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Items: 38

1.

Podoplanin+ tumor lymphatics are rate limiting for breast cancer metastasis.

Chen Y, Keskin D, Sugimoto H, Kanasaki K, Phillips PE, Bizarro L, Sharpe A, LeBleu VS, Kalluri R.

PLoS Biol. 2018 Dec 28;16(12):e2005907. doi: 10.1371/journal.pbio.2005907. eCollection 2018 Dec.

2.

Loss of placental growth factor ameliorates maternal hypertension and preeclampsia in mice.

Parchem JG, Kanasaki K, Kanasaki M, Sugimoto H, Xie L, Hamano Y, Lee SB, Gattone VH, Parry S, Strauss JF, Garovic VD, McElrath TF, Lu KH, Sibai BM, LeBleu VS, Carmeliet P, Kalluri R.

J Clin Invest. 2018 Nov 1;128(11):5008-5017. doi: 10.1172/JCI99026. Epub 2018 Oct 8.

3.

Dual reporter genetic mouse models of pancreatic cancer identify an epithelial-to-mesenchymal transition-independent metastasis program.

Chen Y, LeBleu VS, Carstens JL, Sugimoto H, Zheng X, Malasi S, Saur D, Kalluri R.

EMBO Mol Med. 2018 Oct;10(10). pii: e9085. doi: 10.15252/emmm.201809085.

4.

Endoglin Targeting in Colorectal Tumor Microenvironment.

Becker LM, LeBleu VS.

Clin Cancer Res. 2018 Dec 15;24(24):6110-6111. doi: 10.1158/1078-0432.CCR-18-2023. Epub 2018 Aug 3.

PMID:
30076135
5.

BMP7 Signaling in TGFBR2-Deficient Stromal Cells Provokes Epithelial Carcinogenesis.

Eikesdal HP, Becker LM, Teng Y, Kizu A, Carstens JL, Kanasaki K, Sugimoto H, LeBleu VS, Kalluri R.

Mol Cancer Res. 2018 Oct;16(10):1568-1578. doi: 10.1158/1541-7786.MCR-18-0120. Epub 2018 Jun 22.

PMID:
29934328
6.

A peek into cancer-associated fibroblasts: origins, functions and translational impact.

LeBleu VS, Kalluri R.

Dis Model Mech. 2018 Apr 19;11(4). pii: dmm029447. doi: 10.1242/dmm.029447. Review.

7.

Generation and testing of clinical-grade exosomes for pancreatic cancer.

Mendt M, Kamerkar S, Sugimoto H, McAndrews KM, Wu CC, Gagea M, Yang S, Blanko EVR, Peng Q, Ma X, Marszalek JR, Maitra A, Yee C, Rezvani K, Shpall E, LeBleu VS, Kalluri R.

JCI Insight. 2018 Apr 19;3(8). pii: 99263. doi: 10.1172/jci.insight.99263. [Epub ahead of print]

8.

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer.

Kamerkar S, LeBleu VS, Sugimoto H, Yang S, Ruivo CF, Melo SA, Lee JJ, Kalluri R.

Nature. 2017 Jun 22;546(7659):498-503. doi: 10.1038/nature22341. Epub 2017 Jun 7.

9.

Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer.

Carstens JL, Correa de Sampaio P, Yang D, Barua S, Wang H, Rao A, Allison JP, LeBleu VS, Kalluri R.

Nat Commun. 2017 Apr 27;8:15095. doi: 10.1038/ncomms15095.

10.

Discovery of Double-Stranded Genomic DNA in Circulating Exosomes.

Kalluri R, LeBleu VS.

Cold Spring Harb Symp Quant Biol. 2016;81:275-280. doi: 10.1101/sqb.2016.81.030932. Epub 2017 Apr 19. Review.

PMID:
28424339
11.

Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer.

Yang S, Che SP, Kurywchak P, Tavormina JL, Gansmo LB, Correa de Sampaio P, Tachezy M, Bockhorn M, Gebauer F, Haltom AR, Melo SA, LeBleu VS, Kalluri R.

Cancer Biol Ther. 2017 Mar 4;18(3):158-165. doi: 10.1080/15384047.2017.1281499. Epub 2017 Jan 25.

12.

Heterogeneous perivascular cell coverage affects breast cancer metastasis and response to chemotherapy.

Kim J, de Sampaio PC, Lundy DM, Peng Q, Evans KW, Sugimoto H, Gagea M, Kienast Y, do Amaral NS, Rocha RM, Eikesdal HP, Lønning PE, Meric-Bernstam F, LeBleu VS.

JCI Insight. 2016 Dec 22;1(21):e90733. doi: 10.1172/jci.insight.90733.

13.

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.

Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM.

Nat Med. 2016 May;22(5):497-505. doi: 10.1038/nm.4082. Epub 2016 Apr 18.

14.

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival.

Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver VM, Maitra A, Allison JP, LeBleu VS, Kalluri R.

Cancer Cell. 2015 Dec 14;28(6):831-833. doi: 10.1016/j.ccell.2015.11.002. Epub 2015 Dec 14. No abstract available.

15.

Mass Spectrometry and Antibody-Based Characterization of Blood Vessels from Brachylophosaurus canadensis.

Cleland TP, Schroeter ER, Zamdborg L, Zheng W, Lee JE, Tran JC, Bern M, Duncan MB, Lebleu VS, Ahlf DR, Thomas PM, Kalluri R, Kelleher NL, Schweitzer MH.

J Proteome Res. 2015 Dec 4;14(12):5252-62. doi: 10.1021/acs.jproteome.5b00675. Epub 2015 Nov 23.

16.

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer.

Zheng X, Carstens JL, Kim J, Scheible M, Kaye J, Sugimoto H, Wu CC, LeBleu VS, Kalluri R.

Nature. 2015 Nov 26;527(7579):525-530. doi: 10.1038/nature16064. Epub 2015 Nov 11.

17.

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis.

Lovisa S, LeBleu VS, Tampe B, Sugimoto H, Vadnagara K, Carstens JL, Wu CC, Hagos Y, Burckhardt BC, Pentcheva-Hoang T, Nischal H, Allison JP, Zeisberg M, Kalluri R.

Nat Med. 2015 Sep;21(9):998-1009. doi: 10.1038/nm.3902. Epub 2015 Aug 3.

18.

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer.

Melo SA, Luecke LB, Kahlert C, Fernandez AF, Gammon ST, Kaye J, LeBleu VS, Mittendorf EA, Weitz J, Rahbari N, Reissfelder C, Pilarsky C, Fraga MF, Piwnica-Worms D, Kalluri R.

Nature. 2015 Jul 9;523(7559):177-82. doi: 10.1038/nature14581. Epub 2015 Jun 24.

19.

Imaging the Tumor Microenvironment.

LeBleu VS.

Cancer J. 2015 May-Jun;21(3):174-8. doi: 10.1097/PPO.0000000000000118. Review.

20.

Targeting vascular pericytes in hypoxic tumors increases lung metastasis via angiopoietin-2.

Keskin D, Kim J, Cooke VG, Wu CC, Sugimoto H, Gu C, De Palma M, Kalluri R, LeBleu VS.

Cell Rep. 2015 Feb 24;10(7):1066-81. doi: 10.1016/j.celrep.2015.01.035. Epub 2015 Feb 19.

21.

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis.

LeBleu VS, O'Connell JT, Gonzalez Herrera KN, Wikman H, Pantel K, Haigis MC, de Carvalho FM, Damascena A, Domingos Chinen LT, Rocha RM, Asara JM, Kalluri R.

Nat Cell Biol. 2014 Oct;16(10):992-1003, 1-15. doi: 10.1038/ncb3039. Epub 2014 Sep 21. Erratum in: Nat Cell Biol. 2014 Nov;16(11):1125.

22.

Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival.

Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver VM, Maitra A, Allison JP, LeBleu VS, Kalluri R.

Cancer Cell. 2014 Jun 16;25(6):719-34. doi: 10.1016/j.ccr.2014.04.005. Epub 2014 May 22. Erratum in: Cancer Cell. 2015 Dec 14;28(6):831-3.

23.

Reply to Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3.

Sugimoto H, LeBleu VS, Bosukonda D, Keck P, Taduri G, Bechtel W, Okada H, Carlson W, Bey P, Rusckowski M, Tampe B, Tampe D, Kanasaki K, Zeisberg M, Kalluri R.

Nat Med. 2013 Jul;19(7):810-1. doi: 10.1038/nm.3081. No abstract available.

PMID:
23836214
24.

Origin and function of myofibroblasts in kidney fibrosis.

LeBleu VS, Taduri G, O'Connell J, Teng Y, Cooke VG, Woda C, Sugimoto H, Kalluri R.

Nat Med. 2013 Aug;19(8):1047-53. doi: 10.1038/nm.3218. Epub 2013 Jun 30.

25.

Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis.

LeBleu VS, Teng Y, O'Connell JT, Charytan D, Müller GA, Müller CA, Sugimoto H, Kalluri R.

Nat Med. 2013 Feb;19(2):227-31. doi: 10.1038/nm.2989. Epub 2013 Jan 27.

26.

TGF-β1-containing exosomes from injured epithelial cells activate fibroblasts to initiate tissue regenerative responses and fibrosis.

Borges FT, Melo SA, Özdemir BC, Kato N, Revuelta I, Miller CA, Gattone VH 2nd, LeBleu VS, Kalluri R.

J Am Soc Nephrol. 2013 Feb;24(3):385-92. doi: 10.1681/ASN.2012101031. Epub 2012 Dec 28.

27.

Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis.

Sugimoto H, LeBleu VS, Bosukonda D, Keck P, Taduri G, Bechtel W, Okada H, Carlson W Jr, Bey P, Rusckowski M, Tampe B, Tampe D, Kanasaki K, Zeisberg M, Kalluri R.

Nat Med. 2012 Feb 5;18(3):396-404. doi: 10.1038/nm.2629.

28.

Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway.

Cooke VG, LeBleu VS, Keskin D, Khan Z, O'Connell JT, Teng Y, Duncan MB, Xie L, Maeda G, Vong S, Sugimoto H, Rocha RM, Damascena A, Brentani RR, Kalluri R.

Cancer Cell. 2012 Jan 17;21(1):66-81. doi: 10.1016/j.ccr.2011.11.024.

29.

Blockade of PDGF receptor signaling reduces myofibroblast number and attenuates renal fibrosis.

LeBleu VS, Kalluri R.

Kidney Int. 2011 Dec;80(11):1119-21. doi: 10.1038/ki.2011.300.

30.

VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization.

O'Connell JT, Sugimoto H, Cooke VG, MacDonald BA, Mehta AI, LeBleu VS, Dewar R, Rocha RM, Brentani RR, Resnick MB, Neilson EG, Zeisberg M, Kalluri R.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16002-7. doi: 10.1073/pnas.1109493108. Epub 2011 Sep 12.

31.

Cell growth and size homeostasis in proliferating animal cells.

Tzur A, Kafri R, LeBleu VS, Lahav G, Kirschner MW.

Science. 2009 Jul 10;325(5937):167-71. doi: 10.1126/science.1174294.

32.

Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis.

Schweitzer MH, Zheng W, Organ CL, Avci R, Suo Z, Freimark LM, Lebleu VS, Duncan MB, Vander Heiden MG, Neveu JM, Lane WS, Cottrell JS, Horner JR, Cantley LC, Kalluri R, Asara JM.

Science. 2009 May 1;324(5927):626-31. doi: 10.1126/science.1165069.

33.

Technology for cell cycle research with unstressed steady-state cultures.

Lebleu VS, Thornton M, Gonda SR, Helmstetter CE.

Cytotechnology. 2006 Jul;51(3):149-57. doi: 10.1007/s10616-006-9024-5. Epub 2006 Nov 21.

34.

Stem cell-based therapy for glomerular diseases: an evolving concept.

LeBleu VS, Kalluri R.

J Am Soc Nephrol. 2008 Sep;19(9):1621-3. doi: 10.1681/ASN.2008070735. Epub 2008 Aug 13. No abstract available.

35.

Lymphocytes are dispensable for glomerulonephritis but required for renal interstitial fibrosis in matrix defect-induced Alport renal disease.

Lebleu VS, Sugimoto H, Miller CA, Gattone VH 2nd, Kalluri R.

Lab Invest. 2008 Mar;88(3):284-92. doi: 10.1038/labinvest.3700715. Epub 2008 Jan 7.

36.

Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus.

Kanasaki K, Kanda Y, Palmsten K, Tanjore H, Lee SB, Lebleu VS, Gattone VH Jr, Kalluri R.

Dev Biol. 2008 Jan 15;313(2):584-93. Epub 2007 Nov 12.

37.

Structure and function of basement membranes.

LeBleu VS, Macdonald B, Kalluri R.

Exp Biol Med (Maywood). 2007 Oct;232(9):1121-9. Review.

PMID:
17895520
38.

BMP-7 functions as a novel hormone to facilitate liver regeneration.

Sugimoto H, Yang C, LeBleu VS, Soubasakos MA, Giraldo M, Zeisberg M, Kalluri R.

FASEB J. 2007 Jan;21(1):256-64. Epub 2006 Nov 20.

PMID:
17116741

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