epub 2016 Dec 27.

12.

High-Efficiency Transduction of Primary Human Hematopoietic Stem/Progenitor Cells by AAV6 Vectors: Strategies for Overcoming Donor-Variation and Implications in Genome Editing.

Ling C, Bhukhai K, Yin Z, Tan M, Yoder MC, Leboulch P, Payen E, Srivastava A.

Sci Rep. 2016 Oct 19;6:35495. doi: 10.1038/srep35495.

13.

Current and future alternative therapies for beta-thalassemia major.

de Dreuzy E, Bhukhai K, Leboulch P, Payen E.

Biomed J. 2016 Feb;39(1):24-38. doi: 10.1016/j.bj.2015.10.001. Epub 2016 Apr 6. Review.

14.

Inhibition of the acetyl lysine-binding pocket of bromodomain and extraterminal domain proteins interferes with adipogenesis.

Goupille O, Penglong T, Kadri Z, Granger-Locatelli M, Fucharoen S, Maouche-Chrétien L, Prost S, Leboulch P, Chrétien S.

Biochem Biophys Res Commun. 2016 Apr 15;472(4):624-30. doi: 10.1016/j.bbrc.2016.03.013. Epub 2016 Mar 10.

PMID:
26972250
15.

Gene Therapy of the β-Hemoglobinopathies by Lentiviral Transfer of the β(A(T87Q))-Globin Gene.

Negre O, Eggimann AV, Beuzard Y, Ribeil JA, Bourget P, Borwornpinyo S, Hongeng S, Hacein-Bey S, Cavazzana M, Leboulch P, Payen E.

Hum Gene Ther. 2016 Feb;27(2):148-65. doi: 10.1089/hum.2016.007.

16.

Erythropoietin and IGF-1 signaling synchronize cell proliferation and maturation during erythropoiesis.

Kadri Z, Lefevre C, Goupille O, Penglong T, Granger-Locatelli M, Fucharoen S, Maouche-Chretien L, Leboulch P, Chretien S.

Genes Dev. 2015 Dec 15;29(24):2603-16. doi: 10.1101/gad.267633.115.

17.

Highly efficient in vitro and in vivo delivery of functional RNAs using new versatile MS2-chimeric retrovirus-like particles.

Prel A, Caval V, Gayon R, Ravassard P, Duthoit C, Payen E, Maouche-Chretien L, Creneguy A, Nguyen TH, Martin N, Piver E, Sevrain R, Lamouroux L, Leboulch P, Deschaseaux F, Bouillé P, Sensébé L, Pagès JC.

Mol Ther Methods Clin Dev. 2015 Oct 21;2:15039. doi: 10.1038/mtm.2015.39. eCollection 2015.

18.

Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists.

Prost S, Relouzat F, Spentchian M, Ouzegdouh Y, Saliba J, Massonnet G, Beressi JP, Verhoeyen E, Raggueneau V, Maneglier B, Castaigne S, Chomienne C, Chrétien S, Rousselot P, Leboulch P.

Nature. 2015 Sep 17;525(7569):380-3. doi: 10.1038/nature15248. Epub 2015 Sep 2.

PMID:
26331539
19.

Transplantation of Macaca cynomolgus iPS-derived hematopoietic cells in NSG immunodeficient mice.

Abed S, Tubsuwan A, Chaichompoo P, Park IH, Pailleret A, Benyoucef A, Tosca L, De Dreuzy E, Paulard A, Granger-Locatelli M, Relouzat F, Prost S, Tachdjian G, Fucharoen S, Daley GQ, Payen E, Chrétien S, Leboulch P, Maouche-Chrétien L.

Haematologica. 2015 Oct;100(10):e428-31. doi: 10.3324/haematol.2015.127373. Epub 2015 Jun 18. No abstract available.

20.

Preclinical evaluation of efficacy and safety of an improved lentiviral vector for the treatment of β-thalassemia and sickle cell disease.

Negre O, Bartholomae C, Beuzard Y, Cavazzana M, Christiansen L, Courne C, Deichmann A, Denaro M, de Dreuzy E, Finer M, Fronza R, Gillet-Legrand B, Joubert C, Kutner R, Leboulch P, Maouche L, Paulard A, Pierciey FJ, Rothe M, Ryu B, Schmidt M, von Kalle C, Payen E, Veres G.

Curr Gene Ther. 2015;15(1):64-81.

21.

HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia.

Arlet JB, Ribeil JA, Guillem F, Negre O, Hazoume A, Marcion G, Beuzard Y, Dussiot M, Moura IC, Demarest S, de Beauchêne IC, Belaid-Choucair Z, Sevin M, Maciel TT, Auclair C, Leboulch P, Chretien S, Tchertanov L, Baudin-Creuza V, Seigneuric R, Fontenay M, Garrido C, Hermine O, Courtois G.

Nature. 2014 Oct 9;514(7521):242-6. doi: 10.1038/nature13614. Epub 2014 Aug 24.

PMID:
25156257
22.

An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia.

Dussiot M, Maciel TT, Fricot A, Chartier C, Negre O, Veiga J, Grapton D, Paubelle E, Payen E, Beuzard Y, Leboulch P, Ribeil JA, Arlet JB, Coté F, Courtois G, Ginzburg YZ, Daniel TO, Chopra R, Sung V, Hermine O, Moura IC.

Nat Med. 2014 Apr;20(4):398-407. doi: 10.1038/nm.3468. Epub 2014 Mar 23.

PMID:
24658077
23.

Gene therapy: primed for take-off.

Leboulch P.

Nature. 2013 Aug 15;500(7462):280-2. doi: 10.1038/500280a. No abstract available.

PMID:
23955226
24.

Parallel assessment of globin lentiviral transfer in induced pluripotent stem cells and adult hematopoietic stem cells derived from the same transplanted β-thalassemia patient.

Tubsuwan A, Abed S, Deichmann A, Kardel MD, Bartholomä C, Cheung A, Negre O, Kadri Z, Fucharoen S, von Kalle C, Payen E, Chrétien S, Schmidt M, Eaves CJ, Leboulch P, Maouche-Chrétien L.

Stem Cells. 2013 Sep;31(9):1785-94. doi: 10.1002/stem.1436.

25.

Arrayed lentiviral barcoding for quantification analysis of hematopoietic dynamics.

Grosselin J, Sii-Felice K, Payen E, Chretien S, Tronik-Le Roux D, Leboulch P.

Stem Cells. 2013 Oct;31(10):2162-71. doi: 10.1002/stem.1383.

26.

Advances in stem cell transplantation and gene therapy in the β-hemoglobinopathies.

Payen E, Leboulch P.

Hematology Am Soc Hematol Educ Program. 2012;2012:276-83. doi: 10.1182/asheducation-2012.1.276. Review.

PMID:
23233592
27.

BET bromodomain inhibition rescues erythropoietin differentiation of human erythroleukemia cell line UT7.

Goupille O, Penglong T, Lefèvre C, Granger M, Kadri Z, Fucharoen S, Maouche-Chrétien L, Leboulch P, Chrétien S.

Biochem Biophys Res Commun. 2012 Dec 7;429(1-2):1-5. doi: 10.1016/j.bbrc.2012.10.112. Epub 2012 Nov 5.

PMID:
23137537
28.

Stem cell factor-displaying simian immunodeficiency viral vectors together with a low conditioning regimen allow for long-term engraftment of gene-marked autologous hematopoietic stem cells in macaques.

Verhoeyen E, Relouzat F, Cambot M, Costa C, Nègre D, Legrand F, Joubert C, Le Grand R, Cosset FL, Leboulch P, Dubart-Kupperschmitt A, Prost S.

Hum Gene Ther. 2012 Jul;23(7):754-68. doi: 10.1089/hum.2012.020. Epub 2012 Jul 11.

29.

Lentivirus vectors in β-thalassemia.

Payen E, Colomb C, Negre O, Beuzard Y, Hehir K, Leboulch P.

Methods Enzymol. 2012;507:109-24. doi: 10.1016/B978-0-12-386509-0.00006-5.

PMID:
22365771
30.

Deficiency of the cytoskeletal protein SPECC1L leads to oblique facial clefting.

Saadi I, Alkuraya FS, Gisselbrecht SS, Goessling W, Cavallesco R, Turbe-Doan A, Petrin AL, Harris J, Siddiqui U, Grix AW Jr, Hove HD, Leboulch P, Glover TW, Morton CC, Richieri-Costa A, Murray JC, Erickson RP, Maas RL.

Am J Hum Genet. 2011 Jul 15;89(1):44-55. doi: 10.1016/j.ajhg.2011.05.023. Epub 2011 Jun 23.

31.

Correction of murine β-thalassemia after minimal lentiviral gene transfer and homeostatic in vivo erythroid expansion.

Negre O, Fusil F, Colomb C, Roth S, Gillet-Legrand B, Henri A, Beuzard Y, Bushman F, Leboulch P, Payen E.

Blood. 2011 May 19;117(20):5321-31. doi: 10.1182/blood-2010-01-263582. Epub 2011 Mar 24.

32.

A method to sequence and quantify DNA integration for monitoring outcome in gene therapy.

Brady T, Roth SL, Malani N, Wang GP, Berry CC, Leboulch P, Hacein-Bey-Abina S, Cavazzana-Calvo M, Papapetrou EP, Sadelain M, Savilahti H, Bushman FD.

Nucleic Acids Res. 2011 Jun;39(11):e72. doi: 10.1093/nar/gkr140. Epub 2011 Mar 16.

33.

Distribution of lentiviral vector integration sites in mice following therapeutic gene transfer to treat β-thalassemia.

Ronen K, Negre O, Roth S, Colomb C, Malani N, Denaro M, Brady T, Fusil F, Gillet-Legrand B, Hehir K, Beuzard Y, Leboulch P, Down JD, Payen E, Bushman FD.

Mol Ther. 2011 Jul;19(7):1273-86. doi: 10.1038/mt.2011.20. Epub 2011 Mar 8.

34.

Is normal hematopoiesis maintained solely by long-term multipotent stem cells?

Cavazzana-Calvo M, Fischer A, Bushman FD, Payen E, Hacein-Bey-Abina S, Leboulch P.

Blood. 2011 Apr 28;117(17):4420-4. doi: 10.1182/blood-2010-09-255679. Epub 2011 Feb 8. Review.

35.

Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia.

Cavazzana-Calvo M, Payen E, Negre O, Wang G, Hehir K, Fusil F, Down J, Denaro M, Brady T, Westerman K, Cavallesco R, Gillet-Legrand B, Caccavelli L, Sgarra R, Maouche-Chrétien L, Bernaudin F, Girot R, Dorazio R, Mulder GJ, Polack A, Bank A, Soulier J, Larghero J, Kabbara N, Dalle B, Gourmel B, Socie G, Chrétien S, Cartier N, Aubourg P, Fischer A, Cornetta K, Galacteros F, Beuzard Y, Gluckman E, Bushman F, Hacein-Bey-Abina S, Leboulch P.

Nature. 2010 Sep 16;467(7313):318-22. doi: 10.1038/nature09328.

36.

Dynamics of gene-modified progenitor cells analyzed by tracking retroviral integration sites in a human SCID-X1 gene therapy trial.

Wang GP, Berry CC, Malani N, Leboulch P, Fischer A, Hacein-Bey-Abina S, Cavazzana-Calvo M, Bushman FD.

Blood. 2010 Jun 3;115(22):4356-66. doi: 10.1182/blood-2009-12-257352. Epub 2010 Mar 12.

37.

Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy.

Cartier N, Hacein-Bey-Abina S, Bartholomae CC, Veres G, Schmidt M, Kutschera I, Vidaud M, Abel U, Dal-Cortivo L, Caccavelli L, Mahlaoui N, Kiermer V, Mittelstaedt D, Bellesme C, Lahlou N, Lefrère F, Blanche S, Audit M, Payen E, Leboulch P, l'Homme B, Bougnères P, Von Kalle C, Fischer A, Cavazzana-Calvo M, Aubourg P.

Science. 2009 Nov 6;326(5954):818-23. doi: 10.1126/science.1171242.

38.

Direct binding of pRb/E2F-2 to GATA-1 regulates maturation and terminal cell division during erythropoiesis.

Kadri Z, Shimizu R, Ohneda O, Maouche-Chretien L, Gisselbrecht S, Yamamoto M, Romeo PH, Leboulch P, Chretien S.

PLoS Biol. 2009 Jun 9;7(6):e1000123. doi: 10.1371/journal.pbio.1000123. Epub 2009 Jun 9.

39.

Phenotypic and functional changes induced in hematopoietic stem/progenitor cells after gamma-ray radiation exposure.

Simonnet AJ, Nehmé J, Vaigot P, Barroca V, Leboulch P, Tronik-Le Roux D.

Stem Cells. 2009 Jun;27(6):1400-9. doi: 10.1002/stem.66.

40.

Atypical BSE (BASE) transmitted from asymptomatic aging cattle to a primate.

Comoy EE, Casalone C, Lescoutra-Etchegaray N, Zanusso G, Freire S, Marcé D, Auvré F, Ruchoux MM, Ferrari S, Monaco S, Salès N, Caramelli M, Leboulch P, Brown P, Lasmézas CI, Deslys JP.

PLoS One. 2008 Aug 20;3(8):e3017. doi: 10.1371/journal.pone.0003017.

41.

Activation and inhibition of the erythropoietin receptor by a membrane-anchored erythropoietin.

Negre O, Fusil F, Henri A, Villette JM, Leboulch P, Beuzard Y, Payen E.

Exp Hematol. 2008 Apr;36(4):412-23. doi: 10.1016/j.exphem.2007.12.004. Epub 2008 Mar 4.

PMID:
18295963
42.

Design of a trans protease lentiviral packaging system that produces high titer virus.

Westerman KA, Ao Z, Cohen EA, Leboulch P.

Retrovirology. 2007 Dec 28;4:96. doi: 10.1186/1742-4690-4-96.

43.

Targeted gene correction with 5' acridine-oligonucleotide conjugates.

de Piédoue G, Andrieu-Soler C, Concordet JP, Maurisse R, Sun JS, Lopez B, Kuzniak I, Leboulch P, Feugeas JP.

Oligonucleotides. 2007 Summer;17(2):258-63.

PMID:
17638529
44.

Survival of liver failure pigs by transplantation of reversibly immortalized human hepatocytes with Tamoxifen-mediated self-recombination.

Totsugawa T, Yong C, Rivas-Carrillo JD, Soto-Gutierrez A, Navarro-Alvarez N, Noguchi H, Okitsu T, Westerman KA, Kohara M, Reth M, Tanaka N, Leboulch P, Kobayashi N.

J Hepatol. 2007 Jul;47(1):74-82. Epub 2007 Mar 15.

PMID:
17434229
45.

Postnatal neovascularization by endothelial progenitor cells immortalized with the simian virus 40T antigen gene.

Qiu HY, Fujimori Y, Nishioka K, Yamaguchi N, Hashimoto-Tamaoki T, Sugihara A, Terada N, Nagaya N, Kanda M, Kobayashi N, Tanaka N, Westerman KA, Leboulch P, Hara H.

Int J Oncol. 2006 Apr;28(4):815-21.

PMID:
16525629
46.

A phase I/II clinical trial of beta-globin gene therapy for beta-thalassemia.

Bank A, Dorazio R, Leboulch P.

Ann N Y Acad Sci. 2005;1054:308-16.

PMID:
16339679
47.

A human beta-cell line for transplantation therapy to control type 1 diabetes.

Narushima M, Kobayashi N, Okitsu T, Tanaka Y, Li SA, Chen Y, Miki A, Tanaka K, Nakaji S, Takei K, Gutierrez AS, Rivas-Carrillo JD, Navarro-Alvarez N, Jun HS, Westerman KA, Noguchi H, Lakey JR, Leboulch P, Tanaka N, Yoon JW.

Nat Biotechnol. 2005 Oct;23(10):1274-82. Epub 2005 Sep 25.

PMID:
16186810
48.

Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation.

Kadri Z, Maouche-Chretien L, Rooke HM, Orkin SH, Romeo PH, Mayeux P, Leboulch P, Chretien S.

Mol Cell Biol. 2005 Sep;25(17):7412-22.

49.

Tolerance by selective in vivo expansion of foreign major histocompatibility complex-transduced autologous bone marrow.

Zhang JL, Cai J, Walls S, Jackson JD, Kuszynski CA, Zhao Y, Pawliuk R, Leboulch P, Fox IJ.

Transplantation. 2005 Aug 15;80(3):362-9.

PMID:
16082332
50.

eGFP reporter genes silence LCRbeta-globin transgene expression via CpG dinucleotides.

Dalle B, Rubin JE, Alkan O, Sukonnik T, Pasceri P, Yao S, Pawliuk R, Leboulch P, Ellis J.

Mol Ther. 2005 Apr;11(4):591-9.

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