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Quantitative Sub-Surface Spatial Frequency-Domain Fluorescence Imaging for Enhanced Glioma Resection.

Sibai M, Wirth DJ, Leblond F, Roberts DW, Paulsen KD, Wilson BC.

J Biophotonics. 2018 Oct 24:e201800271. doi: 10.1002/jbio.201800271. [Epub ahead of print]


PBI-4050 Reduces Stellate Cell Activation and Liver Fibrosis through Modulation of Intracellular ATP Levels and the Liver Kinase B1/AMP-Activated Protein Kinase/Mammalian Target of Rapamycin Pathway.

Grouix B, Sarra-Bournet F, Leduc M, Simard JC, Hince K, Geerts L, Blais A, Gervais L, Laverdure A, Felton A, Richard J, Ouboudinar J, Gagnon W, Leblond FA, Laurin P, Gagnon L.

J Pharmacol Exp Ther. 2018 Oct;367(1):71-81. doi: 10.1124/jpet.118.250068. Epub 2018 Aug 9.


Fluorescence hyperspectral imaging for live monitoring of multiple spheroids in microfluidic chips.

St-Georges-Robillard A, Masse M, Cahuzac M, Strupler M, Patra B, Orimoto AM, Kendall-Dupont J, Péant B, Mes-Masson AM, Leblond F, Gervais T.

Analyst. 2018 Aug 6;143(16):3829-3840. doi: 10.1039/c8an00536b.


Rationale for the administration of systemic 5-FU in combination with heated intraperitonal oxaliplatin.

Badrudin D, Sideris L, Leblond FA, Pichette V, Cloutier AS, Drolet P, Dubé P.

Surg Oncol. 2018 Jun;27(2):275-279. doi: 10.1016/j.suronc.2018.05.004. Epub 2018 May 6.


Mesoscopic characterization of prostate cancer using Raman spectroscopy: potential for diagnostics and therapeutics.

Aubertin K, Trinh VQ, Jermyn M, Baksic P, Grosset AA, Desroches J, St-Arnaud K, Birlea M, Vladoiu MC, Latour M, Albadine R, Saad F, Leblond F, Trudel D.

BJU Int. 2018 Aug;122(2):326-336. doi: 10.1111/bju.14199. Epub 2018 Apr 13.


Challenges and opportunities in clinical translation of biomedical optical spectroscopy and imaging.

Wilson BC, Jermyn M, Leblond F.

J Biomed Opt. 2018 Mar;23(3):1-13. doi: 10.1117/1.JBO.23.3.030901.


A Newly Discovered Antifibrotic Pathway Regulated by Two Fatty Acid Receptors: GPR40 and GPR84.

Gagnon L, Leduc M, Thibodeau JF, Zhang MZ, Grouix B, Sarra-Bournet F, Gagnon W, Hince K, Tremblay M, Geerts L, Kennedy CRJ, Hébert RL, Gutsol A, Holterman CE, Kamto E, Gervais L, Ouboudinar J, Richard J, Felton A, Laverdure A, Simard JC, Létourneau S, Cloutier MP, Leblond FA, Abbott SD, Penney C, Duceppe JS, Zacharie B, Dupuis J, Calderone A, Nguyen QT, Harris RC, Laurin P.

Am J Pathol. 2018 May;188(5):1132-1148. doi: 10.1016/j.ajpath.2018.01.009. Epub 2018 Feb 16.


A new method using Raman spectroscopy for in vivo targeted brain cancer tissue biopsy.

Desroches J, Jermyn M, Pinto M, Picot F, Tremblay MA, Obaid S, Marple E, Urmey K, Trudel D, Soulez G, Guiot MC, Wilson BC, Petrecca K, Leblond F.

Sci Rep. 2018 Jan 29;8(1):1792. doi: 10.1038/s41598-018-20233-3.


Comparison of open and closed abdomen techniques for the delivery of intraperitoneal pemetrexed using a murine model.

Badrudin D, Sideris L, Perrault-Mercier C, Hubert J, Leblond FA, Dubé P.

J Surg Oncol. 2018 May;117(6):1318-1322. doi: 10.1002/jso.24960. Epub 2018 Jan 22.


Development and characterization of a handheld hyperspectral Raman imaging probe system for molecular characterization of tissue on mesoscopic scales.

St-Arnaud K, Aubertin K, Strupler M, Madore WJ, Grosset AA, Petrecca K, Trudel D, Leblond F.

Med Phys. 2018 Jan;45(1):328-339. doi: 10.1002/mp.12657. Epub 2017 Nov 27.


Dimension reduction technique using a multilayered descriptor for high-precision classification of ovarian cancer tissue using optical coherence tomography: a feasibility study.

St-Pierre C, Madore WJ, De Montigny E, Trudel D, Boudoux C, Godbout N, Mes-Masson AM, Rahimi K, Leblond F.

J Med Imaging (Bellingham). 2017 Oct;4(4):041306. doi: 10.1117/1.JMI.4.4.041306. Epub 2017 Oct 12.


Fluorescence depth estimation from wide-field optical imaging data for guiding brain tumor resection: a multi-inclusion phantom study.

Wirth D, Kolste K, Kanick S, Roberts DW, Leblond F, Paulsen KD.

Biomed Opt Express. 2017 Jul 14;8(8):3656-3670. doi: 10.1364/BOE.8.003656. eCollection 2017 Aug 1.


Red-light excitation of protoporphyrin IX fluorescence for subsurface tumor detection.

Roberts DW, Olson JD, Evans LT, Kolste KK, Kanick SC, Fan X, Bravo JJ, Wilson BC, Leblond F, Marois M, Paulsen KD.

J Neurosurg. 2018 Jun;128(6):1690-1697. doi: 10.3171/2017.1.JNS162061. Epub 2017 Aug 4.


Preclinical evaluation of spatial frequency domain-enabled wide-field quantitative imaging for enhanced glioma resection.

Sibai M, Fisher C, Veilleux I, Elliott JT, Leblond F, Roberts DW, Wilson BC.

J Biomed Opt. 2017 Jul 1;22(7):76007. doi: 10.1117/1.JBO.22.7.076007.


Highly Accurate Detection of Cancer In Situ with Intraoperative, Label-Free, Multimodal Optical Spectroscopy.

Jermyn M, Mercier J, Aubertin K, Desroches J, Urmey K, Karamchandiani J, Marple E, Guiot MC, Leblond F, Petrecca K.

Cancer Res. 2017 Jul 15;77(14):3942-3950. doi: 10.1158/0008-5472.CAN-17-0668. Epub 2017 Jun 28.


Mechanism of insulin resistance in a rat model of kidney disease and the risk of developing type 2 diabetes.

Dion F, Dumayne C, Henley N, Beauchemin S, Arias EB, Leblond FA, Lesage S, Lefrançois S, Cartee GD, Pichette V.

PLoS One. 2017 May 1;12(5):e0176650. doi: 10.1371/journal.pone.0176650. eCollection 2017.


Optical diagnosis - highlighting the clinical applications of vibrational spectroscopy.

Gough KM, Leblond F.

Analyst. 2017 Apr 10;142(8):1177-1178. doi: 10.1039/c7an90013a. No abstract available.


Raman spectroscopy detects distant invasive brain cancer cells centimeters beyond MRI capability in humans.

Jermyn M, Desroches J, Mercier J, St-Arnaud K, Guiot MC, Leblond F, Petrecca K.

Biomed Opt Express. 2016 Nov 16;7(12):5129-5137. doi: 10.1364/BOE.7.005129. eCollection 2016 Dec 1.


Wide-field spontaneous Raman spectroscopy imaging system for biological tissue interrogation.

St-Arnaud K, Aubertin K, Strupler M, Jermyn M, Petrecca K, Trudel D, Leblond F.

Opt Lett. 2016 Oct 15;41(20):4692-4695. doi: 10.1364/OL.41.004692.


Raman spectroscopy in microsurgery: impact of operating microscope illumination sources on data quality and tissue classification.

Desroches J, Laurence A, Jermyn M, Pinto M, Tremblay MA, Petrecca K, Leblond F.

Analyst. 2017 Apr 10;142(8):1185-1191. doi: 10.1039/c6an02061e.


A review of Raman spectroscopy advances with an emphasis on clinical translation challenges in oncology.

Jermyn M, Desroches J, Aubertin K, St-Arnaud K, Madore WJ, De Montigny E, Guiot MC, Trudel D, Wilson BC, Petrecca K, Leblond F.

Phys Med Biol. 2016 Dec 7;61(23):R370-R400. Epub 2016 Nov 2. Review.


Intraoperative video-rate hemodynamic response assessment in human cortex using snapshot hyperspectral optical imaging.

Pichette J, Laurence A, Angulo L, Lesage F, Bouthillier A, Nguyen DK, Leblond F.

Neurophotonics. 2016 Oct;3(4):045003. Epub 2016 Oct 12.


Neural networks improve brain cancer detection with Raman spectroscopy in the presence of operating room light artifacts.

Jermyn M, Desroches J, Mercier J, Tremblay MA, St-Arnaud K, Guiot MC, Petrecca K, Leblond F.

J Biomed Opt. 2016 Sep 1;21(9):94002. doi: 10.1117/1.JBO.21.9.094002.


Changes in Urinary and Serum Levels of Novel Biomarkers after Administration of Gadolinium-based Contrast Agents.

Mawad H, Laurin LP, Naud JF, Leblond FA, Henley N, Vallée M, Pichette V, Leblanc M.

Biomark Insights. 2016 Jun 29;11:91-4. doi: 10.4137/BMI.S39199. eCollection 2016.


Effects of Chronic Renal Failure on Brain Cytochrome P450 in Rats.

Naud J, Harding J, Lamarche C, Beauchemin S, Leblond FA, Pichette V.

Drug Metab Dispos. 2016 Aug;44(8):1174-9. doi: 10.1124/dmd.116.070052. Epub 2016 Jun 6.


Electrocautery effect on intestinal vascularisation in a murine model.

Tremblay JF, Sideris L, Leblond FA, Trépanier JS, Badrudin D, Drolet P, Mitchell A, Dubé P.

Int J Hyperthermia. 2016 Sep;32(6):643-7. doi: 10.1080/02656736.2016.1181276. Epub 2016 Jun 7.


Pharmacokinetics and the effect of heat on intraperitoneal pemetrexed using a murine model.

Badrudin D, Perrault-Mercier C, Bouchard-Fortier A, Hubert J, Leblond FA, Sideris L, Dubé P.

Surg Oncol. 2016 Dec;25(4):435-440. doi: 10.1016/j.suronc.2016.05.014. Epub 2016 May 20.


Age-Dependent Demethylation of Sod2 Promoter in the Mouse Femoral Artery.

Nguyen A, Leblond F, Mamarbachi M, Geoffroy S, Thorin E.

Oxid Med Cell Longev. 2016;2016:8627384. doi: 10.1155/2016/8627384. Epub 2016 Feb 16.


Improved sensitivity to fluorescence for cancer detection in wide-field image-guided neurosurgery.

Jermyn M, Gosselin Y, Valdes PA, Sibai M, Kolste K, Mercier J, Angulo L, Roberts DW, Paulsen KD, Petrecca K, Daigle O, Wilson BC, Leblond F.

Biomed Opt Express. 2015 Nov 30;6(12):5063-74. doi: 10.1364/BOE.6.005063. eCollection 2015 Dec 1.


Introduction to the optics and the brain 2015 feature issue.

Pavone FS, Hillman E, Leblond F, Shoham S.

Biomed Opt Express. 2015 Nov 20;6(12):4992-3. doi: 10.1364/BOE.6.004992. eCollection 2015 Dec 1.


Quantitative spatial frequency fluorescence imaging in the sub-diffusive domain for image-guided glioma resection.

Sibai M, Veilleux I, Elliott JT, Leblond F, Wilson BC.

Biomed Opt Express. 2015 Nov 19;6(12):4923-33. doi: 10.1364/BOE.6.004923. eCollection 2015 Dec 1.


Validation and Application of a Simple UHPLC-MS-MS Method for the Enantiospecific Determination of Warfarin in Human Urine.

Alshogran OY, Ocque AJ, Leblond FA, Pichette V, Nolin TD.

J Chromatogr Sci. 2016 Apr;54(4):554-60. doi: 10.1093/chromsci/bmv186. Epub 2015 Dec 11.


Sensitivity analysis aimed at blood vessels detection using interstitial optical tomography during brain needle biopsy procedures.

Pichette J, Goyette A, Picot F, Tremblay MA, Soulez G, Wilson BC, Leblond F.

Biomed Opt Express. 2015 Oct 5;6(11):4238-54. doi: 10.1364/BOE.6.004238. eCollection 2015 Nov 1.


In Vitro and In Vivo Mechanistic Studies toward Understanding the Role of 1-Aminobenzotriazole in Rat Drug-Drug Interactions.

Boily MO, Chauret N, Laterreur J, Leblond FA, Boudreau C, Duquet MC, Lévesque JF, Ste-Marie L, Pichette V.

Drug Metab Dispos. 2015 Dec;43(12):1960-5. doi: 10.1124/dmd.115.066357. Epub 2015 Oct 5.


Characterization of a Raman spectroscopy probe system for intraoperative brain tissue classification.

Desroches J, Jermyn M, Mok K, Lemieux-Leduc C, Mercier J, St-Arnaud K, Urmey K, Guiot MC, Marple E, Petrecca K, Leblond F.

Biomed Opt Express. 2015 Jun 8;6(7):2380-97. doi: 10.1364/BOE.6.002380. eCollection 2015 Jul 1.


Quantitative fluorescence using 5-aminolevulinic acid-induced protoporphyrin IX biomarker as a surgical adjunct in low-grade glioma surgery.

Valdés PA, Jacobs V, Harris BT, Wilson BC, Leblond F, Paulsen KD, Roberts DW.

J Neurosurg. 2015 Sep;123(3):771-80. doi: 10.3171/2014.12.JNS14391. Epub 2015 Jul 3.


[Drug pharmacokinetics in renal failure: What's new?].

Naud J, Dumayne C, Nolin TD, Leblond FA, Pichette V.

Nephrol Ther. 2015 Jun;11(3):144-51. doi: 10.1016/j.nephro.2014.12.006. Epub 2015 Apr 7. Review. French.


Macroscopic-imaging technique for subsurface quantification of near-infrared markers during surgery.

Jermyn M, Kolste K, Pichette J, Sheehy G, Angulo-Rodríguez L, Paulsen KD, Roberts DW, Wilson BC, Petrecca K, Leblond F.

J Biomed Opt. 2015 Mar;20(3):036014. doi: 10.1117/1.JBO.20.3.036014.


Sub-diffuse interstitial optical tomography to improve the safety of brain needle biopsies: a proof-of-concept study.

Goyette A, Pichette J, Tremblay MA, Laurence A, Jermyn M, Mok K, Paulsen KD, Roberts DW, Petrecca K, Wilson BC, Leblond F.

Opt Lett. 2015 Jan 15;40(2):170-3. doi: 10.1364/OL.40.000170.


Intraoperative brain cancer detection with Raman spectroscopy in humans.

Jermyn M, Mok K, Mercier J, Desroches J, Pichette J, Saint-Arnaud K, Bernstein L, Guiot MC, Petrecca K, Leblond F.

Sci Transl Med. 2015 Feb 11;7(274):274ra19. doi: 10.1126/scitranslmed.aaa2384.


Macroscopic optical imaging technique for wide-field estimation of fluorescence depth in optically turbid media for application in brain tumor surgical guidance.

Kolste KK, Kanick SC, Valdés PA, Jermyn M, Wilson BC, Roberts DW, Paulsen KD, Leblond F.

J Biomed Opt. 2015 Feb;20(2):26002. doi: 10.1117/1.JBO.20.2.026002.


Effect of experimental kidney disease on the functional expression of hepatic reductases.

Alshogran OY, Naud J, Ocque AJ, Leblond FA, Pichette V, Nolin TD.

Drug Metab Dispos. 2015 Jan;43(1):100-6. doi: 10.1124/dmd.114.061150. Epub 2014 Oct 20.


Effect of parathyroidectomy on vitamin D levels.

Lamarche C, Leblond F, Ouimet D, Pichette V.

World J Surg. 2015 May;39(5):1333-4. doi: 10.1007/s00268-014-2836-0. No abstract available.


The anti-hypercholesterolemic effect of low p53 expression protects vascular endothelial function in mice.

Leblond F, Poirier S, Yu C, Duquette N, Mayer G, Thorin E.

PLoS One. 2014 Mar 19;9(3):e92394. doi: 10.1371/journal.pone.0092394. eCollection 2014.


Methodology to optimize detector geometry in fluorescence tomography of tissue using the minimized curvature of the summed diffuse sensitivity projections.

Holt RW, Leblond FL, Pogue BW.

J Opt Soc Am A Opt Image Sci Vis. 2013 Aug 1;30(8):1613-9. doi: 10.1364/JOSAA.30.001613.


Determination of warfarin alcohols by ultra-high performance liquid chromatography-tandem mass spectrometry: application to in vitro enzyme kinetic studies.

Alshogran OY, Ocque AJ, Zhao J, Day BW, Leblond FA, Pichette V, Nolin TD.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Jan 1;944:63-8. doi: 10.1016/j.jchromb.2013.11.014. Epub 2013 Nov 14.


System and methods for wide-field quantitative fluorescence imaging during neurosurgery.

Valdes PA, Jacobs VL, Wilson BC, Leblond F, Roberts DW, Paulsen KD.

Opt Lett. 2013 Aug 1;38(15):2786-8. doi: 10.1364/OL.38.002786.


5-Aminolevulinic acid-induced protoporphyrin IX fluorescence in meningioma: qualitative and quantitative measurements in vivo.

Valdes PA, Bekelis K, Harris BT, Wilson BC, Leblond F, Kim A, Simmons NE, Erkmen K, Paulsen KD, Roberts DW.

Neurosurgery. 2014 Mar;10 Suppl 1:74-82; discussion 82-3. doi: 10.1227/NEU.0000000000000117.


Bicarbonates for the prevention of postoperative renal failure in endovascular aortic aneurysm repair: a randomized pilot trial.

Brulotte V, Leblond FA, Elkouri S, Thérasse E, Pichette V, Beaulieu P.

Anesthesiol Res Pract. 2013;2013:467326. doi: 10.1155/2013/467326. Epub 2013 Jun 12.


Transplantation of mesenchymal stem cells promotes tissue regeneration in a glaucoma model through laser-induced paracrine factor secretion and progenitor cell recruitment.

Manuguerra-Gagné R, Boulos PR, Ammar A, Leblond FA, Krosl G, Pichette V, Lesk MR, Roy DC.

Stem Cells. 2013 Jun;31(6):1136-48. doi: 10.1002/stem.1364.

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