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Items: 1 to 50 of 79

1.

Structures of K42N and K42Y sperm whale myoglobins point to an inhibitory role of distal water in peroxidase activity.

Wang C, Lovelace LL, Sun S, Dawson JH, Lebioda L.

Acta Crystallogr D Biol Crystallogr. 2014 Nov;70(Pt 11):2833-9. doi: 10.1107/S1399004714017787. Epub 2014 Oct 16.

PMID:
25372675
2.

Influence of heme environment structure on dioxygen affinity for the dual function Amphitrite ornata hemoglobin/dehaloperoxidase. Insights into the evolutional structure-function adaptations.

Sun S, Sono M, Wang C, Du J, Lebioda L, Dawson JH.

Arch Biochem Biophys. 2014 Mar 1;545:108-15. doi: 10.1016/j.abb.2014.01.010. Epub 2014 Jan 16.

PMID:
24440609
3.

Complexes of dual-function hemoglobin/dehaloperoxidase with substrate 2,4,6-trichlorophenol are inhibitory and indicate binding of halophenol to compound I.

Wang C, Lovelace LL, Sun S, Dawson JH, Lebioda L.

Biochemistry. 2013 Sep 10;52(36):6203-10. doi: 10.1021/bi400627w. Epub 2013 Aug 29.

PMID:
23952341
4.

Response to Boguslaw Stec's letter to the editor of Protein Science.

Celeste L, Lovelace L, Lebioda L.

Protein Sci. 2013 Jun;22(6):675-6. doi: 10.1002/pro.2251. Epub 2013 Apr 29. No abstract available.

5.

Complex of myoglobin with phenol bound in a proximal cavity.

Huang X, Wang C, Celeste LR, Lovelace LL, Sun S, Dawson JH, Lebioda L.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Dec 1;68(Pt 12):1465-71. doi: 10.1107/S1744309112045514. Epub 2012 Nov 19.

6.
7.

Mechanism of N10-formyltetrahydrofolate synthetase derived from complexes with intermediates and inhibitors.

Celeste LR, Chai G, Bielak M, Minor W, Lovelace LL, Lebioda L.

Protein Sci. 2012 Feb;21(2):219-28. doi: 10.1002/pro.2005. Epub 2011 Dec 28.

8.
9.

Structural analysis of a putative aminoglycoside N-acetyltransferase from Bacillus anthracis.

Klimecka MM, Chruszcz M, Font J, Skarina T, Shumilin I, Onopryienko O, Porebski PJ, Cymborowski M, Zimmerman MD, Hasseman J, Glomski IJ, Lebioda L, Savchenko A, Edwards A, Minor W.

J Mol Biol. 2011 Jul 15;410(3):411-23. doi: 10.1016/j.jmb.2011.04.076. Epub 2011 May 13.

10.

Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement.

Lovelace LL, Cooper CL, Sodetz JM, Lebioda L.

J Biol Chem. 2011 May 20;286(20):17585-92. doi: 10.1074/jbc.M111.219766. Epub 2011 Mar 25.

11.

Evolution of metamorphism in thymidylate synthases within the primate lineages.

Luo B, Johnson SR, Lebioda L, Berger SH.

J Mol Evol. 2011 Mar;72(3):306-14. doi: 10.1007/s00239-011-9433-8. Epub 2011 Feb 12.

PMID:
21318388
12.

Structures of human thymidylate synthase R163K with dUMP, FdUMP and glutathione show asymmetric ligand binding.

Gibson LM, Celeste LR, Lovelace LL, Lebioda L.

Acta Crystallogr D Biol Crystallogr. 2011 Jan;67(Pt 1):60-6. doi: 10.1107/S0907444910044732. Epub 2010 Dec 16.

13.

Human thymidylate synthase with loop 181-197 stabilized in an inactive conformation: ligand interactions, phosphorylation, and inhibition profiles.

Luo B, Repalli J, Yousef AM, Johnson SR, Lebioda L, Berger SH.

Protein Sci. 2011 Jan;20(1):87-94. doi: 10.1002/pro.539.

14.

Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability .

Huang X, Gibson LM, Bell BJ, Lovelace LL, Peña MM, Berger FG, Berger SH, Lebioda L.

Biochemistry. 2010 Mar 23;49(11):2475-82. doi: 10.1021/bi901457e.

15.

Characterization and inactivation of an agmatine deiminase from Helicobacter pylori.

Jones JE, Causey CP, Lovelace L, Knuckley B, Flick H, Lebioda L, Thompson PR.

Bioorg Chem. 2010 Apr;38(2):62-73. doi: 10.1016/j.bioorg.2009.11.004. Epub 2009 Nov 29.

16.

Variants of human thymidylate synthase with loop 181-197 stabilized in the inactive conformation.

Lovelace LL, Johnson SR, Gibson LM, Bell BJ, Berger SH, Lebioda L.

Protein Sci. 2009 Aug;18(8):1628-36. doi: 10.1002/pro.171.

17.

Structure of the thioredoxin-like domain of yeast glutaredoxin 3.

Gibson LM, Dingra NN, Outten CE, Lebioda L.

Acta Crystallogr D Biol Crystallogr. 2008 Sep;64(Pt 9):927-32. doi: 10.1107/S0907444908021641. Epub 2008 Aug 13.

18.

Data mining of metal ion environments present in protein structures.

Zheng H, Chruszcz M, Lasota P, Lebioda L, Minor W.

J Inorg Biochem. 2008 Sep;102(9):1765-76. doi: 10.1016/j.jinorgbio.2008.05.006. Epub 2008 May 28.

19.

Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit.

Slade DJ, Lovelace LL, Chruszcz M, Minor W, Lebioda L, Sodetz JM.

J Mol Biol. 2008 May 30;379(2):331-42. doi: 10.1016/j.jmb.2008.03.061. Epub 2008 Apr 3.

20.

The R163K mutant of human thymidylate synthase is stabilized in an active conformation: structural asymmetry and reactivity of cysteine 195.

Gibson LM, Lovelace LL, Lebioda L.

Biochemistry. 2008 Apr 22;47(16):4636-43. doi: 10.1021/bi7019386. Epub 2008 Mar 28.

21.

Crystal structure of complement protein C8gamma in complex with a peptide containing the C8gamma binding site on C8alpha: implications for C8gamma ligand binding.

Lovelace LL, Chiswell B, Slade DJ, Sodetz JM, Lebioda L.

Mol Immunol. 2008 Feb;45(3):750-6. Epub 2007 Aug 9.

PMID:
17692377
22.

Structural features of the ligand binding site on human complement protein C8gamma: a member of the lipocalin family.

Chiswell B, Lovelace LL, Brannen C, Ortlund EA, Lebioda L, Sodetz JM.

Biochim Biophys Acta. 2007 May;1774(5):637-44. Epub 2007 Mar 20.

PMID:
17452033
23.

Cooperative inhibition of human thymidylate synthase by mixtures of active site binding and allosteric inhibitors.

Lovelace LL, Gibson LM, Lebioda L.

Biochemistry. 2007 Mar 13;46(10):2823-30. Epub 2007 Feb 13.

24.
25.

Fluoride inhibition of enolase: crystal structure and thermodynamics.

Qin J, Chai G, Brewer JM, Lovelace LL, Lebioda L.

Biochemistry. 2006 Jan 24;45(3):793-800.

26.

Structure of human thymidylate synthase under low-salt conditions.

Lovelace LL, Minor W, Lebioda L.

Acta Crystallogr D Biol Crystallogr. 2005 May;61(Pt 5):622-7. Epub 2005 Apr 20.

PMID:
15858273
27.

Expression, purification and the 1.8 angstroms resolution crystal structure of human neuron specific enolase.

Chai G, Brewer JM, Lovelace LL, Aoki T, Minor W, Lebioda L.

J Mol Biol. 2004 Aug 20;341(4):1015-21.

PMID:
15289101
28.

Effects of ligand binding and conformational switching on intracellular stability of human thymidylate synthase.

Berger SH, Berger FG, Lebioda L.

Biochim Biophys Acta. 2004 Jan 14;1696(1):15-22. Review.

PMID:
14726200
29.

Enzymatic function of loop movement in enolase: preparation and some properties of H159N, H159A, H159F, and N207A enolases.

Brewer JM, Glover CV, Holland MJ, Lebioda L.

J Protein Chem. 2003 May;22(4):353-61.

PMID:
13678299
30.

Crystal structure of a covalent intermediate of endogenous human arylsulfatase A.

Chruszcz M, Laidler P, Monkiewicz M, Ortlund E, Lebioda L, Lewinski K.

J Inorg Biochem. 2003 Aug 1;96(2-3):386-92.

PMID:
12888274
31.

Structure of 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase from Pseudomonas putida.

Bell BJ, Watanabe L, Rios-Steiner JL, Tulinsky A, Lebioda L, Arni RK.

Acta Crystallogr D Biol Crystallogr. 2003 Aug;59(Pt 8):1454-8. Epub 2003 Jul 23.

PMID:
12876349
33.

Crystal structure of human complement protein C8gamma at 1.2 A resolution reveals a lipocalin fold and a distinct ligand binding site.

Ortlund E, Parker CL, Schreck SF, Ginell S, Minor W, Sodetz JM, Lebioda L.

Biochemistry. 2002 Jun 4;41(22):7030-7.

PMID:
12033936
34.

Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.

Phan J, Koli S, Minor W, Dunlap RB, Berger SH, Lebioda L.

Biochemistry. 2001 Feb 20;40(7):1897-902.

PMID:
11329255
35.

Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.

Phan J, Steadman DJ, Koli S, Ding WC, Minor W, Dunlap RB, Berger SH, Lebioda L.

J Biol Chem. 2001 Apr 27;276(17):14170-7. Epub 2001 Jan 24.

36.

The honorary enzyme haemoglobin turns out to be a real enzyme.

Lebioda L.

Cell Mol Life Sci. 2000 Dec;57(13-14):1817-9. No abstract available.

PMID:
11215507
37.

Cation binding and thermostability of FTHFS monovalent cation binding sites and thermostability of N10-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Radfar R, Leaphart A, Brewer JM, Minor W, Odom JD, Dunlap RB, Lovell CR, Lebioda L.

Biochemistry. 2000 Nov 28;39(47):14481-6.

PMID:
11087401
38.

The H159A mutant of yeast enolase 1 has significant activity.

Brewer JM, Holland MJ, Lebioda L.

Biochem Biophys Res Commun. 2000 Oct 5;276(3):1199-202.

PMID:
11027610
39.

Catalytic cysteine of thymidylate synthase is activated upon substrate binding.

Phan J, Mahdavian E, Nivens MC, Minor W, Berger S, Spencer HT, Dunlap RB, Lebioda L.

Biochemistry. 2000 Jun 13;39(23):6969-78.

PMID:
10841779
40.

The crystal structure and amino acid sequence of dehaloperoxidase from Amphitrite ornata indicate common ancestry with globins.

LaCount MW, Zhang E, Chen YP, Han K, Whitton MM, Lincoln DE, Woodin SA, Lebioda L.

J Biol Chem. 2000 Jun 23;275(25):18712-6.

41.

The crystal structure of N(10)-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Radfar R, Shin R, Sheldrick GM, Minor W, Lovell CR, Odom JD, Dunlap RB, Lebioda L.

Biochemistry. 2000 Apr 11;39(14):3920-6.

PMID:
10747779
43.

Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254.

Fantz C, Shaw D, Jennings W, Forsthoefel A, Kitchens M, Phan J, Minor W, Lebioda L, Berger FG, Spencer HT.

Mol Pharmacol. 2000 Feb;57(2):359-66.

PMID:
10648646
44.

Crystal structure of human prostatic acid phosphatase .

Jakob CG, Lewinski K, Kuciel R, Ostrowski W, Lebioda L.

Prostate. 2000 Feb 15;42(3):211-8.

PMID:
10639192
45.

An enzymatic globin from a marine worm.

Lebioda L, LaCount MW, Zhang E, Chen YP, Han K, Whitton MM, Lincoln DE, Woodin SA.

Nature. 1999 Sep 30;401(6752):445. No abstract available.

PMID:
10519547
46.

Structural origins of L(+)-tartrate inhibition of human prostatic acid phosphatase.

LaCount MW, Handy G, Lebioda L.

J Biol Chem. 1998 Nov 13;273(46):30406-9.

47.

Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal.

Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K.

J Biol Chem. 1998 Aug 21;273(34):21790-9.

48.

Significance of the enzymatic properties of yeast S39A enolase to the catalytic mechanism.

Brewer JM, Glover CV, Holland MJ, Lebioda L.

Biochim Biophys Acta. 1998 Apr 2;1383(2):351-5.

PMID:
9602170
49.

Mechanism of enolase: the crystal structure of asymmetric dimer enolase-2-phospho-D-glycerate/enolase-phosphoenolpyruvate at 2.0 A resolution.

Zhang E, Brewer JM, Minor W, Carreira LA, Lebioda L.

Biochemistry. 1997 Oct 14;36(41):12526-34.

PMID:
9376357
50.

Effect of site-directed mutagenesis of His373 of yeast enolase on some of its physical and enzymatic properties.

Brewer JM, Glover CV, Holland MJ, Lebioda L.

Biochim Biophys Acta. 1997 Jun 20;1340(1):88-96.

PMID:
9217018

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